urea has been researched along with Intermittent Claudication in 4 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Safety evaluations performed during 14- and 28-day visits which included in-clinic dosing and assessments at peak drug concentrations provided core data for the DMC review." | 2.76 | Application of adaptive design and decision making to a phase II trial of a phosphodiesterase inhibitor for the treatment of intermittent claudication. ( Brass, EP; Connor, JT; Cooper, LT; Hiatt, WR; Lewis, RJ; Murphy, JR; Teerlink, JR, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lewis, RJ | 1 |
| Connor, JT | 1 |
| Teerlink, JR | 1 |
| Murphy, JR | 1 |
| Cooper, LT | 2 |
| Hiatt, WR | 2 |
| Brass, EP | 2 |
| Morgan, RE | 1 |
| Beevers, DG | 1 |
| Fairman, MJ | 1 |
| Hamilton, M | 1 |
| Harpur, JE | 1 |
| Laursen, B | 1 |
| Gormsen, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00783081] | Phase 2 | 387 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for urea and Intermittent Claudication
| Article | Year |
|---|---|
Application of adaptive design and decision making to a phase II trial of a phosphodiesterase inhibitor for the treatment of intermittent claudication.
Topics: Ankle Brachial Index; Decision Support Techniques; Dose-Response Relationship, Drug; Double-Blind Me | 2011 |
A phase II dose-ranging study of the phosphodiesterase inhibitor K-134 in patients with peripheral artery disease and claudication.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Chi-Square Distribution; Cilostazol; Dose-Resp | 2012 |
2 other studies available for urea and Intermittent Claudication
| Article | Year |
|---|---|
Antihypertensive treatment and the course of established cerebral vascular disease.
Topics: Angina Pectoris; Antihypertensive Agents; Cardiomegaly; Cerebrovascular Disorders; Diuretics; Female | 1973 |
Pharmacological enhancement and short-term stimulation of blood fibrinolytic activity.
Topics: Adolescent; Adult; Aged; Aminocaproates; Anticholesteremic Agents; Arteriosclerosis; Arthritis, Rheu | 1969 |