Page last updated: 2024-10-20

urea and Neoplasms

urea has been researched along with Neoplasms in 191 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Hand-foot syndrome (HFS) is a dose-limiting toxicity of capecitabine for which no effective preventative treatment has been definitively demonstrated."9.14Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. ( Berenberg, JL; Christian, D; Delaune, R; Loprinzi, CL; Menon, SP; Pajon, ER; Qin, R; Rowland, KM; Satele, DV; Thomas, S; Wolf, SL, 2010)
"We retrospectively analysed 36 cancer patients affected by moderate or profound SIAD-induced chronic hyponatremia, who started oral urea (initial daily dose 15 g or 30 g) without fluid restriction between July 2013 and July 2018."7.91Urea in cancer patients with chronic SIAD-induced hyponatremia: Old drug, new evidence. ( Arvat, E; Castellana, E; Cattel, F; D'Angelo, V; Grossi, E; Nervo, A; Rosso, D, 2019)
"Hand-foot syndrome (HFS) is a dose-limiting toxicity of capecitabine for which no effective preventative treatment has been definitively demonstrated."5.14Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. ( Berenberg, JL; Christian, D; Delaune, R; Loprinzi, CL; Menon, SP; Pajon, ER; Qin, R; Rowland, KM; Satele, DV; Thomas, S; Wolf, SL, 2010)
"We retrospectively analysed 36 cancer patients affected by moderate or profound SIAD-induced chronic hyponatremia, who started oral urea (initial daily dose 15 g or 30 g) without fluid restriction between July 2013 and July 2018."3.91Urea in cancer patients with chronic SIAD-induced hyponatremia: Old drug, new evidence. ( Arvat, E; Castellana, E; Cattel, F; D'Angelo, V; Grossi, E; Nervo, A; Rosso, D, 2019)
"We have synthesized a new compound, 3-bromoacetylamino benzoylurea (3-BAABU), which showed strong cancericidal activity by inducing irreversible mitotic arrest and subsequently apoptosis in human T cell leukemic cells (CEM), human biphenotypic leukemic cells (SP), a human prostate cancer cell line (PC-3), murine melanoma cells (B-16), and murine lymphoma/leukemia cells (EL4) in vitro with an ID50 in the range of 0."3.70Inhibition of microtubule assembly in tumor cells by 3-bromoacetylamino benzoylurea, a new cancericidal compound. ( Bekesi, JG; Holland, JF; Jiang, JD; Roboz, J; Strauchen, J; Wang, Y, 1998)
"The maximum-tolerated dose of AZD7762 in combination with gemcitabine 1,000 mg/m(2) was 30 mg."2.79Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors. ( Agbo, F; Azad, N; Barker, P; Carducci, M; Carter, J; Cosgrove, D; Knight, R; Lorusso, P; Malburg, L; Oakes, P; Quinn, MF; Sausville, E; Senderowicz, A; Zabludoff, S, 2014)
"This open-label, Phase I, dose-escalation study evaluated the safety, pharmacokinetics (PK) and preliminary efficacy (RECIST) of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours (NCT00937664)."2.78Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours. ( Agbo, F; Arita, S; Esaki, T; Fujimoto, C; Hamatake, M; Hirai, F; Kometani, T; Makiyama, A; Nosaki, K; Seto, T; Shi, X; Takeoka, H, 2013)
"Patients with advanced, incurable solid tumors or non-Hodgkin's lymphoma received AT9283 as a continuous 24-hour infusion on days 1, 8 of a 21-day cycle."2.78NCIC CTG IND.181: phase I study of AT9283 given as a weekly 24 hour infusion in advanced malignancies. ( Capier, CA; Chen, EX; Chi, KN; Dent, SF; Gelmon, KA; Jonker, DJ; Lyons, JF; Seymour, L; Wainman, N, 2013)
" The mean oral bioavailability of a 0."2.77A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies. ( Arkenau, HT; Calvert, H; Judson, I; Lewis, S; Lock, V; Lyons, J; Molife, LR; Olmos, D; Plummer, R; Squires, M; Yap, TA; Yule, M, 2012)
"To evaluate the effect of the anti-cancer drug carboplatin on plasma concentrations and urinary excretion of L-carnitine (LC) and its main ester, acetyl-L-carnitine (ALC), in cancer patients."2.73Urinary excretion of L-carnitine and its short-chain acetyl-L-carnitine in patients undergoing carboplatin treatment. ( Bisonni, R; Calvani, M; D'Iddio, S; Graziano, F; Lippe, P; Mancinelli, A, 2007)
"In this study, rational dosing guidelines for amphotericin B-deoxycholate (AmB) are proposed for children."2.73Amphotericin B dose optimization in children with malignant diseases. ( Coakley, JC; Earl, JW; McLachlan, AJ; Nath, CE; Shaw, PJ, 2007)
"Patients with advanced solid tumors received escalating doses of bizelesin as an i."2.70A Phase I study of bizelesin (NSC 615291) in patients with advanced solid tumors. ( Adjei, AA; Ames, MM; Atherton, P; Bagniewski, PG; Erlichman, C; Goldberg, RM; Pitot, HC; Rayson, D; Reid, JM; Rubin, J; Sloan, JA, 2002)
"Urea has been utilized as a reductant in diesel fuels to lower emission of nitrogen oxides, igniting interest in probable human health hazards associated with exposure to exogenous urea."2.58Assessment of Health Effects of Exogenous Urea: Summary and Key Findings. ( Dickerson, AS; Hotchkiss, A; Keshava, C; Lee, JS; Persad, AS, 2018)
"The urea NH moiety is a favorable hydrogen bond donor, while the urea oxygen atom is regarded as an excellent acceptor."2.53Diaryl Urea: A Privileged Structure in Anticancer Agents. ( Bottegoni, G; Ferraro, M; Garuti, L; Roberti, M, 2016)
"Aurora A and Aurora B are validated anticancer targets, and the development of Aurora kinase inhibitors has progressed from preclinical to clinical studies."2.52Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress. ( Bastida, CC; Falchook, GS; Kurzrock, R, 2015)
"Cisplatin (CP) is an anticancer medication that is commonly used to treat solid tumors."1.72TGF-β1, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: Comparative modulating role of Melatonin, Vit. E and Ozone. ( Abd El-Emam, MM; Abdel-Rahman Mohamed, A; Bin Emran, T; El-Shetry, ES; Khater, SI; Metwally, MMM; Mostafa-Hedeab, G; Nassan, MA, 2022)
"Multiple solid cancers distantly increase expression of Nnmt and its product 1-methylnicotinamide (MNAM) in the liver."1.72Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase. ( Bamba, T; Enya, S; Hamanishi, J; Harata, A; Hojo, H; Izumi, Y; Kashio, S; Kawamoto, H; Kawaoka, S; Konishi, R; Mandai, M; Miura, M; Mizuno, R; Nakao, M; Suzuki, Y; Takahashi, M; Yoda, M, 2022)
"Seborrheic keratosis is a benign epidermal tumor of cosmetic concern-as it progressively increases in size, thickness, and pigmentation-on which topical treatments are poorly effective."1.72Effectiveness of a cosmetic device containing a combination of alpha- and beta-hydroxy acids, urea, and thuja for the treatment of seborrheic keratoses. ( Baciorri, F; Bianchi, L; Campione, E; Cosio, T; Di Prete, M; Dika, E; Diluvio, L; Lanna, C; Lombardo, P; Orlandi, A; Piccolo, A, 2022)
"5-FU-induced hyperammonaemic encephalopathy started 2 [1-4] days after 5-FU infusion onset."1.565-Fluorouracil-induced hyperammonaemic encephalopathy: A French national survey. ( Boige, V; Boilève, A; Chouchana, L; Ducreux, M; Gaboriau, L; Hillaire-Buys, D; Hollebecque, A; Jozwiak, M; Lillo-Le Louët, A; Malka, D; Thomas, L, 2020)
"The urea derivatives were also evaluated for their antiangiogenic properties, whereby their ability to inhibit tubulogenesis and kinase activity employing flow cytometry, ELISA, immunofluorescence and western blot techniques was measured."1.51Novel multitarget inhibitors with antiangiogenic and immunomodulator properties. ( Carda, M; Conesa-Milián, L; Falomir, E; Marco, JA; Murga, J, 2019)
" Modification of the isoindoline and/or the terminal functionality of screening hit 5 provided inhibitors such as 52 and 58 with nanomolar antiproliferative activity and preclinical pharmacokinetics properties which enabled potent antitumor activity when dosed orally in mouse xenograft models."1.46SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). ( Aguirre, AL; Algire, MA; Badagnani, I; Buchanan, FG; Cheng, D; Cheng, M; Chiang, GG; Clark, RF; Curtin, ML; Doherty, GA; Frey, RR; Guo, J; Hansen, TM; Heyman, HR; Korepanova, AV; Kovar, PJ; Longenecker, KL; Maag, D; Marin, VL; Michaelides, MR; Pliushchev, MA; Raich, D; Richardson, PL; Sarris, KA; Shrestha, A; Soni, NB; Sorensen, BK; Sweis, RF; Tse, C; Tu, N; Vasudevan, A; Wilsbacher, JL; Woller, K, 2017)
"TrkA is a target for chronic pain treatment due to the central position of the nerve growth factor (NGF)/TrkA pathway in nociception."1.43Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition. ( Bernard-Gauthier, V; Schirrmacher, R, 2016)
"Paradoxically, various cancers are HR defective and have apparently acquired characteristics to survive genomic instability."1.42ATR inhibition preferentially targets homologous recombination-deficient tumor cells. ( de Vries, EG; Fehrmann, RS; Franke, L; Krajewska, M; Labib, S; Schoonen, PM; van Vugt, MA, 2015)
"In this study, we investigated the anticancer effects of GSK-3β inhibitors on cancer cell lines and observed centrosome dysregulation which resulted in abnormal mitosis."1.42Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells. ( Ishioka, C; Yoshino, Y, 2015)
" The LD50 value was 160 μg/kg by a subcutaneous route."1.40Toxicity of parasporin-4 and health effects of pro-parasporin-4 diet in mice. ( Inouye, K; Koga, H; Mizuki, E; Okumura, S, 2014)
"Many cancer types show high expression levels of Pim kinases and particularly Pim-1 has been linked to the initiation and progression of the malignant phenotype."1.39Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structure. ( Alexander, LT; Chiaraluce, R; Consalvi, V; Knapp, S; Lantella, A; Lori, C; Pasquo, A, 2013)
"Children with cancer were also evaluated after antineoplasic treatment (CAT, n = 17)."1.38Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment. ( Brito, CX; Guerra, RN; Liberio, SA; Lima, MV; Mendonça, C; Mouchrek-Filho, JC; Nascimento, FR; Oliveira-Junior, JJ; Paim, DB; Pereira, AL, 2012)
"Solid tumors such as hepatocellular carcinoma are very often not amenable to chemotherapy and radiotherapy."1.38Spectroscopic and calorimetric evaluation of chemically induced protein denaturation in HuH-7 liver cancer cells and impact on cell survival. ( Aravalli, RN; Bischof, JC; Choi, J; Cressman, EN; Dong, J; Mehra, D; Mori, S, 2012)
" However, rapid metabolism and shorter half-life of drug mandate higher dose and frequent dosing schedule which subsequently results into higher toxicity."1.38Site specific/targeted delivery of gemcitabine through anisamide anchored chitosan/poly ethylene glycol nanoparticles: an improved understanding of lung cancer therapeutic intervention. ( Campbell, C; Dwivedi, P; Garg, NK; Tyagi, RK, 2012)
"Furthermore, 16c and 16g killed cancer cells with a mechanism independent of mitotic arrest, indicating a change of action mode."1.35Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents. ( Chen, KL; Du, NN; He, WY; Jiang, JD; Song, DQ; Wang, GF; Wang, YM; Wu, LZ; Yang, P; Zhang, XB, 2009)
"Out of 11 human cancer cell lines tested, GPL significantly inhibited proliferation of five lines viz."1.34Characterization of a lectin from Gonatanthus pumilus D. Don having anti-proliferative effect against human cancer cell lines. ( Bhide, SV; Dhuna, V; Kamboj, SS; Kaur, A; Saxena, AK; Singh, J, 2007)
"The majority of cancer therapeutics induces DNA damage to kill cells."1.33Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics. ( Bui, MH; Chen, Z; Gu, WZ; Kovar, P; Li, G; Lin, NH; Rosenberg, SH; Sham, HL; Sowin, TJ; Tao, ZF; Tong, Y; Wang, G; Wang, JY; Xiao, Z; Xue, J; Zhang, H, 2006)
"Fostriecin is an inhibitor of topoisomerase II catalytic activity."1.30Renal toxicity of the anticancer drug fostriecin. ( de Jong, PE; de Jong, RS; de Vries, EG; Meijer, S; Mulder, NH, 1998)
"We decided to test our hypothesis in 32 cancer patients."1.30Must we really fear toxicity of conventional amphotericin B in oncological patients? ( Doubek, M; Mayer, J; Vorlìcek, J, 1999)
"The drug therapies for hypercalcemia of malignancy have been known to be associated with either limited efficacy or cumulative toxicity in patients with advanced renal failure."1.29Calcium-free hemodialysis for the management of hypercalcemia. ( Ahn, SJ; Bang, BK; Jeon, DS; Kim, YS; Koo, WS; Yoon, YS, 1996)
"In anergic and malnourished cancer patients no curative surgical treatment was possible."1.26[Malnutrition and postoperative complication rate in cancer patients (author's transl)]. ( Fritsch, A; Funovics, J; Huk, I; Roth, E; Schemper, M; Schulz, F; Winter, M, 1982)
"As time progressed, the ear tumors increased in size and number in all groups but the greatest incidence was in the group fed 22."1.26Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine. ( , 1976)
"Forty patients with generalized cancer complicated by water and electrolyte retention were treated with "medium" and "large" doses of furosemide and bumetanide with 35% and 40% objective positive response, respectively."1.26Diuretics in malignant effusions and edemas of generalized cancer. ( Athanasiou, A; Dadiotis, L; Razis, DV, 1976)
"In fifty patients with cancer, subjective and objective correlates of anorexia of malignancy were studied."1.25Abnormalities of taste sensation in cancer patients. ( DeWys, WD; Walters, K, 1975)

Research

Studies (191)

TimeframeStudies, this research(%)All Research%
pre-199093 (48.69)18.7374
1990's7 (3.66)18.2507
2000's16 (8.38)29.6817
2010's60 (31.41)24.3611
2020's15 (7.85)2.80

Authors

AuthorsStudies
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L3
Hitosugi, T1
Zhang, L6
Zhang, S3
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y8
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S2
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J2
Frei, E1
Luce, JK1
Loo, TL1
Kaviani, A1
Khansari Nejad, N1
Akour, A1
AlMuhaissen, SA1
Nusair, MB1
Al-Tammemi, AB1
Mahmoud, NN1
Jalouqa, S1
Alrawashdeh, MN1
Shanahan, JP1
Moore, CM1
Kampf, JW1
Szymczak, NK1
Guo, J3
Wang, H3
Luo, Y1
An, H1
Zhang, Z3
Liu, G1
Li, J10
Metcalfe, GD1
Smith, TW1
Hippler, M1
Ayala Izurieta, JE1
Márquez, CO1
García, VJ1
Jara Santillán, CA1
Sisti, JM1
Pasqualotto, N1
Van Wittenberghe, S1
Delegido, J1
Kubo, Y1
Kitagawa, Y1
Miyazaki, T1
Sohda, M1
Yamaji, T1
Sakai, M1
Saeki, H1
Nemoto, K1
Oyama, T2
Muto, M1
Takeuchi, H1
Toh, Y1
Matsubara, H1
Mano, M1
Kono, K1
Kato, K1
Yoshida, M1
Kawakubo, H1
Booka, E1
Yamatsuji, T1
Kato, H1
Ito, Y1
Ishikawa, H1
Ishihara, R1
Tsushima, T1
Kawachi, H1
Kojima, T1
Kuribayashi, S1
Makino, T1
Matsuda, S1
Doki, Y1
Ma, P1
Tang, X2
Wang, X6
Wang, W3
Zhang, X6
Wang, S4
Zhou, N1
Dodd, J1
Jordan, R1
Makhlina, M1
Pesco Koplowitz, L1
Koplowitz, B1
Barnett, K1
Yang, WH1
Spana, C1
Buchanan, SW1
Mafa-Attoye, T1
Dunfield, K1
Thevathasan, NV1
Isaac, ME1
Wu, X3
Huang, JW1
Su, BK1
Yuan, L1
Zheng, WQ1
Zhang, H4
Zheng, YX1
Zhu, W1
Chou, PT1
Manso, AP1
De Morais, DC1
Yamamoto, K1
Owen, G1
de Carvalho, RM1
Palma-Dibb, RG1
Brown, JC1
Yang, S2
Mire, EF1
Miele, L1
Ochoa, A1
Zabaleta, J1
Katzmarzyk, PT1
Moi, CT1
Bhowmick, S1
Qureshi, M1
Wang, K1
Feng, B1
Yang, Y4
Chen, Y5
Wang, Y6
Yang, L1
Jiang, K1
James, TD1
Chaturvedi, V1
Postiglione, WM1
Chakraborty, RD1
Yu, B1
Tabiś, W1
Hameed, S1
Biniskos, N1
Jacobson, A1
Zhou, H1
Greven, M1
Ferry, VE1
Leighton, C1
Wu, F1
Lei, H1
Chen, G3
Chen, C1
Song, Y2
Cao, Z1
Zhang, C2
Zhou, J1
Lu, Y2
Pappone, C1
Santinelli, V1
Mecarocci, V1
Tondi, L1
Ciconte, G1
Manguso, F1
Sturla, F1
Vicedomini, G1
Micaglio, E1
Anastasia, L1
Pica, S1
Camporeale, A1
Lombardi, M1
Shieh, PB1
Elfring, G1
Trifillis, P1
Santos, C1
Peltz, SW1
Parsons, JA1
Apkon, S1
Darras, BT1
Campbell, C2
McDonald, CM1
Galaviz, KI1
Shah, NS1
Gutierrez, M1
Collins, LF1
Lahiri, CD1
Moran, CA1
Szabo, B1
Sumitani, J1
Rhodes, J1
Marconi, VC1
Nguyen, ML1
Cantos, VD1
Armstrong, WS1
Colasanti, JA1
Singh, P1
Kumar Sigalapalli, D1
Sridhar Goud, N1
Swain, B1
Kumar Sahoo, S1
Angeli, A2
Shaik, AB1
Madhavi Yaddanapudi, V1
Supuran, CT3
Arifuddin, M1
Abdel-Rahman Mohamed, A1
Khater, SI1
Metwally, MMM1
Bin Emran, T1
Nassan, MA1
Abd El-Emam, MM1
Mostafa-Hedeab, G1
El-Shetry, ES1
Niu, F1
Yu, Y1
Li, Z6
Ren, Y2
Ye, Q2
Liu, P1
Ji, C1
Qian, L1
Xiong, Y1
Mizuno, R1
Hojo, H1
Takahashi, M1
Kashio, S1
Enya, S1
Nakao, M1
Konishi, R1
Yoda, M1
Harata, A1
Hamanishi, J1
Kawamoto, H1
Mandai, M1
Suzuki, Y1
Miura, M1
Bamba, T1
Izumi, Y1
Kawaoka, S1
Xiong, L1
He, H2
Fan, M1
Hu, L1
Wang, F3
Song, X1
Shi, S1
Qi, B2
Kayapinar, AK1
Calik, B1
Sahin, H1
Tuncer, K1
Bas, K1
Engin, O1
Akbulut, G1
Wu, K2
He, R1
Qiu, K1
Xiao, G1
Peng, L1
Meng, X1
Zheng, C1
Cai, Q2
Gil-Edo, R1
Hernández-Ribelles, G1
Royo, S1
Thawait, N1
Serrels, A1
Carda, M2
Falomir, E2
Boilève, A1
Thomas, L1
Lillo-Le Louët, A1
Gaboriau, L1
Chouchana, L1
Ducreux, M1
Malka, D1
Boige, V1
Hollebecque, A1
Hillaire-Buys, D1
Jozwiak, M1
Nguépy Keubo, FR1
Mboua, PC1
Djifack Tadongfack, T1
Fokouong Tchoffo, E1
Tasson Tatang, C1
Ide Zeuna, J1
Noupoue, EM1
Tsoplifack, CB1
Folefack, GO1
Kettani, M1
Bandelier, P1
Huo, J1
Li, H5
Yu, D1
Arulsamy, N1
AlAbbad, S1
Sardot, T1
Lekashvili, O1
Decato, D1
Lelj, F1
Alexander Ross, JB1
Rosenberg, E1
Nazir, H1
Muthuswamy, N1
Louis, C1
Jose, S1
Prakash, J1
Buan, MEM1
Flox, C1
Chavan, S1
Shi, X2
Kauranen, P1
Kallio, T1
Maia, G1
Tammeveski, K1
Lymperopoulos, N1
Carcadea, E1
Veziroglu, E1
Iranzo, A1
M Kannan, A1
Arunamata, A1
Tacy, TA1
Kache, S1
Mainwaring, RD1
Ma, M1
Maeda, K1
Punn, R1
Noguchi, S1
Hahn, S3
Iwasa, Y3
Ling, J2
Voccio, JP2
Kim, Y3
Song, J3
Bascuñán, J2
Chu, Y1
Tomita, M1
Cazorla, M1
Herrera, E1
Palomeque, E1
Saud, N1
Hoplock, LB1
Lobchuk, MM1
Lemoine, J1
Li, X10
Henson, MA1
Unsihuay, D1
Qiu, J1
Swaroop, S1
Nagornov, KO1
Kozhinov, AN1
Tsybin, YO1
Kuang, S1
Laskin, J1
Zin, NNINM1
Mohamad, MN1
Roslan, K1
Abdul Wafi, S1
Abdul Moin, NI1
Alias, A1
Zakaria, Y1
Abu-Bakar, N1
Naveed, A1
Jilani, K1
Siddique, AB1
Akbar, M1
Riaz, M1
Mushtaq, Z1
Sikandar, M1
Ilyas, S1
Bibi, I1
Asghar, A1
Rasool, G1
Irfan, M1
Li, XY1
Zhao, S1
Fan, XH1
Chen, KP1
Hua, W1
Liu, ZM1
Xue, XD1
Zhou, B1
Xing, YL1
Chen, MA1
Sun, Y2
Neradilek, MB1
Wu, XT1
Zhang, D2
Huang, W1
Cui, Y1
Yang, QQ1
Li, HW1
Zhao, XQ1
Hossein Rashidi, B1
Tarafdari, A1
Ghazimirsaeed, ST1
Shahrokh Tehraninezhad, E1
Keikha, F1
Eslami, B1
Ghazimirsaeed, SM1
Jafarabadi, M1
Silvani, Y1
Lovita, AND1
Maharani, A1
Wiyasa, IWA1
Sujuti, H1
Ratnawati, R1
Raras, TYM1
Lemin, AS1
Rahman, MM1
Pangarah, CA1
Kiyu, A1
Zeng, C2
Du, H1
Lin, D1
Jalan, D1
Rubagumya, F1
Hopman, WM1
Vanderpuye, V1
Lopes, G1
Seruga, B1
Booth, CM1
Berry, S1
Hammad, N1
Sajo, EA1
Okunade, KS1
Olorunfemi, G1
Rabiu, KA1
Anorlu, RI1
Xu, C2
Xiang, Y1
Xu, X2
Dong, X1
Tang, S1
Gao, XC1
Wei, CH1
Zhang, RG1
He, Y1
Tong, F1
Dong, JH1
Wu, G1
Dong, XR1
Tao, F1
Xiang, W1
Zhao, Y2
Jin, L1
Tao, H1
Lei, Y1
Gan, H1
Huang, Y1
Chen, L4
Shan, A1
Zhao, H2
Wu, M2
Ma, Q1
Wang, J5
Zhang, E1
Zhang, J3
Xue, F1
Deng, L1
Liu, L2
Yan, Z2
Meng, J1
Anastassiadou, M1
Bernasconi, G1
Brancato, A1
Carrasco Cabrera, L1
Greco, L1
Jarrah, S1
Kazocina, A1
Leuschner, R1
Magrans, JO1
Miron, I1
Nave, S1
Pedersen, R1
Reich, H1
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Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Urea for Chronic Hyponatremia: A Pilot Study[NCT04588207]Phase 22 participants (Actual)Interventional2021-12-28Terminated (stopped due to Unable to recruit participants)
A Phase I Study of AT9283 Given As a 24 Hour Infusion on Days 1 and 8 Every Three Weeks in Patients With Advanced Incurable Malignancy[NCT00443976]Phase 135 participants (Actual)Interventional2007-01-30Completed
A Phase II, Randomised Controlled Trial to Evaluate the Efficacy and Safety of Moisturising Creams With or Without Palm-oil-derived Vitamin E Concentrate in Addition to Urea-based Cream or Urea-based Cream Alone in Capecitabine-associated Palmar-Plantar E[NCT05939726]90 participants (Anticipated)Interventional2023-05-16Recruiting
A Phase III Randomized, Placebo-controlled, Double-blind Trial to Determine the Effectiveness of a Urea/Lactic Acid-Based Topical Keratolytic Agent and Vitamin B-6 for Prevention of Capecitabine-Induced Hand and Foot Syndrome[NCT00296036]Phase 3137 participants (Actual)Interventional2006-06-30Completed
A Double-blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Orexigenic Therapy With Delta-9-tetrahydrocannabinol in Advanced Cancer Patients With Chemosensory Abnormalities - a Pilot Study[NCT00316563]Phase 280 participants (Anticipated)Interventional2006-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

To Determine Whether the Prophylactic Use of a Topical Urea/Lactic Acid Cream Can Decrease the Incidence/Severity of Capecitabine-caused Palmar-plantar Erythrodysesthesia

A patient self-reported hand-foot syndrome (HFSD), also known as palmar-plantar erythrodysesthesia, was completed daily while applying the cream. Patients rated skin severity symptoms individually in their hands and in their feet. Definitions of symptoms, which were based on Common Terminology Criteria for Adverse Events (CTCAE) v3.0, were provided to patients. The number of patients reporting moderate to severe symptoms in either hands or feet were tabulated and percentages are reported. (NCT00296036)
Timeframe: First 3 weeks of treatment

Interventionpercentage of participants (Number)
Urea/Lactic Acid Cream13.6
Placebo Cream10.2

To Evaluate the Potential Toxicity of Urea/Lactic Acid Cream

Frequency and severity of adverse events reported by patients in weekly diary and evaluated through clinical assessment by NCI CTCAE v3.0. The number of patients reporting grade 3 or higher events are reported in this outcome measure. For a full list of all events, please refer to the Adverse Events section of this report. (NCT00296036)
Timeframe: Up to 4, 21-day cycles

,
Interventionparticipants (Number)
Grade 3+ Adverse EventGrade 4+ Adverse Event
Placebo Cream183
Urea/Lactic Acid Cream213

Reviews

23 reviews available for urea and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
    Biomaterial investigations in dentistry, 2021, Volume: 8, Issue:1

    Topics: Adult; Alcohol Drinking; Ammonia; Animals; Anti-Inflammatory Agents; Area Under Curve; B-Lymphocytes

2021
Arginase: An emerging and promising therapeutic target for cancer treatment.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 149

    Topics: Animals; Arginase; Arginine; Mammals; Neoplasms; Tumor Microenvironment; Urea

2022
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Arylurea Derivatives: A Class of Potential Cancer Targeting Agents.
    Current topics in medicinal chemistry, 2017, Nov-20, Volume: 17, Issue:28

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Humans; Neoplasms; Urea

2017
Assessment of Health Effects of Exogenous Urea: Summary and Key Findings.
    Current environmental health reports, 2018, Volume: 5, Issue:2

    Topics: Animals; Carcinogens; Environmental Exposure; Humans; Neoplasms; Urea

2018
Rewiring urea cycle metabolism in cancer to support anabolism.
    Nature reviews. Cancer, 2018, Volume: 18, Issue:10

    Topics: Animals; Humans; Liver; Metabolic Networks and Pathways; Neoplasms; Urea

2018
Changing mutational patterns.
    Nature reviews. Cancer, 2018, Volume: 18, Issue:10

    Topics: Animals; Carbon-Nitrogen Ligases; Humans; Mice; Mutation; Neoplasms; Pyrimidines; Urea

2018
Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress.
    Seminars in oncology, 2015, Volume: 42, Issue:6

    Topics: Antineoplastic Agents; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Benzamides; Benzazepines; B

2015
Overview of CDK9 as a target in cancer research.
    Cell cycle (Georgetown, Tex.), 2016, Volume: 15, Issue:4

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Fla

2016
Diaryl Urea: A Privileged Structure in Anticancer Agents.
    Current medicinal chemistry, 2016, Volume: 23, Issue:15

    Topics: Animals; Antineoplastic Agents; Hedgehog Proteins; Humans; Neoplasms; Urea

2016
Aurora kinase inhibitors as anti-cancer therapy.
    Anti-cancer drugs, 2010, Volume: 21, Issue:4

    Topics: Antineoplastic Agents; Aurora Kinase B; Aurora Kinase C; Aurora Kinases; Benzamides; Benzimidazoles;

2010
Development of RET kinase inhibitors for targeted cancer therapy.
    Current medicinal chemistry, 2011, Volume: 18, Issue:2

    Topics: Antineoplastic Agents; Humans; Indoles; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Protein

2011
AT-9283, a small-molecule multi-targeted kinase inhibitor for the potential treatment of cancer.
    Current opinion in investigational drugs (London, England : 2000), 2010, Volume: 11, Issue:12

    Topics: Antineoplastic Agents; Benzimidazoles; Clinical Trials as Topic; Drug Approval; Drug Evaluation, Pre

2010
Recent developments in the discovery of protein kinase inhibitors from the urea class.
    Current opinion in drug discovery & development, 2004, Volume: 7, Issue:5

    Topics: Chemistry, Pharmaceutical; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic;

2004
Review of the health effects of urea-formaldehyde foam insulation.
    Environmental research, 1984, Volume: 35, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Air Pollutants; Animals; Construction Materials; Dermatitis, Con

1984
Changes in taste sensation and feeding behaviour in cancer patients: a review.
    Journal of human nutrition, 1978, Volume: 32, Issue:6

    Topics: Anorexia; Energy Intake; Feeding and Eating Disorders; Food Preferences; Humans; Neoplasms; Sucrose;

1978
Alkaline phosphatase.
    Frontiers of gastrointestinal research, 1976, Volume: 2

    Topics: Alkaline Phosphatase; Bone and Bones; Cholecystokinin; Dietary Fats; Electrophoresis, Polyacrylamide

1976
Immune abnormalities in renal failure and hemodialysis.
    Blood purification, 1986, Volume: 4, Issue:1-3

    Topics: Antibody Formation; Graft vs Host Reaction; Hepatitis B; Humans; Immunity, Cellular; Immunosuppressi

1986
Mitochondrial pathology: an overview.
    Annals of the New York Academy of Sciences, 1986, Volume: 488

    Topics: Adenosine Triphosphate; Animals; Autoantibodies; Calcium; Humans; Metabolism, Inborn Errors; Mitocho

1986
Nutrition and nitrosamine formation.
    The Proceedings of the Nutrition Society, 1985, Volume: 44, Issue:1

    Topics: Amides; Amines; Animals; Diet; Food Preservatives; Gastric Mucosa; Humans; Neoplasms; Nitrites; Nitr

1985
[Progress in the drug therapy of cancer].
    Medizinische Klinik, 1968, Apr-26, Volume: 63, Issue:17

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Cytarabine; Daunorubicin; Drug Syn

1968
Factors pertaining to complete drug-induced remission of tumor in animals and man.
    Cancer research, 1969, Volume: 29, Issue:12

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Humans; Leukemia L1210; Methotrexate;

1969

Trials

17 trials available for urea and Neoplasms

ArticleYear
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours.
    Cancer chemotherapy and pharmacology, 2013, Volume: 72, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Checkpoint Kinase 1; Checkpoint Kinase 2; Deox

2013
NCIC CTG IND.181: phase I study of AT9283 given as a weekly 24 hour infusion in advanced malignancies.
    Investigational new drugs, 2013, Volume: 31, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzimidazoles; Drug Administration Schedule;

2013
Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors.
    Cancer chemotherapy and pharmacology, 2014, Volume: 73, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Checkp

2014
Phase I study of RGB-286638, a novel, multitargeted cyclin-dependent kinase inhibitor in patients with solid tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Sep-15, Volume: 20, Issue:18

    Topics: Adult; Aged; Antineoplastic Agents; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Fema

2014
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35

    Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind

2010
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35

    Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind

2010
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35

    Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind

2010
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35

    Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind

2010
A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Aurora Kinases; Benzimidazoles; Cohort Studies; Disease Progress

2012
A phase I study of bizelesin, a highly potent and selective DNA-interactive agent, in patients with advanced solid malignancies.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; DNA; Dose-Response Relationship,

2003
Urinary excretion of L-carnitine and its short-chain acetyl-L-carnitine in patients undergoing carboplatin treatment.
    Cancer chemotherapy and pharmacology, 2007, Volume: 60, Issue:1

    Topics: Acetylcarnitine; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area U

2007
Amphotericin B dose optimization in children with malignant diseases.
    Chemotherapy, 2007, Volume: 53, Issue:2

    Topics: Adolescent; Amphotericin B; Antifungal Agents; Body Weight; Child; Child, Preschool; Computer Simula

2007
[On changes in oxygen transport capacity following osmo- and oncotherapy].
    Der Anaesthesist, 1967, Volume: 16, Issue:11

    Topics: Adult; Blood Volume; Brain Edema; Craniotomy; Dextrans; Humans; Infusions, Parenteral; Mathematics;

1967
A Phase I study of bizelesin (NSC 615291) in patients with advanced solid tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Biological Availability; Duocarmyc

2002
High-dose metoclopramide by infusion: a double-blind study of plasma concentration-effect relationships in patients receiving cancer chemotherapy.
    European journal of clinical pharmacology, 1987, Volume: 33, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Doub

1987
Treatment of Hodgkin's disease and other cancers with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962).
    Cancer chemotherapy reports, 1971, Volume: 55, Issue:5

    Topics: Adenocarcinoma; Adenoma, Islet Cell; Adolescent; Adrenal Gland Neoplasms; Adult; Alkylating Agents;

1971
Nitrosoureas: 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962; BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037; CCNU)--clinical brochure.
    Cancer chemotherapy reports. Part 3, 1968, Volume: 1, Issue:1

    Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Dogs; Humans; Mice; Neoplasms; Neoplasms,

1968
Clinical studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037).
    Cancer research, 1971, Volume: 31, Issue:3

    Topics: Antineoplastic Agents; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Cyclohexanes; Humans

1971
Clinical trials of 1-beta-D-arabinofuranosyl cytosine and 1,3-bis-(2-chloroethyl)-1-nitrosourea combination in metastatic cancer and acute leukemia.
    Cancer, 1971, Volume: 27, Issue:5

    Topics: Age Factors; Blood Cell Count; Blood Platelets; Blood Urea Nitrogen; Clinical Trials as Topic; Cytar

1971

Other Studies

152 other studies available for urea and Neoplasms

ArticleYear
Phase I and phototoxicity studies of pseudourea (NSC-56054).
    Cancer chemotherapy reports, 1971, Volume: 55, Issue:1

    Topics: Anthracenes; Antineoplastic Agents; Humans; Neoplasm Metastasis; Neoplasms; Photosensitivity Disorde

1971
Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors.
    ChemMedChem, 2022, 03-04, Volume: 17, Issue:5

    Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Human

2022
TGF-β1, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: Comparative modulating role of Melatonin, Vit. E and Ozone.
    Gene, 2022, Apr-30, Volume: 820

    Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Creatinine; Disease Mo

2022
Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.
    Nature communications, 2022, 06-15, Volume: 13, Issue:1

    Topics: Animals; Liver; Mice; Neoplasms; Niacinamide; Nicotinamide N-Methyltransferase; Nitrogen; Uracil; Ur

2022
Discovery of novel conjugates of quinoline and thiazolidinone urea as potential anti-colorectal cancer agent.
    Journal of enzyme inhibition and medicinal chemistry, 2022, Volume: 37, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antit

2022
A new prognostic marker in patients undergoing Hartmann's procedure for acute tumoral obstruction of the left colon.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2022, Volume: 28, Issue:9

    Topics: Anastomosis, Surgical; Colon; Colostomy; Humans; Neoplasms; Postoperative Complications; Prognosis;

2022
Discovery of 3,5-diaryl-1H-pyrazol-based ureas as potent RET inhibitors.
    European journal of medicinal chemistry, 2023, May-05, Volume: 251

    Topics: Antineoplastic Agents; Humans; Lung Neoplasms; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene

2023
Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies.
    International journal of molecular sciences, 2023, May-11, Volume: 24, Issue:10

    Topics: Cell Line, Tumor; Cell Proliferation; HEK293 Cells; Humans; Immunomodulation; Neoplasms; Urea

2023
5-Fluorouracil-induced hyperammonaemic encephalopathy: A French national survey.
    European journal of cancer (Oxford, England : 1990), 2020, Volume: 129

    Topics: Aged; Ammonia; Antimetabolites, Antineoplastic; Brain Diseases; Citric Acid Cycle; Dose-Response Rel

2020
Synthesis, in vitro, and in vivo evaluation of novel N-phenylindazolyl diarylureas as potential anti-cancer agents.
    Scientific reports, 2020, 10-21, Volume: 10, Issue:1

    Topics: Amides; Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Dose-Response Rela

2020
Optimization of the
    Journal of medicinal chemistry, 2020, 12-10, Volume: 63, Issue:23

    Topics: Animals; Antineoplastic Agents; Blood; Caspase Inhibitors; Cell Line, Tumor; Female; Half-Life; Huma

2020
Discovery of Potent, Highly Selective, and
    Journal of medicinal chemistry, 2020, 12-10, Volume: 63, Issue:23

    Topics: Animals; Antineoplastic Agents; Caspase Inhibitors; Drug Discovery; Female; Humans; Immunity, Humora

2020
Effectiveness of a cosmetic device containing a combination of alpha- and beta-hydroxy acids, urea, and thuja for the treatment of seborrheic keratoses.
    Journal of cosmetic dermatology, 2022, Volume: 21, Issue:5

    Topics: Cosmetics; Humans; Hydroxy Acids; Keratosis, Seborrheic; Neoplasms; Prospective Studies; Thuja; Urea

2022
Rational drug design of indazole-based diarylurea derivatives as anticancer agents.
    Chemical biology & drug design, 2017, Volume: 90, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Computer-Aided Design; Drug Design; Dru

2017
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
    Bioorganic & medicinal chemistry letters, 2017, 08-01, Volume: 27, Issue:15

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Cytoki

2017
UbasM: An effective balanced optical clearing method for intact biomedical imaging.
    Scientific reports, 2017, 09-22, Volume: 7, Issue:1

    Topics: Amino Sugars; Animals; Brain; Cell Line, Tumor; Disease Models, Animal; Histological Techniques; Mic

2017
Fluoroenesulphonamides: N-sulphonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition.
    Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1

    Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Esters; Humans

2018
Effect of combination sildenafil and gemfibrozil on cisplatin-induced nephrotoxicity; role of heme oxygenase-1.
    Renal failure, 2018, Volume: 40, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Cisplatin; Creatinine; Disease Models, Animal

2018
Cytotoxic and Apoptotic Effects of Novel Pyrrolo[2,3-d]Pyrimidine Derivatives Containing Urea Moieties on Cancer Cell Lines.
    Anti-cancer agents in medicinal chemistry, 2018, Volume: 18, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Hu

2018
The diagnostic value of human epididymis protein 4 as a novel biomarker in patients with renal dysfunction.
    International urology and nephrology, 2018, Volume: 50, Issue:11

    Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Area Under Curve; Biomarkers; Cardi

2018
Effects of a checkpoint kinase inhibitor, AZD7762, on tumor suppression and bone remodeling.
    International journal of oncology, 2018, Volume: 53, Issue:3

    Topics: Animals; Bioprinting; Bone and Bones; Bone Remodeling; Calcification, Physiologic; Carbazoles; Cell

2018
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.
    Cell, 2018, 09-06, Volume: 174, Issue:6

    Topics: Amino Acid Transport Systems, Basic; Animals; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Sy

2018
Metabolic Frugality Marks Cancer Cells for Immune Targeting.
    Cell, 2018, 09-06, Volume: 174, Issue:6

    Topics: Genomics; Humans; Immunotherapy; Neoplasms; Urea

2018
Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling.
    Bioorganic chemistry, 2018, Volume: 81

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Human Umbilical Vein Endot

2018
A pH-responsive bioassay for paper-based diagnosis of exosomes via mussel-inspired surface chemistry.
    Talanta, 2019, Jan-15, Volume: 192

    Topics: Armoracia; Biological Assay; Biomarkers, Tumor; Canavalia; Dopamine; Exosomes; Horseradish Peroxidas

2019
Discovery of N
    European journal of medicinal chemistry, 2019, Feb-01, Volume: 163

    Topics: Apoptosis; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Drug Screening Assays, Anti

2019
[Study of arginase activity of mixed saliva in cancer].
    Voprosy onkologii, 2016, Volume: 62, Issue:5

    Topics: Adult; Aged; Arginase; Female; Humans; Male; Middle Aged; Neoplasm Proteins; Neoplasms; Nitric Oxide

2016
p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis.
    Nature, 2019, Volume: 567, Issue:7747

    Topics: Ammonia; Arginase; Carbamoyl-Phosphate Synthase (Ammonia); Cell Proliferation; Gene Expression Regul

2019
Urea in cancer patients with chronic SIAD-induced hyponatremia: Old drug, new evidence.
    Clinical endocrinology, 2019, Volume: 90, Issue:6

    Topics: Aged; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Middle Aged; Neoplasms; Retros

2019
Novel multitarget inhibitors with antiangiogenic and immunomodulator properties.
    European journal of medicinal chemistry, 2019, May-15, Volume: 170

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Bibenzyls; Cell Line, Tumor; Cell Proliferation; Dru

2019
Novel 7-formyl-naphthyridyl-ureas derivatives as potential selective FGFR4 inhibitors: Design, synthesis, and biological activity studies.
    Bioorganic & medicinal chemistry, 2019, 05-15, Volume: 27, Issue:10

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Design; Drug Screening Assays,

2019
Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro.
    Acta pharmaceutica (Zagreb, Croatia), 2018, Dec-01, Volume: 68, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Design; Drug Screenin

2018
Development of tumor-targeted near infrared probes for fluorescence guided surgery.
    Bioconjugate chemistry, 2013, Jun-19, Volume: 24, Issue:6

    Topics: Animals; Female; Fluorescence; Fluorescent Dyes; Folic Acid; Glutarates; Humans; Infrared Rays; KB C

2013
Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structure.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Amino Acid Substitution; Catalytic Domain; Enzyme Stability; Humans; Kinetics; Neoplasms; Polymorphi

2013
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
    Bioorganic & medicinal chemistry letters, 2013, Sep-01, Volume: 23, Issue:17

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Humans; Mice; Mice, Nude; Models, Molec

2013
Toxicity of parasporin-4 and health effects of pro-parasporin-4 diet in mice.
    Toxins, 2014, Jul-16, Volume: 6, Issue:7

    Topics: Ammonium Compounds; Animals; Bacterial Proteins; Blood Urea Nitrogen; Creatinine; Diet; Endotoxins;

2014
ATR inhibition preferentially targets homologous recombination-deficient tumor cells.
    Oncogene, 2015, Volume: 34, Issue:26

    Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Survival; Checkpoint Kinase 1; D

2015
Design and synthesis of novel 1,2,3-triazole-pyrimidine-urea hybrids as potential anticancer agents.
    Bioorganic & medicinal chemistry letters, 2015, Mar-01, Volume: 25, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; H

2015
Procalcitonin improves the Glasgow Prognostic Score for outcome prediction in emergency patients with cancer: a cohort study.
    Disease markers, 2015, Volume: 2015

    Topics: Aged; Biomarkers, Tumor; C-Reactive Protein; Calcitonin; Calcitonin Gene-Related Peptide; Calcium; C

2015
Photoluminescent carbon dots synthesized by microwave treatment for selective image of cancer cells.
    Journal of colloid and interface science, 2015, Oct-15, Volume: 456

    Topics: Biocompatible Materials; Carbon; Cell Line; Diagnostic Imaging; Fluorescent Dyes; Folic Acid; HeLa C

2015
Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells.
    Scientific reports, 2015, Aug-21, Volume: 5

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Centrosome; Chromosomal

2015
Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as anticancer agents with low toxicity.
    Bioorganic & medicinal chemistry, 2015, Oct-01, Volume: 23, Issue:19

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzothiazoles; Binding Sites; Cell Line, Tumo

2015
Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.
    Oncotarget, 2015, Nov-03, Volume: 6, Issue:34

    Topics: Antineoplastic Agents; Biomarkers, Pharmacological; Cell Cycle; Cell Cycle Proteins; Checkpoint Kina

2015
Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition.
    Expert opinion on therapeutic patents, 2016, Volume: 26, Issue:2

    Topics: Chronic Pain; Drug Design; Humans; Inflammation; Inhibitory Concentration 50; Neoplasms; Neuralgia;

2016
Synthesis and p38 Inhibitory Activity of Some Novel Substituted N,N'-Diarylurea Derivatives.
    Molecules (Basel, Switzerland), 2016, May-23, Volume: 21, Issue:5

    Topics: Cell Line, Tumor; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Ligands;

2016
Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue.
    Nano letters, 2017, 04-12, Volume: 17, Issue:4

    Topics: Aminoquinolines; Animals; Benzene Derivatives; Ethylene Glycol; Fluorescent Dyes; Hot Temperature; M

2017
Uveitis or sarcoma.
    Praxis, 1948, Apr-15, Volume: 37, Issue:15

    Topics: Diagnosis, Differential; Humans; Neoplasms; Sarcoma; Urea; Uvea

1948
Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents.
    Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

    Topics: Antineoplastic Agents; Carboxylic Acids; Cell Proliferation; Chemistry, Pharmaceutical; Drug Design;

2009
(124)I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of (131)I-L19-SIP radioimmunotherapy.
    European journal of nuclear medicine and molecular imaging, 2009, Volume: 36, Issue:8

    Topics: Animals; Antibodies; Cell Line, Tumor; Feasibility Studies; Humans; Injections; Iodine Radioisotopes

2009
Aurora B kinase inhibition in mitosis: strategies for optimising the use of aurora kinase inhibitors such as AT9283.
    Cell cycle (Georgetown, Tex.), 2009, Jun-15, Volume: 8, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Benzimi

2009
Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.
    Journal of medicinal chemistry, 2009, Jul-09, Volume: 52, Issue:13

    Topics: Allosteric Site; Animals; Cell Line; Crystallography, X-Ray; CSK Tyrosine-Protein Kinase; Drug Desig

2009
Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues.
    Annals of the New York Academy of Sciences, 2009, Volume: 1175

    Topics: Animals; Carrier Proteins; Female; Folate Receptors, GPI-Anchored; Folic Acid; Glutarates; HeLa Cell

2009
In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Apr-01, Volume: 16, Issue:7

    Topics: Animals; Cells, Cultured; Checkpoint Kinase 1; DNA Damage; Dose-Response Relationship, Drug; Female;

2010
Accidents due to cinchonine and urea double hydrochloride in the treatment of angiomas.
    Annales de dermatologie et de syphiligraphie, 1947, Volume: 7, Issue:2

    Topics: Cinchona; Hemangioma; Humans; Neoplasms; Urea

1947
ASK1-P38 pathway is important for anoikis induced by microtubule-targeting aryl chloroethylureas.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2010, Volume: 13, Issue:2

    Topics: Animals; Anoikis; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line; Cell Line, Tumor;

2010
Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.
    The Journal of biological chemistry, 2011, Jan-07, Volume: 286, Issue:1

    Topics: Animals; Blood Vessels; Endothelial Cells; Heparitin Sulfate; Humans; Mice; Neoplasms; Permeability;

2011
Bayesian hierarchical changepoint methods in modeling the tumor growth profiles in xenograft experiments.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Mar-01, Volume: 17, Issue:5

    Topics: Animals; Bayes Theorem; Cell Proliferation; Confidence Intervals; Deoxycytidine; Gemcitabine; Mice;

2011
Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates.
    Bioorganic & medicinal chemistry, 2011, Mar-15, Volume: 19, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Humans; Mice; Mice, Nude; Mustard Pla

2011
Spectral-spatial excitation for rapid imaging of DNP compounds.
    NMR in biomedicine, 2011, Volume: 24, Issue:8

    Topics: Acetates; Animals; Carbon Isotopes; Magnetic Resonance Spectroscopy; Neoplasms; Pyruvic Acid; Rats;

2011
Radiosynthesis of three [11C]ureido-substituted benzenesulfonamides as PET probes for carbonic anhydrase IX in tumors.
    Bioorganic & medicinal chemistry letters, 2011, Dec-01, Volume: 21, Issue:23

    Topics: Antigens, Neoplasm; Benzenesulfonamides; Carbon Radioisotopes; Carbonic Anhydrase Inhibitors; Carbon

2011
Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2012, Volume: 41, Issue:7

    Topics: Biomarkers; Blood Glucose; Case-Control Studies; Central Nervous System Neoplasms; Child; Cohort Stu

2012
Spectroscopic and calorimetric evaluation of chemically induced protein denaturation in HuH-7 liver cancer cells and impact on cell survival.
    Technology in cancer research & treatment, 2012, Volume: 11, Issue:5

    Topics: Ablation Techniques; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell Survival; Humans; Ne

2012
Site specific/targeted delivery of gemcitabine through anisamide anchored chitosan/poly ethylene glycol nanoparticles: an improved understanding of lung cancer therapeutic intervention.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2012, Dec-18, Volume: 47, Issue:5

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antimetabolites, Antineoplastic; Aspartate Amin

2012
BZ-55 (CARBUTAMIDE): experimental and clinical studies of an oral antidiabetic agent.
    Canadian Medical Association journal, 1956, Jun-15, Volume: 74, Issue:12

    Topics: Carbutamide; Diabetes Mellitus; Hypoglycemic Agents; Neoplasms; Sulfanilamide; Sulfanilamides; Sulfo

1956
Hypersmolarity (hypernatremia) and azotemia induced by the administration of urea.
    Archives of neurology, 1960, Volume: 2

    Topics: Azotemia; Humans; Hypernatremia; Neoplasms; Pituitary Gland; Sodium; Urea

1960
Histamine formation and tumor growth.
    British journal of cancer, 1962, Volume: 16

    Topics: Animals; Carcinoma, Hepatocellular; Dihydroxyphenylalanine; Histamine; Liver Neoplasms; Liver Neopla

1962
Effect of intravenous urea on the EEG of brain tumor patients.
    Electroencephalography and clinical neurophysiology, 1961, Volume: 13

    Topics: Brain Neoplasms; Electroencephalography; Humans; Neoplasms; Nervous System Physiological Phenomena;

1961
PHYSICO-CHEMICAL PROPERTIES OF YOSHIDA ASCITES MUCOPROTEIN.
    Clinica chimica acta; international journal of clinical chemistry, 1963, Volume: 8

    Topics: Ascites; Electrophoresis; Guanidines; Mucoproteins; Neoplasm Proteins; Neoplasms; Phosphates; Rats;

1963
CYTOTOXICITY OF HYDROXYUREA (NSC-32065) REVERSIBLE BY PYRIMIDINE DEOXYRIBOSIDES IN A MAMMALIAN CELL LINE GROWN IN VITRO.
    Cancer chemotherapy reports, 1964, Volume: 34

    Topics: Antimetabolites; Cell Line; Cricetinae; Hydroxyurea; In Vitro Techniques; Neoplasms; Neoplasms, Expe

1964
ON THE CONCENTRATING DEFECT IN CIRRHOSIS OF THE LIVER.
    The Journal of clinical investigation, 1964, Volume: 43

    Topics: Alcoholism; Arthritis; Arthritis, Rheumatoid; Coronary Disease; Dehydration; Dermatitis; Diabetes Me

1964
TRIAL OF HYDROXYUREA (NSC-32065) IN CANCER IN CHILDREN.
    Cancer chemotherapy reports, 1964, Volume: 37

    Topics: Antineoplastic Agents; Busulfan; Child; Cyclophosphamide; Dactinomycin; Humans; Hydroxyurea; Leukemi

1964
STUDIES ON THE EXOCRINE PANCREAS. I. NONSPECIFIC PANCREATIC DUCTULAR ECTASIA.
    The American journal of pathology, 1964, Volume: 44

    Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Blood; Cardiovascular Diseases; Cholecystitis; Defic

1964
ANURIA DUE TO URIC ACID CRYSTALLURIA: AN UNUSUAL COMPLICATION OF THERAPY IN THE RETICULOSES.
    British journal of cancer, 1964, Volume: 18

    Topics: Abdominal Neoplasms; Anuria; Blood; Genetic Diseases, X-Linked; Humans; Kidney Diseases; Leukemia, H

1964
[USE OF UREA AS A FACILITATING ELEMENT IN THE EXECUTION OF PNEUMOENCEPHALOGRAPHY].
    La Radiologia medica, 1964, Volume: 50

    Topics: Brain Neoplasms; Diagnostic Imaging; Humans; Hypertonic Solutions; Injections; Injections, Intraveno

1964
EXPERIMENTAL STUDIES ON THE ANTITUMOR EFFECT OF BIURET DERIVATIVES.
    The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku, 1964, Volume: 11

    Topics: Animals; Antineoplastic Agents; Biuret; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Rese

1964
[HYPERCORTICISM AND BRONCHIAL CANCER WITH REVEALING HYPOKALEMIC ALKALOSIS].
    Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1964, Jun-19, Volume: 115

    Topics: Adrenocortical Hyperfunction; Alkalosis; Ammonia; Bartter Syndrome; Blood Chemical Analysis; Blood G

1964
ERYTHEMA IN AREAS OF PREVIOUS IRRADIATION IN PATIENTS TREATED WITH HYDROXYUREA (NSC-32065).
    Cancer chemotherapy reports, 1964, Volume: 40

    Topics: Antineoplastic Agents; Drug Therapy; Erythema; Hydroxyurea; Neoplasms; Radiation Injuries; Toxicolog

1964
PEDIATRIC CLINICAL TRIALS WITH HYDROXYUREA (NSC-32065).
    Cancer chemotherapy reports, 1964, Volume: 40

    Topics: Adolescent; Antineoplastic Agents; Child; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Neop

1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: MISCELLANEOUS TUMORS.
    Cancer chemotherapy reports, 1964, Volume: 40

    Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Carcinom

1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CANCER OF THE BREAST.
    Cancer chemotherapy reports, 1964, Volume: 40

    Topics: Anemia; Anemia, Myelophthisic; Antineoplastic Agents; Breast Neoplasms; Drug Therapy; Erythema; Estr

1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: MULTIPLE MYELOMA AND LYMPHOMA.
    Cancer chemotherapy reports, 1964, Volume: 40

    Topics: Antineoplastic Agents; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukopenia; Lymphoma; Lymphoma, L

1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CLINICAL EVALUATION.
    Cancer chemotherapy reports, 1964, Volume: 40

    Topics: Antineoplastic Agents; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leu

1964
HORMONAL THERAPY IN CANCER OF THE BREAST. 23. EFFECT OF 7-ALPHA-METHYL-19-NORTESTOSTERONE ACETATE AND TESTOSTERONE PROPIONATE ON CLINICAL COURSE AND HORMONAL EXCRETION.
    Cancer, 1964, Volume: 17

    Topics: 17-Ketosteroids; Acetates; Antineoplastic Agents; Bilirubin; Biomedical Research; Blood Glucose; Bre

1964
HYPERPARATHYROID-LIKE STATE IN RABBITS WITH THE VX-2 CARCINOMA: FURTHER STUDIES.
    The American surgeon, 1965, Volume: 31

    Topics: Animals; Blood; Blood Urea Nitrogen; Hypercalcemia; Hyperparathyroidism; Neoplasm Transplantation; N

1965
ENCEPHALOGRAPHY WITH UREA.
    Acta radiologica: diagnosis, 1965, Volume: 3

    Topics: Astrocytoma; Brain Neoplasms; Child; Hematoma; Hematoma, Subdural; Humans; Meningeal Neoplasms; Meni

1965
USE OF THE SHOPE PAPILLOMA VIRUS-INDUCED ARGINASE AS A BIOCHEMICAL MARKER IN VITRO.
    Virology, 1965, Volume: 26

    Topics: Animals; Arginase; Biological Assay; Biomarkers; Cottontail rabbit papillomavirus; In Vitro Techniqu

1965
ELECTROLYTE DEPLETION ASSOCIATED WITH VILLOUS TUMOUR OF THE RECTUM.
    The Australian and New Zealand journal of surgery, 1965, Volume: 34

    Topics: Drug Therapy; Electrolytes; Geriatrics; Neoplasms; Pathology; Potassium; Radiography; Rectal Neoplas

1965
PREVENTION OF HYPERURICEMIA IN LEUKEMIA AND LYMPHOMA: USE OF ALOPURINOL, A XANTHINE OXIDASE INHIBITOR.
    JAMA, 1965, Jul-05, Volume: 193

    Topics: Adolescent; Antineoplastic Agents; Blood; Blood Urea Nitrogen; Drug Therapy; Geriatrics; Humans; Hyp

1965
HYDROXYUREA ADMINISTERED INTERMITTENTLY.
    JAMA, 1965, Jun-28, Volume: 192

    Topics: Antineoplastic Agents; Drug Therapy; Geriatrics; Hydroxyurea; Neoplasms; Toxicology; Urea

1965
Studies on the mechanism of catalase depression by toxohormone, with the aid of allylisopropylacetamide, allylisopropylacetylcarbamide, and 3-amino-1,2,4-triazole.
    Gan, 1962, Volume: 53

    Topics: Allylisopropylacetamide; Amides; Amitrole; Azoles; Catalase; Depression; Depressive Disorder; Endoto

1962
Low sodium excretion in SIADH patients with low diuresis.
    Nephron. Physiology, 2004, Volume: 96, Issue:1

    Topics: Aged; Alcohol Withdrawal Seizures; Alcoholism; Creatinine; Diagnosis, Differential; Diuresis; Duoden

2004
Phenacemide in treatment of epilepsy.
    Journal of the American Medical Association, 1951, Sep-01, Volume: 147, Issue:1

    Topics: Anticonvulsants; Benzeneacetamides; Epilepsy; Humans; Neoplasms; Urea

1951
Micro estimations of nitrogenous constituents of the blood and of urea clearance; a study of 100 cases.
    The Indian medical gazette, 1951, Volume: 86, Issue:8

    Topics: Humans; Neoplasms; Nitrogen; Urea

1951
Dialyzer membrane permeability and survival in hemodialysis patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:3

    Topics: Aged; Bicarbonates; Body Composition; Body Mass Index; Cardiovascular Diseases; Cause of Death; Chol

2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
    Bioorganic & medicinal chemistry letters, 2005, May-02, Volume: 15, Issue:9

    Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carb

2005
Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.
    International journal of cancer, 2006, Dec-15, Volume: 119, Issue:12

    Topics: Antibodies; Blotting, Western; Camptothecin; Caspases; CDC2 Protein Kinase; cdc25 Phosphatases; Cell

2006
Characterization of a lectin from Gonatanthus pumilus D. Don having anti-proliferative effect against human cancer cell lines.
    Protein and peptide letters, 2007, Volume: 14, Issue:1

    Topics: Antifungal Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Guanidine; Humans; I

2007
Hydroxyurea in the management of head and neck cancer. II. Surgical aspects.
    Plastic and reconstructive surgery, 1967, Volume: 40, Issue:3

    Topics: Antineoplastic Agents; Head; Head and Neck Neoplasms; Humans; Hydroxyurea; Mandibular Neoplasms; Neo

1967
Significance of extreme elevation of erythrocyte sedimentation rate.
    JAMA, 1967, Oct-23, Volume: 202, Issue:4

    Topics: Blood Protein Electrophoresis; Blood Sedimentation; Bone Marrow Examination; Collagen Diseases; Hema

1967
Flux of amino acids across the leg in weight-losing cancer patients.
    Cancer research, 1984, Volume: 44, Issue:1

    Topics: Acute Disease; Aged; Amino Acids; Body Weight; Humans; Leg; Middle Aged; Neoplasms; Nutrition Disord

1984
Health risks in homes insulated with urea formaldehyde foam.
    Canadian Medical Association journal, 1984, Jan-15, Volume: 130, Issue:2

    Topics: Construction Materials; Formaldehyde; Housing; Humans; Hypersensitivity; Neoplasms; Reproduction; Re

1984
[Malnutrition and postoperative complication rate in cancer patients (author's transl)].
    Langenbecks Archiv fur Chirurgie, 1982, Volume: 357, Issue:2

    Topics: Body Height; Body Weight; Female; Humans; Leukocyte Count; Lymphocytes; Male; Middle Aged; Neoplasms

1982
[The definition of clinical catabolism by the urea production rate and its correlation with cellular immunity].
    Infusionstherapie und klinische Ernahrung, 1980, Volume: 7, Issue:5

    Topics: Body Weight; Female; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Male; Middle Aged; Neopl

1980
[Oxygen multistep therapy and cancer. New perspectives in cancer immunology (author's transl)].
    Archiv fur Geschwulstforschung, 1981, Volume: 51, Issue:3

    Topics: Aged; Animals; Esophageal Neoplasms; Female; Humans; Immunity, Cellular; Neoplasms; Nitriles; Oxygen

1981
Hemodialysis of amino acids: basic studies in vitro.
    Nutrition and cancer, 1981, Volume: 2, Issue:3

    Topics: Amino Acids; Asparagine; Dialysis; Humans; In Vitro Techniques; Kidneys, Artificial; Molecular Weigh

1981
[Urea production and cell-mediated immunity as indicators of preoperative catabolism (author's transl)].
    Chirurgisches Forum fur experimentelle und klinische Forschung, 1980

    Topics: Energy Metabolism; Female; Humans; Immunity, Cellular; Male; Middle Aged; Neoplasms; Urea

1980
Tumour matrix destruction by guanidine and urea.
    Clinical oncology, 1980, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Agents; Cricetinae; Guanidines; Neoplasms; Urea

1980
Strategies for improving the immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections: androgen receptor, estrogen receptor, progesterone receptor, p53 protein, proliferating cell nuclear antigen, and Ki-67 ant
    Human pathology, 1994, Volume: 25, Issue:3

    Topics: Antigens, Neoplasm; Biomarkers, Tumor; Cell Nucleus; Formaldehyde; Glycine; Humans; Immunohistochemi

1994
Calcium-free hemodialysis for the management of hypercalcemia.
    Nephron, 1996, Volume: 72, Issue:3

    Topics: Adult; Aged; Blood Pressure; Calcium; Dialysis Solutions; Female; Humans; Hypercalcemia; Kinetics; M

1996
[Biochemical parameters in the diagnosis of nephrotoxicity of antineoplastic chemotherapy in children].
    Voprosy onkologii, 1997, Volume: 43, Issue:4

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Child; Child, Preschool; Cispl

1997
Serum selenium levels as indicators of body status in cancer patients and their relationship with other nutritional and biochemical markers.
    The Science of the total environment, 1998, Apr-08, Volume: 212, Issue:2-3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alanine Transaminase; Aspartate Aminotransferases; Biomarkers

1998
Inhibition of microtubule assembly in tumor cells by 3-bromoacetylamino benzoylurea, a new cancericidal compound.
    Cancer research, 1998, May-15, Volume: 58, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; DNA Fragmentation; DNA, Neoplasm; Drug Screening Assay

1998
Renal toxicity of the anticancer drug fostriecin.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:2

    Topics: Adult; Aged; Alkenes; Antibiotics, Antineoplastic; Creatine; Electrolytes; Female; Glomerular Filtra

1998
Must we really fear toxicity of conventional amphotericin B in oncological patients?
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1999, Volume: 7, Issue:1

    Topics: Adult; Amphotericin B; Anti-Inflammatory Agents; Antifungal Agents; Creatinine; Diuresis; Female; Fl

1999
Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). IV. Toxicologic and pathophysiologic observations in lactating goats and their suckling kids fed on the irritant herbs Eup
    Journal of cancer research and clinical oncology, 2001, Volume: 127, Issue:1

    Topics: Alanine Transaminase; Animals; Animals, Domestic; Aspartate Aminotransferases; Carcinogens; Creatini

2001
Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine.
    The Journal of nutrition, 1976, Volume: 106, Issue:11

    Topics: Adenocarcinoma; Ammonia; Animals; Blood Urea Nitrogen; Caseins; Cecum; Cholesterol; Colon; Colonic N

1976
Interactions between "fever" proteins and normal serum proteins in febrile cancer patients.
    Cancer research, 1977, Volume: 37, Issue:5

    Topics: Blood Proteins; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide G

1977
Tumor-specific alkaline phosphatase in hepatoma.
    Annals of the New York Academy of Sciences, 1975, Aug-22, Volume: 259

    Topics: Adult; Alkaline Phosphatase; Carcinoma, Hepatocellular; Edetic Acid; Female; Fetus; Humans; Imidazol

1975
Taste and feeding behavior in patients with cancer.
    Current concepts in nutrition, 1977, Volume: 6

    Topics: Energy Intake; Feeding Behavior; Humans; Neoplasms; Sucrose; Taste; Taste Threshold; Urea

1977
[Brdicka's reaction and the effect of denaturants on its result].
    Casopis lekaru ceskych, 1978, Dec-01, Volume: 117, Issue:48

    Topics: Cell Transformation, Neoplastic; Guanidines; Humans; Neoplasms; Urea

1978
[Detection of immuno-stimulation in mice by a new low molecular substance (author's transl)].
    Archiv fur Geschwulstforschung, 1975, Volume: 45, Issue:6

    Topics: Animals; Antibody Formation; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Hemolytic Plaque Techn

1975
Posthypophysectomy taste abnormalities: their relationship to remote effects of cancer.
    Cancer, 1977, Volume: 39, Issue:4

    Topics: Breast Neoplasms; Female; Humans; Hydrochloric Acid; Hypophysectomy; Male; Neoplasms; Pituitary Glan

1977
Acquired stomatocytosis: its prevalence of significance in routine haematology.
    Scandinavian journal of haematology, 1977, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Alcoholism; Anemia, Hemolytic; Cardiovascular Diseases; Drug-Related Side Effects

1977
Diuretics in malignant effusions and edemas of generalized cancer.
    Journal of medicine, 1976, Volume: 7, Issue:6

    Topics: Ascites; Body Weight; Bumetanide; Diuretics; Drinking; Edema; Furosemide; Humans; Neoplasms; Pleuris

1976
Abnormalities of taste sensation in cancer patients.
    Cancer, 1975, Volume: 36, Issue:5

    Topics: Adult; Aged; Anorexia; Body Weight; Female; Humans; Hydrochloric Acid; Male; Middle Aged; Neoplasms;

1975
Serum hyaluronic acid in patients with disseminated neoplasm.
    Journal of clinical pathology, 1987, Volume: 40, Issue:6

    Topics: Adult; Aged; Alkaline Phosphatase; Bilirubin; Calcium; Electrophoresis; Female; Humans; Hyaluronic A

1987
Phosphate treatment of hypercalcaemia due to carcinoma.
    British medical journal, 1968, Oct-05, Volume: 4, Issue:5622

    Topics: Aged; Breast Neoplasms; Bronchial Neoplasms; Calcinosis; Cornea; Female; Humans; Hypercalcemia; Infu

1968
Patterns of intravenous glucose tolerance and insulin response before and after treatment with streptozotocin (NSC-85998) in patients with cancer.
    Cancer chemotherapy reports, 1972, Volume: 56, Issue:1

    Topics: Acute Kidney Injury; Antibiotics, Antineoplastic; Blood Glucose; Creatinine; Drug Tolerance; Electro

1972
Immunodiffusion analysis of Yaba poxvirus structural and associated antigens.
    Journal of virology, 1970, Volume: 5, Issue:2

    Topics: Animals; Antigens; Cell Line; Centrifugation, Density Gradient; Cesium; Chlorides; Complement Fixati

1970
Urea inhibition of lactate dehydrogenase. A convenient routine procedure.
    Acta medica Academiae Scientiarum Hungaricae, 1970, Volume: 27, Issue:1

    Topics: Anemia; Buffers; Clinical Enzyme Tests; Glycine; Humans; Ischemia; L-Lactate Dehydrogenase; Liver; L

1970
The newest development of experimental induced tumors of the central nervous system.
    Journal de genetique humaine, 1969, Volume: 17, Issue:3

    Topics: Age Factors; Animals; Brain Neoplasms; Carcinogens; Humans; Methods; Mice; Neoplasms; Neoplasms, Exp

1969
[The cancer-risk in man from synthetic sweetening agents].
    La Presse medicale, 1971, Mar-13, Volume: 79, Issue:13

    Topics: Animals; Carcinoma, Hepatocellular; Cyclamates; Female; Liver Neoplasms; Lung Neoplasms; Lymphoma, N

1971
[Formation of carcinogenic nitroso compounds in the stomach of laboratory animals and their significance for man. 2].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:11

    Topics: Acetamides; Amides; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Carcinogens; G

1971
Quantitative measurement and chromatography of human urinary carcinoembryonic antigen activity.
    Journal of the National Cancer Institute, 1974, Volume: 53, Issue:6

    Topics: Adolescent; Adult; Carcinoembryonic Antigen; Child; Child, Preschool; Chromatography; Female; Guanid

1974
Chemotherapy and immunity to cancer.
    Clinical bulletin, 1974, Volume: 4, Issue:4

    Topics: Allyl Compounds; Aniline Compounds; Animals; Antineoplastic Agents; Cyclophosphamide; Fluorouracil;

1974
[The spectrum of extra neural tumors in rats following N-methyl-N-nitroso urea treatment].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1972, Volume: 115, Issue:1

    Topics: Abdominal Neoplasms; Animals; Castration; Female; Heart Neoplasms; Hypoxia; Injections, Intraperiton

1972
A spectrum of organ systems that respond to the presence of cancer. Abnormalities of taste as a remote effect of a neoplasm.
    Annals of the New York Academy of Sciences, 1974, Volume: 230

    Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Disease Models, Animal; Food Preferences; Hum

1974
Nitrosation of tertiary amines and some biologic implications.
    Journal of the National Cancer Institute, 1972, Volume: 49, Issue:5

    Topics: Amines; Carcinogens; Dealkylation; Dimethylamines; Dimethylformamide; Environmental Exposure; Ethano

1972
[The detection of immunoglobulin G in the make-up of a high-molecular protein complex in blood serum].
    Ukrains'kyi biokhimichnyi zhurnal, 1972, Volume: 44, Issue:2

    Topics: Animals; Blood Proteins; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchang

1972
[Transumbilical portal vein blood examination in man].
    Acta hepato-gastroenterologica, 1972, Volume: 19, Issue:3

    Topics: Bilirubin; Blood; Blood Proteins; Calcium; Catheterization; Chlorides; Fructose-Bisphosphate Aldolas

1972
Plasma phosphate and potassium levels in the hypercalcemia of malignant disease.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 36, Issue:5

    Topics: Aged; Bone Neoplasms; Breast Neoplasms; Female; Humans; Hypercalcemia; Hyperparathyroidism; Neoplasm

1973
The clinical usefulness of alkaline phosphatase isoenzyme determinations.
    American journal of clinical pathology, 1972, Volume: 57, Issue:5

    Topics: Alkaline Phosphatase; Bone Diseases; Clinical Enzyme Tests; Electrophoresis, Disc; Hot Temperature;

1972
5-Fluorouracil (5-Fu; NSC-19893), 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388), vincristine (NSC-67574), and 1,3-bis(2-chloroethyl)-2-nitrosourea (BCNU; NSC-409962) given concomitantly in the treatment of solid tumors in man.
    Cancer chemotherapy reports, 1972, Volume: 56, Issue:1

    Topics: Adult; Aged; Alkylating Agents; Amides; Carmustine; Drug Combinations; Female; Fluorouracil; Humans;

1972
Combined therapy with cytosine arabinoside (NSC-63878) and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) for advanced solid tumors.
    Cancer chemotherapy reports, 1972, Volume: 56, Issue:1

    Topics: Adult; Alkylating Agents; Blood Cell Count; Carmustine; Cytarabine; Drug Combinations; Humans; Male;

1972
Chronic ingestion by rats of standard diet treated with aluminum phosphide.
    Toxicology and applied pharmacology, 1972, Volume: 23, Issue:1

    Topics: Abdominal Neoplasms; Alanine Transaminase; Aluminum; Aluminum Compounds; Animals; Appetite; Blood Ch

1972
Selective metabolic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea upon de novo purine biosynthesis.
    Cancer research, 1971, Volume: 31, Issue:3

    Topics: Acute Disease; Amino Acids; Animals; Antineoplastic Agents; Ascitic Fluid; Carbon Isotopes; Carcinom

1971
Skin homograft survival in cancer chemotherapy patients.
    Cancer, 1966, Volume: 19, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Carbamates; Female; Fluorouracil; Humans; Immunosuppressive Agen

1966
Syndrome of cellular agony--biochemical characterization.
    Helvetica paediatrica acta, 1969, Volume: 24, Issue:5

    Topics: Autopsy; Child; Death; Gastroenteritis; Humans; Hyperglycemia; Hyperkalemia; Hyponatremia; Kwashiork

1969
Alkaline phosphatase in meningiomas.
    Cancer, 1970, Volume: 26, Issue:1

    Topics: Alkaline Phosphatase; Central Nervous System Diseases; Chemical Phenomena; Chemistry, Physical; Hot

1970
1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) given concomitantly with cytosine arabinoside (NSC-63878) in the treatment of cancer.
    Cancer chemotherapy reports, 1970, Volume: 54, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Cytarabine; Female; Humans; Leukemia; Male; Middle Aged; Neoplas

1970
Pleural fluid glucose. Serial observation of its concentration following oral administration of glucose to patients with rheumatoid pleural effusions and malignant effusions.
    The American review of respiratory disease, 1968, Volume: 97, Issue:2

    Topics: Adult; Arthritis, Rheumatoid; Blood Glucose; Blood Urea Nitrogen; Female; Glucose; Humans; Male; Mid

1968
The induction of tumours in the rat by a single oral dose of N-nitrosomethylurea.
    British journal of cancer, 1969, Volume: 23, Issue:1

    Topics: Animals; Female; Gastric Mucosa; Intestinal Neoplasms; Intestines; Jaw Neoplasms; Keratoacanthoma; K

1969