Page last updated: 2024-10-21

urea and Primary Myelofibrosis

urea has been researched along with Primary Myelofibrosis in 5 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Primary Myelofibrosis: A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19904 (80.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Foran, J1
Ravandi, F1
Wierda, W1
Garcia-Manero, G1
Verstovsek, S1
Kadia, T1
Burger, J1
Yule, M1
Langford, G1
Lyons, J1
Ayrton, J1
Lock, V1
Borthakur, G1
Cortes, J1
Kantarjian, H1
Hanel, HK1
Philip, P1
Lewis, SM1
Pettit, JE1
Tattersall, MH1
Pepys, MB1
Laursen, B1
Gormsen, J1
Jobst, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I/IIa Open-label Study to Assess the Safety, Tolerability and Preliminary Efficacy of AT9283, a Small Molecule Inhibitor of Aurora Kinases, in Patients With Refractory Hematological Malignancies[NCT00522990]Phase 1/Phase 248 participants (Actual)Interventional2006-09-30Terminated (stopped due to Recommended Phase II dose determined)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for urea and Primary Myelofibrosis

ArticleYear
A phase I and pharmacodynamic study of AT9283, a small-molecule inhibitor of aurora kinases in patients with relapsed/refractory leukemia or myelofibrosis.
    Clinical lymphoma, myeloma & leukemia, 2014, Volume: 14, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzimidazoles; Disease Progression; Drug Adm

2014

Other Studies

4 other studies available for urea and Primary Myelofibrosis

ArticleYear
Atypical intraerythrocytic pyruvate kinase in some haematological diseases.
    Scandinavian journal of haematology, 1976, Volume: 17, Issue:1

    Topics: Aged; Erythrocytes; Female; Hemolysis; Humans; Male; Middle Aged; Pedigree; Polycythemia; Polycythem

1976
Myelosclerosis and paroxysmal nocturnal haemoglobinuria.
    Scandinavian journal of haematology, 1971, Volume: 8, Issue:6

    Topics: Adult; Alkaline Phosphatase; Bilirubin; Blood Proteins; Bone Marrow Examination; Chromium Isotopes;

1971
Pharmacological enhancement and short-term stimulation of blood fibrinolytic activity.
    Scandinavian journal of haematology, 1969, Volume: 6, Issue:6

    Topics: Adolescent; Adult; Aged; Aminocaproates; Anticholesteremic Agents; Arteriosclerosis; Arthritis, Rheu

1969
On the DNA and histone content of N-nitrosomethylurea induced rat tumours.
    Neoplasma, 1969, Volume: 16, Issue:1

    Topics: Adenoma; Aneuploidy; Animals; Brain Neoplasms; Bronchial Neoplasms; Carcinoma; DNA; DNA, Neoplasm; F

1969
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