urethane has been researched along with Abnormalities, Drug-Induced in 39 studies
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Teratogenic chemicals (2,3,7, 8-tetrachlorodibenzo-p-dioxin [TCDD], ethyl carbamate [urethane], methylnitrosourea [MNU], or valproic acid [VA]) were given to pregnant mice to induce cleft palate (TCDD, urethane), digital defects (urethane, MNU), or exencephaly (VA)." | 3.70 | Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations. ( Blaylock, BL; Gogal, RM; Holladay, SD; Sharova, L; Smith, BJ; Ward, DL, 2000) |
| "Ethyl carbamate (urethane) was given to pregnant ICR mice on day 10 of gestation to induce cleft palate." | 3.70 | Nonspecific stimulation of the maternal immune system. II. Effects on gene expression in the fetus. ( Gogal, RM; Holladay, SD; Sharov, AA; Sharova, L; Smith, BJ; Sura, P; Ward, DL, 2000) |
| "Urethane treatment caused down-regulated expression of numerous genes involved in cell-cycle control, while maternal immune stimulation caused comparative up-regulation of many of these genes." | 1.31 | Immune stimulation in urethane-exposed pregnant mice increases expression level of spleen leukocyte genes for TGFbeta3 GM-CSF and other cytokines that may play a role in reduced chemical-induced birth defects. ( Chrisman, MV; Gogal, RM; Holladay, SD; Sharov, AA; Sharova, LV, 2002) |
| "Urethane treatment induced hepatic MT 14-fold over control; styrene treatment induced MT 2." | 1.28 | The role of metallothionein induction and altered zinc status in maternally mediated developmental toxicity: comparison of the effects of urethane and styrene in rats. ( Daston, GP; Keen, CL; Lehman-McKeeman, LD; Overmann, GJ; Rogers, JM; Taubeneck, MW, 1991) |
| "Urethane, treated in a similar way, induced somatic mutations and malformations in the offspring." | 1.27 | A method to detect tumors and presumed somatic mutations in mice. ( Hata, S; Nomura, T; Shibata, K, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (74.36) | 18.7374 |
| 1990's | 5 (12.82) | 18.2507 |
| 2000's | 5 (12.82) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharova, LV | 1 |
| Gogal, RM | 3 |
| Sharov, AA | 2 |
| Chrisman, MV | 1 |
| Holladay, SD | 3 |
| TUCHMANN-DUPLESSIS, H | 1 |
| MERCIER-PAROT, L | 1 |
| Nomura, T | 12 |
| Nakajima, H | 3 |
| Ryo, H | 1 |
| Li, LY | 1 |
| Fukudome, Y | 1 |
| Adachi, S | 1 |
| Gotoh, H | 2 |
| Tanaka, H | 1 |
| Tanaka, T | 2 |
| von Kreybig, T | 2 |
| DiPaolo, JA | 2 |
| Elis, J | 2 |
| Miyamoto, S | 2 |
| Shibata, K | 2 |
| Hata, S | 2 |
| Tanaka, S | 1 |
| Kurokawa, N | 1 |
| Kurishita, A | 1 |
| Hongyo, T | 1 |
| Ishii, Y | 1 |
| Edwards, AJ | 2 |
| Anderson, D | 2 |
| Brinkworth, MH | 2 |
| Myers, B | 1 |
| Parry, JM | 1 |
| Jenkinson, PC | 1 |
| Hughes, JA | 1 |
| Sharova, L | 2 |
| Smith, BJ | 2 |
| Ward, DL | 2 |
| Blaylock, BL | 1 |
| Sura, P | 1 |
| Fort, DJ | 1 |
| Rogers, RL | 1 |
| Paul, RR | 1 |
| Stover, EL | 1 |
| Finch, RA | 1 |
| Sonntag, AC | 1 |
| Yasuda, Y | 1 |
| Daston, GP | 1 |
| Overmann, GJ | 1 |
| Taubeneck, MW | 1 |
| Lehman-McKeeman, LD | 1 |
| Rogers, JM | 1 |
| Keen, CL | 1 |
| Kusafuka, T | 1 |
| Collins, TF | 1 |
| Sotomayor, RE | 1 |
| Hasegawa, C | 1 |
| Sakamoto, Y | 1 |
| Burkhard, W | 1 |
| Fritz-Niggli, H | 1 |
| Napalkov, NP | 1 |
| Alexandrov, VA | 1 |
| Okamoto, E | 2 |
| Tateishi, N | 1 |
| Kimura, S | 1 |
| Isa, Y | 1 |
| Diwan, BA | 2 |
| Batra, BK | 2 |
| Aleksandrov, VA | 1 |
| Takaori, S | 1 |
| Tanabe, K | 1 |
| Shimamoto, K | 1 |
| D'Souza, AV | 1 |
| Sinclair, JG | 1 |
| Abreu, BE | 1 |
| Chaube, S | 1 |
| Murphy, ML | 1 |
6 reviews available for urethane and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Transgenerational transmission of radiation- and chemically induced tumors and congenital anomalies in mice: studies of their possible relationship to induced chromosomal and molecular changes.
Topics: 4-Nitroquinoline-1-oxide; Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Ca | 2004 |
Commentary: paternal legacies.
Topics: Abnormalities, Drug-Induced; Animals; Butadienes; Cyclophosphamide; Male; Mice; Paternal Exposure; R | 1999 |
Xenobiotics and molecular teratology.
Topics: Abnormalities, Drug-Induced; Adenocarcinoma; Animals; Carcinogens; Diethylstilbestrol; Drug Interact | 1975 |
Congenital malformations as a consequence of parental exposure to radiation and chemicals in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Dioxins; Dose-Response Relat | 1989 |
Developmental toxicity of urethan.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Cells, Cultured; Cricetinae; Embryonic and F | 1989 |
[Carcinogenesis and teratogenesis. Comparative studies from the viewpoint of teratology].
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Cycloph | 1970 |
33 other studies available for urethane and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Immune stimulation in urethane-exposed pregnant mice increases expression level of spleen leukocyte genes for TGFbeta3 GM-CSF and other cytokines that may play a role in reduced chemical-induced birth defects.
Topics: Abnormalities, Drug-Induced; Adjuvants, Immunologic; Animals; Antigens, Surface; Cytokines; Female; | 2002 |
[REPERCUSSIONS OF NEUROLEPTIC AND ANTITUMOR AGENTS ON PRENATAL DEVELOPMENT].
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ant | 1964 |
[Postnatal fate of polydactyly induced by administration of ethylurethane to pregnant mice].
Topics: Abnormalities, Drug-Induced; Animals; Female; Maternal-Fetal Exchange; Mice; Pregnancy; Pregnancy, A | 1966 |
[Experimental animal teratology and drug tests].
Topics: Abnormalities, Drug-Induced; Amides; Animals; Brain; Colchicine; Cyclophosphamide; Female; Limb Defo | 1966 |
The comparison of teratogenic and carcinogenic effects of some carbamate compounds.
Topics: Abnormalities, Drug-Induced; Animals; Carbamates; Carcinogens; Cricetinae; Female; Injections, Intra | 1967 |
[Association of thyroid drugs on the teratogenic action of ethylurethan in mice].
Topics: Abnormalities, Drug-Induced; Animals; Female; Methylthiouracil; Mice; Pregnancy; Thyroxine; Urethane | 1967 |
Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Caffeine; DNA Repair; Lung Neoplasms; M | 1983 |
A method to detect tumors and presumed somatic mutations in mice.
Topics: Abnormalities, Drug-Induced; Animals; Ethylnitrosourea; Female; Gestational Age; Male; Mice; Mutagen | 1983 |
Cytogenotoxicities of sublimed urethane gas to the mouse embryo.
Topics: Abnormalities, Drug-Induced; Administration, Inhalation; Animals; Female; Gases; Mice; Mice, Inbred | 1996 |
An investigation of male-mediated F1 effects in mice treated acutely and sub-chronically with urethane.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Carcinogens; DNA Mutational Analysis; Female; Inf | 1999 |
Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adjuvants, Immunologic; Animals; BCG Vaccine; | 2000 |
Nonspecific stimulation of the maternal immune system. II. Effects on gene expression in the fetus.
Topics: Abnormalities, Drug-Induced; Adjuvants, Immunologic; Animals; Apoptosis; Cell Cycle; Cleft Palate; E | 2000 |
Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.
Topics: Abnormalities, Drug-Induced; Animals; beta-Naphthoflavone; Biotransformation; Carbon Tetrachloride; | 2001 |
Similarity of the mechanism of chemical carcinogen-initiated teratogenesis and carcinogenesis in mice.
Topics: 4-Nitroquinoline-1-oxide; Abnormalities, Drug-Induced; Animals; Caffeine; Carcinogens; Congenital Ab | 1977 |
Digital anomalies of mouse limbs induced by treatment with urethan in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Extremities; Mice; Mice, Inbred ICR; Organ Culture Techniques; | 1977 |
Letter: Transmission of tumors and malformations to the next generation of mice subsequent to urethan treatment.
Topics: Abnormalities, Drug-Induced; Animals; Carcinogens; Female; Lung Neoplasms; Male; Maternal-Fetal Exch | 1975 |
The role of metallothionein induction and altered zinc status in maternally mediated developmental toxicity: comparison of the effects of urethane and styrene in rats.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetus; Liver; Maternal-Fetal Exchan | 1991 |
Suppression of developmental anomalies by maternal macrophages in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Cell Survival; Congenital Ab | 1990 |
Inhibiting effects of nicotinamide on urethane-induced malformations and tumors in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Dose-Response Relationship, Drug; Fem | 1988 |
Antiteratogenic and anticarcinogenic effects of X-rays in urethane-treated NMRI mice.
Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Chloroquine; Female; Lung Neoplasms; Male; Mice | 1987 |
On the effects of blastomogenic substances on the organism during embryogenesis.
Topics: Abnormalities, Drug-Induced; Aniline Compounds; Animals; Benz(a)Anthracenes; Carcinoma; Carcinoma, S | 1968 |
Transplacental carcinogenesis by urethan in mice: teratogenesis and carcinogenesis in relation to organogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Carcinoma, Hepatocellular; Cystadenoma; Endometrial Hyperplasi | 1972 |
Tumor induction in the progeny of mice receiving 4-nitroquinoline 1-oxide and N-methyl-N-nitrosourethan during pregnancy or lactation.
Topics: Abnormalities, Drug-Induced; Animals; Carcinogens; Carcinoma, Hepatocellular; Female; Fetus; Gestati | 1974 |
Effects of urethane on embryonic development in mouse.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Eye; Female; Hemorrhage; Injections, Intrap | 1972 |
[Natural carcinogens: induction of cancer and malformations in the rat embryo by transplacental passage of various environmental carcinogens].
Topics: Abnormalities, Drug-Induced; Aflatoxins; Animals; Carcinogens; Female; Male; Maternal-Fetal Exchange | 1972 |
An analysis of the changing urethan response of the developing mouse embryo in relation to mortality, malformation, and neoplasm.
Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Embryo Implantation; Embryo, Mammalian; | 1974 |
[Effect of N-nitrosomethyl urethane on rat embryos].
Topics: Abnormalities, Drug-Induced; Animals; Carcinogens; Female; Neoplasms, Experimental; Nitroso Compound | 1972 |
Developmental abnormalities of skeletal system induced by ethylurethan in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Female; Pregnancy; Rats; Urethane | 1966 |
Effect of actinomycin D and urethan on successive litters and generations of mice.
Topics: Abnormalities, Drug-Induced; Animals; Breeding; Dactinomycin; Female; Fetal Death; Lung Neoplasms; M | 1970 |
Effects of urethane on embryonic development in the mouse. I. The period of organogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Liver; Lung; Mice; Pre | 1970 |
[Strain difference as to teratogenicity of ethylurethane on the mouse embryos].
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Gestational Age; Maternal-Fetal Exc | 1968 |
Transplacental effects of drugs in mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Male; Maternal-Fetal Exchange; Methylcell | 1965 |
The effects of hydroxyurea and related compounds on the rat fetus.
Topics: Abnormalities, Drug-Induced; Animals; Hydroxamic Acids; Rats; Urea; Urethane | 1966 |