urea has been researched along with Stroke in 23 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "It remains unclear whether extreme levels of blood urea nitrogen (BUN) and BUN to creatinine ratio (BUN/Cr) can increase future risk of stroke." | 8.02 | Blood urea nitrogen, blood urea nitrogen to creatinine ratio and incident stroke: The Dongfeng-Tongji cohort. ( Gao, H; He, M; Li, W; Liu, K; Niu, R; Peng, R; Wu, T; Xiao, Y; Yang, H; Yuan, Y; Zhang, C; Zhang, X; Zhou, L, 2021) |
| "Elevated serum urea was independently associated with poor clinical outcome and mortality in acute ischaemic stroke patients treated with IV tPA." | 7.79 | Elevated urea level is associated with poor clinical outcome and increased mortality post intravenous tissue plasminogen activator in stroke patients. ( Churilov, L; Davis, SM; Meretoja, A; Teo, S; Yan, B; Zhang, Y, 2013) |
| " Participants were receiving 40 mg pimavanserin daily in addition to concurrent antipsychotics and Parkinson disease medications." | 5.20 | Impact of Current Antipsychotic Medications on Comparative Mortality and Adverse Events in People With Parkinson Disease Psychosis. ( Ballard, C; Burn, DJ; Coate, B; Corbett, A; Isaacson, S; Mills, R; Pahwa, R; Rascol, O; Williams, H, 2015) |
| "The risk of a fatal stroke in a univariate analysis was established in the presence of a general severe condition of the patient and a number of other factors, which included the severity of COVID-19, acute coronary syndrome, multiple organ failure, the need for a ventilator, a history of kidney disease, pneumonia, high NIHSS score, oxygen partial pressure level, respiratory rate, number of hospitalizations, complete blood count (erythrocytes, hemoglobin, hematocrit, leukocytes, neutrophils), coagulogram, glucose, liver and kidney markers (bilirubin, aspartate aminotransferase, alanine aminotransferase, creatinine, urea), levels of creatine phosphokinase, lactate dehydrogenase and C-reactive protein." | 4.12 | [Predictors of unfavorable outcomes of ischemic stroke associated with COVID-19]. ( Latypova, RF; Novikova, LB, 2022) |
| "It remains unclear whether extreme levels of blood urea nitrogen (BUN) and BUN to creatinine ratio (BUN/Cr) can increase future risk of stroke." | 4.02 | Blood urea nitrogen, blood urea nitrogen to creatinine ratio and incident stroke: The Dongfeng-Tongji cohort. ( Gao, H; He, M; Li, W; Liu, K; Niu, R; Peng, R; Wu, T; Xiao, Y; Yang, H; Yuan, Y; Zhang, C; Zhang, X; Zhou, L, 2021) |
| "Elevated serum urea was independently associated with poor clinical outcome and mortality in acute ischaemic stroke patients treated with IV tPA." | 3.79 | Elevated urea level is associated with poor clinical outcome and increased mortality post intravenous tissue plasminogen activator in stroke patients. ( Churilov, L; Davis, SM; Meretoja, A; Teo, S; Yan, B; Zhang, Y, 2013) |
| "We linked clinical data from stroke patients in 2 prospective hospital registers with routine blood urea and creatinine results." | 3.78 | Dehydration in hospital-admitted stroke patients: detection, frequency, and association. ( Dennis, M; Graham, C; Rowat, A, 2012) |
| "Nine (45%) of the 20 stroke patients had clinical signs of dehydration and had a significantly higher admission median urea:creatinine ratio (P = 0·02, Mann-Whitney U-test)." | 3.77 | A pilot study to assess if urine specific gravity and urine colour charts are useful indicators of dehydration in acute stroke patients. ( Dennis, M; Graham, C; Horsburgh, D; Lyle, D; Rowat, A; Smith, L, 2011) |
| " Stroke survivors had higher calculated creatinine clearance and lower serum creatinine, urea, and ratios of urea to creatinine." | 3.71 | Does renal dysfunction predict mortality after acute stroke? A 7-year follow-up study. ( Chen, R; Ersoy, Y; Fraser, CG; Fraser, HW; MacWalter, RS; Ogston, SA; Stewart, G; Wong, KY; Wong, SY, 2002) |
| "Type 1 diabetes mellitus was modeled by streptozotocin (STZ; 50 mg/kg per day intraperitoneally, 5 days) in male mice." | 1.39 | Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus. ( Alkayed, NJ; Jouihan, SA; Krasnow, SM; Marks, DL; Shangraw, RE; Zhang, W; Zuloaga, KL, 2013) |
| "Although it is widely assumed that dehydration predisposes to venous thromboembolism (VTE), there are no clinical studies to support this." | 1.32 | Dehydration and venous thromboembolism after acute stroke. ( Hunt, BJ; Kelly, J; Lewis, RR; Moody, A; Rudd, A; Seed, PT; Swaminathan, R, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 14 (60.87) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Yoshida, H | 1 |
| Itoh, S | 1 |
| Ferdousi, F | 1 |
| Isoda, H | 1 |
| Novikova, LB | 1 |
| Latypova, RF | 1 |
| Lüscher, TF | 1 |
| Peng, R | 1 |
| Liu, K | 1 |
| Li, W | 1 |
| Yuan, Y | 1 |
| Niu, R | 1 |
| Zhou, L | 1 |
| Xiao, Y | 1 |
| Gao, H | 1 |
| Yang, H | 1 |
| Zhang, C | 1 |
| Zhang, X | 1 |
| He, M | 1 |
| Wu, T | 1 |
| S, R | 1 |
| W Y, WN | 1 |
| Tan, HJ | 1 |
| M I, N | 1 |
| Jouihan, SA | 2 |
| Zuloaga, KL | 2 |
| Zhang, W | 3 |
| Shangraw, RE | 2 |
| Krasnow, SM | 2 |
| Marks, DL | 2 |
| Alkayed, NJ | 3 |
| Zhang, Y | 1 |
| Churilov, L | 1 |
| Meretoja, A | 1 |
| Teo, S | 1 |
| Davis, SM | 1 |
| Yan, B | 1 |
| Mondal, P | 1 |
| Trigun, SK | 1 |
| Zhu, X | 1 |
| Olenskaia, TL | 1 |
| Konevalova, NIu | 1 |
| Rapoport, SI | 1 |
| Proshchaev, KI | 1 |
| Kozlov, KL | 1 |
| Korobov, GD | 1 |
| Ballard, C | 1 |
| Isaacson, S | 1 |
| Mills, R | 1 |
| Williams, H | 1 |
| Corbett, A | 1 |
| Coate, B | 1 |
| Pahwa, R | 1 |
| Rascol, O | 1 |
| Burn, DJ | 1 |
| Allende, M | 1 |
| Molina, E | 1 |
| Guruceaga, E | 1 |
| Tamayo, I | 1 |
| González-Porras, JR | 1 |
| Gonzalez-López, TJ | 1 |
| Toledo, E | 1 |
| Rabal, O | 1 |
| Ugarte, A | 1 |
| Roldán, V | 1 |
| Rivera, J | 1 |
| Oyarzabal, J | 1 |
| Montes, R | 1 |
| Hermida, J | 1 |
| Courand, PY | 1 |
| Lesiuk, C | 1 |
| Milon, H | 1 |
| Defforges, A | 1 |
| Fouque, D | 1 |
| Harbaoui, B | 1 |
| Lantelme, P | 1 |
| Thimm, M | 1 |
| Fink, GR | 1 |
| Sturm, W | 1 |
| Idris, I | 1 |
| Hill, R | 1 |
| Sharma, JC | 1 |
| Rowat, A | 2 |
| Smith, L | 1 |
| Graham, C | 2 |
| Lyle, D | 1 |
| Horsburgh, D | 1 |
| Dennis, M | 2 |
| Chiba, T | 1 |
| Itoh, T | 1 |
| Tabuchi, M | 1 |
| Ooshima, K | 1 |
| Satou, T | 1 |
| Ezaki, O | 1 |
| Kelly, J | 1 |
| Hunt, BJ | 1 |
| Lewis, RR | 1 |
| Swaminathan, R | 1 |
| Moody, A | 1 |
| Seed, PT | 1 |
| Rudd, A | 1 |
| Kroft, LJ | 1 |
| Chen, WH | 1 |
| Lui, CC | 1 |
| Chen, CJ | 1 |
| Liu, JS | 1 |
| Koerner, IP | 1 |
| Noppens, R | 1 |
| Grafe, M | 1 |
| Tsai, HJ | 1 |
| Morisseau, C | 1 |
| Luria, A | 1 |
| Hammock, BD | 1 |
| Falck, JR | 1 |
| MacWalter, RS | 1 |
| Wong, SY | 1 |
| Wong, KY | 1 |
| Stewart, G | 1 |
| Fraser, CG | 1 |
| Fraser, HW | 1 |
| Ersoy, Y | 1 |
| Ogston, SA | 1 |
| Chen, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center, Open-Label Extension Study to Examine the Safety and Tolerability of ACP-103 in the Treatment of Psychosis in Parkinson's Disease[NCT00550238] | Phase 3 | 459 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number (%) of patients with drug-related treatment-emergent AEs (i.e. AEs reported by the Investigator as possibly, probably, or highly probably related to study drug) (NCT00550238)
Timeframe: From first to last study drug dose plus 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Pimavanserin | 180 |
1 trial available for urea and Stroke
| Article | Year |
|---|---|
Impact of Current Antipsychotic Medications on Comparative Mortality and Adverse Events in People With Parkinson Disease Psychosis.
Topics: Accidental Falls; Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Antipsychotic Agents; Drug T | 2015 |
22 other studies available for urea and Stroke
| Article | Year |
|---|---|
Post-stroke treatment with K-134, a phosphodiesterase 3 inhibitor, improves stroke outcomes in the stroke-prone spontaneously hypertensive rat model-A comparative evaluation of antiplatelet drugs.
Topics: Animals; Cerebral Hemorrhage; Cerebral Small Vessel Diseases; Disease Models, Animal; Dose-Response | 2022 |
[Predictors of unfavorable outcomes of ischemic stroke associated with COVID-19].
Topics: Aged; Aged, 80 and over; C-Reactive Protein; COVID-19; Female; Humans; Ischemic Stroke; Middle Aged; | 2022 |
Optimizing heart failure management: anticoagulation, diuretic withdrawal, iron substitution, and novel inotropes.
Topics: Acute Disease; Anemia, Iron-Deficiency; Anticoagulants; Cardiotonic Agents; Case-Control Studies; Di | 2019 |
Blood urea nitrogen, blood urea nitrogen to creatinine ratio and incident stroke: The Dongfeng-Tongji cohort.
Topics: Blood Urea Nitrogen; Creatinine; Humans; Nitrogen; Stroke; Urea | 2021 |
Stroke care in Pusat Perubatan UKM; the actual picture.
Topics: Humans; Stroke; Urea | 2013 |
Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Benzoates; Blood Glucose; Cerebral Angiography; Diabetes Melli | 2013 |
Elevated urea level is associated with poor clinical outcome and increased mortality post intravenous tissue plasminogen activator in stroke patients.
Topics: Aged; Aged, 80 and over; Cell Count; Creatinine; Female; Fibrinolytic Agents; Glomerular Filtration | 2013 |
Pannexin1 as a novel cerebral target in pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Brain; Connexins; Energy Metabolism; Glutamic Acid; Heart Arrest; Hepatic Encephalopathy; H | 2014 |
Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke.
Topics: Analysis of Variance; Animals; Benzoates; Blood Glucose; Blotting, Western; Brain; Diabetes Mellitus | 2014 |
[Orthostatic reactions in prognosis of the risks of arterial hypertension as a component of metabolic syndrome].
Topics: Acute Coronary Syndrome; Aged; Blood Glucose; Cholesterol; Female; Humans; Hypertension; Hypotension | 2014 |
Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.
Topics: Animals; Aspirin; Atrial Fibrillation; Bleeding Time; Carotid Artery Diseases; Case-Control Studies; | 2016 |
Association Between Protein Intake and Mortality in Hypertensive Patients Without Chronic Kidney Disease in the OLD-HTA Cohort.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure Determination; Cardiovascular Diseases; Cause o | 2016 |
Neural correlates of recovery from acute hemispatial neglect.
Topics: Acute Disease; Adult; Aged; Attention; Brain; Brain Mapping; Carbamide Peroxide; Drug Combinations; | 2008 |
Effects of admission serum urea, glomerular filtration rate, proteinuria and diabetes status on 3-month mortality after acute stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Diabetes Mellitus; England; Glomerular Filtration Rate; Huma | 2010 |
A pilot study to assess if urine specific gravity and urine colour charts are useful indicators of dehydration in acute stroke patients.
Topics: Aged; Aged, 80 and over; Clinical Nursing Research; Color; Creatinine; Dehydration; Early Diagnosis; | 2011 |
Delay of stroke onset by milk proteins in stroke-prone spontaneously hypertensive rats.
Topics: Amino Acids; Animals; Blood Pressure; Butter; Caseins; Cerebral Hemorrhage; Cerebral Infarction; Die | 2012 |
Dehydration in hospital-admitted stroke patients: detection, frequency, and association.
Topics: Age Factors; Aged; Aged, 80 and over; Brain Ischemia; Cerebral Hemorrhage; Creatinine; Dehydration; | 2012 |
Dehydration and venous thromboembolism after acute stroke.
Topics: Aged; Aged, 80 and over; Creatinine; Dehydration; Female; Humans; Logistic Models; Male; Middle Aged | 2004 |
[Radiotherapy of the neck as a risk factor for stroke].
Topics: Aspirin; Humans; Laryngeal Neoplasms; Radiation Injuries; Stroke; Urea | 2005 |
An increase of anticardiolipin antibody in association with stroke and chronic chemical exposure.
Topics: Adult; Antibodies, Anticardiolipin; Formaldehyde; HLA-DR4 Antigen; Humans; Immunoglobulin M; Male; O | 2006 |
Soluble epoxide hydrolase: a novel therapeutic target in stroke.
Topics: Adamantane; Animals; Antipyrine; Autoradiography; Blood-Brain Barrier; Blotting, Western; Capillarie | 2007 |
Does renal dysfunction predict mortality after acute stroke? A 7-year follow-up study.
Topics: Aged; Cohort Studies; Comorbidity; Creatinine; Female; Follow-Up Studies; Humans; Kidney Diseases; K | 2002 |