urea has been researched along with Multiple System Atrophy in 1 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The compound was also well-tolerated in a first-in-human oral dosing study in healthy and older volunteers with a favorable, dose-dependent pharmacokinetic profile." | 5.72 | The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy. ( Adlard, PA; Barnham, KJ; Billings, JL; Cherny, RA; Finkelstein, DI; Saleh, E; Shukla, JJ; Stefanova, N, 2022) |
| " The compound was also well-tolerated in a first-in-human oral dosing study in healthy and older volunteers with a favorable, dose-dependent pharmacokinetic profile." | 1.72 | The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy. ( Adlard, PA; Barnham, KJ; Billings, JL; Cherny, RA; Finkelstein, DI; Saleh, E; Shukla, JJ; Stefanova, N, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Finkelstein, DI | 1 |
| Shukla, JJ | 1 |
| Cherny, RA | 1 |
| Billings, JL | 1 |
| Saleh, E | 1 |
| Stefanova, N | 1 |
| Barnham, KJ | 1 |
| Adlard, PA | 1 |
1 other study available for urea and Multiple System Atrophy
| Article | Year |
|---|---|
The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Humans; Iron; Mice; Mice, Transgenic; Multiple Sys | 2022 |