urea has been researched along with Orphan Diseases in 4 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Orphan Diseases: Rare diseases that have not been well studied.
Excerpt | Relevance | Reference |
---|---|---|
" Four Phase 1 studies were conducted to characterize the bioavailability (BA) and/or bioequivalence (BE) of ACER-001 (in healthy volunteers) and taste assessment relative to NaPBA powder (in taste panelists)." | 1.91 | Taste-masked formulation of sodium phenylbutyrate (ACER-001) for the treatment of urea cycle disorders. ( Cederbaum, SD; Edwards, J; Kellmeyer, T; Peters, Y; Steiner, RD, 2023) |
"The proportion of females with ornithine transcarbamylase deficiency (fOTC-D), particularly those being asymptomatic (asfOTC-D), was higher in the NA than in the EU sample." | 1.51 | Transatlantic combined and comparative data analysis of 1095 patients with urea cycle disorders-A successful strategy for clinical research of rare diseases. ( Batshaw, ML; Baumgartner, MR; Boy, N; Burgard, P; Burlina, AB; de Lonlay, P; Dionisi-Vici, C; Dobbelaere, D; Garbade, SF; Garcia-Cazorla, A; Hoffmann, GF; Kölker, S; McCandless, SE; Mew, NA; Posset, R; Seminara, J; Summar, M; Teles, EL; Vara, R, 2019) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (25.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (25.00) | 29.6817 |
2010's | 1 (25.00) | 24.3611 |
2020's | 1 (25.00) | 2.80 |
Authors | Studies |
---|---|
Cederbaum, SD | 2 |
Edwards, J | 1 |
Kellmeyer, T | 1 |
Peters, Y | 1 |
Steiner, RD | 1 |
Posset, R | 1 |
Garbade, SF | 1 |
Boy, N | 1 |
Burlina, AB | 1 |
Dionisi-Vici, C | 1 |
Dobbelaere, D | 1 |
Garcia-Cazorla, A | 1 |
de Lonlay, P | 1 |
Teles, EL | 1 |
Vara, R | 1 |
Mew, NA | 1 |
Batshaw, ML | 2 |
Baumgartner, MR | 1 |
McCandless, SE | 1 |
Seminara, J | 1 |
Summar, M | 1 |
Hoffmann, GF | 1 |
Kölker, S | 1 |
Burgard, P | 1 |
Tuchman, M | 1 |
Lee, B | 1 |
Lichter-Konecki, U | 1 |
Summar, ML | 1 |
Yudkoff, M | 1 |
Kerr, DS | 1 |
Diaz, GA | 1 |
Seashore, MR | 1 |
Lee, HS | 1 |
McCarter, RJ | 1 |
Krischer, JP | 1 |
WITTENHAGEN, G | 1 |
MOHNIKE, G | 1 |
LANGENBECK, W | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Longitudinal Study of Urea Cycle Disorders[NCT00237315] | 1,009 participants (Anticipated) | Observational | 2006-02-28 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
4 other studies available for urea and Orphan Diseases
Article | Year |
---|---|
Taste-masked formulation of sodium phenylbutyrate (ACER-001) for the treatment of urea cycle disorders.
Topics: Humans; Hyperammonemia; Nitrogen; Phenylbutyrates; Powders; Rare Diseases; Taste; Urea; Urea Cycle D | 2023 |
Transatlantic combined and comparative data analysis of 1095 patients with urea cycle disorders-A successful strategy for clinical research of rare diseases.
Topics: Cohort Studies; Data Analysis; Delayed Diagnosis; Europe; Female; Humans; Infant, Newborn; Male; Neo | 2019 |
Cross-sectional multicenter study of patients with urea cycle disorders in the United States.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Metabolism, Inborn Errors; Amino Acids; Child | 2008 |
[Contributions to the degradation of N-(4-methylbenzenesulfonyl)-N'-butylurea (D-860) and the separation of the products formed].
Topics: Rare Diseases; Retinal Degeneration; Retinal Detachment; Tolbutamide; Urea | 1959 |