urea has been researched along with Orphan Diseases in 4 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Orphan Diseases: Rare diseases that have not been well studied.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Four Phase 1 studies were conducted to characterize the bioavailability (BA) and/or bioequivalence (BE) of ACER-001 (in healthy volunteers) and taste assessment relative to NaPBA powder (in taste panelists)." | 1.91 | Taste-masked formulation of sodium phenylbutyrate (ACER-001) for the treatment of urea cycle disorders. ( Cederbaum, SD; Edwards, J; Kellmeyer, T; Peters, Y; Steiner, RD, 2023) |
| "The proportion of females with ornithine transcarbamylase deficiency (fOTC-D), particularly those being asymptomatic (asfOTC-D), was higher in the NA than in the EU sample." | 1.51 | Transatlantic combined and comparative data analysis of 1095 patients with urea cycle disorders-A successful strategy for clinical research of rare diseases. ( Batshaw, ML; Baumgartner, MR; Boy, N; Burgard, P; Burlina, AB; de Lonlay, P; Dionisi-Vici, C; Dobbelaere, D; Garbade, SF; Garcia-Cazorla, A; Hoffmann, GF; Kölker, S; McCandless, SE; Mew, NA; Posset, R; Seminara, J; Summar, M; Teles, EL; Vara, R, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cederbaum, SD | 2 |
| Edwards, J | 1 |
| Kellmeyer, T | 1 |
| Peters, Y | 1 |
| Steiner, RD | 1 |
| Posset, R | 1 |
| Garbade, SF | 1 |
| Boy, N | 1 |
| Burlina, AB | 1 |
| Dionisi-Vici, C | 1 |
| Dobbelaere, D | 1 |
| Garcia-Cazorla, A | 1 |
| de Lonlay, P | 1 |
| Teles, EL | 1 |
| Vara, R | 1 |
| Mew, NA | 1 |
| Batshaw, ML | 2 |
| Baumgartner, MR | 1 |
| McCandless, SE | 1 |
| Seminara, J | 1 |
| Summar, M | 1 |
| Hoffmann, GF | 1 |
| Kölker, S | 1 |
| Burgard, P | 1 |
| Tuchman, M | 1 |
| Lee, B | 1 |
| Lichter-Konecki, U | 1 |
| Summar, ML | 1 |
| Yudkoff, M | 1 |
| Kerr, DS | 1 |
| Diaz, GA | 1 |
| Seashore, MR | 1 |
| Lee, HS | 1 |
| McCarter, RJ | 1 |
| Krischer, JP | 1 |
| WITTENHAGEN, G | 1 |
| MOHNIKE, G | 1 |
| LANGENBECK, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Longitudinal Study of Urea Cycle Disorders[NCT00237315] | 1,009 participants (Anticipated) | Observational | 2006-02-28 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for urea and Orphan Diseases
| Article | Year |
|---|---|
Taste-masked formulation of sodium phenylbutyrate (ACER-001) for the treatment of urea cycle disorders.
Topics: Humans; Hyperammonemia; Nitrogen; Phenylbutyrates; Powders; Rare Diseases; Taste; Urea; Urea Cycle D | 2023 |
Transatlantic combined and comparative data analysis of 1095 patients with urea cycle disorders-A successful strategy for clinical research of rare diseases.
Topics: Cohort Studies; Data Analysis; Delayed Diagnosis; Europe; Female; Humans; Infant, Newborn; Male; Neo | 2019 |
Cross-sectional multicenter study of patients with urea cycle disorders in the United States.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Metabolism, Inborn Errors; Amino Acids; Child | 2008 |
[Contributions to the degradation of N-(4-methylbenzenesulfonyl)-N'-butylurea (D-860) and the separation of the products formed].
Topics: Rare Diseases; Retinal Degeneration; Retinal Detachment; Tolbutamide; Urea | 1959 |