urethane has been researched along with Cell Transformation, Neoplastic in 83 studies
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Urethane, a specific lung tumor carcinogen, can induce adenomas in mice." | 7.73 | Altered expression of connexins in urethane-induced mouse lung adenomas. ( Avanzo, JL; da Silva, TC; Dagli, ML; Fukumasu, H; Hernandez-Blazquez, FJ; Mesnil, M; Mori, CM; Yamasaki, H, 2006) |
| "The number of papillomas that develop in mice initiated with a single exposure to urethane and promoted by repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) is increased greater than 4-fold by pretreating the skin once with TPA 24 hr before administration of urethane." | 7.68 | Activation of the rasHa gene in urethane-initiated papillomas induced by protocols with high and low frequencies of malignant conversion. ( Greenhalgh, DG; Hennings, H; Robinson, VA; Welty, DJ; Yuspa, SH, 1991) |
| " In conclusion, AKT1E17K induces hyperplasia of mouse lung epithelium in vivo and cooperates with urethane to induce the fully malignant phenotype." | 3.83 | AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer. ( Belmonte, S; Camastra, C; Colelli, F; De Marco, C; Fagman, H; Gagliardi, M; Malanga, D; Mignogna, C; Mirante, T; Oliveira, DM; Paciello, O; Papparella, S; Rizzuto, A; Scarfò, M; Viglietto, G, 2016) |
| " We show herein that resistant C57BL/6J (B6) and intermediately resistant BALB/cByJ (BALB) mice form very few urethane-induced early microadenomas (i." | 3.73 | Quantitative analysis of early chemically-induced pulmonary lesions in mice of varying susceptibilities to lung tumorigenesis. ( Dwyer-Nield, LD; Kisley, LR; Malkinson, AM; O'Donnell, EP; Zerbe, LK, 2006) |
| " Urethane, a specific lung tumor carcinogen, can induce adenomas in mice." | 3.73 | Altered expression of connexins in urethane-induced mouse lung adenomas. ( Avanzo, JL; da Silva, TC; Dagli, ML; Fukumasu, H; Hernandez-Blazquez, FJ; Mesnil, M; Mori, CM; Yamasaki, H, 2006) |
| "The number of papillomas that develop in mice initiated with a single exposure to urethane and promoted by repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) is increased greater than 4-fold by pretreating the skin once with TPA 24 hr before administration of urethane." | 3.68 | Activation of the rasHa gene in urethane-initiated papillomas induced by protocols with high and low frequencies of malignant conversion. ( Greenhalgh, DG; Hennings, H; Robinson, VA; Welty, DJ; Yuspa, SH, 1991) |
| "Mouse skin tumors, benign papillomas, and squamous cell carcinomas (SCCs) were initiated by a single topical application of urethane followed by repeated promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA)." | 3.67 | Activation of the cellular Harvey ras gene in mouse skin tumors initiated with urethane. ( Bonham, K; Bowden, GT; Cress, AE; Embry, T; Gibson, D; Jaffe, DR; Roberts, RA, 1989) |
| "After exposure to the mutagen, ethylmethanesulfonate (EMS), or the carcinogen, urethane (UR), anchorage independence was observed in cultures derived from normal skin biopsies from patients with the heritable cancer syndrome, adenomatosis of the colon and rectum (ACR)." | 3.66 | Heritable colonic cancer syndromes: induction of anchorage-independence in dermal cultures derived from patients with adenomatosis of the colon and rectum. ( Danes, BS, 1980) |
| "Thus, the tumor growth and metastasis were compared in WT and ApoE knockout (KO) mice." | 1.51 | Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity. ( Han, SB; Hong, JT; Kim, KC; Lee, YS; Yeo, IJ, 2019) |
| "Lung cancer is a deadly disease with increasing cases diagnosed worldwide and still a very poor prognosis." | 1.46 | Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation. ( Enguita, AB; Hernández, P; Lázaro, S; Martínez-Palacio, J; Oteo, M; Paramio, JM; Pérez-Crespo, M; Sage, J; Santos, M, 2017) |
| "LPS-induced pulmonary inflammation did not increase lung carcinogenesis, whereas decreased pulmonary inflammation by macrophage depletion promoted lung carcinogenesis." | 1.42 | The Combination of Three Natural Compounds Effectively Prevented Lung Carcinogenesis by Optimal Wound Healing. ( Cao, N; Du, G; Duan, Y; Geng, S; Guo, Z; Han, G; Li, H; Liu, L; Ma, X; Zheng, Y, 2015) |
| "Hepatic haemangiosarcoma is a deadly malignancy whose aetiology remains poorly understood." | 1.38 | ARF suppresses hepatic vascular neoplasia in a carcinogen-exposed murine model. ( Busch, SE; Gurley, KE; Kemp, CJ; Moser, RD, 2012) |
| "Urethane-treated animals showed 2." | 1.37 | Urban, traffic- related particles and lung tumors in urethane treated mice. ( Assunção, JV; Lemos, M; Mauad, T; Pereira, FA; Saldiva, PH, 2011) |
| "Lung inflammation was assessed after 1 week." | 1.37 | Neutralization of tumor necrosis factor bioactivity ameliorates urethane-induced pulmonary oncogenesis in mice. ( Kairi, CA; Kalomenidis, I; Karabela, SP; Magkouta, S; Moschos, C; Psallidas, I; Roussos, C; Stathopoulos, GT; Stathopoulos, I; Zakynthinos, SG, 2011) |
| "Urethane treatment accelerated number and size of lung tumors developing in SOPten(flox/flox) mice of both ages." | 1.34 | Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. ( Hamada, K; Horie, Y; Kawahara, K; Kishimoto, H; Kubo, H; Mak, TW; Nakano, T; Nakazato, M; Nishio, M; Sasaki, M; Sasaki, T; Suzuki, A; Whitsett, JA; Yajima, N; Yanagi, S, 2007) |
| "The papillomas are heterogeneous in their potential for progression to carcinomas, a property apparently induced at the time of initiation." | 1.28 | Malignant conversion, the first stage in progression, is distinct from phorbol ester promotion in mouse skin. ( Hennings, H, 1991) |
| "Vinyl carbamate (VC) is a suspect metabolic intermediate in ethyl carbamate (EC) carcinogenesis." | 1.27 | Tumorigenesis and genotoxicity of ethyl carbamate and vinyl carbamate in rodent cells. ( Allen, JW; Backer, LC; Campbell, JA; Hatch, GG; Nesnow, S; Pereira, MA; Sharief, Y; Stead, AG; Stoner, GD, 1986) |
| "Urethane treatment is characterized by induction of a transient hypoplasia which is not in agreement with the level of cellular division." | 1.25 | Correlation of initial changes in the mouse epidermal cell population with two stage carcinogenesis-a quantitative study. ( Major, IR, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (51.81) | 18.7374 |
| 1990's | 7 (8.43) | 18.2507 |
| 2000's | 11 (13.25) | 29.6817 |
| 2010's | 21 (25.30) | 24.3611 |
| 2020's | 1 (1.20) | 2.80 |
| Authors | Studies |
|---|---|
| Li, S | 1 |
| Counter, CM | 2 |
| Lee, YS | 1 |
| Yeo, IJ | 1 |
| Kim, KC | 1 |
| Han, SB | 1 |
| Hong, JT | 1 |
| Popovich, IG | 1 |
| Piskunova, TS | 1 |
| Tyndyk, ML | 1 |
| Anikin, IV | 1 |
| Zabezhinskiĭ, MA | 1 |
| Anisimov, VN | 1 |
| Satoh, H | 2 |
| Moriguchi, T | 2 |
| Takai, J | 1 |
| Ebina, M | 2 |
| Yamamoto, M | 2 |
| Zhou, J | 1 |
| Qu, Z | 1 |
| Yan, S | 1 |
| Sun, F | 1 |
| Whitsett, JA | 3 |
| Shapiro, SD | 1 |
| Xiao, G | 1 |
| Westcott, PM | 2 |
| Halliwill, KD | 1 |
| To, MD | 2 |
| Rashid, M | 1 |
| Rust, AG | 1 |
| Keane, TM | 1 |
| Delrosario, R | 1 |
| Jen, KY | 1 |
| Gurley, KE | 2 |
| Kemp, CJ | 2 |
| Fredlund, E | 1 |
| Quigley, DA | 1 |
| Adams, DJ | 1 |
| Balmain, A | 2 |
| Hashizume, O | 1 |
| Yamanashi, H | 1 |
| Taketo, MM | 1 |
| Nakada, K | 1 |
| Hayashi, J | 1 |
| Liu, L | 1 |
| Li, H | 1 |
| Guo, Z | 1 |
| Ma, X | 1 |
| Cao, N | 1 |
| Zheng, Y | 1 |
| Geng, S | 1 |
| Duan, Y | 1 |
| Han, G | 1 |
| Du, G | 1 |
| Malanga, D | 1 |
| Belmonte, S | 1 |
| Colelli, F | 1 |
| Scarfò, M | 1 |
| De Marco, C | 1 |
| Oliveira, DM | 1 |
| Mirante, T | 1 |
| Camastra, C | 1 |
| Gagliardi, M | 1 |
| Rizzuto, A | 1 |
| Mignogna, C | 1 |
| Paciello, O | 1 |
| Papparella, S | 1 |
| Fagman, H | 1 |
| Viglietto, G | 1 |
| Saigusa, D | 1 |
| Baird, L | 1 |
| Yu, L | 1 |
| Rokutan, H | 1 |
| Igarashi, K | 1 |
| Shibata, T | 1 |
| Weyandt, JD | 1 |
| Carney, JM | 1 |
| Pavlisko, EN | 1 |
| Xu, M | 1 |
| Lázaro, S | 1 |
| Pérez-Crespo, M | 1 |
| Enguita, AB | 1 |
| Hernández, P | 1 |
| Martínez-Palacio, J | 1 |
| Oteo, M | 1 |
| Sage, J | 1 |
| Paramio, JM | 1 |
| Santos, M | 1 |
| Franco, MD | 1 |
| Colombo, F | 1 |
| Galvan, A | 1 |
| Cecco, LD | 1 |
| Spada, E | 1 |
| Milani, S | 1 |
| Ibanez, OM | 1 |
| Dragani, TA | 1 |
| Pereira, FA | 1 |
| Lemos, M | 1 |
| Mauad, T | 1 |
| Assunção, JV | 1 |
| Saldiva, PH | 1 |
| Regala, RP | 1 |
| Justilien, V | 1 |
| Walsh, MP | 1 |
| Weems, C | 1 |
| Khoor, A | 1 |
| Murray, NR | 1 |
| Fields, AP | 1 |
| Zaynagetdinov, R | 1 |
| Sherrill, TP | 2 |
| Polosukhin, VV | 2 |
| Han, W | 2 |
| Ausborn, JA | 1 |
| McLoed, AG | 1 |
| McMahon, FB | 1 |
| Gleaves, LA | 1 |
| Degryse, AL | 1 |
| Stathopoulos, GT | 3 |
| Yull, FE | 2 |
| Blackwell, TS | 2 |
| Karabela, SP | 1 |
| Kairi, CA | 1 |
| Magkouta, S | 1 |
| Psallidas, I | 1 |
| Moschos, C | 1 |
| Stathopoulos, I | 1 |
| Zakynthinos, SG | 1 |
| Roussos, C | 1 |
| Kalomenidis, I | 1 |
| Busch, SE | 1 |
| Moser, RD | 1 |
| Zhang, Q | 1 |
| Pan, J | 1 |
| Wang, Y | 1 |
| Lubet, R | 1 |
| You, M | 1 |
| Ihara, S | 1 |
| Kida, H | 1 |
| Arase, H | 1 |
| Tripathi, LP | 1 |
| Chen, YA | 1 |
| Kimura, T | 1 |
| Yoshida, M | 1 |
| Kashiwa, Y | 1 |
| Hirata, H | 1 |
| Fukamizu, R | 1 |
| Inoue, R | 1 |
| Hasegawa, K | 1 |
| Goya, S | 1 |
| Takahashi, R | 1 |
| Minami, T | 1 |
| Tsujino, K | 1 |
| Suzuki, M | 1 |
| Kohmo, S | 1 |
| Inoue, K | 1 |
| Nagatomo, I | 1 |
| Takeda, Y | 1 |
| Kijima, T | 1 |
| Mizuguchi, K | 1 |
| Tachibana, I | 1 |
| Kumanogoh, A | 1 |
| Rosario, RD | 1 |
| Banta, KL | 1 |
| Maeda, Y | 1 |
| Tsuchiya, T | 1 |
| Hao, H | 1 |
| Tompkins, DH | 1 |
| Xu, Y | 1 |
| Mucenski, ML | 1 |
| Du, L | 1 |
| Keiser, AR | 1 |
| Fukazawa, T | 1 |
| Naomoto, Y | 1 |
| Nagayasu, T | 1 |
| Jackson, RJ | 1 |
| Adnane, J | 1 |
| Coppola, D | 1 |
| Cantor, A | 1 |
| Sebti, SM | 1 |
| Pledger, WJ | 1 |
| POUND, AW | 3 |
| BELL, JR | 1 |
| WITHERS, HR | 1 |
| BERWALD, Y | 1 |
| SACHS, L | 1 |
| ROE, FJ | 2 |
| SALAMAN, MH | 1 |
| O'Donnell, EP | 1 |
| Zerbe, LK | 1 |
| Dwyer-Nield, LD | 2 |
| Kisley, LR | 1 |
| Malkinson, AM | 3 |
| Avanzo, JL | 1 |
| Mesnil, M | 1 |
| Hernandez-Blazquez, FJ | 1 |
| da Silva, TC | 1 |
| Fukumasu, H | 1 |
| Mori, CM | 1 |
| Yamasaki, H | 1 |
| Dagli, ML | 1 |
| Redente, EF | 1 |
| Orlicky, DJ | 1 |
| Bouchard, RJ | 1 |
| Peebles, KA | 1 |
| Yanagi, S | 1 |
| Kishimoto, H | 1 |
| Kawahara, K | 1 |
| Sasaki, T | 1 |
| Sasaki, M | 1 |
| Nishio, M | 1 |
| Yajima, N | 1 |
| Hamada, K | 1 |
| Horie, Y | 1 |
| Kubo, H | 1 |
| Mak, TW | 1 |
| Nakano, T | 1 |
| Nakazato, M | 1 |
| Suzuki, A | 1 |
| Cheng, DS | 1 |
| Scoggins, RM | 1 |
| Connelly, L | 1 |
| Fingleton, B | 1 |
| O'Flaherty, EJ | 1 |
| Dourson, ML | 1 |
| Allen, JW | 2 |
| Langenbach, R | 1 |
| Nesnow, S | 2 |
| Sasseville, K | 1 |
| Leavitt, S | 1 |
| Campbell, J | 1 |
| Brock, K | 1 |
| Sharief, Y | 2 |
| Danes, BS | 1 |
| Cazorla, M | 1 |
| Hernández, L | 1 |
| Fernández, PL | 1 |
| Fabra, A | 1 |
| Peinado, MA | 1 |
| Dasenbrock, C | 1 |
| Tillmann, T | 1 |
| Kamino, K | 1 |
| Campo, E | 1 |
| Kohler, M | 1 |
| Morawieltz, G | 1 |
| Cardesa, A | 1 |
| Tomatis, L | 1 |
| Mohr, U | 1 |
| Jakowlew, SB | 1 |
| Moody, TW | 1 |
| You, L | 1 |
| Mariano, JM | 1 |
| Carmichael, NG | 1 |
| Debruyne, EL | 1 |
| Bigot-Lasserre, D | 1 |
| Jiang, YG | 1 |
| Chen, JK | 1 |
| Wu, ZL | 1 |
| D'Agostini, F | 1 |
| Balansky, RM | 1 |
| Camoirano, A | 1 |
| de Flora, S | 1 |
| Sharpless, NE | 1 |
| Bardeesy, N | 1 |
| Lee, KH | 1 |
| Carrasco, D | 1 |
| Castrillon, DH | 1 |
| Aguirre, AJ | 1 |
| Wu, EA | 1 |
| Horner, JW | 1 |
| DePinho, RA | 1 |
| Gullino, PM | 2 |
| Whittemore, AS | 1 |
| Brem, SS | 1 |
| Medina, D | 3 |
| Spandidos, DA | 1 |
| Siminovitch, L | 1 |
| Talageri, VR | 4 |
| Bhide, SV | 2 |
| Ranadive, KJ | 4 |
| Fujii, M | 1 |
| Benedict, WF | 1 |
| Jones, PA | 1 |
| Laug, WE | 1 |
| Igel, HJ | 1 |
| Freeman, AE | 1 |
| Ravishankar, AG | 2 |
| Bapat, CV | 1 |
| Mashelkar, BN | 2 |
| Ranadive, DV | 1 |
| Hennings, H | 2 |
| Robinson, VA | 1 |
| Yuspa, SH | 1 |
| Welty, DJ | 1 |
| Greenhalgh, DG | 1 |
| Leigh, DA | 1 |
| Ferguson, V | 1 |
| Bentel, JM | 2 |
| Miller, JO | 1 |
| Smith, GJ | 2 |
| Pan, YH | 1 |
| Nuzum, EO | 1 |
| Hanson, LA | 1 |
| Beer, DG | 1 |
| Nagahara, N | 1 |
| Kitamura, H | 1 |
| Inoue, T | 1 |
| Ogawa, T | 1 |
| Ito, T | 1 |
| Kanisawa, M | 1 |
| Steele, JG | 1 |
| Loo, CK | 1 |
| Bonham, K | 1 |
| Embry, T | 1 |
| Gibson, D | 1 |
| Jaffe, DR | 1 |
| Roberts, RA | 1 |
| Cress, AE | 1 |
| Bowden, GT | 1 |
| Matsuzawa, A | 1 |
| Chu, KC | 1 |
| Brown, CC | 1 |
| Tarone, RE | 1 |
| Tan, WY | 1 |
| Stoner, GD | 1 |
| Pereira, MA | 1 |
| Backer, LC | 1 |
| Hatch, GG | 1 |
| Campbell, JA | 1 |
| Stead, AG | 1 |
| Altanerová, V | 1 |
| Parkhomenko, II | 1 |
| Irlin, IS | 1 |
| Konovalova, NP | 1 |
| DeOme, KB | 2 |
| Kerckaert, JP | 1 |
| Montreuil, J | 1 |
| Doyennette, MC | 1 |
| Puvion, F | 1 |
| Vlaeminck, MN | 1 |
| Demaille, A | 1 |
| Adenis, L | 1 |
| Driessens, J | 1 |
| Goldfeder, A | 1 |
| Rhim, JS | 1 |
| Park, DK | 1 |
| Weisburger, EK | 1 |
| Weisburger, JH | 1 |
| Kaplan, HS | 1 |
| Kolesnichenko, TS | 1 |
| Dzhioev, FK | 1 |
| Balanski, RM | 1 |
| DiPaolo, JA | 1 |
| Nelson, RL | 1 |
| Donovan, PJ | 1 |
| Mishra, NK | 1 |
| Di Mayorca, G | 1 |
| Brightwell, J | 1 |
| Heppleston, AG | 1 |
| Ryser, HJ | 1 |
| Carter, RL | 1 |
| Mitchley, BC | 1 |
| Peto, R | 1 |
| Hecker, E | 1 |
| Frolov, AF | 1 |
| Shcherbinskaya, AM | 1 |
| Botsman, NE | 1 |
| Major, IR | 1 |
| Grigorovich, NA | 1 |
| Balagovskaia, ZhM | 1 |
| Wittmann, W | 1 |
| Urbaneck, D | 1 |
5 reviews available for urethane and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Quantitative theories of oncogenesis.
Topics: Adult; Age Factors; Aged; Animals; Carcinogens; Cell Division; Cell Survival; Cell Transformation, N | 1978 |
[The role of hormones in neoplastic transformation].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; | 1986 |
Leukemia and lymphoma in experimental and domestic animals.
Topics: Age Factors; Alkylating Agents; Animals; Animals, Domestic; Animals, Laboratory; Bone Marrow; Cell F | 1974 |
In vitro malignant transformation of cells by chemical carcinogens.
Topics: Aflatoxins; Amides; Amines; Animals; Azo Compounds; Binding Sites; Carcinogens; Cell Line; Cell Tran | 1974 |
Chemical carcinogenesis.
Topics: Acetates; Aflatoxins; Alkylating Agents; Alkylation; Amides; Animals; Azo Compounds; Benz(a)Anthrace | 1971 |
78 other studies available for urethane and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Signaling levels mold the RAS mutation tropism of urethane.
Topics: Animals; Carcinogenesis; Cell Transformation, Neoplastic; Genes, ras; Lung Neoplasms; Mice; Mice, 12 | 2021 |
Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity.
Topics: A549 Cells; Animals; Apolipoproteins E; Cell Line, Tumor; Cell Proliferation; Cell Transformation, N | 2019 |
[Metformin effect on urethane-induced tumorigenesis in mice].
Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, N | 2012 |
Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis.
Topics: Adenocarcinoma; Animals; Base Sequence; Cell Transformation, Neoplastic; Cytochrome P-450 CYP2E1; DN | 2013 |
Differential roles of STAT3 in the initiation and growth of lung cancer.
Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Gene Expression Regul | 2015 |
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplasti | 2015 |
A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA.
Topics: Adenoma; AMP-Activated Protein Kinases; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Nuc | 2015 |
The Combination of Three Natural Compounds Effectively Prevented Lung Carcinogenesis by Optimal Wound Healing.
Topics: Animals; Apoptosis; Biological Products; Body Weight; Carcinogenesis; Cell Differentiation; Cell Lin | 2015 |
AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer.
Topics: Animals; Bronchi; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Epithelial Cells; Fe | 2016 |
NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth.
Topics: Animals; Cell Transformation, Neoplastic; Gene Expression Profiling; Lung Neoplasms; Male; Mice; Mic | 2016 |
Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice.
Topics: Alleles; Animals; Cell Transformation, Neoplastic; Isoenzymes; Lung Neoplasms; Mice; Mice, Knockout; | 2016 |
Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.
Topics: Animals; Cell Transformation, Neoplastic; Lung Neoplasms; Mice; Mice, Knockout; Neoplasms, Experimen | 2017 |
Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis.
Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Gene Expression; Gene Expr | 2010 |
Urban, traffic- related particles and lung tumors in urethane treated mice.
Topics: Air Pollutants; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Envir | 2011 |
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
Topics: Animals; Bronchi; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Profiling; Ge | 2011 |
A critical role for macrophages in promotion of urethane-induced lung carcinogenesis.
Topics: Animals; Carcinogens; Cell Separation; Cell Transformation, Neoplastic; Female; Flow Cytometry; Immu | 2011 |
Neutralization of tumor necrosis factor bioactivity ameliorates urethane-induced pulmonary oncogenesis in mice.
Topics: Animals; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Etanerc | 2011 |
ARF suppresses hepatic vascular neoplasia in a carcinogen-exposed murine model.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Gene D | 2012 |
Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Betacyanins; Caspases; Cell Transformat | 2013 |
Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferatio | 2012 |
Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Epistasis, Genetic; Fema | 2013 |
Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung.
Topics: Adenocarcinoma, Mucinous; Amino Acid Substitution; Animals; Base Sequence; Binding Sites; Cell Line, | 2012 |
Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models.
Topics: Animals; Cell Cycle Proteins; Cell Transformation, Neoplastic; Crosses, Genetic; Cyclin-Dependent Ki | 2002 |
The influence of croton oil stimulation on tumour initiation by urethane in mice.
Topics: Animals; Cell Transformation, Neoplastic; Croton Oil; Mice; Neoplasms; Neoplasms, Experimental; Skin | 1962 |
The localisation of the influence of croton oil stimulation on tumour initiation by urethane in mice.
Topics: Animals; Cell Transformation, Neoplastic; Croton Oil; Mice; Neoplasms; Neoplasms, Experimental; Papi | 1963 |
THE INFLUENCE OF SOME IRRITANT CHEMICALS AND SCARIFICATION ON TUMOUR INITIATION BY URETHANE IN MICE.
Topics: Acetates; Acetone; Cantharidin; Cell Transformation, Neoplastic; Dermabrasion; Iodoacetates; Irritan | 1963 |
IN VITRO CELL TRANSFORMATION WITH CHEMICAL CARCINOGENS.
Topics: Animals; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cricetinae; In Vitro Techniques | 1963 |
A quantitative study of the power and persistence of the tumour-initiating effect of ethyl carbamate (urethane) on mouse skin.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Mice; Neoplasms, Experimental; Skin Neoplasms | 1954 |
Quantitative analysis of early chemically-induced pulmonary lesions in mice of varying susceptibilities to lung tumorigenesis.
Topics: Adenoma; Animals; Butylated Hydroxytoluene; Cell Transformation, Neoplastic; Disease Susceptibility; | 2006 |
Altered expression of connexins in urethane-induced mouse lung adenomas.
Topics: Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Connexins; Gene Expression Regulatio | 2006 |
Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice.
Topics: Adenocarcinoma; Adenoma; Animals; Biomarkers, Tumor; Bone Marrow; Carcinogens; Cell Transformation, | 2007 |
Altered expression of splicing factor, heterogeneous nuclear ribonucleoprotein A2/B1, in mouse lung neoplasia.
Topics: Animals; Biomarkers, Tumor; Butylated Hydroxytoluene; Carcinogens; Cell Line; Cell Proliferation; Ce | 2007 |
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
Topics: Adenocarcinoma; Animals; Bronchi; Cell Transformation, Neoplastic; Gene Expression; Lung; Lung Neopl | 2007 |
Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Disease Susceptibility; Epithelial Cells; Female; Lung Neo | 2007 |
Relationship between urethan dose rate and adenoma latency: relevance of tumor growth rate and target cell number.
Topics: Adenoma; Animals; Cell Count; Cell Survival; Cell Transformation, Neoplastic; Diet; Dose-Response Re | 1982 |
Comparative genotoxicity studies of ethyl carbamate and related chemicals: further support for vinyl carbamate as a proximate carcinogenic metabolite.
Topics: Animals; Biotransformation; Bone Marrow Cells; Cell Transformation, Neoplastic; Cricetinae; Cricetul | 1982 |
Heritable colonic cancer syndromes: induction of anchorage-independence in dermal cultures derived from patients with adenomatosis of the colon and rectum.
Topics: Adenoma; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; Ethyl Methanesulfonate | 1980 |
Ki-ras gene mutations and absence of p53 gene mutations in spontaneous and urethane-induced early lung lesions in CBA/J mice.
Topics: Adenoma; Animals; Carcinoma; Cell Transformation, Neoplastic; Codon; Disease Progression; DNA, Neopl | 1998 |
Reduction in transforming growth factor-beta type II receptor in mouse lung carcinogenesis.
Topics: Activin Receptors, Type I; Animals; Carcinogens; Cell Division; Cell Line; Cell Transformation, Neop | 1998 |
The p53 heterozygous knockout mouse as a model for chemical carcinogenesis in vascular tissue.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Genes, p53; | 2000 |
Promotive effect of diethylstilbestrol on urethan-induced mouse lung tumorigenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylstilbestrol; Drug Interactions; Female | 2000 |
Interactions between N-acetylcysteine and ascorbic acid in modulating mutagenesis and carcinogenesis.
Topics: Acetylcysteine; Animals; Ascorbic Acid; Carcinogenicity Tests; Cell Transformation, Neoplastic; Chro | 2000 |
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cell Transformation, Neoplast | 2001 |
Considerations on the preneoplastic lesions of the mammary gland.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast; Breast Neoplasms; Bromocriptine; Cell Transformat | 1977 |
Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Female; Hyperplasia; Iri | 1977 |
The relationship between transformation and somatic mutation in human and Chinese hamster cells.
Topics: Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Drug Resistance; Fructose; Genes; Mutation | 1978 |
In vitro transformation of human cells by n-hydroxyurethan and urethan-DNA complex.
Topics: Cell Transformation, Neoplastic; DNA; Fetus; Fibroblasts; Humans; Hydroxamic Acids; In Vitro Techniq | 1977 |
Carcinogenic effect of N-butyl-N-nitrosourethan on CDF1 mice.
Topics: Administration, Oral; Administration, Topical; Animals; Carcinoma, Squamous Cell; Cell Transformatio | 1976 |
Characterisation of human cells transformed in vitro by urethane.
Topics: Aneuploidy; Cell Line; Cell Transformation, Neoplastic; Fibrinolysis; Humans; Karyotyping; Osteitis | 1975 |
Tumorigenicity of human cell cultures transformed by urethane 'in vitro'.
Topics: Animals; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Cheek; Cricetinae; Female; Hum | 1975 |
Urethan and 3,4-benzpyrene interactions with macromolecules of human cells grown in vitro.
Topics: Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; DNA, Neoplasm; Humans; Neoplasm Prot | 1975 |
Malignant conversion, the first stage in progression, is distinct from phorbol ester promotion in mouse skin.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinoma, Squamous Ce | 1991 |
Activation of the rasHa gene in urethane-initiated papillomas induced by protocols with high and low frequencies of malignant conversion.
Topics: 3T3 Cells; Animals; Blotting, Southern; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, | 1991 |
Activated Ki-ras proto-oncogene in spontaneously transformed and chemical tumor-derived cell lines related to the mouse lung alveologenic carcinoma.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adenoma; Animals; Base Sequence; Cell Transformation, Neoplasti | 1990 |
Ki-ras activation and expression in transformed mouse lung cell lines.
Topics: Adenocarcinoma; Adenoma; Animals; Base Sequence; Cell Division; Cell Transformation, Neoplastic; Gen | 1990 |
Effect of glycerol on cell kinetics and tumorigenesis in mouse lung following urethan administration.
Topics: Animals; Bronchi; Cell Cycle; Cell Transformation, Neoplastic; DNA; Epithelium; Glycerol; Interphase | 1990 |
A cell culture model of chemically and spontaneously derived mouse lung alveologenic carcinoma.
Topics: Adenoma; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Female; Fibronectins; Ker | 1988 |
Activation of the cellular Harvey ras gene in mouse skin tumors initiated with urethane.
Topics: Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; Codon; DNA Pro | 1989 |
Differentiating among proposed mechanisms for tumor promotion in mouse skin with the use of the multievent model for cancer.
Topics: 4-Nitroquinoline-1-oxide; Acetone; Animals; Cell Transformation, Neoplastic; Mathematics; Mice; Mode | 1987 |
Tumorigenesis and genotoxicity of ethyl carbamate and vinyl carbamate in rodent cells.
Topics: Animals; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Female; Lung Neoplasms; | 1986 |
Virus production induced by various chemical carcinogens in a virogenic hamster cell line transformed by Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Azacitidine; Benzopyrenes; Carcinogens; Cell Line; Cell Transformati | 1972 |
[Malignant transformation of cells in vitro by chemical carcinogens and viruses. I. The absence of synergism at a combined action of carcinogens and polyoma virus].
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Movement; Cell Transformation, Neoplast | 1969 |
A new approach to mammary tumorigenesis in rodents.
Topics: Animals; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Female; Mammary Neoplasms, Experimenta | 1969 |
[Isolation of intracytoplasmic type "A" particles from murine lymphoma induced by ethyl-urethan].
Topics: Animals; Biological Assay; Cell Fractionation; Cell Transformation, Neoplastic; Cell-Free System; Ce | 1971 |
Electron microscopic study of neoplasms induced by urethan and x-rays in X-Gf mice.
Topics: Animals; Carcinoma; Cell Membrane; Cell Nucleus; Cell Transformation, Neoplastic; Cytoplasmic Granul | 1972 |
Evaluation of an in vitro assay system for carcinogens based on prior infection of rodent cells with nontransforming RNA tumor virus.
Topics: Amines; Animals; Anthracenes; Azo Compounds; Carcinogens; Cell Line; Cell Transformation, Neoplastic | 1974 |
[Lung organ cultures as a model for the study of mouse sensitivity to urethane action].
Topics: Adenoma; Age Factors; Animals; Cell Transformation, Neoplastic; Culture Techniques; Drug Resistance; | 1974 |
[Inhibition of urethane carcinogenesis by antioxidants and carbon tetrachloride].
Topics: Adenoma; Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Cell Transformation, Neo | 1974 |
In vitro transformation of Syrian hamster embryo cells by diverse chemical carcinogens.
Topics: Aflatoxins; Animals; Azo Compounds; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cells, | 1972 |
'In vitro' studies on chemical carcinogenesis.
Topics: Animals; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Fe | 1972 |
Inhibition of urethane-induced pulmonary adenomas by inhaled plutonium-239.
Topics: Adenoma; Animals; Cell Transformation, Neoplastic; Injections, Intraperitoneal; Lung Neoplasms; Male | 1973 |
Biochemical characterization of cancer cells in vitro. II. Some enzyme levels of the glycolytic and hexosemonophosphate pathways in normal and malignant human cells in vitro.
Topics: Alcohol Oxidoreductases; Animals; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cr | 1973 |
On the persistence of tumour initiation and the acceleration of tumour progression in mouse skin tumorigenesis.
Topics: Acetone; Animals; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Croton Oil; Female; Mice; Neo | 1972 |
Transformation of human embryo lung cells by the action of urethane and influenza virus.
Topics: Cell Transformation, Neoplastic; Culture Techniques; Embryo, Mammalian; Epithelial Cells; Epithelium | 1971 |
Correlation of initial changes in the mouse epidermal cell population with two stage carcinogenesis-a quantitative study.
Topics: Acridines; Animals; Benz(a)Anthracenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; | 1970 |
Carcinogen-induced mammary tumors from preneoplastic nodule outgrowths in BALB-c mice.
Topics: Animals; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Female; Mammary Neoplasms, Experimenta | 1970 |
[Comparative study of the action of blastomogenic agents on the genetic apparatus of animal cells. I. Effect of different types of blastomogenic agents on the DNA nucleotide composition of cells sensitive to blastomogens].
Topics: Animals; Carbon Tetrachloride; Cell Transformation, Neoplastic; DNA; DNA, Neoplasm; Estradiol; Femal | 1970 |
[Etiology of bovine leukosis. 9. Test of the leukemogenic effect of urethane].
Topics: Age Factors; Animals; Cattle; Cattle Diseases; Cell Count; Cell Transformation, Neoplastic; Leukemia | 1970 |