urea and Primary Myelofibrosis
urea has been researched along with Primary Myelofibrosis in 5 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Primary Myelofibrosis: A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
Research
Studies (5)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (80.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (20.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Foran, J | 1 |
Ravandi, F | 1 |
Wierda, W | 1 |
Garcia-Manero, G | 1 |
Verstovsek, S | 1 |
Kadia, T | 1 |
Burger, J | 1 |
Yule, M | 1 |
Langford, G | 1 |
Lyons, J | 1 |
Ayrton, J | 1 |
Lock, V | 1 |
Borthakur, G | 1 |
Cortes, J | 1 |
Kantarjian, H | 1 |
Hanel, HK | 1 |
Philip, P | 1 |
Lewis, SM | 1 |
Pettit, JE | 1 |
Tattersall, MH | 1 |
Pepys, MB | 1 |
Laursen, B | 1 |
Gormsen, J | 1 |
Jobst, K | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Phase I/IIa Open-label Study to Assess the Safety, Tolerability and Preliminary Efficacy of AT9283, a Small Molecule Inhibitor of Aurora Kinases, in Patients With Refractory Hematological Malignancies[NCT00522990] | Phase 1/Phase 2 | 48 participants (Actual) | Interventional | 2006-09-30 | Terminated (stopped due to Recommended Phase II dose determined) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trials
1 trial available for urea and Primary Myelofibrosis
Article | Year |
---|---|
A phase I and pharmacodynamic study of AT9283, a small-molecule inhibitor of aurora kinases in patients with relapsed/refractory leukemia or myelofibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzimidazoles; Disease Progression; Drug Adm | 2014 |
Other Studies
4 other studies available for urea and Primary Myelofibrosis
Article | Year |
---|---|
Atypical intraerythrocytic pyruvate kinase in some haematological diseases.
Topics: Aged; Erythrocytes; Female; Hemolysis; Humans; Male; Middle Aged; Pedigree; Polycythemia; Polycythem | 1976 |
Myelosclerosis and paroxysmal nocturnal haemoglobinuria.
Topics: Adult; Alkaline Phosphatase; Bilirubin; Blood Proteins; Bone Marrow Examination; Chromium Isotopes; | 1971 |
Pharmacological enhancement and short-term stimulation of blood fibrinolytic activity.
Topics: Adolescent; Adult; Aged; Aminocaproates; Anticholesteremic Agents; Arteriosclerosis; Arthritis, Rheu | 1969 |
On the DNA and histone content of N-nitrosomethylurea induced rat tumours.
Topics: Adenoma; Aneuploidy; Animals; Brain Neoplasms; Bronchial Neoplasms; Carcinoma; DNA; DNA, Neoplasm; F | 1969 |