urea has been researched along with Neoplasms in 191 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hand-foot syndrome (HFS) is a dose-limiting toxicity of capecitabine for which no effective preventative treatment has been definitively demonstrated." | 9.14 | Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. ( Berenberg, JL; Christian, D; Delaune, R; Loprinzi, CL; Menon, SP; Pajon, ER; Qin, R; Rowland, KM; Satele, DV; Thomas, S; Wolf, SL, 2010) |
| "We retrospectively analysed 36 cancer patients affected by moderate or profound SIAD-induced chronic hyponatremia, who started oral urea (initial daily dose 15 g or 30 g) without fluid restriction between July 2013 and July 2018." | 7.91 | Urea in cancer patients with chronic SIAD-induced hyponatremia: Old drug, new evidence. ( Arvat, E; Castellana, E; Cattel, F; D'Angelo, V; Grossi, E; Nervo, A; Rosso, D, 2019) |
| "Hand-foot syndrome (HFS) is a dose-limiting toxicity of capecitabine for which no effective preventative treatment has been definitively demonstrated." | 5.14 | Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. ( Berenberg, JL; Christian, D; Delaune, R; Loprinzi, CL; Menon, SP; Pajon, ER; Qin, R; Rowland, KM; Satele, DV; Thomas, S; Wolf, SL, 2010) |
| "We retrospectively analysed 36 cancer patients affected by moderate or profound SIAD-induced chronic hyponatremia, who started oral urea (initial daily dose 15 g or 30 g) without fluid restriction between July 2013 and July 2018." | 3.91 | Urea in cancer patients with chronic SIAD-induced hyponatremia: Old drug, new evidence. ( Arvat, E; Castellana, E; Cattel, F; D'Angelo, V; Grossi, E; Nervo, A; Rosso, D, 2019) |
| "We have synthesized a new compound, 3-bromoacetylamino benzoylurea (3-BAABU), which showed strong cancericidal activity by inducing irreversible mitotic arrest and subsequently apoptosis in human T cell leukemic cells (CEM), human biphenotypic leukemic cells (SP), a human prostate cancer cell line (PC-3), murine melanoma cells (B-16), and murine lymphoma/leukemia cells (EL4) in vitro with an ID50 in the range of 0." | 3.70 | Inhibition of microtubule assembly in tumor cells by 3-bromoacetylamino benzoylurea, a new cancericidal compound. ( Bekesi, JG; Holland, JF; Jiang, JD; Roboz, J; Strauchen, J; Wang, Y, 1998) |
| "The maximum-tolerated dose of AZD7762 in combination with gemcitabine 1,000 mg/m(2) was 30 mg." | 2.79 | Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors. ( Agbo, F; Azad, N; Barker, P; Carducci, M; Carter, J; Cosgrove, D; Knight, R; Lorusso, P; Malburg, L; Oakes, P; Quinn, MF; Sausville, E; Senderowicz, A; Zabludoff, S, 2014) |
| "This open-label, Phase I, dose-escalation study evaluated the safety, pharmacokinetics (PK) and preliminary efficacy (RECIST) of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours (NCT00937664)." | 2.78 | Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours. ( Agbo, F; Arita, S; Esaki, T; Fujimoto, C; Hamatake, M; Hirai, F; Kometani, T; Makiyama, A; Nosaki, K; Seto, T; Shi, X; Takeoka, H, 2013) |
| "Patients with advanced, incurable solid tumors or non-Hodgkin's lymphoma received AT9283 as a continuous 24-hour infusion on days 1, 8 of a 21-day cycle." | 2.78 | NCIC CTG IND.181: phase I study of AT9283 given as a weekly 24 hour infusion in advanced malignancies. ( Capier, CA; Chen, EX; Chi, KN; Dent, SF; Gelmon, KA; Jonker, DJ; Lyons, JF; Seymour, L; Wainman, N, 2013) |
| " The mean oral bioavailability of a 0." | 2.77 | A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies. ( Arkenau, HT; Calvert, H; Judson, I; Lewis, S; Lock, V; Lyons, J; Molife, LR; Olmos, D; Plummer, R; Squires, M; Yap, TA; Yule, M, 2012) |
| "To evaluate the effect of the anti-cancer drug carboplatin on plasma concentrations and urinary excretion of L-carnitine (LC) and its main ester, acetyl-L-carnitine (ALC), in cancer patients." | 2.73 | Urinary excretion of L-carnitine and its short-chain acetyl-L-carnitine in patients undergoing carboplatin treatment. ( Bisonni, R; Calvani, M; D'Iddio, S; Graziano, F; Lippe, P; Mancinelli, A, 2007) |
| "In this study, rational dosing guidelines for amphotericin B-deoxycholate (AmB) are proposed for children." | 2.73 | Amphotericin B dose optimization in children with malignant diseases. ( Coakley, JC; Earl, JW; McLachlan, AJ; Nath, CE; Shaw, PJ, 2007) |
| "Patients with advanced solid tumors received escalating doses of bizelesin as an i." | 2.70 | A Phase I study of bizelesin (NSC 615291) in patients with advanced solid tumors. ( Adjei, AA; Ames, MM; Atherton, P; Bagniewski, PG; Erlichman, C; Goldberg, RM; Pitot, HC; Rayson, D; Reid, JM; Rubin, J; Sloan, JA, 2002) |
| "Urea has been utilized as a reductant in diesel fuels to lower emission of nitrogen oxides, igniting interest in probable human health hazards associated with exposure to exogenous urea." | 2.58 | Assessment of Health Effects of Exogenous Urea: Summary and Key Findings. ( Dickerson, AS; Hotchkiss, A; Keshava, C; Lee, JS; Persad, AS, 2018) |
| "The urea NH moiety is a favorable hydrogen bond donor, while the urea oxygen atom is regarded as an excellent acceptor." | 2.53 | Diaryl Urea: A Privileged Structure in Anticancer Agents. ( Bottegoni, G; Ferraro, M; Garuti, L; Roberti, M, 2016) |
| "Aurora A and Aurora B are validated anticancer targets, and the development of Aurora kinase inhibitors has progressed from preclinical to clinical studies." | 2.52 | Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress. ( Bastida, CC; Falchook, GS; Kurzrock, R, 2015) |
| "Cisplatin (CP) is an anticancer medication that is commonly used to treat solid tumors." | 1.72 | TGF-β1, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: Comparative modulating role of Melatonin, Vit. E and Ozone. ( Abd El-Emam, MM; Abdel-Rahman Mohamed, A; Bin Emran, T; El-Shetry, ES; Khater, SI; Metwally, MMM; Mostafa-Hedeab, G; Nassan, MA, 2022) |
| "Multiple solid cancers distantly increase expression of Nnmt and its product 1-methylnicotinamide (MNAM) in the liver." | 1.72 | Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase. ( Bamba, T; Enya, S; Hamanishi, J; Harata, A; Hojo, H; Izumi, Y; Kashio, S; Kawamoto, H; Kawaoka, S; Konishi, R; Mandai, M; Miura, M; Mizuno, R; Nakao, M; Suzuki, Y; Takahashi, M; Yoda, M, 2022) |
| "Seborrheic keratosis is a benign epidermal tumor of cosmetic concern-as it progressively increases in size, thickness, and pigmentation-on which topical treatments are poorly effective." | 1.72 | Effectiveness of a cosmetic device containing a combination of alpha- and beta-hydroxy acids, urea, and thuja for the treatment of seborrheic keratoses. ( Baciorri, F; Bianchi, L; Campione, E; Cosio, T; Di Prete, M; Dika, E; Diluvio, L; Lanna, C; Lombardo, P; Orlandi, A; Piccolo, A, 2022) |
| "5-FU-induced hyperammonaemic encephalopathy started 2 [1-4] days after 5-FU infusion onset." | 1.56 | 5-Fluorouracil-induced hyperammonaemic encephalopathy: A French national survey. ( Boige, V; Boilève, A; Chouchana, L; Ducreux, M; Gaboriau, L; Hillaire-Buys, D; Hollebecque, A; Jozwiak, M; Lillo-Le Louët, A; Malka, D; Thomas, L, 2020) |
| "The urea derivatives were also evaluated for their antiangiogenic properties, whereby their ability to inhibit tubulogenesis and kinase activity employing flow cytometry, ELISA, immunofluorescence and western blot techniques was measured." | 1.51 | Novel multitarget inhibitors with antiangiogenic and immunomodulator properties. ( Carda, M; Conesa-Milián, L; Falomir, E; Marco, JA; Murga, J, 2019) |
| " Modification of the isoindoline and/or the terminal functionality of screening hit 5 provided inhibitors such as 52 and 58 with nanomolar antiproliferative activity and preclinical pharmacokinetics properties which enabled potent antitumor activity when dosed orally in mouse xenograft models." | 1.46 | SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). ( Aguirre, AL; Algire, MA; Badagnani, I; Buchanan, FG; Cheng, D; Cheng, M; Chiang, GG; Clark, RF; Curtin, ML; Doherty, GA; Frey, RR; Guo, J; Hansen, TM; Heyman, HR; Korepanova, AV; Kovar, PJ; Longenecker, KL; Maag, D; Marin, VL; Michaelides, MR; Pliushchev, MA; Raich, D; Richardson, PL; Sarris, KA; Shrestha, A; Soni, NB; Sorensen, BK; Sweis, RF; Tse, C; Tu, N; Vasudevan, A; Wilsbacher, JL; Woller, K, 2017) |
| "TrkA is a target for chronic pain treatment due to the central position of the nerve growth factor (NGF)/TrkA pathway in nociception." | 1.43 | Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition. ( Bernard-Gauthier, V; Schirrmacher, R, 2016) |
| "Paradoxically, various cancers are HR defective and have apparently acquired characteristics to survive genomic instability." | 1.42 | ATR inhibition preferentially targets homologous recombination-deficient tumor cells. ( de Vries, EG; Fehrmann, RS; Franke, L; Krajewska, M; Labib, S; Schoonen, PM; van Vugt, MA, 2015) |
| "In this study, we investigated the anticancer effects of GSK-3β inhibitors on cancer cell lines and observed centrosome dysregulation which resulted in abnormal mitosis." | 1.42 | Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells. ( Ishioka, C; Yoshino, Y, 2015) |
| " The LD50 value was 160 μg/kg by a subcutaneous route." | 1.40 | Toxicity of parasporin-4 and health effects of pro-parasporin-4 diet in mice. ( Inouye, K; Koga, H; Mizuki, E; Okumura, S, 2014) |
| "Many cancer types show high expression levels of Pim kinases and particularly Pim-1 has been linked to the initiation and progression of the malignant phenotype." | 1.39 | Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structure. ( Alexander, LT; Chiaraluce, R; Consalvi, V; Knapp, S; Lantella, A; Lori, C; Pasquo, A, 2013) |
| "Children with cancer were also evaluated after antineoplasic treatment (CAT, n = 17)." | 1.38 | Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment. ( Brito, CX; Guerra, RN; Liberio, SA; Lima, MV; Mendonça, C; Mouchrek-Filho, JC; Nascimento, FR; Oliveira-Junior, JJ; Paim, DB; Pereira, AL, 2012) |
| "Solid tumors such as hepatocellular carcinoma are very often not amenable to chemotherapy and radiotherapy." | 1.38 | Spectroscopic and calorimetric evaluation of chemically induced protein denaturation in HuH-7 liver cancer cells and impact on cell survival. ( Aravalli, RN; Bischof, JC; Choi, J; Cressman, EN; Dong, J; Mehra, D; Mori, S, 2012) |
| " However, rapid metabolism and shorter half-life of drug mandate higher dose and frequent dosing schedule which subsequently results into higher toxicity." | 1.38 | Site specific/targeted delivery of gemcitabine through anisamide anchored chitosan/poly ethylene glycol nanoparticles: an improved understanding of lung cancer therapeutic intervention. ( Campbell, C; Dwivedi, P; Garg, NK; Tyagi, RK, 2012) |
| "Furthermore, 16c and 16g killed cancer cells with a mechanism independent of mitotic arrest, indicating a change of action mode." | 1.35 | Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents. ( Chen, KL; Du, NN; He, WY; Jiang, JD; Song, DQ; Wang, GF; Wang, YM; Wu, LZ; Yang, P; Zhang, XB, 2009) |
| "Out of 11 human cancer cell lines tested, GPL significantly inhibited proliferation of five lines viz." | 1.34 | Characterization of a lectin from Gonatanthus pumilus D. Don having anti-proliferative effect against human cancer cell lines. ( Bhide, SV; Dhuna, V; Kamboj, SS; Kaur, A; Saxena, AK; Singh, J, 2007) |
| "The majority of cancer therapeutics induces DNA damage to kill cells." | 1.33 | Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics. ( Bui, MH; Chen, Z; Gu, WZ; Kovar, P; Li, G; Lin, NH; Rosenberg, SH; Sham, HL; Sowin, TJ; Tao, ZF; Tong, Y; Wang, G; Wang, JY; Xiao, Z; Xue, J; Zhang, H, 2006) |
| "Fostriecin is an inhibitor of topoisomerase II catalytic activity." | 1.30 | Renal toxicity of the anticancer drug fostriecin. ( de Jong, PE; de Jong, RS; de Vries, EG; Meijer, S; Mulder, NH, 1998) |
| "We decided to test our hypothesis in 32 cancer patients." | 1.30 | Must we really fear toxicity of conventional amphotericin B in oncological patients? ( Doubek, M; Mayer, J; Vorlìcek, J, 1999) |
| "The drug therapies for hypercalcemia of malignancy have been known to be associated with either limited efficacy or cumulative toxicity in patients with advanced renal failure." | 1.29 | Calcium-free hemodialysis for the management of hypercalcemia. ( Ahn, SJ; Bang, BK; Jeon, DS; Kim, YS; Koo, WS; Yoon, YS, 1996) |
| "In anergic and malnourished cancer patients no curative surgical treatment was possible." | 1.26 | [Malnutrition and postoperative complication rate in cancer patients (author's transl)]. ( Fritsch, A; Funovics, J; Huk, I; Roth, E; Schemper, M; Schulz, F; Winter, M, 1982) |
| "As time progressed, the ear tumors increased in size and number in all groups but the greatest incidence was in the group fed 22." | 1.26 | Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine. ( , 1976) |
| "Forty patients with generalized cancer complicated by water and electrolyte retention were treated with "medium" and "large" doses of furosemide and bumetanide with 35% and 40% objective positive response, respectively." | 1.26 | Diuretics in malignant effusions and edemas of generalized cancer. ( Athanasiou, A; Dadiotis, L; Razis, DV, 1976) |
| "In fifty patients with cancer, subjective and objective correlates of anorexia of malignancy were studied." | 1.25 | Abnormalities of taste sensation in cancer patients. ( DeWys, WD; Walters, K, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 93 (48.69) | 18.7374 |
| 1990's | 7 (3.66) | 18.2507 |
| 2000's | 16 (8.38) | 29.6817 |
| 2010's | 60 (31.41) | 24.3611 |
| 2020's | 15 (7.85) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 3 |
| Hitosugi, T | 1 |
| Zhang, L | 6 |
| Zhang, S | 3 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 8 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 2 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 2 |
| Frei, E | 1 |
| Luce, JK | 1 |
| Loo, TL | 1 |
| Kaviani, A | 1 |
| Khansari Nejad, N | 1 |
| Akour, A | 1 |
| AlMuhaissen, SA | 1 |
| Nusair, MB | 1 |
| Al-Tammemi, AB | 1 |
| Mahmoud, NN | 1 |
| Jalouqa, S | 1 |
| Alrawashdeh, MN | 1 |
| Shanahan, JP | 1 |
| Moore, CM | 1 |
| Kampf, JW | 1 |
| Szymczak, NK | 1 |
| Guo, J | 3 |
| Wang, H | 3 |
| Luo, Y | 1 |
| An, H | 1 |
| Zhang, Z | 3 |
| Liu, G | 1 |
| Li, J | 10 |
| Metcalfe, GD | 1 |
| Smith, TW | 1 |
| Hippler, M | 1 |
| Ayala Izurieta, JE | 1 |
| Márquez, CO | 1 |
| García, VJ | 1 |
| Jara Santillán, CA | 1 |
| Sisti, JM | 1 |
| Pasqualotto, N | 1 |
| Van Wittenberghe, S | 1 |
| Delegido, J | 1 |
| Kubo, Y | 1 |
| Kitagawa, Y | 1 |
| Miyazaki, T | 1 |
| Sohda, M | 1 |
| Yamaji, T | 1 |
| Sakai, M | 1 |
| Saeki, H | 1 |
| Nemoto, K | 1 |
| Oyama, T | 2 |
| Muto, M | 1 |
| Takeuchi, H | 1 |
| Toh, Y | 1 |
| Matsubara, H | 1 |
| Mano, M | 1 |
| Kono, K | 1 |
| Kato, K | 1 |
| Yoshida, M | 1 |
| Kawakubo, H | 1 |
| Booka, E | 1 |
| Yamatsuji, T | 1 |
| Kato, H | 1 |
| Ito, Y | 1 |
| Ishikawa, H | 1 |
| Ishihara, R | 1 |
| Tsushima, T | 1 |
| Kawachi, H | 1 |
| Kojima, T | 1 |
| Kuribayashi, S | 1 |
| Makino, T | 1 |
| Matsuda, S | 1 |
| Doki, Y | 1 |
| Ma, P | 1 |
| Tang, X | 2 |
| Wang, X | 6 |
| Wang, W | 3 |
| Zhang, X | 6 |
| Wang, S | 4 |
| Zhou, N | 1 |
| Dodd, J | 1 |
| Jordan, R | 1 |
| Makhlina, M | 1 |
| Pesco Koplowitz, L | 1 |
| Koplowitz, B | 1 |
| Barnett, K | 1 |
| Yang, WH | 1 |
| Spana, C | 1 |
| Buchanan, SW | 1 |
| Mafa-Attoye, T | 1 |
| Dunfield, K | 1 |
| Thevathasan, NV | 1 |
| Isaac, ME | 1 |
| Wu, X | 3 |
| Huang, JW | 1 |
| Su, BK | 1 |
| Yuan, L | 1 |
| Zheng, WQ | 1 |
| Zhang, H | 4 |
| Zheng, YX | 1 |
| Zhu, W | 1 |
| Chou, PT | 1 |
| Manso, AP | 1 |
| De Morais, DC | 1 |
| Yamamoto, K | 1 |
| Owen, G | 1 |
| de Carvalho, RM | 1 |
| Palma-Dibb, RG | 1 |
| Brown, JC | 1 |
| Yang, S | 2 |
| Mire, EF | 1 |
| Miele, L | 1 |
| Ochoa, A | 1 |
| Zabaleta, J | 1 |
| Katzmarzyk, PT | 1 |
| Moi, CT | 1 |
| Bhowmick, S | 1 |
| Qureshi, M | 1 |
| Wang, K | 1 |
| Feng, B | 1 |
| Yang, Y | 4 |
| Chen, Y | 5 |
| Wang, Y | 6 |
| Yang, L | 1 |
| Jiang, K | 1 |
| James, TD | 1 |
| Chaturvedi, V | 1 |
| Postiglione, WM | 1 |
| Chakraborty, RD | 1 |
| Yu, B | 1 |
| Tabiś, W | 1 |
| Hameed, S | 1 |
| Biniskos, N | 1 |
| Jacobson, A | 1 |
| Zhou, H | 1 |
| Greven, M | 1 |
| Ferry, VE | 1 |
| Leighton, C | 1 |
| Wu, F | 1 |
| Lei, H | 1 |
| Chen, G | 3 |
| Chen, C | 1 |
| Song, Y | 2 |
| Cao, Z | 1 |
| Zhang, C | 2 |
| Zhou, J | 1 |
| Lu, Y | 2 |
| Pappone, C | 1 |
| Santinelli, V | 1 |
| Mecarocci, V | 1 |
| Tondi, L | 1 |
| Ciconte, G | 1 |
| Manguso, F | 1 |
| Sturla, F | 1 |
| Vicedomini, G | 1 |
| Micaglio, E | 1 |
| Anastasia, L | 1 |
| Pica, S | 1 |
| Camporeale, A | 1 |
| Lombardi, M | 1 |
| Shieh, PB | 1 |
| Elfring, G | 1 |
| Trifillis, P | 1 |
| Santos, C | 1 |
| Peltz, SW | 1 |
| Parsons, JA | 1 |
| Apkon, S | 1 |
| Darras, BT | 1 |
| Campbell, C | 2 |
| McDonald, CM | 1 |
| Galaviz, KI | 1 |
| Shah, NS | 1 |
| Gutierrez, M | 1 |
| Collins, LF | 1 |
| Lahiri, CD | 1 |
| Moran, CA | 1 |
| Szabo, B | 1 |
| Sumitani, J | 1 |
| Rhodes, J | 1 |
| Marconi, VC | 1 |
| Nguyen, ML | 1 |
| Cantos, VD | 1 |
| Armstrong, WS | 1 |
| Colasanti, JA | 1 |
| Singh, P | 1 |
| Kumar Sigalapalli, D | 1 |
| Sridhar Goud, N | 1 |
| Swain, B | 1 |
| Kumar Sahoo, S | 1 |
| Angeli, A | 2 |
| Shaik, AB | 1 |
| Madhavi Yaddanapudi, V | 1 |
| Supuran, CT | 3 |
| Arifuddin, M | 1 |
| Abdel-Rahman Mohamed, A | 1 |
| Khater, SI | 1 |
| Metwally, MMM | 1 |
| Bin Emran, T | 1 |
| Nassan, MA | 1 |
| Abd El-Emam, MM | 1 |
| Mostafa-Hedeab, G | 1 |
| El-Shetry, ES | 1 |
| Niu, F | 1 |
| Yu, Y | 1 |
| Li, Z | 6 |
| Ren, Y | 2 |
| Ye, Q | 2 |
| Liu, P | 1 |
| Ji, C | 1 |
| Qian, L | 1 |
| Xiong, Y | 1 |
| Mizuno, R | 1 |
| Hojo, H | 1 |
| Takahashi, M | 1 |
| Kashio, S | 1 |
| Enya, S | 1 |
| Nakao, M | 1 |
| Konishi, R | 1 |
| Yoda, M | 1 |
| Harata, A | 1 |
| Hamanishi, J | 1 |
| Kawamoto, H | 1 |
| Mandai, M | 1 |
| Suzuki, Y | 1 |
| Miura, M | 1 |
| Bamba, T | 1 |
| Izumi, Y | 1 |
| Kawaoka, S | 1 |
| Xiong, L | 1 |
| He, H | 2 |
| Fan, M | 1 |
| Hu, L | 1 |
| Wang, F | 3 |
| Song, X | 1 |
| Shi, S | 1 |
| Qi, B | 2 |
| Kayapinar, AK | 1 |
| Calik, B | 1 |
| Sahin, H | 1 |
| Tuncer, K | 1 |
| Bas, K | 1 |
| Engin, O | 1 |
| Akbulut, G | 1 |
| Wu, K | 2 |
| He, R | 1 |
| Qiu, K | 1 |
| Xiao, G | 1 |
| Peng, L | 1 |
| Meng, X | 1 |
| Zheng, C | 1 |
| Cai, Q | 2 |
| Gil-Edo, R | 1 |
| Hernández-Ribelles, G | 1 |
| Royo, S | 1 |
| Thawait, N | 1 |
| Serrels, A | 1 |
| Carda, M | 2 |
| Falomir, E | 2 |
| Boilève, A | 1 |
| Thomas, L | 1 |
| Lillo-Le Louët, A | 1 |
| Gaboriau, L | 1 |
| Chouchana, L | 1 |
| Ducreux, M | 1 |
| Malka, D | 1 |
| Boige, V | 1 |
| Hollebecque, A | 1 |
| Hillaire-Buys, D | 1 |
| Jozwiak, M | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 5 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 2 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
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| Thomas, S | 1 |
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| Yamasaki, T | 1 |
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| Kawamura, K | 1 |
| Fukumura, T | 1 |
| Zhang, MR | 1 |
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| Molife, LR | 1 |
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| Mouchrek-Filho, JC | 1 |
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| Dwivedi, P | 1 |
| Tyagi, RK | 1 |
| Schwartz, GH | 1 |
| Patnaik, A | 1 |
| Hammond, LA | 1 |
| Rizzo, J | 1 |
| Berg, K | 1 |
| Von Hoff, DD | 1 |
| Rowinsky, EK | 1 |
| WISE, BL | 1 |
| BUTTLE, GA | 1 |
| EPERON, J | 1 |
| KAMESWARAN, L | 1 |
| WEST, GB | 1 |
| SILVERMAN, D | 1 |
| PARANDIAN, S | 1 |
| SHENKIN, H | 1 |
| MARCANTE, ML | 1 |
| MOHLER, WC | 1 |
| JICK, H | 1 |
| KAMM, DE | 1 |
| SNYDER, JG | 1 |
| MORRISON, RS | 1 |
| CHALMERS, TC | 1 |
| ORIGENES, ML | 1 |
| BEATTY, EC | 1 |
| BRUBAKER, C | 1 |
| HAMMOND, D | 1 |
| HARTMANN, JR | 1 |
| SHORE, N | 1 |
| WILLIAMS, KO | 1 |
| WALTERS, MN | 1 |
| CONOLLY, ME | 1 |
| ELLIS, H | 1 |
| BACIOCCO, A | 1 |
| CHIAPPETTA, F | 1 |
| ENDO, H | 1 |
| TADA, M | 1 |
| PERGOLA, F | 1 |
| GALIAN, A | 1 |
| BERNADES, P | 1 |
| CACHIN, M | 1 |
| SEARS, ME | 2 |
| FERNBACH, DJ | 1 |
| BLOEDOW, CE | 1 |
| DAVIS, P | 1 |
| KRAKOFF, IH | 2 |
| SAVEL, H | 1 |
| MURPHY, ML | 1 |
| SEGALOFF, A | 1 |
| WEETH, JB | 1 |
| CUNINGHAM, M | 1 |
| MEYER, KK | 1 |
| WILSON, JR | 1 |
| MERRICK, H | 1 |
| VOGEL, SD | 1 |
| WOODWARD, ER | 1 |
| RUGGIERO, G | 1 |
| DETTORI, P | 1 |
| LEIGHTON, RS | 1 |
| PACIFICO, L | 1 |
| PASSEN, S | 1 |
| SCHULTZ, RB | 1 |
| BATTERSBY, C | 1 |
| MEYER, RL | 1 |
| LERNER, HJ | 2 |
| BECKLOFF, GL | 2 |
| HOZUMI, M | 1 |
| SUGIMURA, T | 1 |
| Musch, W | 1 |
| Hedeshi, A | 1 |
| Decaux, G | 1 |
| TYLER, MW | 1 |
| KING, EQ | 1 |
| CHAKRAVARTI, MG | 1 |
| MITRA, S | 1 |
| Dumas, J | 1 |
| Smith, RA | 1 |
| Lowinger, TB | 1 |
| Chauveau, P | 1 |
| Nguyen, H | 1 |
| Combe, C | 1 |
| Chêne, G | 1 |
| Azar, R | 1 |
| Cano, N | 1 |
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| Roth, H | 1 |
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| Fasolis, G | 1 |
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| Winum, JY | 1 |
| Gamberi, A | 1 |
| Montero, JL | 1 |
| Scozzafava, A | 1 |
| Mancinelli, A | 1 |
| D'Iddio, S | 1 |
| Bisonni, R | 1 |
| Graziano, F | 1 |
| Lippe, P | 1 |
| Calvani, M | 1 |
| Chen, Z | 1 |
| Gu, WZ | 1 |
| Xue, J | 1 |
| Bui, MH | 1 |
| Kovar, P | 1 |
| Wang, G | 1 |
| Tao, ZF | 1 |
| Tong, Y | 1 |
| Lin, NH | 1 |
| Sham, HL | 1 |
| Wang, JY | 1 |
| Sowin, TJ | 1 |
| Rosenberg, SH | 1 |
| Dhuna, V | 1 |
| Kamboj, SS | 1 |
| Kaur, A | 1 |
| Saxena, AK | 1 |
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| Earl, JW | 1 |
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| Zacharski, LR | 1 |
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| L'Abbé, KA | 2 |
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| Winter, M | 3 |
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| Fritsch, A | 2 |
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| Young, L | 1 |
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| Ames, MM | 1 |
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| Goldberg, RM | 1 |
| Erlichman, C | 1 |
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| Suzuki, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Urea for Chronic Hyponatremia: A Pilot Study[NCT04588207] | Phase 2 | 2 participants (Actual) | Interventional | 2021-12-28 | Terminated (stopped due to Unable to recruit participants) | ||
| A Phase I Study of AT9283 Given As a 24 Hour Infusion on Days 1 and 8 Every Three Weeks in Patients With Advanced Incurable Malignancy[NCT00443976] | Phase 1 | 35 participants (Actual) | Interventional | 2007-01-30 | Completed | ||
| A Phase II, Randomised Controlled Trial to Evaluate the Efficacy and Safety of Moisturising Creams With or Without Palm-oil-derived Vitamin E Concentrate in Addition to Urea-based Cream or Urea-based Cream Alone in Capecitabine-associated Palmar-Plantar E[NCT05939726] | 90 participants (Anticipated) | Interventional | 2023-05-16 | Recruiting | |||
| A Phase III Randomized, Placebo-controlled, Double-blind Trial to Determine the Effectiveness of a Urea/Lactic Acid-Based Topical Keratolytic Agent and Vitamin B-6 for Prevention of Capecitabine-Induced Hand and Foot Syndrome[NCT00296036] | Phase 3 | 137 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| A Double-blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Orexigenic Therapy With Delta-9-tetrahydrocannabinol in Advanced Cancer Patients With Chemosensory Abnormalities - a Pilot Study[NCT00316563] | Phase 2 | 80 participants (Anticipated) | Interventional | 2006-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A patient self-reported hand-foot syndrome (HFSD), also known as palmar-plantar erythrodysesthesia, was completed daily while applying the cream. Patients rated skin severity symptoms individually in their hands and in their feet. Definitions of symptoms, which were based on Common Terminology Criteria for Adverse Events (CTCAE) v3.0, were provided to patients. The number of patients reporting moderate to severe symptoms in either hands or feet were tabulated and percentages are reported. (NCT00296036)
Timeframe: First 3 weeks of treatment
| Intervention | percentage of participants (Number) |
|---|---|
| Urea/Lactic Acid Cream | 13.6 |
| Placebo Cream | 10.2 |
Frequency and severity of adverse events reported by patients in weekly diary and evaluated through clinical assessment by NCI CTCAE v3.0. The number of patients reporting grade 3 or higher events are reported in this outcome measure. For a full list of all events, please refer to the Adverse Events section of this report. (NCT00296036)
Timeframe: Up to 4, 21-day cycles
| Intervention | participants (Number) | |
|---|---|---|
| Grade 3+ Adverse Event | Grade 4+ Adverse Event | |
| Placebo Cream | 18 | 3 |
| Urea/Lactic Acid Cream | 21 | 3 |
23 reviews available for urea and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Topics: Adult; Alcohol Drinking; Ammonia; Animals; Anti-Inflammatory Agents; Area Under Curve; B-Lymphocytes | 2021 |
Arginase: An emerging and promising therapeutic target for cancer treatment.
Topics: Animals; Arginase; Arginine; Mammals; Neoplasms; Tumor Microenvironment; Urea | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Arylurea Derivatives: A Class of Potential Cancer Targeting Agents.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Humans; Neoplasms; Urea | 2017 |
Assessment of Health Effects of Exogenous Urea: Summary and Key Findings.
Topics: Animals; Carcinogens; Environmental Exposure; Humans; Neoplasms; Urea | 2018 |
Rewiring urea cycle metabolism in cancer to support anabolism.
Topics: Animals; Humans; Liver; Metabolic Networks and Pathways; Neoplasms; Urea | 2018 |
Changing mutational patterns.
Topics: Animals; Carbon-Nitrogen Ligases; Humans; Mice; Mutation; Neoplasms; Pyrimidines; Urea | 2018 |
Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress.
Topics: Antineoplastic Agents; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Benzamides; Benzazepines; B | 2015 |
Overview of CDK9 as a target in cancer research.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Fla | 2016 |
Diaryl Urea: A Privileged Structure in Anticancer Agents.
Topics: Animals; Antineoplastic Agents; Hedgehog Proteins; Humans; Neoplasms; Urea | 2016 |
Aurora kinase inhibitors as anti-cancer therapy.
Topics: Antineoplastic Agents; Aurora Kinase B; Aurora Kinase C; Aurora Kinases; Benzamides; Benzimidazoles; | 2010 |
Development of RET kinase inhibitors for targeted cancer therapy.
Topics: Antineoplastic Agents; Humans; Indoles; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Protein | 2011 |
AT-9283, a small-molecule multi-targeted kinase inhibitor for the potential treatment of cancer.
Topics: Antineoplastic Agents; Benzimidazoles; Clinical Trials as Topic; Drug Approval; Drug Evaluation, Pre | 2010 |
Recent developments in the discovery of protein kinase inhibitors from the urea class.
Topics: Chemistry, Pharmaceutical; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; | 2004 |
Review of the health effects of urea-formaldehyde foam insulation.
Topics: Abnormalities, Drug-Induced; Adult; Air Pollutants; Animals; Construction Materials; Dermatitis, Con | 1984 |
Changes in taste sensation and feeding behaviour in cancer patients: a review.
Topics: Anorexia; Energy Intake; Feeding and Eating Disorders; Food Preferences; Humans; Neoplasms; Sucrose; | 1978 |
Alkaline phosphatase.
Topics: Alkaline Phosphatase; Bone and Bones; Cholecystokinin; Dietary Fats; Electrophoresis, Polyacrylamide | 1976 |
Immune abnormalities in renal failure and hemodialysis.
Topics: Antibody Formation; Graft vs Host Reaction; Hepatitis B; Humans; Immunity, Cellular; Immunosuppressi | 1986 |
Mitochondrial pathology: an overview.
Topics: Adenosine Triphosphate; Animals; Autoantibodies; Calcium; Humans; Metabolism, Inborn Errors; Mitocho | 1986 |
Nutrition and nitrosamine formation.
Topics: Amides; Amines; Animals; Diet; Food Preservatives; Gastric Mucosa; Humans; Neoplasms; Nitrites; Nitr | 1985 |
[Progress in the drug therapy of cancer].
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Cytarabine; Daunorubicin; Drug Syn | 1968 |
Factors pertaining to complete drug-induced remission of tumor in animals and man.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Humans; Leukemia L1210; Methotrexate; | 1969 |
17 trials available for urea and Neoplasms
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Checkpoint Kinase 1; Checkpoint Kinase 2; Deox | 2013 |
NCIC CTG IND.181: phase I study of AT9283 given as a weekly 24 hour infusion in advanced malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzimidazoles; Drug Administration Schedule; | 2013 |
Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Checkp | 2014 |
Phase I study of RGB-286638, a novel, multitargeted cyclin-dependent kinase inhibitor in patients with solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Fema | 2014 |
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind | 2010 |
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind | 2010 |
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind | 2010 |
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind | 2010 |
A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies.
Topics: Adult; Aged; Antineoplastic Agents; Aurora Kinases; Benzimidazoles; Cohort Studies; Disease Progress | 2012 |
A phase I study of bizelesin, a highly potent and selective DNA-interactive agent, in patients with advanced solid malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; DNA; Dose-Response Relationship, | 2003 |
Urinary excretion of L-carnitine and its short-chain acetyl-L-carnitine in patients undergoing carboplatin treatment.
Topics: Acetylcarnitine; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area U | 2007 |
Amphotericin B dose optimization in children with malignant diseases.
Topics: Adolescent; Amphotericin B; Antifungal Agents; Body Weight; Child; Child, Preschool; Computer Simula | 2007 |
[On changes in oxygen transport capacity following osmo- and oncotherapy].
Topics: Adult; Blood Volume; Brain Edema; Craniotomy; Dextrans; Humans; Infusions, Parenteral; Mathematics; | 1967 |
A Phase I study of bizelesin (NSC 615291) in patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Biological Availability; Duocarmyc | 2002 |
High-dose metoclopramide by infusion: a double-blind study of plasma concentration-effect relationships in patients receiving cancer chemotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Doub | 1987 |
Treatment of Hodgkin's disease and other cancers with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962).
Topics: Adenocarcinoma; Adenoma, Islet Cell; Adolescent; Adrenal Gland Neoplasms; Adult; Alkylating Agents; | 1971 |
Nitrosoureas: 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962; BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037; CCNU)--clinical brochure.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Dogs; Humans; Mice; Neoplasms; Neoplasms, | 1968 |
Clinical studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037).
Topics: Antineoplastic Agents; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Cyclohexanes; Humans | 1971 |
Clinical trials of 1-beta-D-arabinofuranosyl cytosine and 1,3-bis-(2-chloroethyl)-1-nitrosourea combination in metastatic cancer and acute leukemia.
Topics: Age Factors; Blood Cell Count; Blood Platelets; Blood Urea Nitrogen; Clinical Trials as Topic; Cytar | 1971 |
152 other studies available for urea and Neoplasms
| Article | Year |
|---|---|
Phase I and phototoxicity studies of pseudourea (NSC-56054).
Topics: Anthracenes; Antineoplastic Agents; Humans; Neoplasm Metastasis; Neoplasms; Photosensitivity Disorde | 1971 |
Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors.
Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Human | 2022 |
TGF-β1, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: Comparative modulating role of Melatonin, Vit. E and Ozone.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Creatinine; Disease Mo | 2022 |
Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.
Topics: Animals; Liver; Mice; Neoplasms; Niacinamide; Nicotinamide N-Methyltransferase; Nitrogen; Uracil; Ur | 2022 |
Discovery of novel conjugates of quinoline and thiazolidinone urea as potential anti-colorectal cancer agent.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antit | 2022 |
A new prognostic marker in patients undergoing Hartmann's procedure for acute tumoral obstruction of the left colon.
Topics: Anastomosis, Surgical; Colon; Colostomy; Humans; Neoplasms; Postoperative Complications; Prognosis; | 2022 |
Discovery of 3,5-diaryl-1H-pyrazol-based ureas as potent RET inhibitors.
Topics: Antineoplastic Agents; Humans; Lung Neoplasms; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene | 2023 |
Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies.
Topics: Cell Line, Tumor; Cell Proliferation; HEK293 Cells; Humans; Immunomodulation; Neoplasms; Urea | 2023 |
5-Fluorouracil-induced hyperammonaemic encephalopathy: A French national survey.
Topics: Aged; Ammonia; Antimetabolites, Antineoplastic; Brain Diseases; Citric Acid Cycle; Dose-Response Rel | 2020 |
Synthesis, in vitro, and in vivo evaluation of novel N-phenylindazolyl diarylureas as potential anti-cancer agents.
Topics: Amides; Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Dose-Response Rela | 2020 |
Optimization of the
Topics: Animals; Antineoplastic Agents; Blood; Caspase Inhibitors; Cell Line, Tumor; Female; Half-Life; Huma | 2020 |
Discovery of Potent, Highly Selective, and
Topics: Animals; Antineoplastic Agents; Caspase Inhibitors; Drug Discovery; Female; Humans; Immunity, Humora | 2020 |
Effectiveness of a cosmetic device containing a combination of alpha- and beta-hydroxy acids, urea, and thuja for the treatment of seborrheic keratoses.
Topics: Cosmetics; Humans; Hydroxy Acids; Keratosis, Seborrheic; Neoplasms; Prospective Studies; Thuja; Urea | 2022 |
Rational drug design of indazole-based diarylurea derivatives as anticancer agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Computer-Aided Design; Drug Design; Dru | 2017 |
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Cytoki | 2017 |
UbasM: An effective balanced optical clearing method for intact biomedical imaging.
Topics: Amino Sugars; Animals; Brain; Cell Line, Tumor; Disease Models, Animal; Histological Techniques; Mic | 2017 |
Fluoroenesulphonamides: N-sulphonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Esters; Humans | 2018 |
Effect of combination sildenafil and gemfibrozil on cisplatin-induced nephrotoxicity; role of heme oxygenase-1.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Cisplatin; Creatinine; Disease Models, Animal | 2018 |
Cytotoxic and Apoptotic Effects of Novel Pyrrolo[2,3-d]Pyrimidine Derivatives Containing Urea Moieties on Cancer Cell Lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Hu | 2018 |
The diagnostic value of human epididymis protein 4 as a novel biomarker in patients with renal dysfunction.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Area Under Curve; Biomarkers; Cardi | 2018 |
Effects of a checkpoint kinase inhibitor, AZD7762, on tumor suppression and bone remodeling.
Topics: Animals; Bioprinting; Bone and Bones; Bone Remodeling; Calcification, Physiologic; Carbazoles; Cell | 2018 |
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.
Topics: Amino Acid Transport Systems, Basic; Animals; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Sy | 2018 |
Metabolic Frugality Marks Cancer Cells for Immune Targeting.
Topics: Genomics; Humans; Immunotherapy; Neoplasms; Urea | 2018 |
Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Human Umbilical Vein Endot | 2018 |
A pH-responsive bioassay for paper-based diagnosis of exosomes via mussel-inspired surface chemistry.
Topics: Armoracia; Biological Assay; Biomarkers, Tumor; Canavalia; Dopamine; Exosomes; Horseradish Peroxidas | 2019 |
Discovery of N
Topics: Apoptosis; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Drug Screening Assays, Anti | 2019 |
[Study of arginase activity of mixed saliva in cancer].
Topics: Adult; Aged; Arginase; Female; Humans; Male; Middle Aged; Neoplasm Proteins; Neoplasms; Nitric Oxide | 2016 |
p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis.
Topics: Ammonia; Arginase; Carbamoyl-Phosphate Synthase (Ammonia); Cell Proliferation; Gene Expression Regul | 2019 |
Urea in cancer patients with chronic SIAD-induced hyponatremia: Old drug, new evidence.
Topics: Aged; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Middle Aged; Neoplasms; Retros | 2019 |
Novel multitarget inhibitors with antiangiogenic and immunomodulator properties.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Bibenzyls; Cell Line, Tumor; Cell Proliferation; Dru | 2019 |
Novel 7-formyl-naphthyridyl-ureas derivatives as potential selective FGFR4 inhibitors: Design, synthesis, and biological activity studies.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Design; Drug Screening Assays, | 2019 |
Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Design; Drug Screenin | 2018 |
Development of tumor-targeted near infrared probes for fluorescence guided surgery.
Topics: Animals; Female; Fluorescence; Fluorescent Dyes; Folic Acid; Glutarates; Humans; Infrared Rays; KB C | 2013 |
Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structure.
Topics: Amino Acid Substitution; Catalytic Domain; Enzyme Stability; Humans; Kinetics; Neoplasms; Polymorphi | 2013 |
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Humans; Mice; Mice, Nude; Models, Molec | 2013 |
Toxicity of parasporin-4 and health effects of pro-parasporin-4 diet in mice.
Topics: Ammonium Compounds; Animals; Bacterial Proteins; Blood Urea Nitrogen; Creatinine; Diet; Endotoxins; | 2014 |
ATR inhibition preferentially targets homologous recombination-deficient tumor cells.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Survival; Checkpoint Kinase 1; D | 2015 |
Design and synthesis of novel 1,2,3-triazole-pyrimidine-urea hybrids as potential anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; H | 2015 |
Procalcitonin improves the Glasgow Prognostic Score for outcome prediction in emergency patients with cancer: a cohort study.
Topics: Aged; Biomarkers, Tumor; C-Reactive Protein; Calcitonin; Calcitonin Gene-Related Peptide; Calcium; C | 2015 |
Photoluminescent carbon dots synthesized by microwave treatment for selective image of cancer cells.
Topics: Biocompatible Materials; Carbon; Cell Line; Diagnostic Imaging; Fluorescent Dyes; Folic Acid; HeLa C | 2015 |
Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Centrosome; Chromosomal | 2015 |
Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as anticancer agents with low toxicity.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzothiazoles; Binding Sites; Cell Line, Tumo | 2015 |
Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.
Topics: Antineoplastic Agents; Biomarkers, Pharmacological; Cell Cycle; Cell Cycle Proteins; Checkpoint Kina | 2015 |
Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition.
Topics: Chronic Pain; Drug Design; Humans; Inflammation; Inhibitory Concentration 50; Neoplasms; Neuralgia; | 2016 |
Synthesis and p38 Inhibitory Activity of Some Novel Substituted N,N'-Diarylurea Derivatives.
Topics: Cell Line, Tumor; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Ligands; | 2016 |
Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue.
Topics: Aminoquinolines; Animals; Benzene Derivatives; Ethylene Glycol; Fluorescent Dyes; Hot Temperature; M | 2017 |
Uveitis or sarcoma.
Topics: Diagnosis, Differential; Humans; Neoplasms; Sarcoma; Urea; Uvea | 1948 |
Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents.
Topics: Antineoplastic Agents; Carboxylic Acids; Cell Proliferation; Chemistry, Pharmaceutical; Drug Design; | 2009 |
(124)I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of (131)I-L19-SIP radioimmunotherapy.
Topics: Animals; Antibodies; Cell Line, Tumor; Feasibility Studies; Humans; Injections; Iodine Radioisotopes | 2009 |
Aurora B kinase inhibition in mitosis: strategies for optimising the use of aurora kinase inhibitors such as AT9283.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Benzimi | 2009 |
Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.
Topics: Allosteric Site; Animals; Cell Line; Crystallography, X-Ray; CSK Tyrosine-Protein Kinase; Drug Desig | 2009 |
Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues.
Topics: Animals; Carrier Proteins; Female; Folate Receptors, GPI-Anchored; Folic Acid; Glutarates; HeLa Cell | 2009 |
In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.
Topics: Animals; Cells, Cultured; Checkpoint Kinase 1; DNA Damage; Dose-Response Relationship, Drug; Female; | 2010 |
Accidents due to cinchonine and urea double hydrochloride in the treatment of angiomas.
Topics: Cinchona; Hemangioma; Humans; Neoplasms; Urea | 1947 |
ASK1-P38 pathway is important for anoikis induced by microtubule-targeting aryl chloroethylureas.
Topics: Animals; Anoikis; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line; Cell Line, Tumor; | 2010 |
Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.
Topics: Animals; Blood Vessels; Endothelial Cells; Heparitin Sulfate; Humans; Mice; Neoplasms; Permeability; | 2011 |
Bayesian hierarchical changepoint methods in modeling the tumor growth profiles in xenograft experiments.
Topics: Animals; Bayes Theorem; Cell Proliferation; Confidence Intervals; Deoxycytidine; Gemcitabine; Mice; | 2011 |
Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Humans; Mice; Mice, Nude; Mustard Pla | 2011 |
Spectral-spatial excitation for rapid imaging of DNP compounds.
Topics: Acetates; Animals; Carbon Isotopes; Magnetic Resonance Spectroscopy; Neoplasms; Pyruvic Acid; Rats; | 2011 |
Radiosynthesis of three [11C]ureido-substituted benzenesulfonamides as PET probes for carbonic anhydrase IX in tumors.
Topics: Antigens, Neoplasm; Benzenesulfonamides; Carbon Radioisotopes; Carbonic Anhydrase Inhibitors; Carbon | 2011 |
Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment.
Topics: Biomarkers; Blood Glucose; Case-Control Studies; Central Nervous System Neoplasms; Child; Cohort Stu | 2012 |
Spectroscopic and calorimetric evaluation of chemically induced protein denaturation in HuH-7 liver cancer cells and impact on cell survival.
Topics: Ablation Techniques; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell Survival; Humans; Ne | 2012 |
Site specific/targeted delivery of gemcitabine through anisamide anchored chitosan/poly ethylene glycol nanoparticles: an improved understanding of lung cancer therapeutic intervention.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antimetabolites, Antineoplastic; Aspartate Amin | 2012 |
BZ-55 (CARBUTAMIDE): experimental and clinical studies of an oral antidiabetic agent.
Topics: Carbutamide; Diabetes Mellitus; Hypoglycemic Agents; Neoplasms; Sulfanilamide; Sulfanilamides; Sulfo | 1956 |
Hypersmolarity (hypernatremia) and azotemia induced by the administration of urea.
Topics: Azotemia; Humans; Hypernatremia; Neoplasms; Pituitary Gland; Sodium; Urea | 1960 |
Histamine formation and tumor growth.
Topics: Animals; Carcinoma, Hepatocellular; Dihydroxyphenylalanine; Histamine; Liver Neoplasms; Liver Neopla | 1962 |
Effect of intravenous urea on the EEG of brain tumor patients.
Topics: Brain Neoplasms; Electroencephalography; Humans; Neoplasms; Nervous System Physiological Phenomena; | 1961 |
PHYSICO-CHEMICAL PROPERTIES OF YOSHIDA ASCITES MUCOPROTEIN.
Topics: Ascites; Electrophoresis; Guanidines; Mucoproteins; Neoplasm Proteins; Neoplasms; Phosphates; Rats; | 1963 |
CYTOTOXICITY OF HYDROXYUREA (NSC-32065) REVERSIBLE BY PYRIMIDINE DEOXYRIBOSIDES IN A MAMMALIAN CELL LINE GROWN IN VITRO.
Topics: Antimetabolites; Cell Line; Cricetinae; Hydroxyurea; In Vitro Techniques; Neoplasms; Neoplasms, Expe | 1964 |
ON THE CONCENTRATING DEFECT IN CIRRHOSIS OF THE LIVER.
Topics: Alcoholism; Arthritis; Arthritis, Rheumatoid; Coronary Disease; Dehydration; Dermatitis; Diabetes Me | 1964 |
TRIAL OF HYDROXYUREA (NSC-32065) IN CANCER IN CHILDREN.
Topics: Antineoplastic Agents; Busulfan; Child; Cyclophosphamide; Dactinomycin; Humans; Hydroxyurea; Leukemi | 1964 |
STUDIES ON THE EXOCRINE PANCREAS. I. NONSPECIFIC PANCREATIC DUCTULAR ECTASIA.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Blood; Cardiovascular Diseases; Cholecystitis; Defic | 1964 |
ANURIA DUE TO URIC ACID CRYSTALLURIA: AN UNUSUAL COMPLICATION OF THERAPY IN THE RETICULOSES.
Topics: Abdominal Neoplasms; Anuria; Blood; Genetic Diseases, X-Linked; Humans; Kidney Diseases; Leukemia, H | 1964 |
[USE OF UREA AS A FACILITATING ELEMENT IN THE EXECUTION OF PNEUMOENCEPHALOGRAPHY].
Topics: Brain Neoplasms; Diagnostic Imaging; Humans; Hypertonic Solutions; Injections; Injections, Intraveno | 1964 |
EXPERIMENTAL STUDIES ON THE ANTITUMOR EFFECT OF BIURET DERIVATIVES.
Topics: Animals; Antineoplastic Agents; Biuret; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Rese | 1964 |
[HYPERCORTICISM AND BRONCHIAL CANCER WITH REVEALING HYPOKALEMIC ALKALOSIS].
Topics: Adrenocortical Hyperfunction; Alkalosis; Ammonia; Bartter Syndrome; Blood Chemical Analysis; Blood G | 1964 |
ERYTHEMA IN AREAS OF PREVIOUS IRRADIATION IN PATIENTS TREATED WITH HYDROXYUREA (NSC-32065).
Topics: Antineoplastic Agents; Drug Therapy; Erythema; Hydroxyurea; Neoplasms; Radiation Injuries; Toxicolog | 1964 |
PEDIATRIC CLINICAL TRIALS WITH HYDROXYUREA (NSC-32065).
Topics: Adolescent; Antineoplastic Agents; Child; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Neop | 1964 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: MISCELLANEOUS TUMORS.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Carcinom | 1964 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CANCER OF THE BREAST.
Topics: Anemia; Anemia, Myelophthisic; Antineoplastic Agents; Breast Neoplasms; Drug Therapy; Erythema; Estr | 1964 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: MULTIPLE MYELOMA AND LYMPHOMA.
Topics: Antineoplastic Agents; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukopenia; Lymphoma; Lymphoma, L | 1964 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CLINICAL EVALUATION.
Topics: Antineoplastic Agents; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leu | 1964 |
HORMONAL THERAPY IN CANCER OF THE BREAST. 23. EFFECT OF 7-ALPHA-METHYL-19-NORTESTOSTERONE ACETATE AND TESTOSTERONE PROPIONATE ON CLINICAL COURSE AND HORMONAL EXCRETION.
Topics: 17-Ketosteroids; Acetates; Antineoplastic Agents; Bilirubin; Biomedical Research; Blood Glucose; Bre | 1964 |
HYPERPARATHYROID-LIKE STATE IN RABBITS WITH THE VX-2 CARCINOMA: FURTHER STUDIES.
Topics: Animals; Blood; Blood Urea Nitrogen; Hypercalcemia; Hyperparathyroidism; Neoplasm Transplantation; N | 1965 |
ENCEPHALOGRAPHY WITH UREA.
Topics: Astrocytoma; Brain Neoplasms; Child; Hematoma; Hematoma, Subdural; Humans; Meningeal Neoplasms; Meni | 1965 |
USE OF THE SHOPE PAPILLOMA VIRUS-INDUCED ARGINASE AS A BIOCHEMICAL MARKER IN VITRO.
Topics: Animals; Arginase; Biological Assay; Biomarkers; Cottontail rabbit papillomavirus; In Vitro Techniqu | 1965 |
ELECTROLYTE DEPLETION ASSOCIATED WITH VILLOUS TUMOUR OF THE RECTUM.
Topics: Drug Therapy; Electrolytes; Geriatrics; Neoplasms; Pathology; Potassium; Radiography; Rectal Neoplas | 1965 |
PREVENTION OF HYPERURICEMIA IN LEUKEMIA AND LYMPHOMA: USE OF ALOPURINOL, A XANTHINE OXIDASE INHIBITOR.
Topics: Adolescent; Antineoplastic Agents; Blood; Blood Urea Nitrogen; Drug Therapy; Geriatrics; Humans; Hyp | 1965 |
HYDROXYUREA ADMINISTERED INTERMITTENTLY.
Topics: Antineoplastic Agents; Drug Therapy; Geriatrics; Hydroxyurea; Neoplasms; Toxicology; Urea | 1965 |
Studies on the mechanism of catalase depression by toxohormone, with the aid of allylisopropylacetamide, allylisopropylacetylcarbamide, and 3-amino-1,2,4-triazole.
Topics: Allylisopropylacetamide; Amides; Amitrole; Azoles; Catalase; Depression; Depressive Disorder; Endoto | 1962 |
Low sodium excretion in SIADH patients with low diuresis.
Topics: Aged; Alcohol Withdrawal Seizures; Alcoholism; Creatinine; Diagnosis, Differential; Diuresis; Duoden | 2004 |
Phenacemide in treatment of epilepsy.
Topics: Anticonvulsants; Benzeneacetamides; Epilepsy; Humans; Neoplasms; Urea | 1951 |
Micro estimations of nitrogenous constituents of the blood and of urea clearance; a study of 100 cases.
Topics: Humans; Neoplasms; Nitrogen; Urea | 1951 |
Dialyzer membrane permeability and survival in hemodialysis patients.
Topics: Aged; Bicarbonates; Body Composition; Body Mass Index; Cardiovascular Diseases; Cause of Death; Chol | 2005 |
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carb | 2005 |
Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.
Topics: Antibodies; Blotting, Western; Camptothecin; Caspases; CDC2 Protein Kinase; cdc25 Phosphatases; Cell | 2006 |
Characterization of a lectin from Gonatanthus pumilus D. Don having anti-proliferative effect against human cancer cell lines.
Topics: Antifungal Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Guanidine; Humans; I | 2007 |
Hydroxyurea in the management of head and neck cancer. II. Surgical aspects.
Topics: Antineoplastic Agents; Head; Head and Neck Neoplasms; Humans; Hydroxyurea; Mandibular Neoplasms; Neo | 1967 |
Significance of extreme elevation of erythrocyte sedimentation rate.
Topics: Blood Protein Electrophoresis; Blood Sedimentation; Bone Marrow Examination; Collagen Diseases; Hema | 1967 |
Flux of amino acids across the leg in weight-losing cancer patients.
Topics: Acute Disease; Aged; Amino Acids; Body Weight; Humans; Leg; Middle Aged; Neoplasms; Nutrition Disord | 1984 |
Health risks in homes insulated with urea formaldehyde foam.
Topics: Construction Materials; Formaldehyde; Housing; Humans; Hypersensitivity; Neoplasms; Reproduction; Re | 1984 |
[Malnutrition and postoperative complication rate in cancer patients (author's transl)].
Topics: Body Height; Body Weight; Female; Humans; Leukocyte Count; Lymphocytes; Male; Middle Aged; Neoplasms | 1982 |
[The definition of clinical catabolism by the urea production rate and its correlation with cellular immunity].
Topics: Body Weight; Female; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Male; Middle Aged; Neopl | 1980 |
[Oxygen multistep therapy and cancer. New perspectives in cancer immunology (author's transl)].
Topics: Aged; Animals; Esophageal Neoplasms; Female; Humans; Immunity, Cellular; Neoplasms; Nitriles; Oxygen | 1981 |
Hemodialysis of amino acids: basic studies in vitro.
Topics: Amino Acids; Asparagine; Dialysis; Humans; In Vitro Techniques; Kidneys, Artificial; Molecular Weigh | 1981 |
[Urea production and cell-mediated immunity as indicators of preoperative catabolism (author's transl)].
Topics: Energy Metabolism; Female; Humans; Immunity, Cellular; Male; Middle Aged; Neoplasms; Urea | 1980 |
Tumour matrix destruction by guanidine and urea.
Topics: Animals; Antineoplastic Agents; Cricetinae; Guanidines; Neoplasms; Urea | 1980 |
Strategies for improving the immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections: androgen receptor, estrogen receptor, progesterone receptor, p53 protein, proliferating cell nuclear antigen, and Ki-67 ant
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Cell Nucleus; Formaldehyde; Glycine; Humans; Immunohistochemi | 1994 |
Calcium-free hemodialysis for the management of hypercalcemia.
Topics: Adult; Aged; Blood Pressure; Calcium; Dialysis Solutions; Female; Humans; Hypercalcemia; Kinetics; M | 1996 |
[Biochemical parameters in the diagnosis of nephrotoxicity of antineoplastic chemotherapy in children].
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Child; Child, Preschool; Cispl | 1997 |
Serum selenium levels as indicators of body status in cancer patients and their relationship with other nutritional and biochemical markers.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alanine Transaminase; Aspartate Aminotransferases; Biomarkers | 1998 |
Inhibition of microtubule assembly in tumor cells by 3-bromoacetylamino benzoylurea, a new cancericidal compound.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; DNA Fragmentation; DNA, Neoplasm; Drug Screening Assay | 1998 |
Renal toxicity of the anticancer drug fostriecin.
Topics: Adult; Aged; Alkenes; Antibiotics, Antineoplastic; Creatine; Electrolytes; Female; Glomerular Filtra | 1998 |
Must we really fear toxicity of conventional amphotericin B in oncological patients?
Topics: Adult; Amphotericin B; Anti-Inflammatory Agents; Antifungal Agents; Creatinine; Diuresis; Female; Fl | 1999 |
Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). IV. Toxicologic and pathophysiologic observations in lactating goats and their suckling kids fed on the irritant herbs Eup
Topics: Alanine Transaminase; Animals; Animals, Domestic; Aspartate Aminotransferases; Carcinogens; Creatini | 2001 |
Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Ammonia; Animals; Blood Urea Nitrogen; Caseins; Cecum; Cholesterol; Colon; Colonic N | 1976 |
Interactions between "fever" proteins and normal serum proteins in febrile cancer patients.
Topics: Blood Proteins; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide G | 1977 |
Tumor-specific alkaline phosphatase in hepatoma.
Topics: Adult; Alkaline Phosphatase; Carcinoma, Hepatocellular; Edetic Acid; Female; Fetus; Humans; Imidazol | 1975 |
Taste and feeding behavior in patients with cancer.
Topics: Energy Intake; Feeding Behavior; Humans; Neoplasms; Sucrose; Taste; Taste Threshold; Urea | 1977 |
[Brdicka's reaction and the effect of denaturants on its result].
Topics: Cell Transformation, Neoplastic; Guanidines; Humans; Neoplasms; Urea | 1978 |
[Detection of immuno-stimulation in mice by a new low molecular substance (author's transl)].
Topics: Animals; Antibody Formation; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Hemolytic Plaque Techn | 1975 |
Posthypophysectomy taste abnormalities: their relationship to remote effects of cancer.
Topics: Breast Neoplasms; Female; Humans; Hydrochloric Acid; Hypophysectomy; Male; Neoplasms; Pituitary Glan | 1977 |
Acquired stomatocytosis: its prevalence of significance in routine haematology.
Topics: Adolescent; Adult; Alcoholism; Anemia, Hemolytic; Cardiovascular Diseases; Drug-Related Side Effects | 1977 |
Diuretics in malignant effusions and edemas of generalized cancer.
Topics: Ascites; Body Weight; Bumetanide; Diuretics; Drinking; Edema; Furosemide; Humans; Neoplasms; Pleuris | 1976 |
Abnormalities of taste sensation in cancer patients.
Topics: Adult; Aged; Anorexia; Body Weight; Female; Humans; Hydrochloric Acid; Male; Middle Aged; Neoplasms; | 1975 |
Serum hyaluronic acid in patients with disseminated neoplasm.
Topics: Adult; Aged; Alkaline Phosphatase; Bilirubin; Calcium; Electrophoresis; Female; Humans; Hyaluronic A | 1987 |
Phosphate treatment of hypercalcaemia due to carcinoma.
Topics: Aged; Breast Neoplasms; Bronchial Neoplasms; Calcinosis; Cornea; Female; Humans; Hypercalcemia; Infu | 1968 |
Patterns of intravenous glucose tolerance and insulin response before and after treatment with streptozotocin (NSC-85998) in patients with cancer.
Topics: Acute Kidney Injury; Antibiotics, Antineoplastic; Blood Glucose; Creatinine; Drug Tolerance; Electro | 1972 |
Immunodiffusion analysis of Yaba poxvirus structural and associated antigens.
Topics: Animals; Antigens; Cell Line; Centrifugation, Density Gradient; Cesium; Chlorides; Complement Fixati | 1970 |
Urea inhibition of lactate dehydrogenase. A convenient routine procedure.
Topics: Anemia; Buffers; Clinical Enzyme Tests; Glycine; Humans; Ischemia; L-Lactate Dehydrogenase; Liver; L | 1970 |
The newest development of experimental induced tumors of the central nervous system.
Topics: Age Factors; Animals; Brain Neoplasms; Carcinogens; Humans; Methods; Mice; Neoplasms; Neoplasms, Exp | 1969 |
[The cancer-risk in man from synthetic sweetening agents].
Topics: Animals; Carcinoma, Hepatocellular; Cyclamates; Female; Liver Neoplasms; Lung Neoplasms; Lymphoma, N | 1971 |
[Formation of carcinogenic nitroso compounds in the stomach of laboratory animals and their significance for man. 2].
Topics: Acetamides; Amides; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Carcinogens; G | 1971 |
Quantitative measurement and chromatography of human urinary carcinoembryonic antigen activity.
Topics: Adolescent; Adult; Carcinoembryonic Antigen; Child; Child, Preschool; Chromatography; Female; Guanid | 1974 |
Chemotherapy and immunity to cancer.
Topics: Allyl Compounds; Aniline Compounds; Animals; Antineoplastic Agents; Cyclophosphamide; Fluorouracil; | 1974 |
[The spectrum of extra neural tumors in rats following N-methyl-N-nitroso urea treatment].
Topics: Abdominal Neoplasms; Animals; Castration; Female; Heart Neoplasms; Hypoxia; Injections, Intraperiton | 1972 |
A spectrum of organ systems that respond to the presence of cancer. Abnormalities of taste as a remote effect of a neoplasm.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Disease Models, Animal; Food Preferences; Hum | 1974 |
Nitrosation of tertiary amines and some biologic implications.
Topics: Amines; Carcinogens; Dealkylation; Dimethylamines; Dimethylformamide; Environmental Exposure; Ethano | 1972 |
[The detection of immunoglobulin G in the make-up of a high-molecular protein complex in blood serum].
Topics: Animals; Blood Proteins; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchang | 1972 |
[Transumbilical portal vein blood examination in man].
Topics: Bilirubin; Blood; Blood Proteins; Calcium; Catheterization; Chlorides; Fructose-Bisphosphate Aldolas | 1972 |
Plasma phosphate and potassium levels in the hypercalcemia of malignant disease.
Topics: Aged; Bone Neoplasms; Breast Neoplasms; Female; Humans; Hypercalcemia; Hyperparathyroidism; Neoplasm | 1973 |
The clinical usefulness of alkaline phosphatase isoenzyme determinations.
Topics: Alkaline Phosphatase; Bone Diseases; Clinical Enzyme Tests; Electrophoresis, Disc; Hot Temperature; | 1972 |
5-Fluorouracil (5-Fu; NSC-19893), 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388), vincristine (NSC-67574), and 1,3-bis(2-chloroethyl)-2-nitrosourea (BCNU; NSC-409962) given concomitantly in the treatment of solid tumors in man.
Topics: Adult; Aged; Alkylating Agents; Amides; Carmustine; Drug Combinations; Female; Fluorouracil; Humans; | 1972 |
Combined therapy with cytosine arabinoside (NSC-63878) and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) for advanced solid tumors.
Topics: Adult; Alkylating Agents; Blood Cell Count; Carmustine; Cytarabine; Drug Combinations; Humans; Male; | 1972 |
Chronic ingestion by rats of standard diet treated with aluminum phosphide.
Topics: Abdominal Neoplasms; Alanine Transaminase; Aluminum; Aluminum Compounds; Animals; Appetite; Blood Ch | 1972 |
Selective metabolic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea upon de novo purine biosynthesis.
Topics: Acute Disease; Amino Acids; Animals; Antineoplastic Agents; Ascitic Fluid; Carbon Isotopes; Carcinom | 1971 |
Skin homograft survival in cancer chemotherapy patients.
Topics: Adult; Aged; Antineoplastic Agents; Carbamates; Female; Fluorouracil; Humans; Immunosuppressive Agen | 1966 |
Syndrome of cellular agony--biochemical characterization.
Topics: Autopsy; Child; Death; Gastroenteritis; Humans; Hyperglycemia; Hyperkalemia; Hyponatremia; Kwashiork | 1969 |
Alkaline phosphatase in meningiomas.
Topics: Alkaline Phosphatase; Central Nervous System Diseases; Chemical Phenomena; Chemistry, Physical; Hot | 1970 |
1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) given concomitantly with cytosine arabinoside (NSC-63878) in the treatment of cancer.
Topics: Adult; Aged; Antineoplastic Agents; Cytarabine; Female; Humans; Leukemia; Male; Middle Aged; Neoplas | 1970 |
Pleural fluid glucose. Serial observation of its concentration following oral administration of glucose to patients with rheumatoid pleural effusions and malignant effusions.
Topics: Adult; Arthritis, Rheumatoid; Blood Glucose; Blood Urea Nitrogen; Female; Glucose; Humans; Male; Mid | 1968 |
The induction of tumours in the rat by a single oral dose of N-nitrosomethylurea.
Topics: Animals; Female; Gastric Mucosa; Intestinal Neoplasms; Intestines; Jaw Neoplasms; Keratoacanthoma; K | 1969 |