urea has been researched along with Malignant Melanoma in 41 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melanoma is a highly aggressive malignancy and early monitoring and diagnosis are challenging at present." | 5.48 | Ultrasensitive Tyrosinase-Activated Turn-On Near-Infrared Fluorescent Probe with a Rationally Designed Urea Bond for Selective Imaging and Photodamage to Melanoma Cells. ( Hu, L; Li, Z; Liang, XJ; Wang, YF; Zeng, C, 2018) |
| "Malignant melanomas are amongst the most aggressive cancers." | 5.48 | Modification, Biological Evaluation and SAR Studies of Novel 1H-Pyrazol Derivatives Containing N,N'-Disubstituted Urea Moiety as Potential Anti-melanoma Agents. ( Bu, CN; Dong, YL; Li, QS; Lin, MX; Ruan, BF; Shao, Q; Wang, TH; Xu, HJ; Zhang, Q; Zhou, BG, 2018) |
| "5-Iodo-2-thiouracil (ITU) is of interest due to its ability to bind specifically to the pigment melanin during melanogenesis and is of potential value in the diagnosis and treatment of malignant melanoma." | 3.67 | Direct electrophilic iodination of 2-thiouracil using Iodo-Gen. ( Coderre, JA; Halle, DA, 1989) |
| " The most common treatment-related treatment-emergent adverse events (TEAEs) of any grade in ≥15% of patients were increased lipase, alopecia, actinic keratosis, myalgia, arthralgia, decreased appetite, fatigue, hyperkeratosis, nausea, and palmar-plantar erythrodysesthesia syndrome." | 3.11 | Efficacy and safety of ripretinib in patients with KIT-altered metastatic melanoma. ( Bauer, S; Chi, P; Janku, F; Jennings, J; Jones, RL; Meade, J; Psoinos, C; Ruiz-Soto, R; Shoumariyeh, K; Spreafico, A, 2022) |
| "Melanoma is a highly aggressive malignancy and early monitoring and diagnosis are challenging at present." | 1.48 | Ultrasensitive Tyrosinase-Activated Turn-On Near-Infrared Fluorescent Probe with a Rationally Designed Urea Bond for Selective Imaging and Photodamage to Melanoma Cells. ( Hu, L; Li, Z; Liang, XJ; Wang, YF; Zeng, C, 2018) |
| "Malignant melanomas are amongst the most aggressive cancers." | 1.48 | Modification, Biological Evaluation and SAR Studies of Novel 1H-Pyrazol Derivatives Containing N,N'-Disubstituted Urea Moiety as Potential Anti-melanoma Agents. ( Bu, CN; Dong, YL; Li, QS; Lin, MX; Ruan, BF; Shao, Q; Wang, TH; Xu, HJ; Zhang, Q; Zhou, BG, 2018) |
| "Malignant melanoma has an increasing incidence rate and the metastatic disease is notoriously resistant to standard chemotherapy." | 1.42 | Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma. ( Emilsen, E; Engesæter, B; Fjær, R; Flørenes, VA; Giller Fleten, K; Magnussen, GI; Nähse-Kumpf, V; Slipicevic, A, 2015) |
| "Malignant melanoma is the deadliest form of skin cancer, known for its drug resistance and high metastatic potential." | 1.37 | Melanoma prevention using topical PBISe. ( Amin, S; Chung, CY; Desai, D; Madhunapantula, SV; Robertson, GP, 2011) |
| "Malignant melanoma is the most deadly form of skin cancer due to its highly metastatic nature." | 1.35 | PBISe, a novel selenium-containing drug for the treatment of malignant melanoma. ( Amin, S; Desai, D; Huh, SJ; Madhunapantula, SV; Robertson, GP; Sharma, A, 2008) |
| "CTAB-urea treated RNA from highly pigmented melanoma cells can be successfully reverse transcribed and labeled to obtain probes which can be subsequently used in cDNA microarray experiments, giving consistent and reproducible results." | 1.32 | CTAB-urea method purifies RNA from melanin for cDNA microarray analysis. ( Carninci, P; De Cecco, L; Di Stasi, D; Gariboldi, M; Lagonigro, MS; Ranzani, T; Rodolfo, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (43.90) | 18.7374 |
| 1990's | 2 (4.88) | 18.2507 |
| 2000's | 5 (12.20) | 29.6817 |
| 2010's | 11 (26.83) | 24.3611 |
| 2020's | 5 (12.20) | 2.80 |
| Authors | Studies |
|---|---|
| Janku, F | 1 |
| Bauer, S | 1 |
| Shoumariyeh, K | 1 |
| Jones, RL | 1 |
| Spreafico, A | 1 |
| Jennings, J | 1 |
| Psoinos, C | 1 |
| Meade, J | 1 |
| Ruiz-Soto, R | 1 |
| Chi, P | 1 |
| Flem-Karlsen, K | 1 |
| McFadden, E | 1 |
| Omar, N | 1 |
| Haugen, MH | 1 |
| Øy, GF | 1 |
| Ryder, T | 1 |
| Gullestad, HP | 1 |
| Hermann, R | 1 |
| Mælandsmo, GM | 1 |
| Flørenes, VA | 2 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 5 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 2 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
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| Huang, W | 1 |
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| Dong, X | 1 |
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1 review available for urea and Malignant Melanoma
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
5 trials available for urea and Malignant Melanoma
| Article | Year |
|---|---|
Efficacy and safety of ripretinib in patients with KIT-altered metastatic melanoma.
Topics: Adult; Gastrointestinal Stromal Tumors; Humans; Melanoma; Naphthyridines; Protein Kinase Inhibitors; | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
1,3-bis (2-chloroethyl)-1-nitrosourea (NSC-409962) in the treatment of brain tumors.
Topics: Adenocarcinoma; Adolescent; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Chordoma; Clinical | 1970 |
Treatment of Hodgkin's disease and other cancers with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962).
Topics: Adenocarcinoma; Adenoma, Islet Cell; Adolescent; Adrenal Gland Neoplasms; Adult; Alkylating Agents; | 1971 |
Triple combination chemotherapy of disseminated melanoma.
Topics: Aged; Alkylating Agents; Antineoplastic Agents; Carmustine; Clinical Trials as Topic; Drug Combinati | 1972 |
36 other studies available for urea and Malignant Melanoma
| Article | Year |
|---|---|
Targeting AXL and the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Melanoma.
Topics: Animals; Apoptosis; Axl Receptor Tyrosine Kinase; Biomarkers, Tumor; Cell Cycle Checkpoints; Cell Pr | 2020 |
Feasibility of Phosphoproteomics on Leftover Samples After RNA Extraction With Guanidinium Thiocyanate.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chloroform; DNA Damage; Feasibility Studies; Guanidin | 2021 |
Watermelon Reduces the Toxicity of Cisplatin Treatment in C57BL/6 Mice with Induced Melanoma.
Topics: Animals; Antineoplastic Agents; Cisplatin; Citrullus; Creatinine; Melanoma; Mice; Mice, Inbred C57BL | 2022 |
Facial spiny follicular hyperkeratosis induced by vemurafenib.
Topics: Aged; Antineoplastic Agents; Diagnosis, Differential; Face; Female; Humans; Keratosis; Melanoma; Sal | 2018 |
Ultrasensitive Tyrosinase-Activated Turn-On Near-Infrared Fluorescent Probe with a Rationally Designed Urea Bond for Selective Imaging and Photodamage to Melanoma Cells.
Topics: Animals; Cell Line, Tumor; Fluorescent Dyes; HeLa Cells; Humans; Melanoma; Methylene Blue; Mice; Mon | 2018 |
Modification, Biological Evaluation and SAR Studies of Novel 1H-Pyrazol Derivatives Containing N,N'-Disubstituted Urea Moiety as Potential Anti-melanoma Agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug | 2018 |
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Melanoma; Naphthalimides; Ph | 2018 |
Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; G1 Phase; Glycogen Synthase Kinase | 2013 |
New diarylamides and diarylureas possessing 8-amino(acetamido)quinoline scaffold: synthesis, antiproliferative activities against melanoma cell lines, kinase inhibition, and in silico studies.
Topics: Acetamides; Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Computer Simulation | 2013 |
Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Cyc | 2015 |
Searching for the Achilles' heel of melanoma cells: new treatment modalities.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzenesulfonates; Clinical Trials as Topic; Enzyme Inhib | 2008 |
Induction of caspase-dependent apoptosis in melanoma cells by the synthetic compound (E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Proliferation; Cell Survival; DNA; Dose-Re | 2009 |
Cyclization of peptides through a urea bond: application to the Arg-Gly-Asp tripeptide.
Topics: Angiogenesis Inhibitors; Animals; Cell Line; Cell Line, Tumor; Cyclization; Humans; Integrin alphaVb | 2010 |
Characterization of the covalent binding of N-phenyl-N'-(2-chloroethyl)ureas to {beta}-tubulin: importance of Glu198 in microtubule stability.
Topics: Acetylation; Acylation; Animals; Antineoplastic Agents; Cells, Cultured; Humans; Melanoma; Mice; Mic | 2011 |
Melanoma prevention using topical PBISe.
Topics: Administration, Topical; Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cells, Cultured; Female | 2011 |
New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: design, synthesis, and antiproliferative activity against melanoma cell line.
Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; Melanoma; | 2012 |
CTAB-urea method purifies RNA from melanin for cDNA microarray analysis.
Topics: Biotechnology; Cetrimonium; Cetrimonium Compounds; Detergents; DNA, Complementary; Melanins; Melanom | 2004 |
New prodrugs derived from 6-aminodopamine and 4-aminophenol as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT).
Topics: Aminophenols; Cell Line, Tumor; Cell Survival; Dopamine; Drug Delivery Systems; Drug Screening Assay | 2005 |
PBISe, a novel selenium-containing drug for the treatment of malignant melanoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caco-2 Cells; Cell Cycle; Cell Line, Tumor; Cell Prolifer | 2008 |
Eleven years experience of oral urea treatment in liver malignancies.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Carcinoma, Hepatocellular; Drug Administration Sc | 1981 |
Comparison and evaluation of different methods for alpha-MSH labelling.
Topics: Animals; Cattle; Chloramines; Chromatography, Gel; Humans; Immune Sera; Immunologic Techniques; Iodi | 1982 |
The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines.
Topics: Amidinotransferases; Arginase; Arginine; Cell Line; Glycine; Humans; Hydrogen-Ion Concentration; Mel | 1982 |
Metastatic potential correlates with cell-surface protein alterations in B16 melanoma variants.
Topics: Animals; Cell Line; Cytoskeleton; Melanoma; Membrane Proteins; Mice; Molecular Weight; Neoplasm Meta | 1981 |
Tumor-associated cysteine proteinase activities in human melanoma cells and fibroblasts of different origin.
Topics: Cell Line; Coumarins; Cysteine Endopeptidases; Diazomethane; Dipeptides; Fibroblasts; Humans; Hydrog | 1997 |
Urea in the treatment of epibulbar malignancies.
Topics: Aged; Carcinoma, Squamous Cell; Eye Neoplasms; Female; Humans; Male; Melanoma; Middle Aged; Powders; | 1975 |
High sensitivity of human melanoma cell lines to the growth inhibitory activity of mycoplasmal arginine deiminase in vitro.
Topics: Antineoplastic Agents; Argininosuccinate Synthase; Bacterial Proteins; Base Sequence; Cell Division; | 1992 |
Direct electrophilic iodination of 2-thiouracil using Iodo-Gen.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Iodine Radioisotopes; Melanins; Melanoma; Rad | 1989 |
Scintiphotographic evaluation of response of brain neoplasms to systemic chemotherapy.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Ependymoma; Follow-Up Studies; Frontal L | 1971 |
[Genetics of malignant melanomas of the uvea].
Topics: Adult; Aged; Chromosome Aberrations; Czechoslovakia; Eye Neoplasms; Female; Humans; Male; Melanoma; | 1973 |
Autoimmune reactions in uveal melanoma.
Topics: Aged; Autoantibodies; Choroid Neoplasms; Ciliary Body; Complement System Proteins; Cross Reactions; | 1971 |
The tyrosinases of mouse melanoma. Isolation and molecular properties.
Topics: Acrylates; Alcohols; Amino Acids; Animals; Catechol Oxidase; Chemical Phenomena; Chemistry; Chlorpro | 1971 |
Primary malignant melanoma of the skin metastatic to the eye.
Topics: Adult; Blindness; Eye; Eye Neoplasms; Female; Humans; Inflammation; Male; Melanoma; Middle Aged; Neo | 1972 |
Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and two related compounds on a spectrum of tumors.
Topics: Adenocarcinoma; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Fibrosarcoma; Glioma; Hydroxy | 1967 |
Effect of 1, 3-diallylurea and related compounds on growth of transplanted animal tumors.
Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Female; | 1967 |
Combination chemotherapy in malignant melanoma.
Topics: Adult; Bone Marrow Examination; Bone Neoplasms; Brain Neoplasms; Female; Hemoglobins; Humans; Inject | 1970 |
In vivo effect of hydroxyurea on orotic acid synthesis.
Topics: Adult; Aged; Antimetabolites; DNA; Humans; Leukemia; Melanoma; Middle Aged; Nucleosides; Orotic Acid | 1966 |