urea has been researched along with Joint Pain in 4 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that 24-h after CFA-induced knee inflammation, knee neurons show a decreased action potential generation threshold, as well as increased GABA and capsaicin sensitivity, but have unaltered acid sensitivity." | 3.88 | Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. ( Callejo, G; Chakrabarti, S; Hockley, JRF; Pattison, LA; Singhal, K; Smith, ESJ, 2018) |
| "Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH." | 3.73 | TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. ( Bayburt, EK; Bianchi, B; Brown, B; Chandran, P; Cui, M; Decker, MW; Faltynek, CR; Gauvin, D; Gomtsyan, A; Hernandez, G; Honore, P; Lee, CH; Marsh, K; McDonald, H; Mikusa, J; Moreland, RB; Neelands, TR; Niforatos, W; Sullivan, JP; Zhong, C, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chakrabarti, S | 1 |
| Pattison, LA | 1 |
| Singhal, K | 1 |
| Hockley, JRF | 1 |
| Callejo, G | 1 |
| Smith, ESJ | 1 |
| Huggins, JP | 1 |
| Smart, TS | 1 |
| Langman, S | 1 |
| Taylor, L | 1 |
| Young, T | 1 |
| Di Marzo, V | 1 |
| Cui, M | 1 |
| Honore, P | 1 |
| Zhong, C | 1 |
| Gauvin, D | 1 |
| Mikusa, J | 1 |
| Hernandez, G | 1 |
| Chandran, P | 1 |
| Gomtsyan, A | 1 |
| Brown, B | 1 |
| Bayburt, EK | 1 |
| Marsh, K | 1 |
| Bianchi, B | 1 |
| McDonald, H | 1 |
| Niforatos, W | 1 |
| Neelands, TR | 1 |
| Moreland, RB | 1 |
| Decker, MW | 1 |
| Lee, CH | 1 |
| Sullivan, JP | 1 |
| Faltynek, CR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Osteoarthritis of the Knee Pain Study Using CBD and THC in Rapidly Dissolvable Sublingual Tablet[NCT04195269] | Phase 2 | 30 participants (Anticipated) | Interventional | 2020-04-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for urea and Joint Pain
| Article | Year |
|---|---|
An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of th
Topics: Adult; Aged; Amidohydrolases; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Cross | 2012 |
3 other studies available for urea and Joint Pain
| Article | Year |
|---|---|
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Capsaicin; Cells, Cultured; Disease Mo | 2018 |
Inhibitors of endocannabinoid breakdown for pain: not so FA(AH)cile, after all.
Topics: Amidohydrolases; Analgesics; Arthralgia; Female; Humans; Knee Joint; Male; Pyridazines; Urea | 2012 |
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Calcium; Capsaicin; Cell Line; Cells, Culture | 2006 |