Page last updated: 2024-11-05

urethane and Disease Models, Animal

urethane has been researched along with Disease Models, Animal in 82 studies

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
" Animals, under urethane anesthesia, were exposed to high ambient temperature of 42 degrees C until mean arterial pressure and local cerebral blood flow in the striatum began to decrease, which was arbitrarily defined as the onset of heatstroke."7.73Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005)
"The severity and incidences of arrhythmias induced by left coronary artery occlusion (7 min) and reperfusion (7 min) were compared in two groups of rats anaesthetized by using urethane (1."7.69Comparison of sodium pentobarbitone and urethane anaesthesia in a rat model of coronary artery occlusion and reperfusion arrhythmias: interaction with L-NAME. ( Guc, MO; Iskit, AB, 1996)
"Topical 2% l- or d-timolol reduced the elevation of intraocular pressure induced by water-loading in conscious rabbits."7.66Effects of l- and d-timolol on cyclic AMP synthesis and intraocular pressure in water-loaded, albino and pigmented rabbits. ( Bartels, SP; Liu, JH; Neufeld, AH, 1983)
"Urethane is a recognized genotoxic carcinogen in fermented foods and beverages."5.43Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016)
"Lung cancer is a common and highly frequent cause of cancer‑associated mortality worldwide."5.43Inflammation has a role in urethane‑induced lung cancer in C57BL/6J mice. ( Chen, T; Lian, X; Lin, X; Lu, L; Wei, S; Xu, C; Zhou, L, 2016)
" We elucidated the relationship between Nrf2 expression levels and whole exon mutation patterns using an ethyl-carbamate (urethane)-induced lung carcinogenesis model employing Nrf2-deficient and Keap1-kd mice, the latter of which express high levels of Nrf2."4.12Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels. ( Arai, Y; Furukawa, E; Hama, N; Kato, M; Moriguchi, T; Ohe, Y; Satoh, H; Shibata, T; Totoki, Y; Urushidate, T; Yamamoto, M, 2022)
" A mouse model of urethane-induced lung adenocarcinoma was used in the study."3.80Fulvestrant-mediated inhibition of estrogen receptor signaling slows lung cancer progression. ( Chen, G; Fu, S; Liao, Y; Liu, Z; Tang, H; Xu, L; Yu, L; Zhang, C; Zhou, S, 2014)
"We retrospectively analyzed data from urethane-anesthetized rats (15) to assess anesthesia requirements immediately after complete thoracic transection of the spinal cord."3.77Spinal cord injury immediately decreases anesthetic requirements in rats. ( Aguilar, J; Calderon-Muñoz, F; Foffani, G; Humanes-Valera, D; Oliviero, A, 2011)
" Pentobarbital had no effect on arrhythmias, whereas thiopental was antiarrhythmic."3.76Comparison of thiopental, urethane, and pentobarbital in the study of experimental cardiology in rats in vivo. ( Bialka, S; Krzeminski, TF; Mitrega, K; Porc, M; Zorniak, M, 2010)
" The mice were subjected to the development of OVA-induced allergic asthma and urethane-induced lung cancer."3.76In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. ( Chen, Y; Ding, Q; Li, Z; Luo, X; Mao, K; Pan, Y; Sun, B; Wang, M; Wang, Z; Zang, YQ, 2010)
" The goal of this work was to monitor quantitatively the development and progression of adenocarcinoma in a time course study of mice treated with the carcinogen urethane using in vivo small-animal magnetic resonance imaging (MRI)."3.74Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging. ( Garbow, JR; Lubet, RA; Wang, M; Wang, Y; You, M, 2008)
" Animals, under urethane anesthesia, were exposed to high ambient temperature of 42 degrees C until mean arterial pressure and local cerebral blood flow in the striatum began to decrease, which was arbitrarily defined as the onset of heatstroke."3.73Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005)
"Urethane anaesthesia strongly reduced the peripheral edema (31+/-5 and 96+/-8% reduction of carrageenan-enhanced paw and ankle diameters, respectively; P<0."3.71Urethane anaesthesia could partly mask antinociceptive effects of non-steroidal anti-inflammatory drugs: a spinal c-Fos protein study. ( Besson, JM; Buritova, J, 2001)
"The severity and incidences of arrhythmias induced by left coronary artery occlusion (7 min) and reperfusion (7 min) were compared in two groups of rats anaesthetized by using urethane (1."3.69Comparison of sodium pentobarbitone and urethane anaesthesia in a rat model of coronary artery occlusion and reperfusion arrhythmias: interaction with L-NAME. ( Guc, MO; Iskit, AB, 1996)
"Acute alveolar injury induced by subcutaneous injection of N-nitroso-N-methylurethane (NNNMU) closely resembles the pathology of human adult respiratory distress syndrome (ARDS)."3.67Hemodynamic alterations in canine acute lung injury induced with N-nitroso-N-methylurethane. ( Mathru, M; Shirakawa, Y; Smith, RA; Venus, B, 1984)
"Topical 2% l- or d-timolol reduced the elevation of intraocular pressure induced by water-loading in conscious rabbits."3.66Effects of l- and d-timolol on cyclic AMP synthesis and intraocular pressure in water-loaded, albino and pigmented rabbits. ( Bartels, SP; Liu, JH; Neufeld, AH, 1983)
"aeruginosa are important pathogens in wound infections, while A."1.46The ability of quaternary ammonium groups attached to a urethane bandage to inhibit bacterial attachment and biofilm formation in a mouse wound model. ( de Souza, A; Hamood, AN; Huynh, E; Liesenfeld, B; Mehta, D; Reid, TW; Schultz, G; Tran, PL; Webster, D, 2017)
"Urethane is a recognized genotoxic carcinogen in fermented foods and beverages."1.43Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016)
"Lung cancer is a common and highly frequent cause of cancer‑associated mortality worldwide."1.43Inflammation has a role in urethane‑induced lung cancer in C57BL/6J mice. ( Chen, T; Lian, X; Lin, X; Lu, L; Wei, S; Xu, C; Zhou, L, 2016)
"During the carcinogenesis phase, no detectable Th1- or Th2-associated cytokine responses were observed, but levels of pro-inflammatory cytokines were increased with distinctive kinetics."1.39Antitumor effects of L-BLP25 antigen-specific tumor immunotherapy in a novel human MUC1 transgenic lung cancer mouse model. ( DeGregorio, MW; Greenberg, BE; Griffey, SM; Gutierrez, AM; Kao, CJ; Vang, DP; Wolf, M; Wurz, GT, 2013)
"Lung cancer is one of the leading causes of cancer-related deaths worldwide, including Japan."1.39SPECT/CT of lung nodules using 111In-DOTA-c(RGDfK) in a mouse lung carcinogenesis model. ( Fujii, H; Hayakawa, T; Imai, T; Mutoh, M; Tsuta, K; Yanaka, A; Yoshimoto, M, 2013)
"Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer."1.38The influence of physical activity in the progression of experimental lung cancer in mice. ( Cal, RN; Cordeiro, JA; Cury, PM; dos Santos, CH; Nagamine, KK; Neiva, CM; Paceli, RB, 2012)
"Urethane-treated animals showed 2."1.37Urban, traffic- related particles and lung tumors in urethane treated mice. ( Assunção, JV; Lemos, M; Mauad, T; Pereira, FA; Saldiva, PH, 2011)
"Urethane is a chemical carcinogen which causes lung tumorigenesis in mice with similarities to human adenocarcinoma (AC)."1.35Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720. ( Bueno, V; Lopes, CT; Oshima, CT; Palma, PV; Salinas, NR, 2009)
"The urethane-treated MAK-4, MAK-5 and MAK4+5-fed mice had significantly higher activities of liver cytosolic enzymes compared to the urethane-treated controls and to untreated mice: GPX(0."1.34MAK-4 and -5 supplemented diet inhibits liver carcinogenesis in mice. ( Di Lorenzo, D; Hsiao, WL; Jeremic, M; Marra, M; Mazzoleni, G; Montani, C; Penza, M; Sharma, H, 2007)
"Bexarotene (Targretin), is a synthetic high-affinity RXR receptor agonist with limited affinity for RAR receptors."1.33Prevention of lung cancer progression by bexarotene in mouse models. ( Jia, D; Lubet, RA; Wang, D; Wang, Y; Yao, R; You, M; Zhang, Z, 2006)
"Urethane/chloralose-treated mice demonstrated hypoglycaemia and enhanced serum levels of ALT and creatinine in response to LPS, but failed to show LPS-induced increases in serum lipase and lung MPO activity."1.33Comparison of urethane/chloralose and pentobarbitone anaesthesia for examining effects of bacterial lipopolysaccharide in mice. ( Furman, BL; Kazerani, HR, 2006)
" Ten weekly ethyl carbamate (EC) doses caused a nearly 100% lung tumor incidence with a tumor multiplicity >2; multiple EC dosing is thus an alternative to the time-consuming transfer of transgenes and null mutations to susceptible backgrounds."1.32Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injections. ( Dwyer-Nield, LD; Franklin, WA; Keith, RL; Le, M; Malkinson, AM; Miller, YE, 2003)
"There was a higher risk of aneuploidy in the 6-months-of-air-pollution-exposure group (relative risk: 1."1.31Urban levels of air pollution modifies the progression of urethane-induced lung tumours in mice. ( Capelozzi, VL; Conceição, GM; Cury, PM; Lichtenfels, AJ; Reymão, MS; Saldiva, PH, 2000)
"coli bacteremia was studied in rats and compared to the effect of two other anesthetic procedures in previously published studies."1.30E. Coli bacteremia-induced changes in the skeletal muscle microcirculation vary with anesthetics. ( Garrison, RN; Harris, PD; Lüebbe, AS, 1998)
"All types of ductal hyperplasias are characterized by intraductal epithelial hyperplasia and have been shown to give rise to mammal adenocarcinomas in situ or by transplantation into the mammary gland-free fat pads of syngeneic mice."1.26Preneoplastic lesions in murine mammary cancer. ( Medina, D, 1976)

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-199012 (14.63)18.7374
1990's9 (10.98)18.2507
2000's30 (36.59)29.6817
2010's26 (31.71)24.3611
2020's5 (6.10)2.80

Authors

AuthorsStudies
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
Eastman, RT1
Malik, N1
Zakharov, AV1
Li, W1
Bachani, M1
Brimacombe, K1
Steiner, JP1
Hall, MD1
Balasubramanian, A1
Jadhav, A1
Padmanabhan, R1
Simeonov, A1
Nath, A1
Satoh, H1
Arai, Y1
Furukawa, E1
Moriguchi, T1
Hama, N1
Urushidate, T1
Totoki, Y1
Kato, M1
Ohe, Y1
Yamamoto, M1
Shibata, T1
Dwyer-Nield, L1
Keith, RL2
Tennis, MA1
Rojas, A1
Wang, J1
Glover, A1
Dingledine, R1
Radwan, E1
Ali, M1
Faied, SMA1
Omar, HM1
Mohamed, WS1
Abd-Elghaffar, SK1
Sayed, AA1
Champeris Tsaniras, S2
Villiou, M1
Giannou, AD2
Nikou, S1
Petropoulos, M1
Pateras, IS1
Tserou, P1
Karousi, F1
Lalioti, ME1
Gorgoulis, VG1
Patmanidi, AL1
Stathopoulos, GT3
Bravou, V1
Lygerou, Z1
Taraviras, S2
Kanellakis, NI1
Pepe, MAA1
Agalioti, T1
Zazara, DE1
Giopanou, I1
Psallidas, I1
Spella, M1
Marazioti, A1
Arendt, KAM1
Lamort, AS1
Papadaki, H1
Lilis, I1
Reynolds, CA1
O'Leary, DS1
Ly, C1
Smith, SA1
Minic, Z1
Sato, A1
Yamada, N1
Ogawa, Y1
Ikegami, M1
Wurz, GT1
Gutierrez, AM1
Greenberg, BE1
Vang, DP1
Griffey, SM1
Kao, CJ1
Wolf, M1
DeGregorio, MW1
Hayakawa, T1
Mutoh, M2
Imai, T1
Tsuta, K1
Yanaka, A1
Fujii, H1
Yoshimoto, M1
Bencze, M1
Behuliak, M1
Zicha, J1
Chee, SS1
Menard, JL1
Dringenberg, HC1
Naggar, I1
Nakase, K1
Lazar, J1
Salciccioli, L1
Selesnick, I1
Stewart, M2
Tang, H1
Liao, Y1
Zhang, C1
Chen, G1
Xu, L1
Liu, Z1
Fu, S1
Yu, L1
Zhou, S1
Ma, X2
Deng, J1
Cao, N2
Guo, Z2
Zheng, Y2
Geng, S2
Meng, M2
Lin, H1
Duan, Y2
Du, G2
Tran, PL1
Huynh, E1
Hamood, AN1
de Souza, A1
Schultz, G1
Liesenfeld, B1
Mehta, D1
Webster, D1
Reid, TW1
Honda, M1
Hikita, K1
Kawamoto, B1
Muraoka, K1
Shimizu, S1
Saito, M1
Sejima, T1
Chancellor, MB1
Yoshimura, N1
Takenaka, A1
Du, Z1
Li, J1
Xu, C1
Zhou, L1
Lu, L1
Chen, T1
Wei, S1
Lin, X1
Lian, X1
Kozuka, Y1
Kawamata, M1
Furue, H1
Ishida, T1
Tanaka, S1
Namiki, A1
Yamakage, M1
Hori, Y1
Takasuka, N1
Kitahashi, T1
Kojima, S1
Imaida, K1
Suzuki, M1
Kohara, K1
Yamamoto, S1
Moriyama, N1
Sugimura, T1
Wakabayashi, K1
To, MD1
Wong, CE1
Karnezis, AN1
Del Rosario, R1
Di Lauro, R1
Balmain, A1
Manenti, G1
Galvan, A2
Pettinicchio, A1
Trincucci, G1
Spada, E2
Zolin, A1
Milani, S2
Gonzalez-Neira, A1
Dragani, TA3
Salinas, NR1
Lopes, CT1
Palma, PV1
Oshima, CT1
Bueno, V2
Kelly-Spratt, KS1
Philipp-Staheli, J1
Gurley, KE1
Hoon-Kim, K1
Knoblaugh, S1
Kemp, CJ1
Herzog, CR1
Blake, DC1
Mikse, OR1
Grigoryeva, LS1
Gundermann, EL1
Franco, MD1
Colombo, F1
Cecco, LD1
Ibanez, OM1
Zorniak, M1
Mitrega, K1
Bialka, S1
Porc, M1
Krzeminski, TF1
Luo, X1
Ding, Q1
Wang, M2
Li, Z1
Mao, K1
Sun, B1
Pan, Y1
Wang, Z1
Zang, YQ1
Chen, Y1
Parra, ER1
Bielecki, LC1
Ribeiro, JM1
Andrade Balsalobre, Fd1
Teodoro, WR1
Capelozzi, VL2
Doris, K1
Karabela, SP1
Kairi, CA1
Simoes, DC1
Roussos, C1
Zakynthinos, SG1
Kalomenidis, I1
Blackwell, TS1
Foffani, G1
Humanes-Valera, D1
Calderon-Muñoz, F1
Oliviero, A1
Aguilar, J1
Pereira, FA1
Lemos, M1
Mauad, T1
Assunção, JV1
Saldiva, PH2
Paceli, RB1
Cal, RN1
dos Santos, CH1
Cordeiro, JA2
Neiva, CM1
Nagamine, KK1
Cury, PM3
Liu, X1
Lin, T1
Gao, Y1
Xu, Z1
Huang, C1
Yao, G1
Jiang, L1
Tang, Y1
Wang, X1
Lee, NJ1
Choi, DY1
Song, JK1
Jung, YY1
Kim, DH1
Kim, TM1
Kim, DJ1
Kwon, SM1
Kim, KB1
Choi, KE1
Moon, DC1
Kim, Y1
Han, SB1
Hong, JT1
Jackson, RJ1
Adnane, J1
Coppola, D1
Cantor, A1
Sebti, SM1
Pledger, WJ1
Miller, YE1
Dwyer-Nield, LD3
Le, M1
Franklin, WA1
Malkinson, AM3
Premkumar, K1
Abraham, SK1
Santhiya, ST1
Ramesh, A1
Golder, FJ1
Davenport, PW1
Johnson, RD1
Reier, PJ1
Bolser, DC1
Stinn, W1
Teredesai, A1
Kuhl, P1
Knörr-Wittmann, C1
Kindt, R1
Coggins, C1
Haussmann, HJ1
Ozaki, M1
Ozaki, K1
Watanabe, T1
Uwagawa, S1
Okuno, Y1
Shirai, T1
Jokinen, MP1
Lieuallen, WG1
Johnson, CL1
Dunnick, J1
Nyska, A1
Chang, CP1
Chen, SH1
Lin, MT1
Wang, Y3
Zhang, Z2
Lubet, RA5
You, M3
Yao, R1
Jia, D1
Wang, D1
Saito, T1
Sakamoto, K1
Koizumi, K1
Singh, RP1
Deep, G1
Chittezhath, M1
Kaur, M1
Agarwal, R1
Kazerani, HR1
Furman, BL1
Alyaqoub, FS1
Tao, L1
Kramer, PM2
Steele, VE2
Gunning, WT2
Pereira, MA2
Penza, M1
Montani, C1
Jeremic, M1
Mazzoleni, G1
Hsiao, WL1
Marra, M1
Sharma, H1
Di Lorenzo, D1
Garbow, JR1
Lucas da Silva, LB1
Ribeiro, DA1
Field, JR1
Gunatillake, P1
Adhikari, R1
Ramshaw, JA1
Werkmeister, JA1
Liu, JH1
Bartels, SP1
Neufeld, AH1
Sozzi, G1
Della Porta, G1
Smith, RA1
Venus, B1
Mathru, M1
Shirakawa, Y1
Woodside, B1
Robinson, B1
Amir, S1
Kawano, R1
Nishisaka, T1
Takeshima, Y1
Yonehara, S1
Inai, K1
Renis, M1
Di Giacomo, C1
Sorrenti, V1
Russo, A1
La Delfa, C1
Reale, S1
Barcellona, ML1
Vanella, A1
Iskit, AB1
Guc, MO1
Yano, T1
Uchida, M1
Yuasa, M1
Murakami, A1
Hagiwara, K1
Ichikawa, T1
Yakovlev, AY1
Pavlova, LV1
Lüebbe, AS1
Harris, PD1
Garrison, RN1
Imianitov, EN1
Togo, AV1
Anisimov, VN1
Lichtenfels, AJ1
Reymão, MS1
Conceição, GM1
Buritova, J1
Besson, JM1
Thompson, JA1
Carlson, TJ1
Sun, Y1
Piegari, M1
Salvador, AF1
Muñoz, SE1
Valentich, MA1
Eynard, AR1
Koujitani, T1
Yasuhara, K1
Tamura, T1
Onodera, H1
Takagi, H1
Takizawa, T1
Hirose, M1
Hayashi, Y1
Mitsumori, K1
Medina, D1
Ryan, SF2
Bell, AL1
Barrett, CR1
Holder, DS1
Blakley, BR1
Small, PM1
Täuber, MG1
Hackbarth, CJ1
Sande, MA1
Bellhorn, RW1
Bellhorn, M1
Friedman, AH1
Henkind, P1
Denys, A1
Machlanński, T1
Arnold, Z1
Schlom, J1
Michalides, R1
Kufe, D1
Hehlmann, R1
Spiegelman, S1
Bentvelzen, P1
Hageman, P1
Stelzner, M1
Helmstedt, C1
Junghänel, S1
Görisch, V1

Other Studies

82 other studies available for urethane and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels.
    Carcinogenesis, 2022, 08-30, Volume: 43, Issue:7

    Topics: Animals; Carcinogenesis; Disease Models, Animal; Genomics; Humans; Kelch-Like ECH-Associated Protein

2022
Protocol for intranasal chemoprevention delivery in a urethane mouse lung cancer model.
    STAR protocols, 2022, 12-16, Volume: 3, Issue:4

    Topics: Animals; Carcinogens; Chemoprevention; Disease Models, Animal; Enzyme Inhibitors; Iloprost; Lung Neo

2022
Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
    Neurobiology of disease, 2020, Volume: 140

    Topics: Acetylcholinesterase; Animals; Brain Injuries; Diazepam; Disease Models, Animal; Electroencephalogra

2020
Novel therapeutic regimens for urethane-induced early lung cancer in rats: Combined cisplatin nanoparticles with vitamin-D
    IUBMB life, 2021, Volume: 73, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogens; Cholecalciferol; Cisplatin; Disease Models,

2021
Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.
    The Journal of pathology, 2018, Volume: 246, Issue:2

    Topics: Adenoma; Animals; Ataxia Telangiectasia Mutated Proteins; Azoxymethane; Carcinoma; Colonic Neoplasms

2018
Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter.
    Carcinogenesis, 2019, Nov-25, Volume: 40, Issue:11

    Topics: Adenocarcinoma of Lung; Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Diethylnitrosamine;

2019
Development of a decerebrate model for investigating mechanisms mediating viscero-sympathetic reflexes in the spinalized rat.
    American journal of physiology. Heart and circulatory physiology, 2019, 06-01, Volume: 316, Issue:6

    Topics: Anesthetics, Intravenous; Animals; Autonomic Dysreflexia; Chloralose; Decerebrate State; Disease Mod

2019
CCAAT/enhancer-binding protein-α suppresses lung tumor development in mice through the p38α MAP kinase pathway.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Animals; CCAAT-Enhancer-Binding Protein-alpha; Cell Death; Cell Proliferation; Disease Models, Anima

2013
Antitumor effects of L-BLP25 antigen-specific tumor immunotherapy in a novel human MUC1 transgenic lung cancer mouse model.
    Journal of translational medicine, 2013, Mar-13, Volume: 11

    Topics: Adenoma; Animals; Antigens, Neoplasm; Cancer Vaccines; Carcinogenesis; Cyclophosphamide; Cytokines;

2013
SPECT/CT of lung nodules using 111In-DOTA-c(RGDfK) in a mouse lung carcinogenesis model.
    Annals of nuclear medicine, 2013, Volume: 27, Issue:7

    Topics: Animals; Autoradiography; Cell Line, Tumor; Disease Models, Animal; Epithelial Cells; Gene Expressio

2013
The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats.
    Physiological research, 2013, Volume: 62, Issue:5

    Topics: Anesthetics; Anesthetics, Combined; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressur

2013
Behavioral anxiolysis without reduction of hippocampal theta frequency after histamine application in the lateral septum of rats.
    Hippocampus, 2014, Volume: 24, Issue:6

    Topics: Anesthetics, Intravenous; Animals; Anti-Anxiety Agents; Anxiety Disorders; Buspirone; Disease Models

2014
Vagal control of cardiac electrical activity and wall motion during ventricular fibrillation in large animals.
    Autonomic neuroscience : basic & clinical, 2014, Volume: 183

    Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Coronary Vessels; Disease Models, Animal; Echocar

2014
Fulvestrant-mediated inhibition of estrogen receptor signaling slows lung cancer progression.
    Oncology research, 2014, Volume: 22, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Animals; Antineoplastic Agents, Hormonal; Carcinogenesis; Disease Model

2014
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
    Toxicology letters, 2016, Jan-05, Volume: 240, Issue:1

    Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas

2016
The ability of quaternary ammonium groups attached to a urethane bandage to inhibit bacterial attachment and biofilm formation in a mouse wound model.
    International wound journal, 2017, Volume: 14, Issue:1

    Topics: Animals; Bacterial Infections; Biofilms; Dimethylamines; Disease Models, Animal; Mice; Occlusive Dre

2017
Spinal glycine transporter-1 inhibition influences the micturition reflex in urethane-anesthetized rats.
    International urology and nephrology, 2016, Volume: 48, Issue:3

    Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Female; Glycine Plasma Membrane Transport

2016
Gingerol Reverses the Cancer-Promoting Effect of Capsaicin by Increased TRPV1 Level in a Urethane-Induced Lung Carcinogenic Model.
    Journal of agricultural and food chemistry, 2016, Aug-10, Volume: 64, Issue:31

    Topics: Animals; Capsaicin; Carcinogenesis; Catechols; Disease Models, Animal; ErbB Receptors; Fatty Alcohol

2016
Inflammation has a role in urethane‑induced lung cancer in C57BL/6J mice.
    Molecular medicine reports, 2016, Volume: 14, Issue:4

    Topics: Animals; Body Weight; Bronchoalveolar Lavage Fluid; Carcinogens; Disease Models, Animal; Humans; Inf

2016
Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording.
    Molecular pain, 2016, Volume: 12

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Functi

2016
Periodic analysis of urethane-induced pulmonary tumors in living A/J mice by respiration-gated X-ray microcomputed tomography.
    Cancer science, 2008, Volume: 99, Issue:9

    Topics: Animals; Carcinogens; Disease Models, Animal; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Resp

2008
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.
    Nature genetics, 2008, Volume: 40, Issue:10

    Topics: Animals; Carcinogens; Disease Models, Animal; Exons; Genes, ras; Humans; Lung; Lung Neoplasms; Mice;

2008
Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci.
    PLoS genetics, 2009, Volume: 5, Issue:1

    Topics: Animals; Carcinogens; Chromosome Mapping; Disease Models, Animal; Female; Gene Expression Regulation

2009
Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720.
    Pathology oncology research : POR, 2009, Volume: 15, Issue:4

    Topics: Adenoma; Animals; Apoptosis; Caspase 3; Cell Proliferation; Disease Models, Animal; Dose-Response Re

2009
Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.
    Oncogene, 2009, Oct-15, Volume: 28, Issue:41

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Nucleus; Chromones; Cyclin-Dependent Kinase Inhibitor

2009
FoxO3a gene is a target of deletion in mouse lung adenocarcinoma.
    Oncology reports, 2009, Volume: 22, Issue:4

    Topics: Adenocarcinoma; Aflatoxin B1; Animals; Carcinogens; Disease Models, Animal; Forkhead Box Protein O3;

2009
Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis.
    Cancer letters, 2010, Aug-28, Volume: 294, Issue:2

    Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Gene Expression; Gene Expr

2010
Comparison of thiopental, urethane, and pentobarbital in the study of experimental cardiology in rats in vivo.
    Journal of cardiovascular pharmacology, 2010, Volume: 56, Issue:1

    Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Arrhythmias, Cardiac; Blood Pressure; Dise

2010
In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse.
    PloS one, 2010, Apr-13, Volume: 5, Issue:4

    Topics: Animals; Asthma; Cytokines; Disease Models, Animal; Genetic Therapy; Inflammation; Lung Neoplasms; M

2010
Association between decreases in type V collagen and apoptosis in mouse lung chemical carcinogenesis: a preliminary model to study cancer cell behavior.
    Clinics (Sao Paulo, Brazil), 2010, Volume: 65, Issue:4

    Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinogens; Caspase 9; Collagen Type V; Disease Models, Anim

2010
Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice.
    Respiratory research, 2010, Aug-26, Volume: 11

    Topics: Animals; Bronchoalveolar Lavage Fluid; Carcinogenicity Tests; Disease Models, Animal; Lung; Lung Neo

2010
Spinal cord injury immediately decreases anesthetic requirements in rats.
    Spinal cord, 2011, Volume: 49, Issue:7

    Topics: Anesthesia; Anesthetics, Intravenous; Animals; Disease Models, Animal; Male; Pain; Pain Threshold; R

2011
Urban, traffic- related particles and lung tumors in urethane treated mice.
    Clinics (Sao Paulo, Brazil), 2011, Volume: 66, Issue:6

    Topics: Air Pollutants; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Envir

2011
The influence of physical activity in the progression of experimental lung cancer in mice.
    Pathology, research and practice, 2012, Jul-15, Volume: 208, Issue:7

    Topics: Animals; Carcinogens; Disease Models, Animal; Disease Progression; Hyperplasia; Lung Neoplasms; Male

2012
Antimicrobial electrospun nanofibers of cellulose acetate and polyester urethane composite for wound dressing.
    Journal of biomedical materials research. Part B, Applied biomaterials, 2012, Volume: 100, Issue:6

    Topics: Animals; Anti-Infective Agents; Bandages; Cellulose; Disease Models, Animal; Escherichia coli; Membr

2012
Deficiency of C-C chemokine receptor 5 suppresses tumor development via inactivation of NF-κB and inhibition of monocyte chemoattractant protein-1 in urethane-induced lung tumor model.
    Carcinogenesis, 2012, Volume: 33, Issue:12

    Topics: Animals; Apoptosis; CCR5 Receptor Antagonists; CD8-Positive T-Lymphocytes; Chemokine CCL2; Dendritic

2012
Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models.
    Oncogene, 2002, Dec-05, Volume: 21, Issue:55

    Topics: Animals; Cell Cycle Proteins; Cell Transformation, Neoplastic; Crosses, Genetic; Cyclin-Dependent Ki

2002
Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injections.
    Cancer letters, 2003, Aug-20, Volume: 198, Issue:2

    Topics: Adenocarcinoma; Animals; Butylated Hydroxytoluene; Carcinogens; Disease Models, Animal; Incidence; L

2003
Inhibitory effects of aqueous crude extract of Saffron (Crocus sativus L.) on chemical-induced genotoxicity in mice.
    Asia Pacific journal of clinical nutrition, 2003, Volume: 12, Issue:4

    Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Chromosome Disorders; Cisplatin; Complex Mixtures

2003
Augmented breath phase volume and timing relationships in the anesthetized rat.
    Neuroscience letters, 2005, Jan-10, Volume: 373, Issue:2

    Topics: Anesthesia, General; Anesthetics, Intravenous; Animals; Disease Models, Animal; Female; Phrenic Nerv

2005
Mechanisms involved in A/J mouse lung tumorigenesis induced by inhalation of an environmental tobacco smoke surrogate.
    Inhalation toxicology, 2005, Volume: 17, Issue:6

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Body Weight; Bronchoalveolar Lavage Fluid; Carboxyhemo

2005
Susceptibilities of p53 knockout and rasH2 transgenic mice to urethane-induced lung carcinogenesis are inherited from their original strains.
    Toxicologic pathology, 2005, Volume: 33, Issue:2

    Topics: Adenocarcinoma; Adenoma; Animals; Body Weight; Disease Models, Animal; Genes, p53; Genes, ras; Genet

2005
Characterization of spontaneous and chemically induced cardiac lesions in rodent model systems: the national toxicology program experience.
    Cardiovascular toxicology, 2005, Volume: 5, Issue:2

    Topics: Acetates; Animals; Databases, Factual; Disease Models, Animal; Environmental Pollutants; Ethanolamin

2005
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
    Shock (Augusta, Ga.), 2005, Volume: 24, Issue:4

    Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid;

2005
A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice.
    Oncogene, 2006, Feb-23, Volume: 25, Issue:8

    Topics: Adenocarcinoma; Animals; Cocarcinogenesis; Disease Models, Animal; Disease Progression; Genes, ras;

2006
Prevention of lung cancer progression by bexarotene in mouse models.
    Oncogene, 2006, Mar-02, Volume: 25, Issue:9

    Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Bexarotene; Carcinogens; Carcinoma, Non-S

2006
Repeatable focal seizure suppression: a rat preparation to study consequences of seizure activity based on urethane anesthesia and reversible carotid artery occlusion.
    Journal of neuroscience methods, 2006, Sep-15, Volume: 155, Issue:2

    Topics: Anesthetics, Intravenous; Animals; Arterial Occlusive Diseases; Blood Pressure; Carotid Artery Disea

2006
Effect of silibinin on the growth and progression of primary lung tumors in mice.
    Journal of the National Cancer Institute, 2006, Jun-21, Volume: 98, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell P

2006
Comparison of urethane/chloralose and pentobarbitone anaesthesia for examining effects of bacterial lipopolysaccharide in mice.
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:4

    Topics: Alanine Transaminase; Anesthetics, Combined; Anesthetics, General; Animals; Blood Glucose; Chloralos

2006
Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra MT).
    Carcinogenesis, 2007, Volume: 28, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Budesonide; Chemoprevention; Disease Models, Animal; DNA Methylat

2007
MAK-4 and -5 supplemented diet inhibits liver carcinogenesis in mice.
    BMC complementary and alternative medicine, 2007, Jun-08, Volume: 7

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Disease Models, Animal; Gluta

2007
Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Mar-01, Volume: 14, Issue:5

    Topics: Adenocarcinoma; Animals; Carcinogens; Disease Models, Animal; Image Interpretation, Computer-Assiste

2008
FTY720 treatment in experimentally urethane-induced lung tumors.
    Journal of experimental therapeutics & oncology, 2008, Volume: 7, Issue:1

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Anticarcinogenic Agents; Carcinogens; Disease Models,

2008
Use of biodegradable urethane-based adhesives to appose meniscal defect edges in an ovine model: a preliminary study.
    Australian veterinary journal, 2008, Volume: 86, Issue:6

    Topics: Adhesives; Animals; Disease Models, Animal; Menisci, Tibial; Sheep; Tibial Meniscus Injuries; Treatm

2008
Effects of l- and d-timolol on cyclic AMP synthesis and intraocular pressure in water-loaded, albino and pigmented rabbits.
    Investigative ophthalmology & visual science, 1983, Volume: 24, Issue:9

    Topics: Animals; Cyclic AMP; Disease Models, Animal; Hemodynamics; Intraocular Pressure; Propanolamines; Rab

1983
Spontaneous and urethan-induced tumor incidence in B6C3F1 versus B6CF1 mice.
    Tumori, 1984, Dec-31, Volume: 70, Issue:6

    Topics: Animals; Disease Models, Animal; Female; Hybridization, Genetic; Liver Neoplasms, Experimental; Lung

1984
Hemodynamic alterations in canine acute lung injury induced with N-nitroso-N-methylurethane.
    Critical care medicine, 1984, Volume: 12, Issue:7

    Topics: Animals; Disease Models, Animal; Dogs; Heart; Hemodynamics; Nitrosomethylurethane; Oxygen; Respirati

1984
Induction of Fos protein in a model of closed head injury in rats.
    Brain research, 1995, Aug-28, Volume: 690, Issue:1

    Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Female; Head Injuries, Closed; Immunohistochem

1995
Role of point mutation of the K-ras gene in tumorigenesis of B6C3F1 mouse lung lesions induced by urethane.
    Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:9

    Topics: Adenocarcinoma; Adenoma; Animals; Base Sequence; Disease Models, Animal; Dose-Response Relationship,

1995
Heat shock proteins following rat cerebral ischemic/reperfusion episode: effect of ketamine.
    Biochemistry and molecular biology international, 1994, Volume: 33, Issue:2

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Hippocampus; HSP70 Heat-Shock Prot

1994
Comparison of sodium pentobarbitone and urethane anaesthesia in a rat model of coronary artery occlusion and reperfusion arrhythmias: interaction with L-NAME.
    Pharmacological research, 1996, Volume: 33, Issue:1

    Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Arrhythmias, Cardiac; Arterial Occlusive D

1996
The inhibitory effect of vitamin E on K-ras mutation at an early stage of lung carcinogenesis in mice.
    European journal of pharmacology, 1997, Mar-26, Volume: 323, Issue:1

    Topics: Animals; Blotting, Southern; Cell Division; Disease Models, Animal; Genes, ras; Lung; Lung Neoplasms

1997
Mechanistic modeling of multiple tumorigenesis: an application to data on lung tumors in mice exposed to urethane.
    Annals of the New York Academy of Sciences, 1997, Dec-26, Volume: 837

    Topics: Adenoma; Animals; Disease Models, Animal; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimen

1997
E. Coli bacteremia-induced changes in the skeletal muscle microcirculation vary with anesthetics.
    Croatian medical journal, 1998, Volume: 39, Issue:4

    Topics: Anesthetics; Animals; Bacteremia; Chloralose; Decerebrate State; Disease Models, Animal; Escherichia

1998
[Search for Ki-ras codon 61 mutations in lung adenomas induced in neonatal BALB/c mice with 5-bromodesoxyuridine injection followed by urethane treatment].
    Voprosy onkologii, 1999, Volume: 45, Issue:5

    Topics: Animals; Animals, Newborn; Bromodeoxyuridine; Codon; Disease Models, Animal; DNA, Neoplasm; Female;

1999
Urban levels of air pollution modifies the progression of urethane-induced lung tumours in mice.
    Pathology, research and practice, 2000, Volume: 196, Issue:9

    Topics: Adenoma; Air Pollutants; Air Pollution; Aneuploidy; Animals; Animals, Newborn; Brazil; Carcinogens;

2000
Urethane anaesthesia could partly mask antinociceptive effects of non-steroidal anti-inflammatory drugs: a spinal c-Fos protein study.
    Brain research, 2001, Feb-09, Volume: 891, Issue:1-2

    Topics: Anesthetics, Intravenous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Count;

2001
Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice.
    Experimental lung research, 2000, Volume: 26, Issue:8

    Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Dexamethaso

2000
Studies using structural analogs and inbred strain differences to support a role for quinone methide metabolites of butylated hydroxytoluene (BHT) in mouse lung tumor promotion.
    Toxicology, 2001, Mar-07, Volume: 160, Issue:1-3

    Topics: Animals; Butylated Hydroxytoluene; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Femal

2001
Delayed-type hypersensitivity and humoral immunity modulation by dietary lipids in a murine model of pulmonary tumorigenesis induced by urethan.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2001, Volume: 53, Issue:2-3

    Topics: Adenocarcinoma; Animals; Antibody Formation; Carcinogens; Dietary Fats, Unsaturated; Disease Models,

2001
Lack of modifying effects of eugenol on development of lung proliferative lesions induced by urethane in transgenic mice carrying the human prototype c-Ha-ras gene.
    The Journal of toxicological sciences, 2001, Volume: 26, Issue:3

    Topics: Adenoma; Animals; Bronchi; Carcinogenicity Tests; Carcinogens; Carcinoma; Cocarcinogenesis; Disease

2001
Preneoplastic lesions in murine mammary cancer.
    Cancer research, 1976, Volume: 36, Issue:7 PT 2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Models, Animal; Female; Hyperplasia; Mammary Neop

1976
Experimental acute alveolar injury in the dog. Morphologic--mechanical correlations.
    The American journal of pathology, 1976, Volume: 82, Issue:2

    Topics: Acute Disease; Animals; Disease Models, Animal; Dogs; Epithelium; Lung Compliance; Male; Microscopy,

1976
Effects of urethane, alphaxolone/alphadolone, or halothane with or without neuromuscular blockade on survival during repeated episodes of global cerebral ischaemia in the rat.
    Laboratory animals, 1992, Volume: 26, Issue:2

    Topics: Anesthetics; Animals; Arterial Occlusive Diseases; Brain Ischemia; Carotid Artery Diseases; Disease

1992
The effect of arsenic on urethan-induced adenoma formation in Swiss mice.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 1987, Volume: 51, Issue:2

    Topics: Adenoma; Animals; Arsenates; Arsenic; Arsenites; Body Weight; Disease Models, Animal; Drinking; Fema

1987
Influence of body temperature on bacterial growth rates in experimental pneumococcal meningitis in rabbits.
    Infection and immunity, 1986, Volume: 52, Issue:2

    Topics: Animals; Body Temperature; Disease Models, Animal; Fever; Meningitis, Pneumococcal; Pentobarbital; R

1986
Urethan-induced retinopathy in pigmented rats.
    Investigative ophthalmology, 1973, Volume: 12, Issue:1

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Epithelium; Fluorescein Angiography; Fundus Oculi

1973
Association between chemical structure and antiviral activity of biguanide, sulfonylurethane, and sulfonamide derivatives.
    Acta microbiologica Polonica. Series A: Microbiologia generalis, 1973, Volume: 5, Issue:3

    Topics: Animals; Antiviral Agents; Biguanides; Disease Models, Animal; Evaluation Studies as Topic; Mice; Mi

1973
A comparative study of the biologic and molecular basis of murine mammary carcinoma: a model for human breast cancer.
    Journal of the National Cancer Institute, 1973, Volume: 51, Issue:2

    Topics: Aging; Animals; Disease Models, Animal; DNA, Neoplasm; Epididymis; Female; Kidney; Male; Mammary Gla

1973
Experimental fibrosing alveolitis.
    The American review of respiratory disease, 1972, Volume: 105, Issue:5

    Topics: Animals; Cricetinae; Disease Models, Animal; Injections, Subcutaneous; Methylation; Microscopy, Elec

1972
[Studies on the ammonium chloride induced pulmonary edema of the rat. I. Influence of narcosis on ammonium chloride induced pulmonary edema].
    Acta biologica et medica Germanica, 1971, Volume: 26, Issue:4

    Topics: Ammonium Chloride; Anesthesia; Anesthetics; Animals; Barbiturates; Disease Models, Animal; Electroen

1971