urea has been researched along with Inflammation in 175 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to evaluate whether the administration of riboflavin to septic animals reduces inflammation, oxidative stress, organ dysfunction, and mortality." | 8.12 | Riboflavin did not provide anti-inflammatory or antioxidant effects in an experimental model of sepsis. ( Alves-Filho, JC; Aragon, DC; Carlotti, APCP; Cunha, FQ; Ferreira, RG; Nascimento, DC; Pineros, AR; Ramalho, FS; Santos, JD; Vale, AHF, 2022) |
| "To develop new anti-inflammatory drugs for the prevention and treatment of acute kidney injury, a series of novel glycyrrhetic ureas were designed, synthesized and evaluated for anti-inflammatory activity using RAW264." | 8.02 | Design and synthesis of novel glycyrrhetin ureas as anti-inflammatory agents for the treatment of acute kidney injury. ( Jiang, X; Shi, T; Tang, W; Wang, H; Wu, C; Yang, YA; Zha, L; Zuo, J, 2021) |
| "This study aimed to investigate the protective effects of berberine (BBR) against D-galactose (D-gal)-induced renal aging in rats, pointing to its ability to modulate phosphatase and tensin homolog deleted on chromosome ten (PTEN)/Akt signalling, and to attenuate oxidative stress, inflammation and apoptosis." | 7.96 | Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism. ( El-Horany, HE; Gaballah, HH; Helal, DS, 2020) |
| " The present study investigated the toxic potential of 35% carbamide peroxide (CPO) containing tooth whitening product (TWP) on the liver, kidney, heart, and stomach of mice, pointing to the role of oxidative stress and inflammation." | 7.91 | Chronic exposure to 35% carbamide peroxide tooth bleaching agent induces histological and hematological alterations, oxidative stress, and inflammation in mice. ( Al-Basher, G; Al-Dosary, M; Al-Farraj, S; Al-Kubaisi, N; Al-Motiri, H; Al-Otibi, F; Al-Sarar, D; Al-Sultan, N; Bin-Jumah, M; Mahmoud, AM, 2019) |
| "While body weight was decreased, kidney weight increased in DEP+adenine versus saline+adenine or DEP." | 7.83 | Prolonged Pulmonary Exposure to Diesel Exhaust Particles Exacerbates Renal Oxidative Stress, Inflammation and DNA Damage in Mice with Adenine-Induced Chronic Renal Failure. ( Ali, BH; Beegam, S; Hamadi, NK; Karaca, T; Nemmar, A; Yasin, J; Yuvaraju, P, 2016) |
| " Hydroxychloroquine (HCQ), an anti-inflammatory drug, has been shown to have multiple pleiotropic actions relevant to atherosclerosis." | 7.81 | Impact of Hydroxychloroquine on Atherosclerosis and Vascular Stiffness in the Presence of Chronic Kidney Disease. ( Apostolov, EO; Bose, C; Fahmi, T; Karaduta, OK; Kaushal, GP; Segal, MS; Shah, SV; Shukla, AM, 2015) |
| " Here, we investigated the effects of orally administered SA13353 on leukocyte infiltration in lipopolysaccharide (LPS)-induced acute lung injury and ovalbumin-induced allergic airway inflammation." | 7.76 | Effects of SA13353, a transient receptor potential vanilloid 1 agonist, on leukocyte infiltration in lipopolysaccharide-induced acute lung injury and ovalbumin-induced allergic airway inflammation. ( Aono, H; Inagaki, N; Inoue, H; Murai, M; Oki, K; Sasano, M; Tanaka, H; Tsuji, F, 2010) |
| "Thalidomide treatment also induced a significant decrease in the expression of ET-1 (1." | 5.72 | Thalidomide modulates renal inflammation induced by brain death experimental model. ( Andraus, W; Brasil, S; de Moraes, EL; de Oliveira-Braga, KA; Dellê, H; Dos Santos, MJ; Feliciano, R; Figueiredo, EG; Nepomuceno, NA; Neri, LHM; Pêgo-Fernandes, PM; Pepineli, R; Ruiz, LM; Sala, ACG; Santana, AC; Schust, AS; Silva, FMO, 2022) |
| "Chronic inflammation is linked to diverse disease processes, but the intrinsic mechanisms that determine cellular sensitivity to inflammation are incompletely understood." | 5.56 | Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation. ( Alvarez-Perez, JC; Avizonis, D; Badur, MG; Bird, GH; Bridon, G; Choi, DW; Danial, NN; Dhe-Paganon, S; Evans, L; Ficarro, SB; Fu, A; Garcia-Ocana, A; James Shapiro, AM; Jones, RG; Kamphorst, JJ; Karakose, E; Kin, T; Marto, JA; Rosselot, C; Seo, HS; Stewart, AF; Walensky, LD, 2020) |
| " Removal of small (urea, phosphate, creatinine and indoxyl sulfate [IS]), middle and large-middle molecules (beta-2 microglobulin [β2M], albumin), markers of inflammation (interleukin-6 [IL-6], malondialdehyde-modified low density lipoprotein [MDA-LDL] and alpha-1 microglobulin [α1M]), was evaluated in serum and dialysate samples." | 5.51 | A pilot study comparing the efficiency of a novel asymmetric cellulose triacetate (ATA) dialyser membrane (Solacea-190H) to a standard high flux polysulfone dialyser membrane (FX-80) in the setting of extended hours haemodialysis. ( Damasiewicz, MJ; Kameshwar, K; Kerr, PG; Polkinghorne, KR, 2022) |
| "The urea cycle is an endogenous source of arginine that also supports removal of nitrogenous waste following protein metabolism." | 5.51 | Rainbow trout (Oncorhynchus mykiss) urea cycle and polyamine synthesis gene families show dynamic expression responses to inflammation. ( Clark, TC; Macqueen, DJ; Martin, SAM; Tinsley, J, 2019) |
| "Early-life inflammation has been shown to exert profound effects on brain development and behavior, including altered emotional behavior, stress responsivity and neurochemical/neuropeptide receptor expression and function." | 5.43 | Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. ( Doenni, VM; Gray, JM; Hill, MN; Patel, S; Pittman, QJ; Song, CM, 2016) |
| "Cotreatment with landiolol was associated with significantly less severe disease, as assessed by lung histopathology and cardiac function metrics." | 5.35 | Landiolol, an ultrashort-acting beta1-adrenoceptor antagonist, has protective effects in an LPS-induced systemic inflammation model. ( Hagiwara, S; Iwasaka, H; Maeda, H; Noguchi, T, 2009) |
| " Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties." | 5.34 | Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model. ( Bayburt, EK; Didomenico, S; Drizin, I; Faltynek, CR; Gomtsyan, A; Honore, P; Jinkerson, TK; Keddy, R; Koenig, JR; Lee, CH; Marsh, KC; McDonald, HA; Mikusa, J; Perner, RJ; Surowy, CS; Turner, SC; Wetter, JM, 2007) |
| "Urea plays an important role in the urinary concentrating mechanism and expression of the urea transporters UT-A1, UT-A2, UT-A3, UT-A4, and UT-B is essential for tubular urea reabsorption." | 5.34 | Cytokine-mediated regulation of urea transporters during experimental endotoxemia. ( Bucher, M; Höcherl, K; Schmidt, C, 2007) |
| " Furthermore, A-425619 maintained efficacy in the postoperative pain model after twice daily dosing p." | 5.33 | A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. ( El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ, 2005) |
| "Low-dose continuous infusion of landiolol reduced the incidence of postoperative atrial fibrillation, and significantly suppressed inflammation." | 5.17 | Perioperative use of a beta blocker in coronary artery bypass grafting. ( Aoki, M; Baba, H; Goto, Y; Ogawa, S; Okawa, Y, 2013) |
| " Guanidinosuccinate correlated positively with plasma urea and negatively with inflammation markers." | 5.13 | Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. ( De Deyn, PP; De Vriese, A; Delanghe, JR; Marescau, B; Schepers, E; Taes, YE; Vanholder, R, 2008) |
| " Increase of uNGAL in absence of clinical signs or alterations in creatinine, urea, or GFR might suggest that there is metabolic adaptation to endurance exercise, or possibly predisposition to acute kidney injury over time." | 4.98 | Quantification of NGAL in Urine of Endurance Cycling Athletes. ( Machado, JCQ; Nogueira-Machado, JA; Vasconcellos, LS; Volpe, CMO, 2018) |
| "We aimed to evaluate whether the administration of riboflavin to septic animals reduces inflammation, oxidative stress, organ dysfunction, and mortality." | 4.12 | Riboflavin did not provide anti-inflammatory or antioxidant effects in an experimental model of sepsis. ( Alves-Filho, JC; Aragon, DC; Carlotti, APCP; Cunha, FQ; Ferreira, RG; Nascimento, DC; Pineros, AR; Ramalho, FS; Santos, JD; Vale, AHF, 2022) |
| " The indicators of hematological, renal function (urea, serum creatinine [Scr], estimated glomerular filtration rate [eGFR], and urine albumin to creatinine ratio [ACR]) and the markers of inflammation (high-sensitivity C-reactive protein [hsCRP] and fibrinogen [FIB]) were recorded." | 4.12 | Association of mean platelet volume/lymphocyte ratio with inflammation in non-dialysis patients with chronic kidney disease stages 1-4: A retrospective study. ( Chen, G; Feng, J; Gan, L; Xu, B; Zhang, Y, 2022) |
| "Among the 350 COVID-19 patients studied, there was a significant increase in the WBC count, neutrophils, aggregate index of systemic inflammation (AISI), neutrophil-to-lymphocyte ratio (dNLR), neutrophil-to-lymphocyte and platelet ratio (NLPR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), D-dimer, interleukin-6 (IL-6), ferritin, lactate dehydrogenase (LDH), prothrombin time (PT), glucose, urea, urea nitrogen, creatinine, alanine phosphatase (ALP), and aspartate aminotransferase (AST) and a significant decrease in lymphocytes, eosinophils, total protein, albumin, prealbumin serum, and albumin/globulin (A/G) ratio in the severe group when compared with the mild and moderate groups." | 4.12 | Diagnostic Values of Laboratory Biomarkers in Predicting a Severe Course of COVID-19 on Hospital Admission. ( Balakrishna, N; Koyyada, R; Manda, SV; Narreddy, S; Patnam, S; Ramesh, V; Satish Kumar, M; Singh, AD; Tummala, A; Varahala, S, 2022) |
| "To develop new anti-inflammatory drugs for the prevention and treatment of acute kidney injury, a series of novel glycyrrhetic ureas were designed, synthesized and evaluated for anti-inflammatory activity using RAW264." | 4.02 | Design and synthesis of novel glycyrrhetin ureas as anti-inflammatory agents for the treatment of acute kidney injury. ( Jiang, X; Shi, T; Tang, W; Wang, H; Wu, C; Yang, YA; Zha, L; Zuo, J, 2021) |
| "This study aimed to investigate the protective effects of berberine (BBR) against D-galactose (D-gal)-induced renal aging in rats, pointing to its ability to modulate phosphatase and tensin homolog deleted on chromosome ten (PTEN)/Akt signalling, and to attenuate oxidative stress, inflammation and apoptosis." | 3.96 | Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism. ( El-Horany, HE; Gaballah, HH; Helal, DS, 2020) |
| " In correlation with the cisplatin group, Rutin and alpha-lipoic acid ameliorated cisplatin-induction increase in serum urea, creatinine, albumin, oxidative stress and inflammation were observed." | 3.91 | Potential Protective Role of Rutin and Alpha-lipoic Acid Against Cisplatin-induced Nephrotoxicity in Rats. ( Aniss, NN; Motelp, BAAE; Zaazaa, AM, 2019) |
| " The present study investigated the toxic potential of 35% carbamide peroxide (CPO) containing tooth whitening product (TWP) on the liver, kidney, heart, and stomach of mice, pointing to the role of oxidative stress and inflammation." | 3.91 | Chronic exposure to 35% carbamide peroxide tooth bleaching agent induces histological and hematological alterations, oxidative stress, and inflammation in mice. ( Al-Basher, G; Al-Dosary, M; Al-Farraj, S; Al-Kubaisi, N; Al-Motiri, H; Al-Otibi, F; Al-Sarar, D; Al-Sultan, N; Bin-Jumah, M; Mahmoud, AM, 2019) |
| " We also analysed fasting blood levels of urea, NAD+ and its metabolites, and inflammation-linked biomarkers, including interleukin-6 (IL-6), Kynurenine (Kyn), and Tryptophan (Trp)." | 3.88 | High protein intake is associated with low plasma NAD+ levels in a healthy human cohort. ( Berg, J; Bilgin, AA; Braidy, N; Grant, R; Salonikas, C; Seyedsadjadi, N, 2018) |
| " Adenine treatment reduced body weight, creatinine renal clearance, and increased water intake and urine output, as well as the plasma concentrations of urea and creatinine, neutrophil gelatinase-associated lipocalin, and N-acetyl-β-D-glucosaminidase activity, and albumin in urine." | 3.88 | The effect of sildenafil on rats with adenine-Induced chronic kidney disease. ( Adham, SA; Al Kalbani, J; Al Suleimani, Y; Al Za'abi, M; Ali, BH; Karaca, T; Manoj, P; Nemmar, A; Yasin, J, 2018) |
| " We found that 24-h after CFA-induced knee inflammation, knee neurons show a decreased action potential generation threshold, as well as increased GABA and capsaicin sensitivity, but have unaltered acid sensitivity." | 3.88 | Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. ( Callejo, G; Chakrabarti, S; Hockley, JRF; Pattison, LA; Singhal, K; Smith, ESJ, 2018) |
| " Nutritional status related to inflammation was measured by the Malnutrition-Inflammation Score and nutritional status assessment using biochemical indicators that used urea, creatinine and albumin." | 3.88 | Malnutrition associated with inflammation in the chronic renal patient on hemodialysis. ( Almeida, HRM; Dourado, K; Mota, C; Peixoto, R; Santos, EMC, 2018) |
| " Previously, we demonstrated that DAGLβ inactivation using the triazole urea inhibitor KT109 blocked macrophage inflammatory signaling and reversed allodynic responses of mice in inflammatory and neuropathic pain models." | 3.88 | Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo. ( Donvito, G; Fox, TE; Hsu, KL; Kester, M; Lichtman, AH; Schurman, LD; Shin, M; Snyder, HW, 2018) |
| "The arachidonic acid cascade is a key player in inflammation, and numerous well-established drugs interfere with this pathway." | 3.83 | Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase. ( Angioni, C; Blöcher, R; Fürst, R; Geisslinger, G; Glatzel, D; Hartmann, M; Hofmann, B; Kretschmer, S; Meirer, K; Proschak, E; Steinhilber, D; Wittmann, SK, 2016) |
| "The aim of present study was to investigate the effect of vitamin U (vit U, S-methylmethionine) on oxidative stress, inflammation, and fibrosis within the context of valproic acid (VPA)-induced renal damage." | 3.83 | Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties. ( Bolkent, S; Ercin, M; Gezginci-Oktayoglu, S; Turkyilmaz, IB; Yanardag, R, 2016) |
| "While body weight was decreased, kidney weight increased in DEP+adenine versus saline+adenine or DEP." | 3.83 | Prolonged Pulmonary Exposure to Diesel Exhaust Particles Exacerbates Renal Oxidative Stress, Inflammation and DNA Damage in Mice with Adenine-Induced Chronic Renal Failure. ( Ali, BH; Beegam, S; Hamadi, NK; Karaca, T; Nemmar, A; Yasin, J; Yuvaraju, P, 2016) |
| " Hydroxychloroquine (HCQ), an anti-inflammatory drug, has been shown to have multiple pleiotropic actions relevant to atherosclerosis." | 3.81 | Impact of Hydroxychloroquine on Atherosclerosis and Vascular Stiffness in the Presence of Chronic Kidney Disease. ( Apostolov, EO; Bose, C; Fahmi, T; Karaduta, OK; Kaushal, GP; Segal, MS; Shah, SV; Shukla, AM, 2015) |
| "Development of arthritis and renal involvement was accompanied by significant raise in total leukocyte count, clinical score of inflammation, blood urea and serum creatinine as compared to healthy control rats (group A) till day 15 (p < 0." | 3.81 | Comparison of the Therapeutic Effects of Thymoquinone and Methotrexate on Renal Injury in Pristane Induced Arthritis in Rats. ( Faisal, R; Jehangir, T; Shinwari, L, 2015) |
| "The high level of leptin and correlated inflammation were involved in the initiation and development of uremia; moreover, leptin was an important mediator." | 3.80 | Relationship between leptin and chronic inflammatory state in uremic patients. ( Huang, L; Liu, XW; Peng, DZ; Wang, LX; Zheng, YQ; Zhu, XF, 2014) |
| " Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient's serums." | 3.80 | Oxidative status parameters in children with urinary tract infection. ( Bogavac-Stanojevic, N; Ivanisevic, I; Ivanisevic, J; Jelic-Ivanovic, Z; Kotur-Stevuljevic, J; Paripovic, D; Peco-Antic, A; Petrovic, S, 2014) |
| " Glycerol in T2DM microdialysate (but not in T1DM) was higher than in healthy volunteers, which is likely explained by sc insulin resistance (insulin is a potent antilipolytic hormone)." | 3.76 | Analyte flux at a biomaterial-tissue interface over time: implications for sensors for type 1 and 2 diabetes mellitus. ( Adamson, U; Brismar, K; Ekberg, NR; Hedblad, MA; Malmstedt, J; Ungerstedt, U; Wisniewski, N, 2010) |
| "Inflammation is a multi-staged process whose expansive phase is thought to be driven by acutely released arachidonic acid (AA) and its metabolites." | 3.76 | Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. ( Chiamvimonvat, N; Hammock, BD; Hwang, SH; Inceoglu, B; Liu, JY; Qiu, H; Ulu, A; Yang, J, 2010) |
| " Here, we investigated the effects of orally administered SA13353 on leukocyte infiltration in lipopolysaccharide (LPS)-induced acute lung injury and ovalbumin-induced allergic airway inflammation." | 3.76 | Effects of SA13353, a transient receptor potential vanilloid 1 agonist, on leukocyte infiltration in lipopolysaccharide-induced acute lung injury and ovalbumin-induced allergic airway inflammation. ( Aono, H; Inagaki, N; Inoue, H; Murai, M; Oki, K; Sasano, M; Tanaka, H; Tsuji, F, 2010) |
| "To investigate the possible mechanism of the therapeutic action of propolis, we studied: (a) the effect of propolis, its components, caffeic acid phenethyl ester (CAPE), caffeic acid (CA), quercetin and naringenin, as well as the synthetic compounds indomethacin (IM) and nordihydroguaiaretic acid (NDGA), and a novel lipoxygenase inhibitor N,N'-dicyclohexyl-O-(3,4-dihydroxycinnamoyl)isourea (DCHCU) on eicosanoid production by mouse peritoneal macrophages in vitro; (b) the effect of IM, NDGA, CA, CAPE, DCHCU and propolis on eicosanoid production during acute inflammation in vivo; and (c) the ex vivo and in vivo effect of dietary propolis on arachidonic acid metabolism." | 3.69 | The effect of propolis and its components on eicosanoid production during the inflammatory response. ( Calder, PC; Mirzoeva, OK, 1996) |
| "To determine the permeability characteristics of the rat air pouch model of inflammation using permeability extremes within which the NSAIDs S[+] ibuprofen, piroxicam and diclofenac could be evaluated." | 3.69 | Regional drug delivery I: permeability characteristics of the rat 6-day-old air pouch model of inflammation. ( Brennan, BS; Gifford, LA; Houston, JB; Martin, SW; Reis, ML; Rowland, M; Stevens, AJ, 1995) |
| "Hypertension is a long-term medical condition in which the blood pressure is gradually elevated." | 2.90 | Effects of Olive Leaf Extract on Metabolic Response, Liver and Kidney Functions and Inflammatory Biomarkers in Hypertensive Patients. ( Esfahani, Z; Javadi, H; Mehdi Mirhashemi, S; Reza Memarzadeh, M; Yaghoobzadeh, H, 2019) |
| "Inflammation is catabolic and causes muscle loss." | 2.82 | Amino acid supplementation is anabolic during the acute phase of endotoxin-induced inflammation: A human randomized crossover trial. ( Bach, E; Jessen, N; Johannsen, M; Jørgensen, JO; Møller, N; Richelsen, B; Rittig, N; Thomsen, HH, 2016) |
| " SB-705498 is a potent, selective and orally bioavailable TRPV1 antagonist with demonstrated efficacy in a number of preclinical pain models." | 2.73 | The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans. ( Appleby, JM; Aylott, MC; Brooke, AC; Bullman, JN; Chizh, BA; Gray, EJ; Lai, RY; Napolitano, A; O'Donnell, MB; Wang, J; Williams, PM, 2007) |
| "Nutrition and inflammation have to be evaluated and their role seems to be more important than peritoneal membrane status in patient survival." | 2.48 | Adequacy in peritoneal dialysis. ( Castrale, C; Ficheux, M; Henri, P; Lobbedez, T; Ryckelynck, JP, 2012) |
| "Thalidomide treatment also induced a significant decrease in the expression of ET-1 (1." | 1.72 | Thalidomide modulates renal inflammation induced by brain death experimental model. ( Andraus, W; Brasil, S; de Moraes, EL; de Oliveira-Braga, KA; Dellê, H; Dos Santos, MJ; Feliciano, R; Figueiredo, EG; Nepomuceno, NA; Neri, LHM; Pêgo-Fernandes, PM; Pepineli, R; Ruiz, LM; Sala, ACG; Santana, AC; Schust, AS; Silva, FMO, 2022) |
| "Chronic inflammation is linked to diverse disease processes, but the intrinsic mechanisms that determine cellular sensitivity to inflammation are incompletely understood." | 1.56 | Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation. ( Alvarez-Perez, JC; Avizonis, D; Badur, MG; Bird, GH; Bridon, G; Choi, DW; Danial, NN; Dhe-Paganon, S; Evans, L; Ficarro, SB; Fu, A; Garcia-Ocana, A; James Shapiro, AM; Jones, RG; Kamphorst, JJ; Karakose, E; Kin, T; Marto, JA; Rosselot, C; Seo, HS; Stewart, AF; Walensky, LD, 2020) |
| "(1) Background: Successful treatment of acute kidney injury (AKI)-induced chronic kidney disease (CKD) is unresolved." | 1.56 | Post-Ischemic Renal Fibrosis Progression Is Halted by Delayed Contralateral Nephrectomy: The Involvement of Macrophage Activation. ( Bukosza, EN; Fintha, A; Hamar, P; Kaucsár, T; Krenács, T; Róka, B; Szénási, G; Tod, P, 2020) |
| "The urea cycle is an endogenous source of arginine that also supports removal of nitrogenous waste following protein metabolism." | 1.51 | Rainbow trout (Oncorhynchus mykiss) urea cycle and polyamine synthesis gene families show dynamic expression responses to inflammation. ( Clark, TC; Macqueen, DJ; Martin, SAM; Tinsley, J, 2019) |
| "These data were further explored using Experimental Autoimmune Encephalomyelitis (EAE) in mice." | 1.48 | Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis. ( Clements, DR; Easton, AS; Gujar, SA; Hoskin, DW; Kennedy, BE; Kim, Y; Lamport, AC; Malone, A; Warford, JR, 2018) |
| "Renal injury is a hallmark adverse reaction to sodium valproate (SVP), and caffeic acid (CAFF) is a phenolic compound that has anti-inflammatory and antioxsidant properties." | 1.48 | Study on the influence of caffeic acid against sodium valproate-induced nephrotoxicity in rats. ( Gad, AM, 2018) |
| "TrkA is a target for chronic pain treatment due to the central position of the nerve growth factor (NGF)/TrkA pathway in nociception." | 1.43 | Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition. ( Bernard-Gauthier, V; Schirrmacher, R, 2016) |
| "Early-life inflammation has been shown to exert profound effects on brain development and behavior, including altered emotional behavior, stress responsivity and neurochemical/neuropeptide receptor expression and function." | 1.43 | Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. ( Doenni, VM; Gray, JM; Hill, MN; Patel, S; Pittman, QJ; Song, CM, 2016) |
| "Type 2 diabetes was induced using low-dose streptozotocin in male Wistar rats." | 1.43 | Combination of Vildagliptin and Pioglitazone in Experimental Type 2 Diabetes in Male Rats. ( El Sarha, A; Refaat, R; Sakr, A; Salama, M, 2016) |
| "Area of atherosclerotic plaques in aortic roots or BCA from LCHP diet fed mice was substantially increased as compared to mice fed control diet and was characterized by increased lipids and cholesterol contents (ORO staining, FT-IR analysis), increased macrophage infiltration (MOMA-2) and activity of MMPs (zymography)." | 1.42 | Characterisation of Atherogenic Effects of Low Carbohydrate, High Protein Diet (LCHP) in ApoE/LDLR-/- Mice. ( Baranska, M; Chlopicki, S; Czyżyńska, I; Drahun, A; Franczyk-Żarów, M; Gajda, M; Jasztal, A; Jezkova, K; Johann, C; Kostogrys, RB; Maślak, E; Mateuszuk, Ł; Nachtigal, P; Wrobel, TP; Wybrańska, I, 2015) |
| "Chrysin did not cause any overt adverse effect on the treated rats." | 1.42 | Ameliorative effect of chrysin on adenine-induced chronic kidney disease in rats. ( Adham, SA; Al Za'abi, M; Ali, BH; Nemmar, A; Schupp, N; Waly, MI; Yasin, J, 2015) |
| " Therefore, new potent inhibitors with the adamantyl group replaced by a substituted phenyl group were synthesized to presumptively offer better pharmacokinetic (PK) properties." | 1.39 | Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. ( Chiamvimonvat, N; Hammock, BD; Hwang, SH; Lin, YP; Liu, JY; Morisseau, C; Qiu, H; Rose, TE, 2013) |
| "When treated with serum from an acute liver failure patient, rat hepatocyte monoculture showed reduction of cell viability and loss of liver-specific functions." | 1.38 | Maintenance of rat hepatocytes under inflammation by coculture with human orbital fat-derived stem cells. ( Chen, X; Liu, T; Liu, Y; Wang, Y; Zhang, S, 2012) |
| "PK parameters of 11 sEHIs in cynomolgus monkeys were determined after oral dosing with 0." | 1.38 | Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. ( Adams, MR; Appt, S; Dong, H; Fortenbach, C; Hammock, BD; Hwang, SH; Jones, PD; Lango, J; Miyabe, C; Morisseau, C; Rose, TE; Tsai, HJ; Ulu, A; Yang, J, 2012) |
| "Visceral hypersensitivity was induced in rats by either restraint stress or injection of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) into the proximal colon." | 1.36 | A selective, high affinity 5-HT 2B receptor antagonist inhibits visceral hypersensitivity in rats. ( Furness, JB; Gale, JD; Himaki, D; Kawai, M; Kurebayashi, Y; Nagao, K; Ohashi-Doi, K, 2010) |
| "Cotreatment with landiolol was associated with significantly less severe disease, as assessed by lung histopathology and cardiac function metrics." | 1.35 | Landiolol, an ultrashort-acting beta1-adrenoceptor antagonist, has protective effects in an LPS-induced systemic inflammation model. ( Hagiwara, S; Iwasaka, H; Maeda, H; Noguchi, T, 2009) |
| " Although a single dose of ABT-102 produced a self-limiting increase in core body temperature that remained in the normal range, the hyperthermic effects of ABT-102 effectively tolerated following twice-daily dosing for 2 days." | 1.35 | Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. ( Banfor, PN; Bayburt, E; Chandran, P; Daanen, JF; Faltynek, CR; Fryer, RM; Gauvin, DM; Ghilardi, JR; Gomtsyan, A; Hernandez, G; Honore, P; Jarvis, MF; Joshi, SK; Kort, ME; Kym, PR; Lee, CH; Mantyh, PW; Marsh, K; Mikusa, JP; Neelands, T; Reilly, RM; Segreti, JA; Sevcik, MA; Sullivan, JP; Surowy, CS; Zhong, C, 2009) |
| "This sensitisation reached a maximum in 60-90 min, at which time responses had risen to approximately twice that of control levels seen before the application of inflammatory soup." | 1.35 | The effects of the TRPV1 receptor antagonist SB-705498 on trigeminovascular sensitisation and neurotransmission. ( Appleby, JM; Chizh, BA; Davis, JB; Hoskin, KL; Lambert, GA; Zagami, AS, 2009) |
| " However, their long-term use has been associated with considerable morbidity, limiting their application." | 1.35 | Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats. ( Beck, P; Bonacorso, HG; Duarte, MM; Ferreira, J; Machado, P; Martins, MA; Mello, CF; Rubin, MA; Sant'Anna, Gda S; Sauzem, PD; Zanatta, N, 2009) |
| " Here we present the evaluation of four sEHIs for improved pharmacokinetic properties and the anti-inflammatory effects of one sEHI." | 1.35 | Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. ( Hammock, BD; Hwang, SH; Jones, PD; Liu, JY; Morisseau, C; Tsai, HJ, 2009) |
| "Urea plays an important role in the urinary concentrating mechanism and expression of the urea transporters UT-A1, UT-A2, UT-A3, UT-A4, and UT-B is essential for tubular urea reabsorption." | 1.34 | Cytokine-mediated regulation of urea transporters during experimental endotoxemia. ( Bucher, M; Höcherl, K; Schmidt, C, 2007) |
| " Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties." | 1.34 | Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model. ( Bayburt, EK; Didomenico, S; Drizin, I; Faltynek, CR; Gomtsyan, A; Honore, P; Jinkerson, TK; Keddy, R; Koenig, JR; Lee, CH; Marsh, KC; McDonald, HA; Mikusa, J; Perner, RJ; Surowy, CS; Turner, SC; Wetter, JM, 2007) |
| " The potency of 32 for mouse CCR3 (chemotaxis IC(50) = 41 nM) and its oral bioavailability in mice (20% F ) were adequate to assess the efficacy in animal models of allergic airway inflammation." | 1.33 | Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency. ( Covington, M; Das, AM; Davies, P; De Lucca, GV; Decicco, CP; Duncia, JV; Emmett, G; Gardner, DS; Graden, DM; Kim, UT; Ko, SS; Liauw, A; Newton, RC; Santella, JB; Solomon, KA; Stowell, NC; Trainor, GL; Vargo, BJ; Wacker, DA; Wadman, EA; Wang, Z; Welch, PK; Yeleswaram, S; Zheng, C, 2005) |
| " Furthermore, A-425619 maintained efficacy in the postoperative pain model after twice daily dosing p." | 1.33 | A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. ( El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ, 2005) |
| "Ischemia-reperfusion injury is caused by the activation of inflammatory and cytoprotective genes, such as macrophage chemoattractant protein-1 and heme oxygenase-1, respectively." | 1.33 | Influence of bradykinin B1 and B2 receptors in the immune response triggered by renal ischemia-reperfusion injury. ( Câmara, NO; Cenedeze, MA; Pacheco-Silva, A; Pesquero, JB; Wang, PH, 2006) |
| "The inflammation was mainly located in the anterior uvea, and spontaneously recovered." | 1.31 | [Urea soluble fraction of bovine melanin associated antigen and experimental study on its uveitogenic activity]. ( Gao, Z; Huang, X; Li, S; Pan, S; Xie, C; Yang, P; Zhou, H, 2002) |
| "Furthermore, whereas protein deficiency reduces the plasma albumin pool via a reduction in albumin synthesis, inflammation reduces it through a stimulation of catabolism and/or loss from the intravascular space." | 1.30 | Chronic protein undernutrition and an acute inflammatory stimulus elicit different protein kinetic responses in plasma but not in muscle of piglets. ( Del Rosario, M; Frazer, M; Jahoor, F; Reeds, PJ; Wykes, L, 1999) |
| "Pyelonephritis was a very common complication, but was present only in patients from groups 2 and 3, in whom a lumen was present in the draining ureter, and not in patients from group 1 in whom the ureter was atretic or absent, and the kidney not functioning." | 1.25 | Renal dysplasia. I. A clinico-pathological study of 76 cases. ( Risdon, RA, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (9.71) | 18.7374 |
| 1990's | 11 (6.29) | 18.2507 |
| 2000's | 31 (17.71) | 29.6817 |
| 2010's | 82 (46.86) | 24.3611 |
| 2020's | 34 (19.43) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 3 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Bilen, A | 1 |
| Calik, I | 2 |
| Yayla, M | 1 |
| Dincer, B | 1 |
| Tavaci, T | 1 |
| Cinar, I | 1 |
| Bilen, H | 1 |
| Cadirci, E | 1 |
| Halici, Z | 1 |
| Mercantepe, F | 1 |
| Melekoglu, E | 1 |
| Cetinkaya, MA | 1 |
| Kepekci-Tekkeli, SE | 1 |
| Kul, O | 1 |
| Samur, G | 1 |
| Zareie, F | 1 |
| Ghalebandi, S | 1 |
| Askari, K | 1 |
| Mousavi, Z | 1 |
| Haghparast, A | 2 |
| Heaf, JG | 1 |
| Yahya, R | 1 |
| Dahl, M | 1 |
| Kameshwar, K | 1 |
| Damasiewicz, MJ | 1 |
| Polkinghorne, KR | 1 |
| Kerr, PG | 1 |
| ALRashdi, BM | 1 |
| Elgebaly, HA | 1 |
| Germoush, MO | 1 |
| Qarmush, MM | 1 |
| Azab, MS | 1 |
| Alruhaimi, RS | 1 |
| Ahmeda, AF | 1 |
| Abukhalil, MH | 1 |
| Kamel, EM | 1 |
| Arab, HH | 1 |
| Alzoghaibi, MA | 1 |
| Alotaibi, MF | 1 |
| Mahmoud, AM | 2 |
| Xu, B | 4 |
| Zheng, J | 2 |
| Tian, X | 1 |
| Yuan, F | 1 |
| Liu, Z | 3 |
| Zhou, Y | 1 |
| Yang, Z | 1 |
| Ding, X | 1 |
| Schmitz, J | 1 |
| Brauns, N | 1 |
| Hüsing, AM | 1 |
| Flechsig, M | 1 |
| Glomb, T | 1 |
| Bräsen, JH | 1 |
| Haller, H | 1 |
| von Vietinghoff, S | 1 |
| Xu, YY | 1 |
| Xu, CZ | 1 |
| Liang, YF | 1 |
| Jin, DQ | 1 |
| Ding, J | 1 |
| Sheng, Y | 1 |
| Zhang, L | 4 |
| Deng, F | 1 |
| Vale, AHF | 1 |
| Nascimento, DC | 1 |
| Pineros, AR | 1 |
| Ferreira, RG | 1 |
| Santos, JD | 1 |
| Aragon, DC | 1 |
| Cunha, FQ | 2 |
| Ramalho, FS | 1 |
| Alves-Filho, JC | 1 |
| Carlotti, APCP | 1 |
| Kim, SA | 1 |
| Lee, AS | 1 |
| Lee, HB | 1 |
| Hur, HJ | 1 |
| Lee, SH | 1 |
| Sung, MJ | 1 |
| Yang, F | 1 |
| Shi, X | 2 |
| Yang, W | 1 |
| Gao, C | 2 |
| Cui, Z | 1 |
| Wang, W | 2 |
| Santana, AC | 1 |
| Andraus, W | 1 |
| Silva, FMO | 1 |
| Sala, ACG | 1 |
| Schust, AS | 1 |
| Neri, LHM | 1 |
| Feliciano, R | 1 |
| Pepineli, R | 1 |
| Dellê, H | 1 |
| Ruiz, LM | 1 |
| de Oliveira-Braga, KA | 1 |
| Nepomuceno, NA | 1 |
| Pêgo-Fernandes, PM | 1 |
| Dos Santos, MJ | 1 |
| de Moraes, EL | 1 |
| Brasil, S | 1 |
| Figueiredo, EG | 1 |
| Alves, GF | 1 |
| Stoppa, I | 1 |
| Aimaretti, E | 1 |
| Monge, C | 1 |
| Mastrocola, R | 1 |
| Porchietto, E | 1 |
| Einaudi, G | 1 |
| Collotta, D | 1 |
| Bertocchi, I | 1 |
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| Gigliotti, CL | 1 |
| Clemente, N | 1 |
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| Fernandes, D | 1 |
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| Collino, M | 1 |
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| Zhang, ML | 1 |
| Hou, YM | 1 |
| Zhang, K | 1 |
| Yao, DH | 1 |
| Li, GY | 1 |
| Kou, WB | 1 |
| Wang, HY | 1 |
| Wang, JH | 1 |
| Schmitt, R | 1 |
| Pieper, L | 1 |
| Borchardt, S | 1 |
| Swinkels, JM | 1 |
| Gelfert, CC | 1 |
| Staufenbiel, R | 1 |
| Zhang, Y | 9 |
| Chen, G | 5 |
| Feng, J | 5 |
| Gan, L | 3 |
| Zang, L | 1 |
| Cheng, Q | 2 |
| Bai, S | 1 |
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| Lopes, FF | 1 |
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| Kamphorst, JJ | 1 |
| Stewart, AF | 1 |
| James Shapiro, AM | 1 |
| Marto, JA | 1 |
| Walensky, LD | 1 |
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| Garcia-Ocana, A | 1 |
| Danial, NN | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Synbiotics Supplementation on the Concentration of the Uremic Toxin Indoxyl Sulfate, Symptoms of Constipation, and Constipation-related Quality of Life in End-stage Renal Disease Patients Undergoing Hemodialysis[NCT04527640] | 60 participants (Anticipated) | Interventional | 2020-09-15 | Not yet recruiting | |||
| Prebiotic Therapy to Improve Outcomes of Renal Transplant[NCT04428190] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2022-02-23 | Recruiting | ||
| Metabolic Effects of Endotoxin Induced Acute Inflammation in Healthy Young Men With and Without Supplement of Amino Acids.[NCT01705782] | 8 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Role of Innate and Adaptive Immunity After Acute Myocardial Infarction BATTLE-AMI Study (B And T Types of Lymphocytes Evaluation in Acute Myocardial Infarction)[NCT02428374] | Phase 4 | 300 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting | ||
| Potential Role of Gum Arabic as Antioxidant and Anti-inflammatory Agent in Hemodialysis Patients[NCT03214692] | 50 participants (Anticipated) | Interventional | 2017-07-31 | Enrolling by invitation | |||
| Reproducibility of Cell Counts in Nasal Lavage: A Comparison of Pooled Versus Non-Pooled Nasal Lavage Samples[NCT00229190] | 21 participants | Interventional | 2004-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for urea and Inflammation
| Article | Year |
|---|---|
Oxidative Stress in the Pathophysiology of Kidney Disease: Implications for Noninvasive Monitoring and Identification of Biomarkers.
Topics: Acute Kidney Injury; Animals; Biomarkers; Cytokines; Glutathione; Humans; Inflammation; Kidney Tubul | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Quantification of NGAL in Urine of Endurance Cycling Athletes.
Topics: Acute Kidney Injury; Adult; Athletes; Bicycling; Biomarkers; Brazil; Creatinine; Exercise; Female; G | 2018 |
[Contemporary concepts on metabolic abnormalities in critically ill patients].
Topics: Carbohydrate Metabolism; Critical Illness; Glucose; Humans; Inflammation; Lipid Metabolism; Muscle P | 2008 |
Adequacy of peritoneal dialysis: beyond small solute clearance.
Topics: Creatinine; Humans; Inflammation; Kidney Failure, Chronic; Minerals; Nutritional Status; Peritoneal | 2009 |
Adequacy in peritoneal dialysis.
Topics: Creatinine; Humans; Inflammation; Nutritional Status; Peritoneal Dialysis; Ultrafiltration; Urea | 2012 |
11 trials available for urea and Inflammation
| Article | Year |
|---|---|
A pilot study comparing the efficiency of a novel asymmetric cellulose triacetate (ATA) dialyser membrane (Solacea-190H) to a standard high flux polysulfone dialyser membrane (FX-80) in the setting of extended hours haemodialysis.
Topics: Albumins; beta 2-Microglobulin; Cellulose; Creatinine; Dialysis Solutions; Fluorocarbons; Furans; Hu | 2022 |
Effects of a single transdermal administration of flunixin meglumine in early postpartum Holstein Friesian dairy cows: Part 2. Milk yield, culling risk, and reproductive performance.
Topics: Administration, Cutaneous; Animals; Cattle; Cattle Diseases; Female; Inflammation; Lactation; Parity | 2023 |
Effects of Olive Leaf Extract on Metabolic Response, Liver and Kidney Functions and Inflammatory Biomarkers in Hypertensive Patients.
Topics: Adult; Aged; Albumins; Biomarkers; Body Mass Index; Body Weight; Creatinine; Double-Blind Method; Fe | 2019 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Beneficial effect of Burdock complex on asymptomatic Helicobacter pylori-infected subjects: A randomized, double-blind placebo-controlled clinical trial.
Topics: Angelica sinensis; Anti-Inflammatory Agents; Arctium; Cell Adhesion; Cell Line, Tumor; Cell Survival | 2018 |
Perioperative use of a beta blocker in coronary artery bypass grafting.
Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Atrial Fibrilla | 2013 |
[Effect of Chuanhuang No. 1 recipe on renal function and micro-inflammation in phase 3 chronic kidney disease patients].
Topics: Adult; Blood Urea Nitrogen; C-Reactive Protein; Drugs, Chinese Herbal; Female; Humans; Inflammation; | 2015 |
Amino acid supplementation is anabolic during the acute phase of endotoxin-induced inflammation: A human randomized crossover trial.
Topics: Adaptor Proteins, Signal Transducing; Adult; Amino Acids; Body Mass Index; Cell Cycle Proteins; Cros | 2016 |
The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans.
Topics: Administration, Oral; Adolescent; Adult; Analgesics; Cohort Studies; Dose-Response Relationship, Dru | 2007 |
Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status.
Topics: Administration, Oral; Aged; Arginine; Biomarkers; C-Reactive Protein; Creatine; Cross-Over Studies; | 2008 |
Serum level of soluble tumor necrosis factor receptor II (sTNF-R75) is apparently an index of overall monocyte-related infectious and inflammatory activity.
Topics: Adult; Age Factors; Alkaline Phosphatase; C-Reactive Protein; Communicable Diseases; Creatinine; Fem | 2000 |
159 other studies available for urea and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Does daily fasting shielding kidney on hyperglycemia-related inflammatory cytokine via TNF-α, NLRP3, TGF-β1 and VCAM-1 mRNA expression.
Topics: Animals; Apoptosis; Blood Glucose; Blood Urea Nitrogen; Caspase 9; Creatinine; Diabetes Mellitus, Ex | 2021 |
Effects of prebiotic oligofructose-enriched inulin on gut-derived uremic toxins and disease progression in rats with adenine-induced chronic kidney disease.
Topics: Adenine; Animals; Blood Urea Nitrogen; Cresols; Disease Models, Animal; Dysbiosis; Humans; Indican; | 2021 |
Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzoxazoles; CA1 Region, Hippocampal; Cycl | 2022 |
The ratio of measured to estimated glomerular filtration rate may be a marker of early mortality and dialysis requirement.
Topics: Age Factors; Aged; Biomarkers; Creatinine; Glomerular Filtration Rate; Humans; Inflammation; Kidney | 2021 |
A flavonoid-rich fraction of Monolluma quadrangula inhibits xanthine oxidase and ameliorates potassium oxonate-induced hyperuricemia in rats.
Topics: Animals; Catalase; Creatinine; Cytokines; Flavonoids; Hyperuricemia; Inflammation; Kidney; Molecular | 2022 |
Protective mechanism of traditional Chinese medicine guizhi fuling pills against carbon tetrachloride-induced kidney damage is through inhibiting oxidative stress, inflammation and regulating the intestinal flora.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cytokines; Female; Gastrointestinal Microbiome; Humans; | 2022 |
Renal medullary osmolytes NaCl and urea differentially modulate human tubular cell cytokine expression and monocyte recruitment.
Topics: Animals; Cytokines; Epithelial Cells; Humans; Inflammation; Kidney Medulla; Mice; Monocytes; Sodium | 2022 |
Ascorbic acid and hydrocortisone synergistically inhibit septic organ injury via improving oxidative stress and inhibiting inflammation.
Topics: Alanine; Animals; Anti-Inflammatory Agents; Ascorbic Acid; Aspartate Aminotransferases; Creatinine; | 2022 |
Riboflavin did not provide anti-inflammatory or antioxidant effects in an experimental model of sepsis.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antioxidants; Bayes Theorem; Chemokines; C | 2022 |
Soluble epoxide hydrolase inhibitor, TPPU, attenuates progression of atherosclerotic lesions and vascular smooth muscle cell phenotypic switching.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Epoxide Hydrolases; Homocysteine; Humans; Inflammation; | 2022 |
Pueraria montana (Kudzu vine) Ameliorate the Inflammation and Oxidative Stress against Fe-NTA Induced Renal Cancer.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Body Weight; Creatinine; Cyclooxygenase 2; Diethylnitrosam | 2022 |
Thalidomide modulates renal inflammation induced by brain death experimental model.
Topics: Animals; Brain Death; Creatinine; Cytokines; Disease Models, Animal; Inflammation; Interleukin-6; Ma | 2022 |
ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis.
Topics: Animals; Creatinine; Cytokines; Immune Checkpoint Proteins; Immunity; Immunomodulation; Inducible T- | 2022 |
The
Topics: Acute Kidney Injury; Amomum; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Assoc | 2022 |
Association of mean platelet volume/lymphocyte ratio with inflammation in non-dialysis patients with chronic kidney disease stages 1-4: A retrospective study.
Topics: C-Reactive Protein; Fibrinogen; Humans; Inflammation; Lymphocytes; Mean Platelet Volume; Renal Insuf | 2022 |
Association of mean platelet volume/lymphocyte ratio with inflammation in non-dialysis patients with chronic kidney disease stages 1-4: A retrospective study.
Topics: C-Reactive Protein; Fibrinogen; Humans; Inflammation; Lymphocytes; Mean Platelet Volume; Renal Insuf | 2022 |
Association of mean platelet volume/lymphocyte ratio with inflammation in non-dialysis patients with chronic kidney disease stages 1-4: A retrospective study.
Topics: C-Reactive Protein; Fibrinogen; Humans; Inflammation; Lymphocytes; Mean Platelet Volume; Renal Insuf | 2022 |
Association of mean platelet volume/lymphocyte ratio with inflammation in non-dialysis patients with chronic kidney disease stages 1-4: A retrospective study.
Topics: C-Reactive Protein; Fibrinogen; Humans; Inflammation; Lymphocytes; Mean Platelet Volume; Renal Insuf | 2022 |
Electrospun membranes of carboxylated poly(ester urethane)urea/gelatin encapsulating pterostilbene for adaptive and antioxidative purposes.
Topics: Animals; Antioxidants; Esters; Gelatin; Human Umbilical Vein Endothelial Cells; Humans; Inflammation | 2023 |
Evaluation of oxidative damage to biomolecules and inflammation in patients with urea cycle disorders.
Topics: Adolescent; Child; Child, Preschool; Cytokines; Humans; Infant; Infant, Newborn; Inflammation; Oxida | 2023 |
Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes.
Topics: Animals; Antioxidants; Apoptosis; Arsenic; Creatinine; Inflammation; Kidney; Male; Oxidative Stress; | 2023 |
Eucalcemia during lipopolysaccharide challenge in postpartum dairy cows: I. Clinical, inflammatory, and metabolic response.
Topics: 3-Hydroxybutyric Acid; Acute-Phase Proteins; Animals; Cattle; Cattle Diseases; Cytokines; Fatty Acid | 2023 |
Diagnostic Values of Laboratory Biomarkers in Predicting a Severe Course of COVID-19 on Hospital Admission.
Topics: Albumins; Biomarkers; COVID-19; COVID-19 Testing; Hospitals; Humans; Inflammation; Neutrophils; Retr | 2022 |
Systemic effect of calcium silicate-based cements with different radiopacifiers-histopathological analysis in rats.
Topics: Animals; Creatinine; Inflammation; Male; Polyethylene; Rats; Urea | 2023 |
Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea.
Topics: Animals; Arthritis; C-Reactive Protein; Camphanes; Cyclooxygenase 2; Freund's Adjuvant; Inflammation | 2023 |
N-Acetyl cysteine amide and cerium oxide nanoparticles as a drug delivery for ischemic stroke treatment: Inflammation and oxidative stress crosstalk.
Topics: Acetylcysteine; Amides; Animals; Anti-Bacterial Agents; Antioxidants; Cerium; Chitinase-3-Like Prote | 2023 |
Potential Protective Role of Rutin and Alpha-lipoic Acid Against Cisplatin-induced Nephrotoxicity in Rats.
Topics: Albumins; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cisplatin; Creatinine; Erythr | 2019 |
HIV-1 Transcription Inhibitor 1E7-03 Restores LPS-Induced Alteration of Lung Leukocytes' Infiltration Dynamics and Resolves Inflammation in HIV Transgenic Mice.
Topics: Animals; Cytokines; HIV Infections; HIV-1; Indoles; Inflammation; Lipopolysaccharides; Lung; Macroph | 2020 |
Post-Ischemic Renal Fibrosis Progression Is Halted by Delayed Contralateral Nephrectomy: The Involvement of Macrophage Activation.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Chemokine CCL2; Disease Progression; Fibrosis; In | 2020 |
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation.
Topics: Adolescent; Adult; Aged; Arginine; Aspartic Acid; Cell Survival; Citric Acid Cycle; Female; Glucose; | 2020 |
Blockade of the G-CSF Receptor Is Protective in a Mouse Model of Renal Ischemia-Reperfusion Injury.
Topics: Animals; Chemokines; Complement Activation; Creatinine; Disease Models, Animal; Gene Expression; Inf | 2020 |
Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cell Adhesion; Cyclopentanes; Dose | 2021 |
Design and synthesis of novel glycyrrhetin ureas as anti-inflammatory agents for the treatment of acute kidney injury.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Cisplatin; Drug Design; Glycyrrhetinic Acid; | 2021 |
Urea cycle pathway targeted therapeutic action of naringin against ammonium chloride induced hyperammonemic rats.
Topics: Ammonium Chloride; Animals; Biomarkers; Down-Regulation; Flavanones; Flavonoids; Hyperammonemia; Inf | 2017 |
Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Huma | 2018 |
Influence of C-reactive protein on the occurrence and assessing of albuminuria severity in diabetics.
Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Biomarkers; Blood Glucose; C-Reactive Protein; Creatini | 2018 |
Functional hepatocyte clusters on bioactive blend silk matrices towards generating bioartificial liver constructs.
Topics: Albumins; Animals; Animals, Newborn; Bombyx; Cell Adhesion; Cell Aggregation; Cell Proliferation; Ce | 2018 |
Role of dorsal hippocampal orexin-1 receptors in modulation of antinociception induced by chemical stimulation of the lateral hypothalamus.
Topics: Analgesics; Animals; Benzoxazoles; CA1 Region, Hippocampal; Carbachol; Catheters, Indwelling; Cholin | 2018 |
Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis.
Topics: Animals; Bone Marrow; CD4-Positive T-Lymphocytes; Cells, Cultured; Chemokines; Corpus Callosum; Ence | 2018 |
A novel IgG1 monoclonal antibody against xanthine oxidase alleviates inflammation induced by potassium oxonate in mice.
Topics: Allopurinol; Animals; Antibodies, Monoclonal; Antibody Affinity; Antioxidants; Creatinine; Cross Rea | 2018 |
Dietary Fermentable Fibers Attenuate Chronic Kidney Disease in Mice by Protecting the Intestinal Barrier.
Topics: Adenine; Animals; Cecum; Colon; Diet; Dietary Fiber; Dysbiosis; Fatty Acids, Volatile; Fermentation; | 2018 |
Study on the influence of caffeic acid against sodium valproate-induced nephrotoxicity in rats.
Topics: Animals; Anticonvulsants; Biomarkers; Caffeic Acids; Caspase 3; Creatinine; Inflammation; Interferon | 2018 |
Nigella sativa extract is a potent therapeutic agent for renal inflammation, apoptosis, and oxidative stress in a rat model of unilateral ureteral obstruction.
Topics: Angiotensin II; Animals; Apoptosis; Captopril; Chemokine CCL2; Creatinine; Fibrosis; Inflammation; K | 2018 |
High protein intake is associated with low plasma NAD+ levels in a healthy human cohort.
Topics: Adult; Aged; Australia; Biomarkers; Cohort Studies; Diet, High-Protein; Female; Healthy Volunteers; | 2018 |
Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Aging; Animals; Anti-Inflammatory Agents; Antioxi | 2020 |
The effect of sildenafil on rats with adenine-Induced chronic kidney disease.
Topics: Adenine; Animals; Biomarkers; Blood Pressure; Body Weight; Creatinine; Cytokines; Fibrosis; Inflamma | 2018 |
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Capsaicin; Cells, Cultured; Disease Mo | 2018 |
Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients.
Topics: Adult; Aged; Arginine; beta 2-Microglobulin; Biomarkers; C-Reactive Protein; Female; Hand Strength; | 2018 |
Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration.
Topics: Animals; Arrestins; Calcium-Binding Proteins; Cell Movement; Chemokine CCL2; Cytokines; Disease Mode | 2018 |
Malnutrition associated with inflammation in the chronic renal patient on hemodialysis.
Topics: Adult; Anthropometry; Atherosclerosis; Creatinine; Cross-Sectional Studies; Female; Humans; Inflamma | 2018 |
Renal effects of exendin-4 in an animal model of brain death.
Topics: Animals; Apoptosis; Brain Death; Creatine; Cytokines; Disease Models, Animal; Exenatide; Genes, bcl- | 2019 |
Rainbow trout (Oncorhynchus mykiss) urea cycle and polyamine synthesis gene families show dynamic expression responses to inflammation.
Topics: Animals; Fish Diseases; Gene Expression; Inflammation; Multigene Family; Oncorhynchus mykiss; Phylog | 2019 |
Chronic exposure to 35% carbamide peroxide tooth bleaching agent induces histological and hematological alterations, oxidative stress, and inflammation in mice.
Topics: Animals; Carbamide Peroxide; Drug Combinations; Humans; Hydrogen Peroxide; Inflammation; Kidney; Liv | 2019 |
Combination of oxymatrine and diammonium glycyrrhizinate significantly mitigates mice allergic contact dermatitis induced by dinitrofluorobenzene.
Topics: Alkaloids; Animals; Creatinine; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Drug Therapy, Co | 2019 |
The relationship between N-acetylcysteine, hyperbaric oxygen, and inflammation in a rat model of acetaminophen-induced nephrotoxicity.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Creatinine; F | 2013 |
Oral activated charcoal adsorbent (AST-120) ameliorates chronic kidney disease-induced intestinal epithelial barrier disruption.
Topics: Administration, Oral; Adsorption; Animals; Carbon; Claudin-1; Endotoxemia; Endotoxins; Gastrointesti | 2013 |
p38 MAP kinase inhibitors as anti inflammatory agents.
Topics: Amides; Animals; Anti-Inflammatory Agents; Arthritis; Binding Sites; Cyclooxygenase 2; Cytokines; Di | 2013 |
Polymyxin B protects against hepatic ischemia/reperfusion injury in a rat model of obstructive jaundice.
Topics: Alanine Transaminase; Animals; Anti-Bacterial Agents; Antioxidants; Apoptosis; Aspartate Aminotransf | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase.
Topics: Animals; Arginase; Arginine; Cell Line; Inflammation; Intracellular Signaling Peptides and Proteins; | 2014 |
Effects of the small-molecule inhibitor of integrin α4, TBC3486, on pre-B-ALL cells.
Topics: Animals; Antineoplastic Agents; Coculture Techniques; Drug Resistance, Neoplasm; Humans; Inflammatio | 2014 |
Oxidative status parameters in children with urinary tract infection.
Topics: Acute Kidney Injury; Antioxidants; C-Reactive Protein; Child; Child, Preschool; Colony Count, Microb | 2014 |
Platelet factor 4 protects kidney allograft in a rat kidney transplantation model.
Topics: Allografts; Animals; Cell Differentiation; Cells, Cultured; Creatinine; Fibrosis; Graft Rejection; I | 2015 |
Relationship between leptin and chronic inflammatory state in uremic patients.
Topics: Adult; Aged; Body Mass Index; Female; Humans; Inflammation; Inflammation Mediators; Leptin; Male; Mi | 2014 |
Chronotherapeutic effect of fisetin on expression of urea cycle enzymes and inflammatory markers in hyperammonaemic rats.
Topics: Ammonium Chloride; Animals; Antioxidants; Biomarkers; Blotting, Western; Brain; Drug Chronotherapy; | 2014 |
Comparison of inflammatory responses and muscle damage indices following a soccer, basketball, volleyball and handball game at an elite competitive level.
Topics: Adult; Ammonia; Basketball; Biomarkers; C-Reactive Protein; Case-Control Studies; Creatine Kinase; C | 2015 |
Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blotting, Western; Catalase; Collagen Type I; Creat | 2016 |
Ameliorative effect of chrysin on adenine-induced chronic kidney disease in rats.
Topics: Acetylglucosaminidase; Adenine; Animals; Antioxidants; Creatinine; Disease Models, Animal; Fibrosis; | 2015 |
Characterisation of Atherogenic Effects of Low Carbohydrate, High Protein Diet (LCHP) in ApoE/LDLR-/- Mice.
Topics: Acute-Phase Reaction; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Brachiocephalic Trunk; Cho | 2015 |
Comparison of the Therapeutic Effects of Thymoquinone and Methotrexate on Renal Injury in Pristane Induced Arthritis in Rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Creati | 2015 |
Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Blood Urea Nitrogen; Cell Line; Cell | 2015 |
Impact of Hydroxychloroquine on Atherosclerosis and Vascular Stiffness in the Presence of Chronic Kidney Disease.
Topics: Animals; Aorta; Atherosclerosis; Bilirubin; Blood Glucose; Elasticity; Hydroxychloroquine; Inflammat | 2015 |
Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-κB in renal tubular epithelial cells.
Topics: Angiotensin II; Animals; Antioxidants; Chemokine CCL2; Cofilin 1; Creatinine; Cytoskeleton; Epitheli | 2015 |
Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition.
Topics: Chronic Pain; Drug Design; Humans; Inflammation; Inhibitory Concentration 50; Neoplasms; Neuralgia; | 2016 |
Prolonged Pulmonary Exposure to Diesel Exhaust Particles Exacerbates Renal Oxidative Stress, Inflammation and DNA Damage in Mice with Adenine-Induced Chronic Renal Failure.
Topics: Adenine; Animals; Antioxidants; Blood Pressure; Body Weight; Catalase; Creatinine; DNA Damage; Femal | 2016 |
Antioxidant, Antiapoptotic and Inflammatory Effects of Interleukin-18 Binding Protein on Kidney Damage Induced by Hepatic Ischemia Reperfusion.
Topics: Acute Kidney Injury; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Caspase | 2016 |
Development and characterization of solid dispersion-microsphere controlled release system for poorly water-soluble drug.
Topics: Administration, Oral; Animals; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Flurbipr | 2016 |
Evaluation of inflammation during fixed orthodontic treatment.
Topics: Adolescent; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Biomarkers; C-R | 2016 |
Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Behavior, Animal; Endocannabinoids; Female; G | 2016 |
Combination of Vildagliptin and Pioglitazone in Experimental Type 2 Diabetes in Male Rats.
Topics: Adamantane; Animals; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2016 |
Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase.
Topics: Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Adhesion; Cell Line, T | 2016 |
Incorporation of amoxicillin-loaded organic montmorillonite into poly(ester-urethane) urea nanofibers as a functional tissue engineering scaffold.
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Bentonite; Cell Line; Cell Proliferation; Delayed-Actio | 2017 |
Landiolol, an ultrashort-acting beta1-adrenoceptor antagonist, has protective effects in an LPS-induced systemic inflammation model.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Blotting, Western; Disease Models, Animal; Hea | 2009 |
Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models.
Topics: Analgesics; Aniline Compounds; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fr | 2009 |
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia.
Topics: Analgesics; Animals; Body Temperature; Bone Neoplasms; Calcium; Disease Models, Animal; Drug Interac | 2009 |
Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Benzoates; | 2009 |
Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Body Weight; Chronic Disease | 2009 |
The effects of the TRPV1 receptor antagonist SB-705498 on trigeminovascular sensitisation and neurotransmission.
Topics: Analgesics; Animals; Blood Pressure; Cats; Cerebrovascular Circulation; Disease Models, Animal; Dura | 2009 |
A selective, high affinity 5-HT 2B receptor antagonist inhibits visceral hypersensitivity in rats.
Topics: Analysis of Variance; Animals; Colon; Dose-Response Relationship, Drug; Hypersensitivity; Indoles; I | 2010 |
Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asp | 2010 |
A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice.
Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Respo | 2010 |
Tumor necrosis factor-alpha acutely up-regulates urea synthesis in vivo in rats--a hepatic component of inflammatory catabolism?
Topics: Acute-Phase Proteins; Animals; Blood Glucose; Corticosterone; Female; Glucagon; Inflammation; Insuli | 2010 |
Effects of SA13353, a transient receptor potential vanilloid 1 agonist, on leukocyte infiltration in lipopolysaccharide-induced acute lung injury and ovalbumin-induced allergic airway inflammation.
Topics: Animals; Inflammation; Leukocytes; Lipopolysaccharides; Lung; Mice; Ovalbumin; Pyridines; Trachea; T | 2010 |
The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice.
Topics: Abdominal Pain; Aggression; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non | 2011 |
Potent in vivo suppression of inflammation by selectively targeting the high affinity conformation of integrin α4β1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; Hypersensitivity; Inflammation; Integrin a | 2010 |
Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.
Topics: Amygdala; Animals; Behavior, Animal; Dipeptides; Disease Models, Animal; Excitatory Postsynaptic Pot | 2010 |
[Loss of weight in hemodialysis patients after hospitalization is related with length of stay and degree of inflammation].
Topics: Adult; Aged; Aged, 80 and over; Comorbidity; Creatinine; Diabetic Nephropathies; Female; Hospitaliza | 2010 |
Analyte flux at a biomaterial-tissue interface over time: implications for sensors for type 1 and 2 diabetes mellitus.
Topics: Adult; Aged; Biocompatible Materials; Biopsy; Biosensing Techniques; Diabetes Mellitus, Type 1; Diab | 2010 |
Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer.
Topics: Animals; Behavior, Animal; Brain Edema; Cell Culture Techniques; Cell Line, Tumor; Disease Models, A | 2011 |
Modulation of NF-κB and FOXOs by baicalein attenuates the radiation-induced inflammatory process in mouse kidney.
Topics: Animals; Antioxidants; Catalase; Creatinine; Extracellular Signal-Regulated MAP Kinases; Flavanones; | 2011 |
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
Topics: Amidohydrolases; Animals; Enzyme Inhibitors; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; P | 2011 |
Effect of orexin-A on phagocytic activity of peritoneal macrophage in starved rats.
Topics: Animals; Benzoxazoles; Chondrus; Exudates and Transudates; Fasting; Inflammation; Intracellular Sign | 2011 |
L-arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Arginine; Cell Line; Cell Survival; Cells, Cultured; | 2011 |
Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Cytosol; Eicosanoids; Enzyme | 2012 |
Anti-inflammatory effects of LASSBio-998, a new drug candidate designed to be a p38 MAPK inhibitor, in an experimental model of acute lung inflammation.
Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Respon | 2011 |
PAR-1-dependent and PAR-independent pro-inflammatory signaling in human lung fibroblasts exposed to thrombin.
Topics: Cells, Cultured; Chemokine CCL2; ErbB Receptors; Fibroblasts; Gene Expression Regulation; Humans; In | 2012 |
Maintenance of rat hepatocytes under inflammation by coculture with human orbital fat-derived stem cells.
Topics: Adipose Tissue; Albumins; Animals; Cell Differentiation; Cell Survival; Coculture Techniques; Cytoch | 2012 |
[Effects of soluble epoxide hydrolase inhibitors on the expression of fatty acid synthase in peripheral blood mononuclear cell of patients and inflammatory response with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Aged; Benzoates; Case-Control Studies; Epoxide Hydrolases; Fatty Acid Synth | 2012 |
Effect of resistance training during Ramadan on body composition and markers of renal function, metabolism, inflammation, and immunity in recreational bodybuilders.
Topics: Adult; Biomarkers; Body Composition; Body Mass Index; Carbon Dioxide; Cholesterol, LDL; Creatinine; | 2012 |
Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hyd | 2013 |
Changes in the hepatic mitochondrial and membrane proteome in mice fed a non-alcoholic steatohepatitis inducing diet.
Topics: Animals; Cations; Cell Membrane; Cholesterol; Diet; Disease Models, Animal; Electrophoresis, Gel, Tw | 2013 |
Association of body fat with inflammation in peritoneal dialysis.
Topics: Adipose Tissue; Adiposity; Body Composition; Body Height; Body Mass Index; Body Weight; C-Reactive P | 2013 |
Effect of gum arabic on oxidative stress and inflammation in adenine-induced chronic renal failure in rats.
Topics: Adenine; Animals; Creatinine; Gum Arabic; Histones; Immunohistochemistry; Inflammation; Interleukin- | 2013 |
[On the antiphlogistic effect of 3-phenylpropyl carbamate (MH 532), a new central muscle relaxant with tranquilizing properties].
Topics: Carbamates; Hypnotics and Sedatives; Inflammation; Muscle Relaxants, Central; Tranquilizing Agents; | 1959 |
[On the antiphlogistic effect of gamma-phenylpropyl carbamate and some of its derivatives].
Topics: Carbamates; Humans; Inflammation; Muscle Relaxants, Central; Tranquilizing Agents; Urea | 1960 |
Hypotensive effect of urea in inflamed and noninflamed eye.
Topics: Eye Diseases; Inflammation; Intraocular Pressure; Tonometry, Ocular; Urea | 1962 |
THE EFFECT OF INFLAMMATION ON THE PERMEABILITY OF HUMAN PALATAL EPITHELIUM TO UREA.
Topics: Epithelium; Geriatrics; Humans; Inflammation; Mouth Mucosa; Mouth, Edentulous; Palate; Permeability; | 1964 |
Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPbeta gene.
Topics: Adenoviridae; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromodeoxyuridine; Carbon | 2005 |
Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
Topics: Animals; Biological Availability; Caco-2 Cells; Calcium; Chemotaxis, Leukocyte; CHO Cells; Cricetina | 2005 |
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
Topics: Acute Disease; Analgesics; Animals; Capsaicin; Carrageenan; Chronic Disease; Dose-Response Relations | 2005 |
Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property.
Topics: Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Boswellia; Cell Proliferation; Cell Sur | 2005 |
Soluble epoxide hydrolase is a therapeutic target for acute inflammation.
Topics: Adamantane; Animals; Arachidonic Acids; Blood Pressure; Chromatography, High Pressure Liquid; Cytoki | 2005 |
Effects of the celecoxib on the acute necrotizing pancreatitis in rats.
Topics: Animals; Celecoxib; Ceruletide; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Glycodeoxy | 2004 |
Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists.
Topics: Calcium; Cell Line; Chemistry, Pharmaceutical; Chemokine CXCL11; Chemokines, CXC; Chemotaxis; Dose-R | 2006 |
In hepatocytes the regulation of NOS-2 activity at physiological L-arginine levels suggests a close link to the urea cycle.
Topics: Amino Acid Transport Systems, Basic; Animals; Arginase; Arginine; Base Sequence; Cells, Cultured; Cy | 2006 |
Proinflammatory changes in human umbilical cord vein endothelial cells can be induced neither by native nor by modified CRP.
Topics: Atherosclerosis; C-Reactive Protein; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial | 2006 |
Influence of bradykinin B1 and B2 receptors in the immune response triggered by renal ischemia-reperfusion injury.
Topics: Animals; Chemokine CCL2; Creatine; Gene Expression; Heme Oxygenase-1; Inflammation; Kidney; Male; Mi | 2006 |
Cytokine-mediated regulation of urea transporters during experimental endotoxemia.
Topics: Animals; Cytokines; Dexamethasone; Diuresis; Dose-Response Relationship, Drug; Endotoxemia; Gene Exp | 2007 |
The metabolic changes caused by dexamethasone in the adjuvant-induced arthritic rat.
Topics: Alanine; Ammonia; Animals; Arthritis, Experimental; Blood Glucose; Body Weight; Dexamethasone; Fasti | 2007 |
MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.
Topics: Animals; Arginase; Arginine; Cell Cycle Proteins; Cell Line; Dual Specificity Phosphatase 1; Gene Ex | 2007 |
Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model.
Topics: Analgesics; Animals; Inflammation; Methylation; Models, Biological; Pain; Rats; TRPV Cation Channels | 2007 |
Therapy of anemia in kidney failure, using plasmid encoding erythropoietin.
Topics: Anemia; Animals; Creatinine; Disease Models, Animal; Erythropoietin; Female; Genetic Therapy; Inflam | 2008 |
Significance of extreme elevation of erythrocyte sedimentation rate.
Topics: Blood Protein Electrophoresis; Blood Sedimentation; Bone Marrow Examination; Collagen Diseases; Hema | 1967 |
Changes in plasma, tissue, and urinary nitrogen metabolites due to an inflammatory challenge.
Topics: Amino Acids; Ammonia; Animals; Chickens; Erythrocytes; Escherichia coli; Hemocyanins; Inflammation; | 1984 |
Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators.
Topics: Acyltransferases; Animals; Benzenesulfonates; Cells, Cultured; Enzyme Inhibitors; Humans; Imidazoles | 1995 |
Changes in inflammation-related blood constituents of mastitic cows.
Topics: Alkaline Phosphatase; Animals; Biomarkers; Cattle; Cyclic AMP; Dinoprostone; Electric Conductivity; | 1996 |
Regional drug delivery I: permeability characteristics of the rat 6-day-old air pouch model of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Delivery Systems; Ibuprofen; Inflammation; Mo | 1995 |
The effect of propolis and its components on eicosanoid production during the inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arachidonic Acid; Caffeic Acids; Cyclooxygenase Inh | 1996 |
Studies on 5-lipoxygenase inhibitors. I. Synthesis and 5-lipoxygenase-inhibitory activity of novel hydroxamic acid derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Galactosamine; Hepatitis, Animal; H | 1998 |
Chronic protein undernutrition and an acute inflammatory stimulus elicit different protein kinetic responses in plasma but not in muscle of piglets.
Topics: Animals; Blood Proteins; Deuterium; Dietary Proteins; Female; Fibrin; Fibrinogen; Inflammation; Insu | 1999 |
Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus.
Topics: Adult; Albumins; Asthma; Body Water; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoscopy; Collagenas | 1999 |
An evaluative system for the response of antibacterial therapy: based on the morphological change of Helicobacter pylori and mucosal inflammation.
Topics: Anti-Bacterial Agents; Biopsy; Breath Tests; Evaluation Studies as Topic; Female; Follow-Up Studies; | 1999 |
Effect of Withania somnifera on cyclophosphamide-induced urotoxicity.
Topics: Animals; Blood Proteins; Cyclophosphamide; Glutathione; Inflammation; Liver; Mice; Nitrogen; Phytoth | 2000 |
Association of reactive nitrogen species metabolites, myeloperoxidase, and airway inflammation in lung transplants.
Topics: Adult; Aged; Biomarkers; Bronchoalveolar Lavage Fluid; Enzyme-Linked Immunosorbent Assay; Female; Hu | 2001 |
Nasal lavage as a tool for the assessment of upper-airway inflammation in adults and children.
Topics: Adolescent; Adult; Albumins; alpha 1-Antitrypsin; Biomarkers; Cell Count; Child; Enzyme-Linked Immun | 2002 |
[Urea soluble fraction of bovine melanin associated antigen and experimental study on its uveitogenic activity].
Topics: Adjuvants, Immunologic; Animals; Autoantigens; Autoimmune Diseases; Cattle; Ciliary Body; Disease Mo | 2002 |
Identification of diacylated ureas as a novel family of fungus-specific leukocyte-activating pathogen-associated molecules.
Topics: Acylation; Calcium Signaling; Humans; Inflammation; Magnetic Resonance Spectroscopy; Molecular Struc | 2002 |
[Studies on the influence of an artifically induced inflammatory reaction by creatinine, urea and guanidine injection (author's transl)].
Topics: Animals; Creatinine; Disease Models, Animal; Drug Antagonism; Drug Interactions; Edema; Formaldehyde | 1975 |
Hyperosmolality impairs ammonia-mediated inflammation: implications for the renal medulla.
Topics: Ammonia; Animals; Cell Degranulation; Complement C3; Humans; Inflammation; Kidney Medulla; Neutrophi | 1992 |
Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes.
Topics: Adult; Albumins; Antigens; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell | 1991 |
Action of dexamethasone in an equine model of acute non-immune inflammation.
Topics: Animals; Blood Cell Count; Blood Glucose; Cholesterol; Dexamethasone; Dexamethasone Isonicotinate; D | 1990 |
The acute-phase response of the brain-injured patient.
Topics: Acute-Phase Reaction; Adolescent; Adult; Aged; Blood Proteins; Body Temperature; Brain Injuries; Cop | 1988 |
[Results of several blood studies in sows with acute urinary tract inflammation].
Topics: Acute Disease; Animals; Blood Proteins; Creatinine; Female; Inflammation; Swine; Swine Diseases; Ure | 1988 |
Inhibition of cathepsin D-type proteinase of macrophages by pepstatin, a specific pepsin inhibitor, and other substances.
Topics: Acetophenones; Animals; Ascitic Fluid; Barbiturates; Butanones; Cathepsins; Cattle; Chelating Agents | 1973 |
Intestinal ammonia in uraemia: the effect of a urease inhibitor, acetohydroxamic acid.
Topics: Ammonia; Animals; Blood Proteins; Cecum; Colitis; Colon; Edema; Erythrocytes; Hydroxamic Acids; Infl | 1972 |
Chemical similarity among amyloid substances associated with long standing inflammation.
Topics: Acrylamides; Adult; Aged; Amino Acid Sequence; Amyloid; Amyloidosis; Arthritis, Juvenile; Arthritis, | 1972 |
Primary malignant melanoma of the skin metastatic to the eye.
Topics: Adult; Blindness; Eye; Eye Neoplasms; Female; Humans; Inflammation; Male; Melanoma; Middle Aged; Neo | 1972 |
Renal dysplasia. I. A clinico-pathological study of 76 cases.
Topics: Cartilage; Child; Child, Preschool; Chronic Disease; Epithelium; Female; Humans; Hydronephrosis; Inf | 1971 |
[Multicausal diseases].
Topics: Allergens; Animals; Body Temperature; Calcinosis; Cold Temperature; Drug Therapy; Glucocorticoids; G | 1967 |
[Postoperative changes in the water-salt balance in patients undergoing surgery in connection with diseases of organs of the chest cavity].
Topics: Cardiac Surgical Procedures; Chlorides; Creatinine; Esophageal Neoplasms; Hematuria; Humans; Inflamm | 1968 |
Studies on the pathogenesis of acute inflammation. VII. The influence of osmolality upon the phagocytic and clumping activity by human leukocytes.
Topics: Glucose; Hemagglutination; Humans; In Vitro Techniques; Inflammation; Leukocytes; Mannitol; Neutroph | 1966 |