Page last updated: 2024-10-20

urea and Nephrotic Syndrome

urea has been researched along with Nephrotic Syndrome in 48 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.

Research Excerpts

ExcerptRelevanceReference
"The long-term effects of high dose steroid treatment with either prednisone (PDN) or deflazacort (DFZ) were examined on various parts of the skeleton in 29 patients with nephrotic syndrome."9.07Glucocorticoid-induced osteoporosis in the lumbar spine, forearm, and mandible of nephrotic patients: a double-blind study on the high-dose, long-term effects of prednisone versus deflazacort. ( Brandi, L; Daugaard, H; Egfjord, M; Lewin, E; Olgaard, K; Storm, T; van Wowern, N, 1992)
"Nephrotic syndrome is associated with abnormal regulation of renal water excretion."5.30Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome. ( Andrews, P; Ecelbarger, CA; Fernández-Llama, P; Knepper, MA; Nielsen, S, 1998)
"The long-term effects of high dose steroid treatment with either prednisone (PDN) or deflazacort (DFZ) were examined on various parts of the skeleton in 29 patients with nephrotic syndrome."5.07Glucocorticoid-induced osteoporosis in the lumbar spine, forearm, and mandible of nephrotic patients: a double-blind study on the high-dose, long-term effects of prednisone versus deflazacort. ( Brandi, L; Daugaard, H; Egfjord, M; Lewin, E; Olgaard, K; Storm, T; van Wowern, N, 1992)
" Serum adiponectin levels, blood chemistry (protein/albumin, serum creatinine, blood urea and electrolytes levels) and 24-hour proteinuria w studied as well."4.31Elevated baseline adiponectin level predicting an increased risk of disease activity in idiopathic nephrotic syndrome and chronic kidney disease in children. ( Abo El Fotoh, WM; El Mashad, GM, 2023)
"The purpose of the study was to assess the efficacy of Helicobacter pylori (HP) infection treatment in children with the nephrotic syndrome, using non-invasive urea breathing test (13C UBT)."3.70[The assessment of Helicobacter pylori eradication with the urea breathing test (13C UBT)]. ( Durakiewicz, T; Papierkowski, A; Zajaczkowska, M, 2000)
"We explored the role of angiotensin II and vasopressin in the maintenance of blood pressure during the nephrotic syndrome of adriamycin-induced nephropathy in rats."3.69Pressor mechanisms in adriamycin-induced nephropathy with hypertension in rats. ( Ferrari-Spadotto, A; Franco, R; Gavras, H; Gavras, I; Georgette, J; Gut, A, 1994)
"The clinical and biochemical features of 54 children with Nephrotic Syndrome seen over a period of 6 years and the response to Prednisolone therapy in 43 cases is presented."3.65Nephrotic syndrome in children-a clinical study. ( Rahimtoola, RJ; Wazir, MD, 1976)
" One became oedema-free with frusemide 240 mg daily, three became oedema-free with frusemide 500 mg daily, and two required a combination of high-dose frusemide and spironolactone."3.65Salt-poor human albumin in management of nephrotic syndrome. ( Cash, JD; Davison, AM; Lambie, AT; Verth, AH, 1974)

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-199034 (70.83)18.7374
1990's9 (18.75)18.2507
2000's2 (4.17)29.6817
2010's1 (2.08)24.3611
2020's2 (4.17)2.80

Authors

AuthorsStudies
Hejazian, SM1
Rahbar Saadat, Y1
Bahmanpour, Z1
Hosseiniyan Khatibi, SM1
Ardalan, M1
Zununi Vahed, S1
Abo El Fotoh, WM1
El Mashad, GM1
Wang, L1
Sun, Y1
Cai, X1
Fu, G1
Artunc, F1
Nasir, O1
Amann, K1
Boini, KM1
Häring, HU1
Risler, T1
Lang, F1
GOTZE, H1
MCCAUGHEY, WT1
WOMERSLEY, RA1
SCHUMACHER, RR1
RIDOLFO, AS1
MARTZ, BL1
SAFAR, M1
BARIETY, J1
LAGRUE, G1
SAMARCQ, P1
MILLIEZ, P1
BERLYNE, GM1
VARLEY, H1
NILWARANGKUR, S1
HOERNI, M1
WEIL, WB1
WALLACE, WM1
SCHNABEL, R1
LAHL, R1
HORNER, WH1
CHAMBLISS, JF1
MAHANAND, D1
PASTERNACK, A1
KUHLBAECK, B1
TALLGREN, LG1
Nagasawa, HT1
Swingle, KF1
Alexander, CS1
Kozhevnikov, AD1
Sazonets, GI1
Chantler, C1
Franco, R1
Gut, A1
Ferrari-Spadotto, A1
Georgette, J1
Gavras, I1
Gavras, H1
Garini, G1
Mazzi, A1
Allegri, L1
Buzio, C1
Borghetti, A1
Kamitsuji, H1
Nakajima, M1
Kawahara, S1
Nishimura, T1
Fernández-Llama, P1
Andrews, P1
Nielsen, S1
Ecelbarger, CA1
Knepper, MA1
Sands, JM1
Zajaczkowska, M1
Durakiewicz, T1
Papierkowski, A1
Srivastava, RN2
Mayekar, G2
Anand, R1
Choudhry, VP1
Ghai, OP2
Tandon, HD1
Wazir, MD1
Rahimtoola, RJ1
Saito, A1
Maeda, K1
Naotsuka, T1
Kobayashi, K1
Sugiyama, S1
D'Amico, G1
Gentile, MG1
Manna, G1
Fellin, G1
Ciceri, R1
Cofano, F1
Petrini, C1
Lavarda, F1
Perolini, S1
Porrini, M1
Olgaard, K1
Storm, T1
van Wowern, N1
Daugaard, H1
Egfjord, M1
Lewin, E1
Brandi, L1
Sergeeva, KM1
Olmer, M1
Pain, C1
Dussol, B1
Berland, Y1
Sjöström, PA1
Odlind, BG1
Beermann, BA1
Karlberg, BE1
Mansy, H1
Goodship, TH1
Tapson, JS1
Hartley, GH1
Keavey, P1
Wilkinson, R1
Ben Ammar, S1
Ben Abdallah, T1
Beikahia, C1
el-Matri, A1
Ben Ayed, H1
Birtwistle, RJ1
Hardwicke, J1
Bouton, JM1
Coulter, JB1
Stickler, GB2
Shin, MH1
Burke, EC2
Holley, KE2
Miller, RH1
Segar, WE1
Kennedy, AC1
Burton, JA1
Allison, ME1
Ramachandran, S1
Rajapakse, CN1
Yoganathan, M1
Cameron, JS2
Turner, DR1
Ogg, CS2
Sharpstone, P1
Brown, CB1
Chandra, RK1
Olbing, H1
Greifer, I1
Bennett, BP1
Bernstein, J1
Spitzer, A1
Addae, SK1
Davison, AM1
Lambie, AT1
Verth, AH1
Cash, JD1
Anders, D1
Schlenk, R1
Viethen, J1
Wilkinson, JH1
Harman, JW1
McDonald, R1
Wiggelinkhuizen, J1
Kaschula, RO1
Naish, PF1
Sevitt, LH1
Pitney, WR1
Peters, DK1
Ellis, FG1
Salmon, MA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multinational Prospective Study on the Duration of Steroid Therapy in Steroid Sensitive Nephrotic Syndrome[NCT03878914]Phase 434 participants (Actual)Interventional2019-08-06Terminated (stopped due to The study was terminated at all but one site because of the pandemic)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for urea and Nephrotic Syndrome

ArticleYear
The medullary collecting duct urea transporters.
    Current opinion in nephrology and hypertension, 1999, Volume: 8, Issue:4

    Topics: Animals; Carrier Proteins; Diabetes Mellitus, Experimental; Gene Expression Regulation; Humans; Kidn

1999
Diagnostic significance of enzyme determinations in urine.
    Current problems in clinical biochemistry, 1968, Volume: 2, Issue:0

    Topics: Acute Disease; Alkaline Phosphatase; Chronic Disease; Clinical Enzyme Tests; Cysts; Diabetes Mellitu

1968

Trials

4 trials available for urea and Nephrotic Syndrome

ArticleYear
Effectiveness of dietary protein augmentation associated with angiotensin-converting enzyme inhibition in the management of the nephrotic syndrome.
    Mineral and electrolyte metabolism, 1996, Volume: 22, Issue:1-3

    Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Blood Proteins; Body We

1996
Glucocorticoid-induced osteoporosis in the lumbar spine, forearm, and mandible of nephrotic patients: a double-blind study on the high-dose, long-term effects of prednisone versus deflazacort.
    Calcified tissue international, 1992, Volume: 50, Issue:6

    Topics: Absorptiometry, Photon; Anti-Inflammatory Agents; Blood Pressure; Bone Density; Calcium; Double-Blin

1992
Pharmacokinetics and effects of frusemide in patients with the nephrotic syndrome.
    European journal of clinical pharmacology, 1989, Volume: 37, Issue:2

    Topics: Adult; Albuminuria; Chromatography, High Pressure Liquid; Electrolytes; Female; Furosemide; Humans;

1989
Effect of a high protein diet in patients with the nephrotic syndrome.
    Clinical science (London, England : 1979), 1989, Volume: 77, Issue:4

    Topics: Adult; Aged; Blood Proteins; Creatinine; Dietary Proteins; Female; Humans; Male; Middle Aged; Nephro

1989

Other Studies

42 other studies available for urea and Nephrotic Syndrome

ArticleYear
Dicer and Drosha expression in patients with nephrotic syndrome.
    BioFactors (Oxford, England), 2020, Volume: 46, Issue:4

    Topics: Adult; Case-Control Studies; Creatinine; DEAD-box RNA Helicases; Female; Gene Expression Regulation;

2020
Elevated baseline adiponectin level predicting an increased risk of disease activity in idiopathic nephrotic syndrome and chronic kidney disease in children.
    Minerva pediatrics, 2023, Volume: 75, Issue:3

    Topics: Adiponectin; Child; Chronic Disease; Creatinine; Humans; Nephrotic Syndrome; Proteinuria; Recurrence

2023
The diagnostic value of human epididymis protein 4 as a novel biomarker in patients with renal dysfunction.
    International urology and nephrology, 2018, Volume: 50, Issue:11

    Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Area Under Curve; Biomarkers; Cardi

2018
Serum- and glucocorticoid-inducible kinase 1 in doxorubicin-induced nephrotic syndrome.
    American journal of physiology. Renal physiology, 2008, Volume: 295, Issue:6

    Topics: Albuminuria; Animals; Body Weight; Doxorubicin; Fibrosis; Immediate-Early Proteins; Mice; Mice, Inbr

2008
STEROIDS IN TREATMENT OF THE NEPHROTIC SYNDROME IN ADULTS.
    British medical journal, 1964, Feb-08, Volume: 1, Issue:5379

    Topics: Adolescent; Adult; Biopsy; Blood Chemical Analysis; Cholesterol; Creatine; Creatinine; Glomeruloneph

1964
PERIODIC PERITONEAL DIALYSIS FOR CHRONIC RENAL FAILURE. A CASE STUDY OF SIXTEEN MONTHS' EXPERIENCE.
    Annals of internal medicine, 1964, Volume: 60

    Topics: Blood Chemical Analysis; Creatine; Creatinine; Dialysis; Glomerulonephritis; Heart Failure; Kidney F

1964
[ASSOCIATION OF A NEPHROTIC SYNDROME AND A GOUGEROT-SJOGREN SYNDROME].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1964, May-14, Volume: 40

    Topics: Blood Protein Electrophoresis; Cholesterol; Erythrocytes; Hematuria; Humans; Lipids; Nephrotic Syndr

1964
ENDOGENOUS-CREATININE CLEARANCE AND GLOMERULAR-FILTRATION RATE.
    Lancet (London, England), 1964, Oct-24, Volume: 2, Issue:7365

    Topics: Blood; Creatine; Creatinine; Glomerular Filtration Rate; Glomerulonephritis; Humans; Inulin; Kidney

1964
FLUID THERAPY IN RENAL DISEASE.
    Pediatric clinics of North America, 1964, Volume: 11

    Topics: Acute Kidney Injury; Child; Diuresis; Fluid Therapy; Glomerulonephritis; Humans; Hyperkalemia; Hypoc

1964
[LIVER PARENCHYMA NECROSES CAUSED BY THE NEW ANTIEPILEPTIC ALPHA-ACETOXYPHENURONE. REPORT ON ANIMAL EXPERIMENTAL STUDIES AND 4 CASES WITH FATAL OUTCOME].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1964, Jul-31, Volume: 106

    Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Fatal Outcome; Hemorrhagic Disorders; Hepat

1964
SERUM TRANSAMIDINASE IN RENAL DISEASE.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 118

    Topics: Acute Kidney Injury; Amidinotransferases; Blood; Blood Urea Nitrogen; Chromatography; Clinical Enzym

1965
SERUM INDICAN IN RENAL DISEASE.
    Acta medica Scandinavica, 1964, Volume: 176

    Topics: Blood; Creatine; Creatinine; Glomerulonephritis; Indican; Kidney Diseases; Nephrotic Syndrome; Urea;

1964
Metabolism of aminonucleoside-8-14C in the rat and guinea pig.
    Biochemical pharmacology, 1967, Volume: 16, Issue:11

    Topics: Adenine; Adrenal Glands; Allantoin; Amines; Animals; Biliary Tract; Carbon Dioxide; Carbon Isotopes;

1967
[Urea binding by serum proteins under normal conditions, in chronic renal failure and in the nephrotic syndrome].
    Terapevticheskii arkhiv, 1984, Volume: 56, Issue:7

    Topics: Animals; Cattle; Humans; Kidney Failure, Chronic; Nephrotic Syndrome; Protein Binding; Serum Albumin

1984
What is the significance of the ratio of the plasma urea to the plasma creatinine?
    Pediatric nephrology (Berlin, Germany), 1994, Volume: 8, Issue:5

    Topics: Child, Preschool; Creatinine; Glomerular Filtration Rate; Humans; Nephrotic Syndrome; Urea

1994
Pressor mechanisms in adriamycin-induced nephropathy with hypertension in rats.
    Hypertension (Dallas, Tex. : 1979), 1994, Volume: 23, Issue:1 Suppl

    Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Cholesterol; Creatinine; Doxorubicin; H

1994
Detection of activated platelets in urine by double immunofluorescence in children with IgA nephropathy.
    Nephron, 1998, Volume: 78, Issue:2

    Topics: Adolescent; Blood Platelets; Child; Female; Fluorescein-5-isothiocyanate; Fluorescent Antibody Techn

1998
Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome.
    Kidney international, 1998, Volume: 53, Issue:5

    Topics: Adenylyl Cyclases; Animals; Aquaporin 1; Aquaporin 2; Aquaporin 3; Aquaporin 4; Aquaporin 6; Aquapor

1998
[The assessment of Helicobacter pylori eradication with the urea breathing test (13C UBT)].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2000, Volume: 8, Issue:46

    Topics: Adolescent; Anti-Inflammatory Agents; Breath Tests; Child; Child, Preschool; Female; Helicobacter In

2000
Nephrotic syndrome in indian children.
    Archives of disease in childhood, 1975, Volume: 50, Issue:8

    Topics: Adolescent; Age Factors; Amyloidosis; Child; Child, Preschool; Edema; Female; Glomerulonephritis; He

1975
Nephrotic syndrome in children-a clinical study.
    JPMA. The Journal of the Pakistan Medical Association, 1976, Volume: 26, Issue:6

    Topics: Age Factors; Albuminuria; Child; Child, Preschool; Cholesterol; Female; Hematuria; Humans; Infant; I

1976
Studies on protein and nitrogen metabolism in nephrotic syndrome using 15N-labelled glycine and urea.
    Contributions to nephrology, 1977, Volume: 6

    Topics: Glycine; Humans; Nephrotic Syndrome; Nitrogen; Nitrogen Radioisotopes; Serum Albumin; Urea

1977
Effect of vegetarian soy diet on hyperlipidaemia in nephrotic syndrome.
    Lancet (London, England), 1992, May-09, Volume: 339, Issue:8802

    Topics: Adolescent; Adult; Aged; Apolipoproteins A; Apolipoproteins B; Blood Pressure; Blood Proteins; Body

1992
[Intrarenal mechanisms of the regulation of homeostasis in children with nephrotic syndrome].
    Pediatriia, 1991, Issue:7

    Topics: Acute Disease; Child; Creatine; Diuresis; Humans; Kidney; Kidney Function Tests; Nephrotic Syndrome;

1991
Protein diet and nephrotic syndrome.
    Kidney international. Supplement, 1989, Volume: 27

    Topics: Adult; Aged; Albuminuria; Creatinine; Dietary Proteins; Female; Glomerular Filtration Rate; Humans;

1989
[A discordance between urea and creatinine figures. Apropos of several patients].
    La Tunisie medicale, 1987, Volume: 65, Issue:11

    Topics: Adult; Creatinine; Diabetic Nephropathies; Humans; Kidney Failure, Chronic; Lupus Erythematosus, Sys

1987
The role of urea in albumin dimerisation in nephrotic urines.
    Clinica chimica acta; international journal of clinical chemistry, 1985, Sep-16, Volume: 151, Issue:1

    Topics: Albuminuria; Electric Conductivity; Humans; Hydrogen-Ion Concentration; Macromolecular Substances; M

1985
The nephrotic syndrome of infancy.
    Acta paediatrica Scandinavica, 1974, Volume: 63, Issue:5

    Topics: Adrenal Cortex Hormones; Alpha-Globulins; Amino Acids; Erythrocytes; Female; gamma-Globulins; Humans

1974
Diffuse glomerulonephritis associated with infected ventriculoatrial shunt.
    The New England journal of medicine, 1968, Nov-14, Volume: 279, Issue:20

    Topics: Beta-Globulins; Biopsy; Catheterization; Child; Child, Preschool; Drainage; Female; Fluorescent Anti

1968
Tuberculosis as a continuing cause of renal amyloidosis.
    British medical journal, 1974, Sep-28, Volume: 3, Issue:5934

    Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Amyloidosis; Arthritis, Rheumatoid; Autopsy; Biopsy; C

1974
The diabetic kidney in the tropics.
    The Medical journal of Australia, 1974, Aug-24, Volume: 2, Issue:8

    Topics: Adult; Aged; Creatinine; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Humans; Kidney;

1974
The nephrotic syndrome in adults with 'minimal change' glomerular lesions.
    The Quarterly journal of medicine, 1974, Volume: 43, Issue:171

    Topics: Adolescent; Adult; Age Factors; Aged; Biopsy; Creatinine; Cyclophosphamide; Female; Follow-Up Studie

1974
Familial nephrotic syndrome with nephrocalcinosis and tubular dysfunction.
    The Journal of pediatrics, 1973, Volume: 82, Issue:2

    Topics: Alkaline Phosphatase; Calcium; Child; Chronic Kidney Disease-Mineral and Bone Disorder; Creatinine;

1973
Clinicopathologic correlations in 100 children with the nephrotic syndrome.
    Indian pediatrics, 1973, Volume: 10, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Female; Hematuria; Humans; Hypertension; Infant; Kidney; Male;

1973
Idiopathic membranous nephropathy in children.
    Kidney international, 1973, Volume: 3, Issue:6

    Topics: Adolescent; Age Factors; Aminohippuric Acids; Basement Membrane; Biopsy; Child; Child, Preschool; Cr

1973
The kidney in sickle cell disease V: Clinical manifestations.
    Ghana medical journal, 1973, Volume: 12, Issue:4

    Topics: Anemia, Sickle Cell; Bacteriuria; Enuresis; Erythrocyte Count; Glomerulonephritis; Hematuria; Humans

1973
Salt-poor human albumin in management of nephrotic syndrome.
    British medical journal, 1974, Mar-16, Volume: 1, Issue:5906

    Topics: Adolescent; Adult; Aged; Albumins; Body Weight; Creatinine; Diet Therapy; Dietary Proteins; Edema; F

1974
[Long-term study of the idiopathic nephrotic syndrome in childhood (67 children of the Pediatric clinic in Erlangen from 1948-1973) (author's transl)].
    Klinische Padiatrie, 1974, Volume: 186, Issue:1

    Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Biopsy; Blood Sedimentation; Child; Child, Prescho

1974
Chronic glomerulonephritis and the nephrotic syndrome induced in rats with N,N'-diacetylbenzidine.
    The Journal of pathology, 1971, Volume: 104, Issue:2

    Topics: Anemia; Animals; Basement Membrane; Biphenyl Compounds; Blood Protein Electrophoresis; Capillaries;

1971
The nephrotic syndrome in very young infants.
    American journal of diseases of children (1960), 1971, Volume: 122, Issue:6

    Topics: Basement Membrane; Cholesterol; Cyclophosphamide; Edema; Female; Humans; Infant; Infant, Newborn; Ki

1971
Fibrinogen derivatives in renal disease.
    Clinical science, 1970, Volume: 39, Issue:6

    Topics: Blood Pressure; Fibrinogen; Glomerulonephritis; Hemagglutination Inhibition Tests; Humans; Kidney Di

1970
Femoral arterial thrombosis in nephrotic syndrome.
    Archives of disease in childhood, 1971, Volume: 46, Issue:246

    Topics: Amputation, Surgical; Blood Coagulation; Child, Preschool; Cyclophosphamide; Female; Femoral Artery;

1971