urea and Lymphoma studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.

Research Excerpts

Excerpt	Relevance	Reference
"Lymphoma L5178Y cells were treated with neuraminidase of Vibrio cholerae, potassium iodine, dithiotreitol (DTT), mercaptoethanol, glutaraldehyde, iodoacetamide, merthiolate, sodium periodate, urea, papaine, trypsine and EDTA, to increase immunoreaction in tumor cells."	3.65	[Immunogenicity of L5178Y cells modified by different reagents]. ( Arellano-Blanco, J; Becerril-Meza, G; Fernández-Quintero, P; Gómez-Estrada, H; López-de la Rosa, LM, 1977)
"Children with cancer were also evaluated after antineoplasic treatment (CAT, n = 17)."	1.38	Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment. ( Brito, CX; Guerra, RN; Liberio, SA; Lima, MV; Mendonça, C; Mouchrek-Filho, JC; Nascimento, FR; Oliveira-Junior, JJ; Paim, DB; Pereira, AL, 2012)
" Our data indicates that only certain types of chemotherapy would give rise to a synergistic lethal response in combination with specific Chk2 inhibitors, which will be important if Chk2 inhibitors enter the clinic."	1.37	Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. ( Forshell, LP; Höglund, A; Li, Y; Nilsson, JA; Strömvall, K, 2011)
"Lymphomas were seen only at the higher dose when the animals were were young, at the beginning of the test."	1.26	Large bowel carcinogenesis in mice and rats by several intrarectal doses of methylnitrosourea and negative effect of nitrite plus methylurea. ( Maronpot, RR; Narisawa, T; Weisburger, JH; Wong, CQ, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (81.82)	18.7374
1990's	2 (6.06)	18.2507
2000's	1 (3.03)	29.6817
2010's	3 (9.09)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Höglund, A	1
Strömvall, K	1
Li, Y	1
Forshell, LP	1
Nilsson, JA	1
Guerra, RN	1
Oliveira-Junior, JJ	1
Mouchrek-Filho, JC	1
Liberio, SA	1
Lima, MV	1
Paim, DB	1
Brito, CX	1
Mendonça, C	1
Nascimento, FR	1
Pereira, AL	1
Mahadevan, D	1
Northfelt, DW	1
Chalasani, P	1
Rensvold, D	1
Kurtin, S	1
Von Hoff, DD	1
Borad, MJ	1
Tibes, R	1
CONOLLY, ME	1
ELLIS, H	1
DAVIS, P	1
SAMUELS, ML	1
HOWE, CD	1
KRAKOFF, IH	1
MEYER, RL	1
Kien, CL	1
Camitta, BM	1
Fujii, K	1
Nomoto, K	1
Clinkenbeard, KD	1
Clinkenbeard, PA	1
Waurzyniak, BJ	1
Kharbangar, A	1
Khynriam, D	1
Prasad, SB	1
Gómez-Estrada, H	1
López-de la Rosa, LM	1
Becerril-Meza, G	1
Arellano-Blanco, J	1
Fernández-Quintero, P	1
Koestner, A	1
Denlinger, RH	1
Narisawa, T	1
Wong, CQ	1
Maronpot, RR	1
Weisburger, JH	1
Badger, CC	1
Wilbur, DS	1
Hadley, SW	1
Fritzberg, AR	1
Bernstein, ID	1
Humberstone, DA	1
Shaw, JH	1
Drewinko, B	1
Novak, JK	1
Barranco, SC	1
Martin, NH	1
Casey, TP	1
Frei, JV	3
McCullough, JL	1
Bertino, JR	1
Hess, M	1
Davies, DA	1
Kirschbaum, J	1
Wriston, JC	1
Ratych, OT	1
Faber, AJ	1
Tamaoki, T	1
Mirvish, SS	1
Greenblatt, M	1
Kommineni, VR	1
Hiraki, S	1
Marchalonis, JJ	1
Cone, RE	1
Santer, V	1
Tibbling, G	1
Cat, I	1
Marçallo, FA	1
Marinoni, LP	1
Giraldi, DJ	1
Costa, O	1
Braga, H	1
Bonmassar, E	1
Cudkowicz, G	1
Vadlamudi, S	1
Goldin, A	1
Valeriote, FA	1
Bruce, WR	1
Meeker, BE	1

Article	Year
Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. Cell cycle (Georgetown, Tex.), 2011, Oct-15, Volume: 10, Issue:20 Topics: Animals; Apoptosis; Cell Line; Checkpoint Kinase 2; DNA Damage; Fluorescent Antibody Technique; Huma	2011
Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2012, Volume: 41, Issue:7 Topics: Biomarkers; Blood Glucose; Case-Control Studies; Central Nervous System Neoplasms; Child; Cohort Stu	2012
ANURIA DUE TO URIC ACID CRYSTALLURIA: AN UNUSUAL COMPLICATION OF THERAPY IN THE RETICULOSES. British journal of cancer, 1964, Volume: 18 Topics: Abdominal Neoplasms; Anuria; Blood; Genetic Diseases, X-Linked; Humans; Kidney Diseases; Leukemia, H	1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: MULTIPLE MYELOMA AND LYMPHOMA. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Antineoplastic Agents; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukopenia; Lymphoma; Lymphoma, L	1964
RENAL ABNORMALITIES INDUCED BY HYDROXYUREA (NSC-32065). Cancer chemotherapy reports, 1964, Volume: 40 Topics: Antineoplastic Agents; Blood; Hematologic Diseases; Hematuria; Hydroxyurea; Kidney Diseases; Kidney	1964
PREVENTION OF HYPERURICEMIA IN LEUKEMIA AND LYMPHOMA: USE OF ALOPURINOL, A XANTHINE OXIDASE INHIBITOR. JAMA, 1965, Jul-05, Volume: 193 Topics: Adolescent; Antineoplastic Agents; Blood; Blood Urea Nitrogen; Drug Therapy; Geriatrics; Humans; Hyp	1965
Increased whole-body protein turnover in sick children with newly diagnosed leukemia or lymphoma. Cancer research, 1983, Volume: 43, Issue:11 Topics: Ammonia; Glycine; Humans; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Nitrogen	1983
Tumor induction by a single subcutaneous injection of 1-butyl-1-nitrosourea or 1-butylurea in newborn mice. Cancer letters, 1983, Volume: 18, Issue:3 Topics: Adenocarcinoma; Adenoma; Animals; Animals, Newborn; Carcinogens; Female; Injections, Subcutaneous; L	1983
Chaotropic agents cause disaggregation and enhanced activity of Pasteurella haemolytica leukotoxin. Veterinary microbiology, 1995, Volume: 45, Issue:2-3 Topics: Animals; Bacterial Toxins; Cattle; Guanidine; Guanidines; L-Lactate Dehydrogenase; Lymphoma; Mannhei	1995
Effect of cisplatin on mitochondrial protein, glutathione, and succinate dehydrogenase in Dalton lymphoma-bearing mice. Cell biology and toxicology, 2000, Volume: 16, Issue:6 Topics: Animals; Antineoplastic Agents; Cisplatin; Enzyme Activation; Glutathione; Kidney; Lipid Peroxidatio	2000
[Immunogenicity of L5178Y cells modified by different reagents]. Archivos de investigacion medica, 1977, Volume: 8, Issue:2 Topics: Animals; Antibody Formation; Dithiothreitol; Glutaral; Immunity, Cellular; Iodoacetamide; Lymphoma;	1977
Induction of neurogenic and lymphoid neoplasms by the feeding of threshold levels of methyl- and ethylnitrousourea precursors to adult rats. Food and cosmetics toxicology, 1975, Volume: 13, Issue:6 Topics: Animals; Brain Neoplasms; Ethylnitrosourea; Female; Lymphoma; Mammary Neoplasms, Experimental; Methy	1975
Large bowel carcinogenesis in mice and rats by several intrarectal doses of methylnitrosourea and negative effect of nitrite plus methylurea. Cancer research, 1976, Volume: 36, Issue:2 Pt 1 Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma, Squamous Cell; Colonic Neoplasms; Dose-Response Relatio	1976
Biodistribution of p-iodobenzoyl (PIP) labeled antibodies in a murine lymphoma model. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1990, Volume: 17, Issue:4 Topics: Animals; Antibodies, Monoclonal; Iodine Radioisotopes; Iodobenzoates; Isotope Labeling; Lymphoma; Ma	1990
Metabolism in hematologic malignancy. Cancer, 1988, Oct-15, Volume: 62, Issue:8 Topics: Adult; Aged; Calorimetry; Energy Metabolism; Female; Glucose; Humans; Leukemia; Lymphoma; Male; Midd	1988
The response of human lymphoma cells in vitro to bleomycin and 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer research, 1972, Volume: 32, Issue:6 Topics: Antibiotics, Antineoplastic; Bleomycin; Cell Line; Cells, Cultured; Humans; In Vitro Techniques; Lym	1972
Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice. Clinical and experimental immunology, 1968, Volume: 3, Issue:4 Topics: Albuminuria; Anemia, Hemolytic, Autoimmune; Animals; Azathioprine; Coombs Test; Glomerulonephritis;	1968
Toxicity, tissue changes, and tumor induction in inbred Swiss mice by methylnitrosamine and -amide compounds. Cancer research, 1970, Volume: 30, Issue:1 Topics: Adenoma; Animals; Animals, Newborn; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Carcinoma, Hep	1970
Dihydrofolate reductase from mouse liver and spleen. Purification, properties and inhibition by substituted 2,4-diaminopyrimidines and 4,6-diaminotriazines. Biochemical pharmacology, 1971, Volume: 20, Issue:3 Topics: Animals; Antigen-Antibody Reactions; Cell Line; Chromatography; Chromatography, Gel; Enzyme Activati	1971
Basic structure of mouse histocompatibility antigens. European journal of biochemistry, 1974, Jan-03, Volume: 41, Issue:1 Topics: Animals; Azirines; Cell Membrane; Chromatography, Gel; Chromatography, Ion Exchange; Chromium Radioi	1974
Subunit structure of L-asparaginase from Escherichia coli B. Biochimica et biophysica acta, 1969, Nov-11, Volume: 194, Issue:1 Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Cyste	1969
Isolation of active ribosomal subunits from L5178Y mouse lymphoma cells. Archives of biochemistry and biophysics, 1972, Volume: 149, Issue:1 Topics: Animals; Carbon Isotopes; Cell Line; Centrifugation, Density Gradient; Chemical Precipitation; Elect	1972
Nitrosamide formation in vivo: induction of lung adenomas in Swiss mice by concurrent feeding of nitrite and methylurea or ethylurea. Journal of the National Cancer Institute, 1972, Volume: 48, Issue:5 Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Female; Kinetics; Lung Neoplasms; Lymphoma; Male; Mic	1972
Induction of malignant lymphomas by N,N'-dimethylnitrosourea in adult mice. Gan, 1971, Volume: 62, Issue:2 Topics: Animals; Carcinogens; Female; Lymphatic Metastasis; Lymphoma; Male; Methylation; Methylnitrosourea;	1971
Enzymic iodination. A probe for accessible surface proteins of normal and neoplastic lymphocytes. The Biochemical journal, 1971, Volume: 124, Issue:5 Topics: Animals; Autoradiography; Cell Line; Cell Membrane; Chromatography, Gel; Electrophoresis, Disc; Hydr	1971
Tumour induction by low molecular weight alkylating agents. Chemico-biological interactions, 1971, Volume: 3, Issue:2 Topics: Adenoma; Alkanes; Alkylating Agents; Animals; Carcinogens; DNA Replication; DNA, Neoplasm; Guanine;	1971
Glycerol and free fatty acid turnover in leukaemia and hyperthyroidism. Scandinavian journal of clinical and laboratory investigation, 1970, Volume: 26, Issue:2 Topics: Adult; Blood Glucose; Carbon Isotopes; Colorimetry; Fatty Acids, Nonesterified; Female; Fluorometry;	1970
Syndrome of cellular agony--biochemical characterization. Helvetica paediatrica acta, 1969, Volume: 24, Issue:5 Topics: Autopsy; Child; Death; Gastroenteritis; Humans; Hyperglycemia; Hyperkalemia; Hyponatremia; Kwashiork	1969
Influence of tumor-host differences at a single histocompatibility locus (H-1) on the antileukemic effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962). Cancer research, 1970, Volume: 30, Issue:10 Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Cyclophosphamide; Female; Histocompatibility; Lym	1970
Tissue-dependent differences in DNA methylation products of mice treated with methyl-labelled methylnitrosourea. International journal of cancer, 1971, May-15, Volume: 7, Issue:3 Topics: Adenine; Adenoma; Animals; Bone Marrow; Carbon Isotopes; DNA, Neoplasm; Guanine; Kidney; Liver; Lung	1971
Synergistic action of cyclophosphamide and 1,3-bis(2-chloroethyl)-1-nitrosourea on a transplanted murine lymphoma. Journal of the National Cancer Institute, 1968, Volume: 40, Issue:5 Topics: Animals; Cyclophosphamide; Drug Synergism; Injections, Intraperitoneal; Lymphoma; Mice; Neoplasm Tra	1968

urea and Lymphoma

Research Excerpts

Research

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