urea has been researched along with Leukemia in 51 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A series of substituted urea derivatives, compounds 1-14, were synthesized and evaluated for their cytotoxic activities against the human-leukemia K562 cell line." | 7.74 | Synthesis and cytotoxic evaluation of substituted urea derivatives as inhibitors of human-leukemia K562 cells. ( Cao, P; Ding, H; Ge, HM; Huang, XF; Li, HQ; Ruan, BF; Zhu, HL, 2007) |
| "A series of substituted urea derivatives, compounds 1-14, were synthesized and evaluated for their cytotoxic activities against the human-leukemia K562 cell line." | 3.74 | Synthesis and cytotoxic evaluation of substituted urea derivatives as inhibitors of human-leukemia K562 cells. ( Cao, P; Ding, H; Ge, HM; Huang, XF; Li, HQ; Ruan, BF; Zhu, HL, 2007) |
| "We have synthesized a new compound, 3-bromoacetylamino benzoylurea (3-BAABU), which showed strong cancericidal activity by inducing irreversible mitotic arrest and subsequently apoptosis in human T cell leukemic cells (CEM), human biphenotypic leukemic cells (SP), a human prostate cancer cell line (PC-3), murine melanoma cells (B-16), and murine lymphoma/leukemia cells (EL4) in vitro with an ID50 in the range of 0." | 3.70 | Inhibition of microtubule assembly in tumor cells by 3-bromoacetylamino benzoylurea, a new cancericidal compound. ( Bekesi, JG; Holland, JF; Jiang, JD; Roboz, J; Strauchen, J; Wang, Y, 1998) |
| "Acetohydroxamic acid has been identified, by paper chromatography, in the blood of three patients with chronic myelogenous leukemia on hydroxyurea therapy." | 3.64 | HYDROXYUREA: MECHANISM OF ACTION. ( CARBONE, PP; FISHBEIN, WN, 1963) |
| "Data from Phase I dose-escalation studies in adults and children were used to build a population pharmacokinetic model (NONMEM v7." | 1.46 | A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia. ( Boddy, AV; Duong, JK; Edwards, D; Griffin, MJ; Hargrave, D; Vormoor, J, 2017) |
| "Children with cancer were also evaluated after antineoplasic treatment (CAT, n = 17)." | 1.38 | Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment. ( Brito, CX; Guerra, RN; Liberio, SA; Lima, MV; Mendonça, C; Mouchrek-Filho, JC; Nascimento, FR; Oliveira-Junior, JJ; Paim, DB; Pereira, AL, 2012) |
| " A major side effect of CyA is nephrotoxicity." | 1.27 | Nephrotoxicity in bone marrow transplant recipients treated with cyclosporin A. ( Baughan, A; Chipping, PM; Fairhead, S; Gordon-Smith, EC; Hows, JM; Smith, J, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (76.47) | 18.7374 |
| 1990's | 2 (3.92) | 18.2507 |
| 2000's | 3 (5.88) | 29.6817 |
| 2010's | 6 (11.76) | 24.3611 |
| 2020's | 1 (1.96) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, M | 1 |
| Li, T | 1 |
| Chen, Y | 1 |
| Zhai, X | 1 |
| Foran, J | 1 |
| Ravandi, F | 1 |
| Wierda, W | 1 |
| Garcia-Manero, G | 1 |
| Verstovsek, S | 1 |
| Kadia, T | 1 |
| Burger, J | 1 |
| Yule, M | 1 |
| Langford, G | 1 |
| Lyons, J | 1 |
| Ayrton, J | 1 |
| Lock, V | 1 |
| Borthakur, G | 1 |
| Cortes, J | 1 |
| Kantarjian, H | 1 |
| Hsieh, YT | 1 |
| Gang, EJ | 1 |
| Shishido, SN | 1 |
| Kim, HN | 1 |
| Pham, J | 1 |
| Khazal, S | 1 |
| Osborne, A | 1 |
| Esguerra, ZA | 1 |
| Kwok, E | 1 |
| Jang, J | 1 |
| Bonig, H | 1 |
| Biediger, RJ | 1 |
| Vanderslice, P | 1 |
| Kim, YM | 1 |
| Vormoor, B | 1 |
| Veal, GJ | 1 |
| Griffin, MJ | 2 |
| Boddy, AV | 2 |
| Irving, J | 1 |
| Minto, L | 1 |
| Case, M | 1 |
| Banerji, U | 1 |
| Swales, KE | 1 |
| Tall, JR | 1 |
| Moore, AS | 2 |
| Toguchi, M | 1 |
| Acton, G | 1 |
| Dyer, K | 1 |
| Schwab, C | 1 |
| Harrison, CJ | 1 |
| Grainger, JD | 1 |
| Lancaster, D | 1 |
| Kearns, P | 1 |
| Hargrave, D | 2 |
| Vormoor, J | 2 |
| Duong, JK | 1 |
| Edwards, D | 1 |
| Podesta, JE | 1 |
| Sugar, R | 1 |
| Squires, M | 1 |
| Linardopoulos, S | 1 |
| Pearson, AD | 1 |
| Guerra, RN | 1 |
| Oliveira-Junior, JJ | 1 |
| Mouchrek-Filho, JC | 1 |
| Liberio, SA | 1 |
| Lima, MV | 1 |
| Paim, DB | 1 |
| Brito, CX | 1 |
| Mendonça, C | 1 |
| Nascimento, FR | 1 |
| Pereira, AL | 1 |
| Lim, S | 1 |
| Ryu, JH | 1 |
| Im, C | 1 |
| Yim, CB | 1 |
| OTTO, H | 1 |
| FISHBEIN, WN | 1 |
| CARBONE, PP | 1 |
| WEISS, HJ | 1 |
| KRONFIELD, SJ | 1 |
| REYNOLDS, TB | 1 |
| HELBIG, W | 1 |
| VOIGT, KG | 1 |
| ORIGENES, ML | 1 |
| BEATTY, EC | 1 |
| BRUBAKER, C | 1 |
| HAMMOND, D | 1 |
| HARTMANN, JR | 1 |
| SHORE, N | 1 |
| WILLIAMS, KO | 1 |
| STEARNS, B | 1 |
| LOSEE, KA | 1 |
| BERNSTEIN, J | 1 |
| FERNBACH, DJ | 1 |
| SHULLENBERGER, CC | 1 |
| KRAKOFF, IH | 2 |
| SAVEL, H | 1 |
| MURPHY, ML | 1 |
| GOLDIN, A | 1 |
| VENDITTI, JM | 1 |
| MEAD, JA | 1 |
| GLYNN, JP | 1 |
| ALPERIN, JB | 1 |
| LEVIN, WC | 1 |
| MEYER, RL | 1 |
| Jackson, JA | 1 |
| Trevino, AV | 1 |
| Herzig, MC | 1 |
| Herman, TS | 1 |
| Woynarowski, JM | 1 |
| Cao, P | 1 |
| Huang, XF | 1 |
| Ding, H | 1 |
| Ge, HM | 1 |
| Li, HQ | 1 |
| Ruan, BF | 1 |
| Zhu, HL | 1 |
| Frei, E | 1 |
| Hows, JM | 1 |
| Chipping, PM | 1 |
| Fairhead, S | 1 |
| Smith, J | 1 |
| Baughan, A | 1 |
| Gordon-Smith, EC | 1 |
| Jiang, JD | 1 |
| Wang, Y | 1 |
| Roboz, J | 1 |
| Strauchen, J | 1 |
| Holland, JF | 2 |
| Bekesi, JG | 1 |
| Israili, ZH | 1 |
| Vogler, WR | 4 |
| Mingioli, ES | 2 |
| Pirkle, JL | 1 |
| Smithwick, RW | 1 |
| Goldstein, JH | 1 |
| Ekert, H | 1 |
| Waters, KD | 1 |
| Powles, R | 1 |
| Smith, C | 1 |
| Milan, S | 1 |
| Treleaven, J | 1 |
| Millar, J | 1 |
| McElwain, T | 1 |
| Gordon-Smith, E | 1 |
| Milliken, S | 1 |
| Tiley, C | 1 |
| Grünert, A | 1 |
| Heim, F | 1 |
| Humberstone, DA | 1 |
| Shaw, JH | 1 |
| Baugh, CM | 1 |
| Krumdieck, CL | 1 |
| Nair, MG | 1 |
| Druckrey, H | 1 |
| Ivankovic, S | 1 |
| Bücheler, J | 1 |
| Preussmann, R | 1 |
| Thomas, C | 1 |
| Howard, N | 1 |
| Arfi, S | 1 |
| Baglin, A | 1 |
| Alterescu, R | 1 |
| Goguel, A | 1 |
| Fendler, JP | 1 |
| Fritel, D | 1 |
| Billing, R | 1 |
| Terasaki, PI | 1 |
| Peto, R | 1 |
| Hong, CI | 1 |
| Chheda, GB | 1 |
| Dutta, SP | 1 |
| O'Grady-Curtis, A | 1 |
| Tritsch, GL | 1 |
| Beal, RW | 1 |
| Gizis, E | 1 |
| Meyer, LM | 1 |
| Groth, DP | 1 |
| D'Angelo, JM | 1 |
| Betz, B | 1 |
| Harris, JW | 1 |
| Allen, NP | 1 |
| Teng, SS | 1 |
| Takizawa, S | 1 |
| Nishihara, H | 1 |
| Hosokawa, M | 1 |
| Gotoda, E | 1 |
| Kobayashi, H | 1 |
| Alberto, P | 1 |
| Sullivan, MP | 1 |
| Vietti, TJ | 1 |
| Haggard, ME | 1 |
| Donaldson, MH | 1 |
| Krall, JM | 1 |
| Gehan, EA | 1 |
| Harrod, EK | 1 |
| Cortner, JA | 1 |
| Henderson, ES | 1 |
| van Eden, EB | 1 |
| Falkson, HC | 1 |
| Falkson, G | 1 |
| Bain, JA | 1 |
| Huguley, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I/IIa Open-label Study to Assess the Safety, Tolerability and Preliminary Efficacy of AT9283, a Small Molecule Inhibitor of Aurora Kinases, in Patients With Refractory Hematological Malignancies[NCT00522990] | Phase 1/Phase 2 | 48 participants (Actual) | Interventional | 2006-09-30 | Terminated (stopped due to Recommended Phase II dose determined) | ||
| International Prospective Observational Cohort Study of Zika in Infants[NCT02856984] | 6,461 participants (Actual) | Observational | 2016-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for urea and Leukemia
| Article | Year |
|---|---|
Nucleoside and Non-Nucleoside DOT1L Inhibitors: Dawn of MLLrearranged Leukemia.
Topics: Carbamates; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Humans; Leukemia; Nucleosides; St | 2021 |
Serum protein binding of vitamin B12.
Topics: Anticoagulants; Biological Transport; Blood Proteins; C-Reactive Protein; Cerebrospinal Fluid; Charc | 1969 |
5 trials available for urea and Leukemia
| Article | Year |
|---|---|
A phase I and pharmacodynamic study of AT9283, a small-molecule inhibitor of aurora kinases in patients with relapsed/refractory leukemia or myelofibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzimidazoles; Disease Progression; Drug Adm | 2014 |
A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia.
Topics: Acute Disease; Adolescent; Aurora Kinases; Benzimidazoles; Child; Child, Preschool; Female; Humans; | 2017 |
Human recombinant GM-CSF in allogeneic bone-marrow transplantation for leukaemia: double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Bilirubin; Bone Marrow Transplantation; Creatinine; Double-Blind Method; Female; | 1990 |
Myeloma and leukaemia trials.
Topics: Clinical Trials as Topic; Humans; Leukemia; Multiple Myeloma; Prognosis; Serum Albumin; Urea | 1972 |
Clinical trials of 1-beta-D-arabinofuranosyl cytosine and 1,3-bis-(2-chloroethyl)-1-nitrosourea combination in metastatic cancer and acute leukemia.
Topics: Age Factors; Blood Cell Count; Blood Platelets; Blood Urea Nitrogen; Clinical Trials as Topic; Cytar | 1971 |
44 other studies available for urea and Leukemia
| Article | Year |
|---|---|
Effects of the small-molecule inhibitor of integrin α4, TBC3486, on pre-B-ALL cells.
Topics: Animals; Antineoplastic Agents; Coculture Techniques; Drug Resistance, Neoplasm; Humans; Inflammatio | 2014 |
A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzimidazoles; Body Surface Area | 2017 |
Adaptation of the plasma inhibitory activity assay to detect Aurora, ABL and FLT3 kinase inhibition by AT9283 in pediatric leukemia.
Topics: Age of Onset; Antineoplastic Agents; Aurora Kinases; Benzimidazoles; Blood Chemical Analysis; Calibr | 2011 |
Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment.
Topics: Biomarkers; Blood Glucose; Case-Control Studies; Central Nervous System Neoplasms; Child; Cohort Stu | 2012 |
Synthesis and cytotoxicity of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide.
Topics: Ceramides; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Kidney | 2003 |
[Relationship of nephritis, leukemia and azotemia].
Topics: Azotemia; Blood; Humans; Leukemia; Nephritis; Urea | 1955 |
HYDROXYUREA: MECHANISM OF ACTION.
Topics: Blood Chemical Analysis; Chromatography; Humans; Hydroxamic Acids; Hydroxyurea; Leukemia; Leukemia, | 1963 |
INCREASED UREA SOLUBILITY OF THE BLOOD CLOT IN CHRONIC GRANULOCYTIC LEUKEMIA AND ITS RELATION TO THE ABNORMAL THROMBELASTOGRAM.
Topics: Blood Coagulation; Chemical Phenomena; Chemistry; Humans; Leukemia; Leukemia, Myelogenous, Chronic, | 1963 |
LEUKEMIA AND HYPERCALCEMIA; REPORT OF A CASE AND REVIEW OF THE LITERATURE.
Topics: Adolescent; Blood; Calcium; Calcium, Dietary; Creatine; Creatinine; Humans; Hypercalcemia; Leukemia; | 1964 |
[CLINICAL KIDNEY FINDINGS IN LEUKEMIA AND THEIR CORRELATION WITH AUTOPSY RESULTS].
Topics: Autopsy; Blood Chemical Analysis; Blood Urea Nitrogen; Hematuria; Hemorrhagic Disorders; Humans; Kid | 1963 |
TRIAL OF HYDROXYUREA (NSC-32065) IN CANCER IN CHILDREN.
Topics: Antineoplastic Agents; Busulfan; Child; Cyclophosphamide; Dactinomycin; Humans; Hydroxyurea; Leukemi | 1964 |
HYDROXYUREA. A NEW TYPE OF POTENTIAL ANTITUMOR AGENT.
Topics: Animals; Antineoplastic Agents; Hydroxyurea; Leukemia; Leukemia L1210; Leukemia, Experimental; Mice; | 1963 |
PEDIATRIC CLINICAL TRIALS WITH HYDROXYUREA (NSC-32065).
Topics: Adolescent; Antineoplastic Agents; Child; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Neop | 1964 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: LEUKEMIA.
Topics: Antineoplastic Agents; Drug Therapy; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; L | 1964 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CLINICAL EVALUATION.
Topics: Antineoplastic Agents; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leu | 1964 |
ANTILEUKEMIC ACTIVITY OF HYDROXYUREA (NSC-32065) AND OTHER UREA DERIVATIVES.
Topics: Antineoplastic Agents; Biological Assay; Hydroxyurea; Leukemia; Leukemia, Experimental; Mice; Resear | 1964 |
EXTREME HYPERURICEMIA ASSOCIATED WITH PREDNISONE THERAPY FOR ACUTE LYMPHOBLASTIC LEUKEMIA.
Topics: Adolescent; Blood; Blood Urea Nitrogen; Humans; Hyperuricemia; Leukemia; Leukemia, Lymphoid; Lymphoc | 1964 |
PREVENTION OF HYPERURICEMIA IN LEUKEMIA AND LYMPHOMA: USE OF ALOPURINOL, A XANTHINE OXIDASE INHIBITOR.
Topics: Adolescent; Antineoplastic Agents; Blood; Blood Urea Nitrogen; Drug Therapy; Geriatrics; Humans; Hyp | 1965 |
Matrix attachment region (MAR) properties and abnormal expansion of AT island minisatellites in FRA16B fragile sites in leukemic CEM cells.
Topics: AT Rich Sequence; Binding Sites; Cell Line, Tumor; Chromosome Fragility; Chromosomes, Human, Pair 16 | 2003 |
Synthesis and cytotoxic evaluation of substituted urea derivatives as inhibitors of human-leukemia K562 cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; K562 Cells; Leukemia; Molecular Structure; Structur | 2007 |
Informal discussion: experimental basis for the chemical eradication of leukemia.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cytarabine; Drug Antagonism; Drug Synergism; Huma | 1967 |
Nephrotoxicity in bone marrow transplant recipients treated with cyclosporin A.
Topics: Adolescent; Adult; Anemia, Aplastic; Bilirubin; Bone Marrow Transplantation; Child; Creatinine; Cycl | 1983 |
Inhibition of microtubule assembly in tumor cells by 3-bromoacetylamino benzoylurea, a new cancericidal compound.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; DNA Fragmentation; DNA, Neoplasm; Drug Screening Assay | 1998 |
The disposition and pharmacokinetics in humans of 5-azacytidine administered intravenously as a bolus or by continuous infusion.
Topics: Azacitidine; Chromatography, Thin Layer; Erythrocytes; Feces; Humans; Hydrogen-Ion Concentration; In | 1976 |
Hematologic emergencies in children.
Topics: Acute Disease; Acute Kidney Injury; Adolescent; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Asp | 1978 |
[Adjuvant parenteral nutrition in chemo- and radiotherapeutic measures in hematology].
Topics: Amino Acids; Blood Proteins; Bone Marrow Transplantation; Combined Modality Therapy; Electrolytes; H | 1986 |
Metabolism in hematologic malignancy.
Topics: Adult; Aged; Calorimetry; Energy Metabolism; Female; Glucose; Humans; Leukemia; Lymphoma; Male; Midd | 1988 |
Polygammaglutamyl metabolites of methotrexate.
Topics: Acute Disease; Animals; Chloroform; Chromatography, DEAE-Cellulose; Chromatography, Paper; Enterococ | 1973 |
[Production of stomach and pancreatic cancer in the guinea pig using methylnitroso-urea and methylnitroso-urethane].
Topics: Animals; Body Weight; Carcinoma; Ear Neoplasms; Guinea Pigs; Laryngeal Neoplasms; Leukemia; Lung Neo | 1968 |
Acute renal failure in leukaemia and malignant lymphoma.
Topics: Acute Kidney Injury; Blood; Hodgkin Disease; Humans; Leukemia; Male; Middle Aged; Radioisotope Telet | 1966 |
[Acute kidney failure in acute leukemia].
Topics: Acute Kidney Injury; Adult; Aged; Blood Cell Count; Female; Furosemide; Humans; Leukemia; Leukemia, | 1973 |
Human leukemia antigen. II. Purification.
Topics: Animals; Antigens, Neoplasm; Burkitt Lymphoma; Cell Line; Chromatography, Affinity; Concanavalin A; | 1974 |
Synthesis and biological activity of analogs of naturally occurring 6-ureidopurines and their nucleosides.
Topics: Cells, Cultured; Chromatography, Thin Layer; Culture Techniques; Glycine max; Humans; Leukemia; Magn | 1973 |
Selective metabolic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea upon de novo purine biosynthesis.
Topics: Acute Disease; Amino Acids; Animals; Antineoplastic Agents; Ascitic Fluid; Carbon Isotopes; Carcinom | 1971 |
Evaluation of a new glutathione-oxidizing reagent for studies of nucleated mammalian cells.
Topics: Amides; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cell Movement; Cell Survival; Cells, Cultured; | 1971 |
Induction of tumors in the brain, kidney, and other extra-mammary gland organs by a continuous oral administration of N-nitrosobutylurea in Wistar-Furth rats.
Topics: Administration, Oral; Animals; Brain Neoplasms; Carcinogens; Castration; Duodenal Neoplasms; Ear Neo | 1971 |
Leukemia and mammary tumor in rats administered N-nitrosobutylurea.
Topics: Administration, Oral; Animals; Carcinogens; Female; Leukemia; Male; Mammary Neoplasms, Experimental; | 1971 |
[Significance of cellular kinetics in relation to chemotherapy of human leukemias].
Topics: Adult; Aged; Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Blood Platelets; | 1971 |
Remission maintenance therapy for meningeal leukemia: intrathecal methotrexate vs. intravenous bis-nitrosourea.
Topics: Adolescent; Bone Marrow Examination; Child; Child, Preschool; Fever; Headache; Humans; Injections, I | 1971 |
Summary: recent advances in the treatment of acute leukemia and Burkitt's tumor.
Topics: Antineoplastic Agents; Asparaginase; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Daunorubicin; H | 1967 |
Prolonged survival of lymphocytes with chromosomal defects in children treated with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Acute Disease; Adolescent; Antineoplastic Agents; Child; Child, Preschool; Chromosome Aberrations; C | 1968 |
Combinations, schedules, and new agents for the chemotherapy of acute leukemia.
Topics: Acute Disease; Adult; Antineoplastic Agents; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Huma | 1970 |
1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) given concomitantly with cytosine arabinoside (NSC-63878) in the treatment of cancer.
Topics: Adult; Aged; Antineoplastic Agents; Cytarabine; Female; Humans; Leukemia; Male; Middle Aged; Neoplas | 1970 |
In vivo effect of hydroxyurea on orotic acid synthesis.
Topics: Adult; Aged; Antimetabolites; DNA; Humans; Leukemia; Melanoma; Middle Aged; Nucleosides; Orotic Acid | 1966 |