urea has been researched along with Lesch-Nyhan Syndrome in 5 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nyhan, WL | 1 |
| Rassin, DK | 1 |
| Lloyd, KG | 1 |
| Kelley, WN | 1 |
| Fox, I | 1 |
| Ferrer, I | 1 |
| Costell, M | 1 |
| Grisolía, S | 1 |
| Omenn, GS | 1 |
| Ceccarelli, M | 1 |
| Ciompi, ML | 1 |
| Pasero, G | 1 |
2 reviews available for urea and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Understanding inherited metabolic disease.
Topics: Amniocentesis; Carboxy-Lyases; Female; Genetic Carrier Screening; Homocystinuria; Humans; Infant, Ne | 1980 |
Inborn errors of metabolism: clues to understanding human behavioral disorders.
Topics: Adrenal Hyperplasia, Congenital; Brain; Galactosemias; Glycine; Hepatolenticular Degeneration; Heter | 1976 |
3 other studies available for urea and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Decreased amino acids in various brain areas of patients with Lesch-Nyhan syndrome.
Topics: Adolescent; Adult; Amino Acids; Brain Chemistry; Child; Child, Preschool; Glutamine; Glycine; Humans | 1982 |
Lesch-Nyhan syndrome-like behavior in rats from caffeine ingestion: changes in HGPRTase activity, urea and some nitrogen metabolism enzymes.
Topics: Acetylcholinesterase; Animals; Aspartate Carbamoyltransferase; Brain; Caffeine; Carbamoyl-Phosphate | 1982 |
Acute renal failure during adenine therapy in Lesch-Nyhan syndrome.
Topics: Acute Kidney Injury; Adenine; Body Weight; Child, Preschool; Creatinine; Erythrocytes; Humans; Hydro | 1974 |