urea has been researched along with Leucocythaemia in 51 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A series of substituted urea derivatives, compounds 1-14, were synthesized and evaluated for their cytotoxic activities against the human-leukemia K562 cell line." | 7.74 | Synthesis and cytotoxic evaluation of substituted urea derivatives as inhibitors of human-leukemia K562 cells. ( Cao, P; Ding, H; Ge, HM; Huang, XF; Li, HQ; Ruan, BF; Zhu, HL, 2007) |
| "A series of substituted urea derivatives, compounds 1-14, were synthesized and evaluated for their cytotoxic activities against the human-leukemia K562 cell line." | 3.74 | Synthesis and cytotoxic evaluation of substituted urea derivatives as inhibitors of human-leukemia K562 cells. ( Cao, P; Ding, H; Ge, HM; Huang, XF; Li, HQ; Ruan, BF; Zhu, HL, 2007) |
| "We have synthesized a new compound, 3-bromoacetylamino benzoylurea (3-BAABU), which showed strong cancericidal activity by inducing irreversible mitotic arrest and subsequently apoptosis in human T cell leukemic cells (CEM), human biphenotypic leukemic cells (SP), a human prostate cancer cell line (PC-3), murine melanoma cells (B-16), and murine lymphoma/leukemia cells (EL4) in vitro with an ID50 in the range of 0." | 3.70 | Inhibition of microtubule assembly in tumor cells by 3-bromoacetylamino benzoylurea, a new cancericidal compound. ( Bekesi, JG; Holland, JF; Jiang, JD; Roboz, J; Strauchen, J; Wang, Y, 1998) |
| "Acetohydroxamic acid has been identified, by paper chromatography, in the blood of three patients with chronic myelogenous leukemia on hydroxyurea therapy." | 3.64 | HYDROXYUREA: MECHANISM OF ACTION. ( CARBONE, PP; FISHBEIN, WN, 1963) |
| "Data from Phase I dose-escalation studies in adults and children were used to build a population pharmacokinetic model (NONMEM v7." | 1.46 | A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia. ( Boddy, AV; Duong, JK; Edwards, D; Griffin, MJ; Hargrave, D; Vormoor, J, 2017) |
| "Children with cancer were also evaluated after antineoplasic treatment (CAT, n = 17)." | 1.38 | Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment. ( Brito, CX; Guerra, RN; Liberio, SA; Lima, MV; Mendonça, C; Mouchrek-Filho, JC; Nascimento, FR; Oliveira-Junior, JJ; Paim, DB; Pereira, AL, 2012) |
| " A major side effect of CyA is nephrotoxicity." | 1.27 | Nephrotoxicity in bone marrow transplant recipients treated with cyclosporin A. ( Baughan, A; Chipping, PM; Fairhead, S; Gordon-Smith, EC; Hows, JM; Smith, J, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (76.47) | 18.7374 |
| 1990's | 2 (3.92) | 18.2507 |
| 2000's | 3 (5.88) | 29.6817 |
| 2010's | 6 (11.76) | 24.3611 |
| 2020's | 1 (1.96) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, M | 1 |
| Li, T | 1 |
| Chen, Y | 1 |
| Zhai, X | 1 |
| Foran, J | 1 |
| Ravandi, F | 1 |
| Wierda, W | 1 |
| Garcia-Manero, G | 1 |
| Verstovsek, S | 1 |
| Kadia, T | 1 |
| Burger, J | 1 |
| Yule, M | 1 |
| Langford, G | 1 |
| Lyons, J | 1 |
| Ayrton, J | 1 |
| Lock, V | 1 |
| Borthakur, G | 1 |
| Cortes, J | 1 |
| Kantarjian, H | 1 |
| Hsieh, YT | 1 |
| Gang, EJ | 1 |
| Shishido, SN | 1 |
| Kim, HN | 1 |
| Pham, J | 1 |
| Khazal, S | 1 |
| Osborne, A | 1 |
| Esguerra, ZA | 1 |
| Kwok, E | 1 |
| Jang, J | 1 |
| Bonig, H | 1 |
| Biediger, RJ | 1 |
| Vanderslice, P | 1 |
| Kim, YM | 1 |
| Vormoor, B | 1 |
| Veal, GJ | 1 |
| Griffin, MJ | 2 |
| Boddy, AV | 2 |
| Irving, J | 1 |
| Minto, L | 1 |
| Case, M | 1 |
| Banerji, U | 1 |
| Swales, KE | 1 |
| Tall, JR | 1 |
| Moore, AS | 2 |
| Toguchi, M | 1 |
| Acton, G | 1 |
| Dyer, K | 1 |
| Schwab, C | 1 |
| Harrison, CJ | 1 |
| Grainger, JD | 1 |
| Lancaster, D | 1 |
| Kearns, P | 1 |
| Hargrave, D | 2 |
| Vormoor, J | 2 |
| Duong, JK | 1 |
| Edwards, D | 1 |
| Podesta, JE | 1 |
| Sugar, R | 1 |
| Squires, M | 1 |
| Linardopoulos, S | 1 |
| Pearson, AD | 1 |
| Guerra, RN | 1 |
| Oliveira-Junior, JJ | 1 |
| Mouchrek-Filho, JC | 1 |
| Liberio, SA | 1 |
| Lima, MV | 1 |
| Paim, DB | 1 |
| Brito, CX | 1 |
| Mendonça, C | 1 |
| Nascimento, FR | 1 |
| Pereira, AL | 1 |
| Lim, S | 1 |
| Ryu, JH | 1 |
| Im, C | 1 |
| Yim, CB | 1 |
| OTTO, H | 1 |
| FISHBEIN, WN | 1 |
| CARBONE, PP | 1 |
| WEISS, HJ | 1 |
| KRONFIELD, SJ | 1 |
| REYNOLDS, TB | 1 |
| HELBIG, W | 1 |
| VOIGT, KG | 1 |
| ORIGENES, ML | 1 |
| BEATTY, EC | 1 |
| BRUBAKER, C | 1 |
| HAMMOND, D | 1 |
| HARTMANN, JR | 1 |
| SHORE, N | 1 |
| WILLIAMS, KO | 1 |
| STEARNS, B | 1 |
| LOSEE, KA | 1 |
| BERNSTEIN, J | 1 |
| FERNBACH, DJ | 1 |
| SHULLENBERGER, CC | 1 |
| KRAKOFF, IH | 2 |
| SAVEL, H | 1 |
| MURPHY, ML | 1 |
| GOLDIN, A | 1 |
| VENDITTI, JM | 1 |
| MEAD, JA | 1 |
| GLYNN, JP | 1 |
| ALPERIN, JB | 1 |
| LEVIN, WC | 1 |
| MEYER, RL | 1 |
| Jackson, JA | 1 |
| Trevino, AV | 1 |
| Herzig, MC | 1 |
| Herman, TS | 1 |
| Woynarowski, JM | 1 |
| Cao, P | 1 |
| Huang, XF | 1 |
| Ding, H | 1 |
| Ge, HM | 1 |
| Li, HQ | 1 |
| Ruan, BF | 1 |
| Zhu, HL | 1 |
| Frei, E | 1 |
| Hows, JM | 1 |
| Chipping, PM | 1 |
| Fairhead, S | 1 |
| Smith, J | 1 |
| Baughan, A | 1 |
| Gordon-Smith, EC | 1 |
| Jiang, JD | 1 |
| Wang, Y | 1 |
| Roboz, J | 1 |
| Strauchen, J | 1 |
| Holland, JF | 2 |
| Bekesi, JG | 1 |
| Israili, ZH | 1 |
| Vogler, WR | 4 |
| Mingioli, ES | 2 |
| Pirkle, JL | 1 |
| Smithwick, RW | 1 |
| Goldstein, JH | 1 |
| Ekert, H | 1 |
| Waters, KD | 1 |
| Powles, R | 1 |
| Smith, C | 1 |
| Milan, S | 1 |
| Treleaven, J | 1 |
| Millar, J | 1 |
| McElwain, T | 1 |
| Gordon-Smith, E | 1 |
| Milliken, S | 1 |
| Tiley, C | 1 |
| Grünert, A | 1 |
| Heim, F | 1 |
| Humberstone, DA | 1 |
| Shaw, JH | 1 |
| Baugh, CM | 1 |
| Krumdieck, CL | 1 |
| Nair, MG | 1 |
| Druckrey, H | 1 |
| Ivankovic, S | 1 |
| Bücheler, J | 1 |
| Preussmann, R | 1 |
| Thomas, C | 1 |
| Howard, N | 1 |
| Arfi, S | 1 |
| Baglin, A | 1 |
| Alterescu, R | 1 |
| Goguel, A | 1 |
| Fendler, JP | 1 |
| Fritel, D | 1 |
| Billing, R | 1 |
| Terasaki, PI | 1 |
| Peto, R | 1 |
| Hong, CI | 1 |
| Chheda, GB | 1 |
| Dutta, SP | 1 |
| O'Grady-Curtis, A | 1 |
| Tritsch, GL | 1 |
| Beal, RW | 1 |
| Gizis, E | 1 |
| Meyer, LM | 1 |
| Groth, DP | 1 |
| D'Angelo, JM | 1 |
| Betz, B | 1 |
| Harris, JW | 1 |
| Allen, NP | 1 |
| Teng, SS | 1 |
| Takizawa, S | 1 |
| Nishihara, H | 1 |
| Hosokawa, M | 1 |
| Gotoda, E | 1 |
| Kobayashi, H | 1 |
| Alberto, P | 1 |
| Sullivan, MP | 1 |
| Vietti, TJ | 1 |
| Haggard, ME | 1 |
| Donaldson, MH | 1 |
| Krall, JM | 1 |
| Gehan, EA | 1 |
| Harrod, EK | 1 |
| Cortner, JA | 1 |
| Henderson, ES | 1 |
| van Eden, EB | 1 |
| Falkson, HC | 1 |
| Falkson, G | 1 |
| Bain, JA | 1 |
| Huguley, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I/IIa Open-label Study to Assess the Safety, Tolerability and Preliminary Efficacy of AT9283, a Small Molecule Inhibitor of Aurora Kinases, in Patients With Refractory Hematological Malignancies[NCT00522990] | Phase 1/Phase 2 | 48 participants (Actual) | Interventional | 2006-09-30 | Terminated (stopped due to Recommended Phase II dose determined) | ||
| International Prospective Observational Cohort Study of Zika in Infants[NCT02856984] | 6,461 participants (Actual) | Observational | 2016-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for urea and Leucocythaemia
| Article | Year |
|---|---|
Nucleoside and Non-Nucleoside DOT1L Inhibitors: Dawn of MLLrearranged Leukemia.
Topics: Carbamates; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Humans; Leukemia; Nucleosides; St | 2021 |
Serum protein binding of vitamin B12.
Topics: Anticoagulants; Biological Transport; Blood Proteins; C-Reactive Protein; Cerebrospinal Fluid; Charc | 1969 |
5 trials available for urea and Leucocythaemia
| Article | Year |
|---|---|
A phase I and pharmacodynamic study of AT9283, a small-molecule inhibitor of aurora kinases in patients with relapsed/refractory leukemia or myelofibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzimidazoles; Disease Progression; Drug Adm | 2014 |
A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia.
Topics: Acute Disease; Adolescent; Aurora Kinases; Benzimidazoles; Child; Child, Preschool; Female; Humans; | 2017 |
Human recombinant GM-CSF in allogeneic bone-marrow transplantation for leukaemia: double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Bilirubin; Bone Marrow Transplantation; Creatinine; Double-Blind Method; Female; | 1990 |
Myeloma and leukaemia trials.
Topics: Clinical Trials as Topic; Humans; Leukemia; Multiple Myeloma; Prognosis; Serum Albumin; Urea | 1972 |
Clinical trials of 1-beta-D-arabinofuranosyl cytosine and 1,3-bis-(2-chloroethyl)-1-nitrosourea combination in metastatic cancer and acute leukemia.
Topics: Age Factors; Blood Cell Count; Blood Platelets; Blood Urea Nitrogen; Clinical Trials as Topic; Cytar | 1971 |
44 other studies available for urea and Leucocythaemia
| Article | Year |
|---|---|
Effects of the small-molecule inhibitor of integrin α4, TBC3486, on pre-B-ALL cells.
Topics: Animals; Antineoplastic Agents; Coculture Techniques; Drug Resistance, Neoplasm; Humans; Inflammatio | 2014 |
A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzimidazoles; Body Surface Area | 2017 |
Adaptation of the plasma inhibitory activity assay to detect Aurora, ABL and FLT3 kinase inhibition by AT9283 in pediatric leukemia.
Topics: Age of Onset; Antineoplastic Agents; Aurora Kinases; Benzimidazoles; Blood Chemical Analysis; Calibr | 2011 |
Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment.
Topics: Biomarkers; Blood Glucose; Case-Control Studies; Central Nervous System Neoplasms; Child; Cohort Stu | 2012 |
Synthesis and cytotoxicity of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide.
Topics: Ceramides; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Kidney | 2003 |
[Relationship of nephritis, leukemia and azotemia].
Topics: Azotemia; Blood; Humans; Leukemia; Nephritis; Urea | 1955 |
HYDROXYUREA: MECHANISM OF ACTION.
Topics: Blood Chemical Analysis; Chromatography; Humans; Hydroxamic Acids; Hydroxyurea; Leukemia; Leukemia, | 1963 |
INCREASED UREA SOLUBILITY OF THE BLOOD CLOT IN CHRONIC GRANULOCYTIC LEUKEMIA AND ITS RELATION TO THE ABNORMAL THROMBELASTOGRAM.
Topics: Blood Coagulation; Chemical Phenomena; Chemistry; Humans; Leukemia; Leukemia, Myelogenous, Chronic, | 1963 |
LEUKEMIA AND HYPERCALCEMIA; REPORT OF A CASE AND REVIEW OF THE LITERATURE.
Topics: Adolescent; Blood; Calcium; Calcium, Dietary; Creatine; Creatinine; Humans; Hypercalcemia; Leukemia; | 1964 |
[CLINICAL KIDNEY FINDINGS IN LEUKEMIA AND THEIR CORRELATION WITH AUTOPSY RESULTS].
Topics: Autopsy; Blood Chemical Analysis; Blood Urea Nitrogen; Hematuria; Hemorrhagic Disorders; Humans; Kid | 1963 |
TRIAL OF HYDROXYUREA (NSC-32065) IN CANCER IN CHILDREN.
Topics: Antineoplastic Agents; Busulfan; Child; Cyclophosphamide; Dactinomycin; Humans; Hydroxyurea; Leukemi | 1964 |
HYDROXYUREA. A NEW TYPE OF POTENTIAL ANTITUMOR AGENT.
Topics: Animals; Antineoplastic Agents; Hydroxyurea; Leukemia; Leukemia L1210; Leukemia, Experimental; Mice; | 1963 |
PEDIATRIC CLINICAL TRIALS WITH HYDROXYUREA (NSC-32065).
Topics: Adolescent; Antineoplastic Agents; Child; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Neop | 1964 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: LEUKEMIA.
Topics: Antineoplastic Agents; Drug Therapy; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; L | 1964 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CLINICAL EVALUATION.
Topics: Antineoplastic Agents; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leu | 1964 |
ANTILEUKEMIC ACTIVITY OF HYDROXYUREA (NSC-32065) AND OTHER UREA DERIVATIVES.
Topics: Antineoplastic Agents; Biological Assay; Hydroxyurea; Leukemia; Leukemia, Experimental; Mice; Resear | 1964 |
EXTREME HYPERURICEMIA ASSOCIATED WITH PREDNISONE THERAPY FOR ACUTE LYMPHOBLASTIC LEUKEMIA.
Topics: Adolescent; Blood; Blood Urea Nitrogen; Humans; Hyperuricemia; Leukemia; Leukemia, Lymphoid; Lymphoc | 1964 |
PREVENTION OF HYPERURICEMIA IN LEUKEMIA AND LYMPHOMA: USE OF ALOPURINOL, A XANTHINE OXIDASE INHIBITOR.
Topics: Adolescent; Antineoplastic Agents; Blood; Blood Urea Nitrogen; Drug Therapy; Geriatrics; Humans; Hyp | 1965 |
Matrix attachment region (MAR) properties and abnormal expansion of AT island minisatellites in FRA16B fragile sites in leukemic CEM cells.
Topics: AT Rich Sequence; Binding Sites; Cell Line, Tumor; Chromosome Fragility; Chromosomes, Human, Pair 16 | 2003 |
Synthesis and cytotoxic evaluation of substituted urea derivatives as inhibitors of human-leukemia K562 cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; K562 Cells; Leukemia; Molecular Structure; Structur | 2007 |
Informal discussion: experimental basis for the chemical eradication of leukemia.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cytarabine; Drug Antagonism; Drug Synergism; Huma | 1967 |
Nephrotoxicity in bone marrow transplant recipients treated with cyclosporin A.
Topics: Adolescent; Adult; Anemia, Aplastic; Bilirubin; Bone Marrow Transplantation; Child; Creatinine; Cycl | 1983 |
Inhibition of microtubule assembly in tumor cells by 3-bromoacetylamino benzoylurea, a new cancericidal compound.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; DNA Fragmentation; DNA, Neoplasm; Drug Screening Assay | 1998 |
The disposition and pharmacokinetics in humans of 5-azacytidine administered intravenously as a bolus or by continuous infusion.
Topics: Azacitidine; Chromatography, Thin Layer; Erythrocytes; Feces; Humans; Hydrogen-Ion Concentration; In | 1976 |
Hematologic emergencies in children.
Topics: Acute Disease; Acute Kidney Injury; Adolescent; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Asp | 1978 |
[Adjuvant parenteral nutrition in chemo- and radiotherapeutic measures in hematology].
Topics: Amino Acids; Blood Proteins; Bone Marrow Transplantation; Combined Modality Therapy; Electrolytes; H | 1986 |
Metabolism in hematologic malignancy.
Topics: Adult; Aged; Calorimetry; Energy Metabolism; Female; Glucose; Humans; Leukemia; Lymphoma; Male; Midd | 1988 |
Polygammaglutamyl metabolites of methotrexate.
Topics: Acute Disease; Animals; Chloroform; Chromatography, DEAE-Cellulose; Chromatography, Paper; Enterococ | 1973 |
[Production of stomach and pancreatic cancer in the guinea pig using methylnitroso-urea and methylnitroso-urethane].
Topics: Animals; Body Weight; Carcinoma; Ear Neoplasms; Guinea Pigs; Laryngeal Neoplasms; Leukemia; Lung Neo | 1968 |
Acute renal failure in leukaemia and malignant lymphoma.
Topics: Acute Kidney Injury; Blood; Hodgkin Disease; Humans; Leukemia; Male; Middle Aged; Radioisotope Telet | 1966 |
[Acute kidney failure in acute leukemia].
Topics: Acute Kidney Injury; Adult; Aged; Blood Cell Count; Female; Furosemide; Humans; Leukemia; Leukemia, | 1973 |
Human leukemia antigen. II. Purification.
Topics: Animals; Antigens, Neoplasm; Burkitt Lymphoma; Cell Line; Chromatography, Affinity; Concanavalin A; | 1974 |
Synthesis and biological activity of analogs of naturally occurring 6-ureidopurines and their nucleosides.
Topics: Cells, Cultured; Chromatography, Thin Layer; Culture Techniques; Glycine max; Humans; Leukemia; Magn | 1973 |
Selective metabolic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea upon de novo purine biosynthesis.
Topics: Acute Disease; Amino Acids; Animals; Antineoplastic Agents; Ascitic Fluid; Carbon Isotopes; Carcinom | 1971 |
Evaluation of a new glutathione-oxidizing reagent for studies of nucleated mammalian cells.
Topics: Amides; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cell Movement; Cell Survival; Cells, Cultured; | 1971 |
Induction of tumors in the brain, kidney, and other extra-mammary gland organs by a continuous oral administration of N-nitrosobutylurea in Wistar-Furth rats.
Topics: Administration, Oral; Animals; Brain Neoplasms; Carcinogens; Castration; Duodenal Neoplasms; Ear Neo | 1971 |
Leukemia and mammary tumor in rats administered N-nitrosobutylurea.
Topics: Administration, Oral; Animals; Carcinogens; Female; Leukemia; Male; Mammary Neoplasms, Experimental; | 1971 |
[Significance of cellular kinetics in relation to chemotherapy of human leukemias].
Topics: Adult; Aged; Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Blood Platelets; | 1971 |
Remission maintenance therapy for meningeal leukemia: intrathecal methotrexate vs. intravenous bis-nitrosourea.
Topics: Adolescent; Bone Marrow Examination; Child; Child, Preschool; Fever; Headache; Humans; Injections, I | 1971 |
Summary: recent advances in the treatment of acute leukemia and Burkitt's tumor.
Topics: Antineoplastic Agents; Asparaginase; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Daunorubicin; H | 1967 |
Prolonged survival of lymphocytes with chromosomal defects in children treated with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Acute Disease; Adolescent; Antineoplastic Agents; Child; Child, Preschool; Chromosome Aberrations; C | 1968 |
Combinations, schedules, and new agents for the chemotherapy of acute leukemia.
Topics: Acute Disease; Adult; Antineoplastic Agents; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Huma | 1970 |
1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) given concomitantly with cytosine arabinoside (NSC-63878) in the treatment of cancer.
Topics: Adult; Aged; Antineoplastic Agents; Cytarabine; Female; Humans; Leukemia; Male; Middle Aged; Neoplas | 1970 |
In vivo effect of hydroxyurea on orotic acid synthesis.
Topics: Adult; Aged; Antimetabolites; DNA; Humans; Leukemia; Melanoma; Middle Aged; Nucleosides; Orotic Acid | 1966 |