Page last updated: 2024-10-21

urea and Infant, Premature, Diseases

urea has been researched along with Infant, Premature, Diseases in 13 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Infant, Premature, Diseases: Diseases that occur in PREMATURE INFANTS.

Research Excerpts

ExcerptRelevanceReference
"To determine whether premature infants who have necrotizing enterocolitis (NEC) have deficiencies in glutamine (GLN) and arginine (ARG), which are essential to intestinal integrity."3.70Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. ( Becker, RM; Bose, CL; Chen, W; Galanko, JA; Maynor, AR; Rhoads, JM; Wu, G, 2000)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19908 (61.54)18.7374
1990's1 (7.69)18.2507
2000's4 (30.77)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gawlowski, Z1
Aladangady, N1
Coen, PG1
Thayyil, S1
Sheik, S1
Kempley, ST1
Sinha, A1
Arad, ID1
Eyal, FG1
Jaeken, J1
Devlieger, H1
Evens, M1
Casaer, P1
Eggermont, E1
Mathew, OP1
Jones, AS1
James, E1
Bland, H1
Groshong, T1
Sann, L1
Dellamonica, C1
Miall, LS1
Henderson, MJ1
Turner, AJ1
Brownlee, KG1
Brocklebank, JT1
Newell, SJ1
Allgar, VL1
Bos, AF1
van Asselt, WA1
Okken, A1
Becker, RM1
Wu, G1
Galanko, JA1
Chen, W1
Maynor, AR1
Bose, CL1
Rhoads, JM1
Zobel, G1
Ring, E1
Müller, W1
Hofert, C1
Panteliadis, C1
Dolif, D1
Jürgens, P1
Johnson, JD1
Albritton, WL1
Sunshine, P1
Poliakova, GP1
Nikitina, II1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Early Sodium Intake in Preterm Newborns; Randomized Clinical Trial[NCT04035564]Phase 452 participants (Actual)Interventional2018-03-30Completed
Predicting Acute Kidney Injury in Infants Exposed to Nephrotoxic Drugs: A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs. (NeoAKI STOP)[NCT05851222]4,200 participants (Anticipated)Observational2023-08-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

% Weight Change

The difference between initial weight and 72hrs weight, expressed in percentage of birth weight. (NCT04035564)
Timeframe: Initial weight (baseline) vs 72 hours

Intervention% of birth weight (Mean)
Sodium < 1mEq/kg/Day-9.206
Sodium 5mEq/kg/Day-6.345

Change in Serum Sodium

The difference between current serum sodium and initial serum sodium (NCT04035564)
Timeframe: Initial serum sodium (baseline) vs 72 hours

InterventionmEq/L (Mean)
Sodium < 1mEq/kg/Day1.921
Sodium 5mEq/kg/Day5.71

Hypernatremia

serum sodium >150mEq/L (NCT04035564)
Timeframe: 72 hours

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day1
Sodium 5mEq/kg/Day1

Hyponatremia

serum sodium <130mEq/L (NCT04035564)
Timeframe: 72 hours

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day6
Sodium 5mEq/kg/Day1

Mortality

Death during hospitalization. (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day5
Sodium 5mEq/kg/Day2

Number of Participants With Intraventricular Hemorrhage

Bleeding into the brain´s ventricular system (intracranial ultrasound). (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day6
Sodium 5mEq/kg/Day4

Number of Participants With Late-onset Sepsis

Positive blood culture and/or 5 days of continuous antimicrobial therapy (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day8
Sodium 5mEq/kg/Day5

Number of Participants With Necrotizing Enterocolitis

"Number of patients with Bell stage II or greater necrotizing enterocolitis~Bell's Staging:~Stage II A:~Gastrointestinal signs: Increasing gastric aspirates, mild abdominal distention, fecal occult blood, absent bowel sounds.~Systemic signs: Temperature instability, apnea, bradycardia, lethargy. Radiological findings: Intestinal dilatation, ileus, pneumatosis intestinalis.~Stage II B:~Gastrointestinal signs: As stage IIA plus abdominal tenderness. Systemic signs: As stage IIA plus metabolic acidosis and thrombocytopenia. Radiological findings: As stage IIA plus portal vein gas and ascites.~Stage III A:~Gastrointestinal signs: As stage IIB plus marked abdominal tenderness and generalised peritonitis.~Systemic signs: As stage IIB plus hypotension and severe apnea. Radiological findings: As stage IIB~Stage III B:~Gastrointestinal signs: As stage IIIA As stage IIIA As stage IIIA plus pneumoperitoneum" (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

InterventionParticipants (Count of Participants)
Sodium < 1mEq/kg/Day2
Sodium 5mEq/kg/Day2

Weight Change

The difference between current weight and initial weight (NCT04035564)
Timeframe: Initial weight (baseline) vs 72 hours

InterventionGrams (Mean)
Sodium < 1mEq/kg/Day-135.43
Sodium 5mEq/kg/Day-96.05

Other Studies

13 other studies available for urea and Infant, Premature, Diseases

ArticleYear
Hypernatraemia in preterm infants born at less than 27 weeks gestation.
    Journal of paediatrics and child health, 2006, Volume: 42, Issue:12

    Topics: Birth Weight; Creatine; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Female; Fluid Therapy

2006
A gestation- and postnatal age-based reference chart for assessing renal function in extremely premature infants.
    Journal of perinatology : official journal of the California Perinatal Association, 2008, Volume: 28, Issue:3

    Topics: Acute Kidney Injury; Creatinine; Glomerular Filtration Rate; Humans; Infant, Newborn; Infant, Premat

2008
High plasma ascorbic acid levels in premature neonates with intraventricular hemorrhage.
    American journal of diseases of children (1960), 1983, Volume: 137, Issue:10

    Topics: Apgar Score; Ascorbic Acid; Biological Transport, Active; Birth Weight; Cerebral Hemorrhage; Gestati

1983
[Neonatal hyperammonemia].
    Tijdschrift voor kindergeneeskunde, 1983, Volume: 51, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Argininosuccinic Aciduria; Carbamoyl-Phosphate Syntha

1983
Neonatal renal failure: usefulness of diagnostic indices.
    Pediatrics, 1980, Volume: 65, Issue:1

    Topics: Acute Kidney Injury; Anuria; Creatine; Diagnosis, Differential; Gestational Age; Humans; Infant, New

1980
Hyperammonemia in hypoglycemic preterm neonates.
    Biology of the neonate, 1983, Volume: 44, Issue:1

    Topics: Alanine; Ammonia; Blood Glucose; Blood Urea Nitrogen; Gluconeogenesis; Humans; Hypoglycemia; Infant,

1983
Plasma creatinine rises dramatically in the first 48 hours of life in preterm infants.
    Pediatrics, 1999, Volume: 104, Issue:6

    Topics: Birth Weight; Creatinine; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Infant, Premature;

1999
Dexamethasone treatment and fluid balance in preterm infants at risk for chronic lung disease.
    Acta paediatrica (Oslo, Norway : 1992), 2000, Volume: 89, Issue:5

    Topics: Anti-Inflammatory Agents; Blood Glucose; Blood Pressure; Chronic Disease; Creatinine; Dexamethasone;

2000
Reduced serum amino acid concentrations in infants with necrotizing enterocolitis.
    The Journal of pediatrics, 2000, Volume: 137, Issue:6

    Topics: Age Factors; Arginine; Chromatography, High Pressure Liquid; Cohort Studies; Enterocolitis, Necrotiz

2000
Continuous arteriovenous hemofiltration in premature infants.
    Critical care medicine, 1989, Volume: 17, Issue:6

    Topics: Acute Kidney Injury; Blood Pressure; Body Weight; Creatinine; Hemofiltration; Humans; Infant, Newbor

1989
[Parenteral feeding of premature infants (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1973, Volume: 121, Issue:8

    Topics: Acetates; Amino Acids; Blood Urea Nitrogen; Chlorides; Dietary Fats; Emulsions; Fructose; Humans; In

1973
Hyperammonemia accompanying parenteral nutrition in newborn infants.
    The Journal of pediatrics, 1972, Volume: 81, Issue:1

    Topics: Ammonia; Arginine; Body Weight; Dietary Proteins; Humans; Infant Nutritional Physiological Phenomena

1972
[Blood content and urinary excretion of the end products of protein metabolism in newborn infants born to mothers with diabetes mellitus].
    Voprosy okhrany materinstva i detstva, 1973, Volume: 18, Issue:9

    Topics: Blood Urea Nitrogen; Circadian Rhythm; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; I

1973