urea has been researched along with Hyponatremia in 133 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Hyponatremia: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical trial confirmed the better palatability of the commercial oral urea formulation, containing citrus flavor, which therefore represents a therapeutic strategy that could improve adherence to the therapy in chronic patients with hyponatremia." | 9.69 | Palatability of two different formulations of urea for the treatment of hyponatremia: A double-blind, randomized, cross-over study. ( Colombo, F; Milani, M, 2023) |
| "These preliminary data show that urea appears to be an effective therapeutic approach for the polydipsiahyponatremia syndrome." | 9.11 | Treatment of the polydipsia-hyponatremia syndrome with urea. ( Decaux, G; Musch, W; Verhoeven, A, 2005) |
| "Small case series conducted in Europe since the early 1980s suggest that urea, an oral osmotic diuretic that increases urinary water excretion, is safe and effective for the treatment of chronic hyponatremia." | 9.05 | Urea for Chronic Hyponatremia. ( Rondon-Berrios, H, 2020) |
| " Following failed attempts to correct hyponatremia with fluid restriction and other therapeutics, urea normalized sodium levels and allowed liberalization of formula volumes, which resulted in improved weight gain." | 8.31 | Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1. ( Cui, J; Halpin, K; Paprocki, E, 2023) |
| "We retrospectively analysed 36 cancer patients affected by moderate or profound SIAD-induced chronic hyponatremia, who started oral urea (initial daily dose 15 g or 30 g) without fluid restriction between July 2013 and July 2018." | 7.91 | Urea in cancer patients with chronic SIAD-induced hyponatremia: Old drug, new evidence. ( Arvat, E; Castellana, E; Cattel, F; D'Angelo, V; Grossi, E; Nervo, A; Rosso, D, 2019) |
| "In our Department, enteral urea is routinely administered to patients with acute brain injury who develop hyponatremia consistent with SIADH and do not respond to an initial sodium load." | 7.85 | Early Effects of Enteral Urea on Intracranial Pressure in Patients With Acute Brain Injury and Hyponatremia. ( Annoni, F; Brimioulle, S; Creteur, J; Fontana, V; Taccone, FS; Vincent, JL, 2017) |
| "Once the standard of care for cerebral edema, urea can also be used to treat hyponatremia." | 7.81 | Urea for hyponatremia? ( Hix, JK; Silver, SM; Sterns, RH, 2015) |
| " The first one is represented by a retrospective study of 50 consecutive patients with mild hyponatremia treated with urea." | 7.76 | Treatment of euvolemic hyponatremia in the intensive care unit by urea. ( Andres, C; Decaux, G; Gankam Kengne, F; Soupart, A, 2010) |
| "We report the successful use of oral urea in the management of children with chronic syndrome of inappropriate antidiuretic hormone secretion (SIAD)." | 7.73 | Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. ( Feldman, BJ; Geller, DH; Gitelman, SE; Huang, EA; Rosenthal, SM; Schwartz, ID, 2006) |
| "It was recently demonstrated that renal failure and exogenous urea prevent myelinolysis induced by rapid correction of experimental hyponatremia." | 7.71 | Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. ( Decaux, G; Schroöeder, B; Silver, S; Soupart, A; Sterns, R, 2002) |
| "We analyzed the serum anion gap (AG = sodium plus potassium minus chloride plus bicarbonate, N = 11-21 mEq/l), serum uric acid and urea concentrations in hyponatremia of various origins." | 7.69 | Uric acid, anion gap and urea concentration in the diagnostic approach to hyponatremia. ( Brimioulle, S; Coffernils, M; Decaux, G; Namias, B; Prospert, F; Schlesser, M; Soupart, A, 1994) |
| "We have studied the efficiency of urea in the treatment of hyponatremia and hydrosaline retention in a 76-year-old man with chronic ischemic congestive heart failure." | 7.67 | Urea treatment for water retention in hyponatremic congestive heart failure. ( Cauchie, P; Decaux, G; Vincken, W, 1987) |
| "We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics." | 7.67 | Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. ( Cauchie, P; Decaux, G; Delwiche, F; Flamion, B; Mols, P, 1986) |
| "Hyponatremia is a common electrolyte disorder that carries significant morbidity and mortality." | 5.42 | Urea minimizes brain complications following rapid correction of chronic hyponatremia compared with vasopressin antagonist or hypertonic saline. ( Couturier, BS; Decaux, G; Gankam Kengne, F; Soupart, A, 2015) |
| "Myoinositol-treated animals had significantly fewer demyelinating lesions than mannitol (2." | 5.33 | Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. ( Rojiani, AM; Schroeder, BM; Silver, SM; Sterns, RH, 2006) |
| "Reported successes in the treatment of hyponatremia due to SIADH by administration of urea and normal saline led to the authors' routine use of this therapy for hyponatremic neurosurgical patients." | 5.28 | Administration of intravenous urea and normal saline for the treatment of hyponatremia in neurosurgical patients. ( Harbaugh, RE; Reeder, RF, 1989) |
| " Urea and vaptans can be effective treatments for the syndrome of inappropriate antidiuresis and hyponatremia in patients with heart failure, but have adverse effects (eg, poor palatability and gastric intolerance with urea; and overly rapid correction of hyponatremia and increased thirst with vaptans)." | 5.22 | Diagnosis and Management of Hyponatremia: A Review. ( Adrogué, HJ; Madias, NE; Tucker, BM, 2022) |
| "These preliminary data show that urea appears to be an effective therapeutic approach for the polydipsiahyponatremia syndrome." | 5.11 | Treatment of the polydipsia-hyponatremia syndrome with urea. ( Decaux, G; Musch, W; Verhoeven, A, 2005) |
| "Small case series conducted in Europe since the early 1980s suggest that urea, an oral osmotic diuretic that increases urinary water excretion, is safe and effective for the treatment of chronic hyponatremia." | 5.05 | Urea for Chronic Hyponatremia. ( Rondon-Berrios, H, 2020) |
| "Urea has been recently proposed for the management of hyponatremia linked to the syndrome of inappropriate secretion of ADH (SIADH)." | 4.90 | Urea for management of the syndrome of inappropriate secretion of ADH: A systematic review. ( de Solà-Morales, O; Riera, M, 2014) |
| "Approaches, such as vasopressin receptor antagonists or urea, have been shown to reverse moderate hyponatremia." | 4.89 | Hyponatremia: an update on current pharmacotherapy. ( Schrier, RW; Shchekochikhin, D; Tkachenko, O, 2013) |
| "Malignancy; liver cirrhosis; dialysis treatment; increased Charlson comorbidity index, urea, and C-reactive protein values and the use of antineoplastic drugs are associated with mortality." | 4.31 | Risk factors and mortality in elderly patients with severe hyponatremia admitted to the emergency department. ( Bozkurt Babuş, S; Erdoğan, S; İyikesici, F; Kiraz, M; Köse, A, 2023) |
| " Following failed attempts to correct hyponatremia with fluid restriction and other therapeutics, urea normalized sodium levels and allowed liberalization of formula volumes, which resulted in improved weight gain." | 4.31 | Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1. ( Cui, J; Halpin, K; Paprocki, E, 2023) |
| " Anorexia and the combination of thiazide together with furosemide, rather than thiazide use alone, were risk factors for hypovolemic hyponatremia without affecting FE-UA." | 4.12 | Thiazide-associated hyponatremia in internal medicine patients: analysis of epidemiological and biochemical profiles. ( Klhůfek, J; Šálek, T, 2022) |
| " The risk factors at admission associated with CE development were high serum urea levels, hyponatremia, and hypocapnia." | 3.96 | Prevalence of cerebral edema among diabetic ketoacidosis patients. ( Balboa, R; Ferraro, M; González Pannia, P; Mannucci, C; Navarro, R; Nocita, MF, 2020) |
| "We retrospectively analysed 36 cancer patients affected by moderate or profound SIAD-induced chronic hyponatremia, who started oral urea (initial daily dose 15 g or 30 g) without fluid restriction between July 2013 and July 2018." | 3.91 | Urea in cancer patients with chronic SIAD-induced hyponatremia: Old drug, new evidence. ( Arvat, E; Castellana, E; Cattel, F; D'Angelo, V; Grossi, E; Nervo, A; Rosso, D, 2019) |
| "In our Department, enteral urea is routinely administered to patients with acute brain injury who develop hyponatremia consistent with SIADH and do not respond to an initial sodium load." | 3.85 | Early Effects of Enteral Urea on Intracranial Pressure in Patients With Acute Brain Injury and Hyponatremia. ( Annoni, F; Brimioulle, S; Creteur, J; Fontana, V; Taccone, FS; Vincent, JL, 2017) |
| "Urea administration appears useful for the treatment of SIADH-associated hyponatremia in critically ill patients." | 3.78 | Treatment of the syndrome of inappropriate secretion of antidiuretic hormone with urea in critically ill patients. ( Bankir, L; Biston, P; Coussement, J; Danguy, C; Defrance, P; Piagnerelli, M; Zouaoui-Boudjeltia, K, 2012) |
| "We report the successful use of oral urea in the management of children with chronic syndrome of inappropriate antidiuretic hormone secretion (SIAD)." | 3.73 | Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. ( Feldman, BJ; Geller, DH; Gitelman, SE; Huang, EA; Rosenthal, SM; Schwartz, ID, 2006) |
| "It was recently demonstrated that renal failure and exogenous urea prevent myelinolysis induced by rapid correction of experimental hyponatremia." | 3.71 | Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. ( Decaux, G; Schroöeder, B; Silver, S; Soupart, A; Sterns, R, 2002) |
| "The high fractional excretion (FE) of uric acid observed in hyponatremia associated with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is commonly attributed to the volume-expanded state, although volume expansion in normonatremic volunteers is unable to increase urate clearance to a degree similar to that in SIADH." | 3.70 | Evidence that chronicity of hyponatremia contributes to the high urate clearance observed in the syndrome of inappropriate antidiuretic hormone secretion. ( Decaux, G; Musch, W; Prospert, F; Soupart, A, 2000) |
| "We analyzed the serum anion gap (AG = sodium plus potassium minus chloride plus bicarbonate, N = 11-21 mEq/l), serum uric acid and urea concentrations in hyponatremia of various origins." | 3.69 | Uric acid, anion gap and urea concentration in the diagnostic approach to hyponatremia. ( Brimioulle, S; Coffernils, M; Decaux, G; Namias, B; Prospert, F; Schlesser, M; Soupart, A, 1994) |
| "The present study was designed to investigate in rats the influence of converting enzyme inhibition with captopril on blood pressure, plasma urea, plasma renin concentration (PRC), plasma aldosterone and plasma vasopressin, and to define the interrelationships between PRC and these variables during equal degrees of either hyponatraemic (furosemide, 40 mg/kg for 2 days) or hypernatraemic (48-h water deprivation) dehydration." | 3.67 | Influence of converting enzyme inhibition on the hormonal and renal adaptation to hyper- and hyponatraemic dehydration. ( Corvol, P; Gardes, J; Gonzalez, MF; Ménard, J, 1986) |
| "We have studied the efficiency of urea in the treatment of hyponatremia and hydrosaline retention in a 76-year-old man with chronic ischemic congestive heart failure." | 3.67 | Urea treatment for water retention in hyponatremic congestive heart failure. ( Cauchie, P; Decaux, G; Vincken, W, 1987) |
| "We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics." | 3.67 | Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. ( Cauchie, P; Decaux, G; Delwiche, F; Flamion, B; Mols, P, 1986) |
| "Urea has efficacy similar to that of vaptans for treatment of chronic SIADH." | 2.77 | Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH. ( Coffernils, M; Couturier, B; Decaux, G; Gankam-Kengne, F; Soupart, A, 2012) |
| "The occurrence of renal failure is associated to an increased death risk." | 2.73 | Hypertonic saline solution for renal failure prevention in patients with decompensated heart failure. ( Azevedo, CH; Bacal, F; Bocchi, EA; Carneiro, RM; Chizzola, PR; Ferreira, SM; Issa, VS; Mangini, S, 2007) |
| "The rationale for treating the hyponatremia, even when apparently asymptomatic, is discussed, with attention to cognitive function, gait, and bone structure disturbances that increase the risk for fractures." | 2.49 | An elderly patient with chronic hyponatremia. ( Berl, T, 2013) |
| " In short and long term studies, tolvaptane has been shown to be effective in raising serum sodium levels in a predictable fashion in patients with SIADH with only few side effects, when serum sodium was frequently monitored and dosage of tolvaptans was properly adjusted." | 2.47 | [Treatment of hyponatremia: new developments and controversies]. ( Hensen, J, 2011) |
| "Inadequate treatment of severe hyponatremia (<120 mEq/L) can be associated with severe neurological damage." | 2.42 | Treatment of symptomatic hyponatremia. ( Decaux, G; Soupart, A, 2003) |
| "Inadequate treatment of severe hyponatremia (< 120 mEq/l) can be associated with severe neurological damage." | 2.41 | [Treatment of severe hyponatremia (<120mEq/l)]. ( Decaux, G, 2001) |
| " The osmole gap may also be helpful for confirming pseudohyponatremia, as a gauge for dosing mannitol and glycerol when used to treat intracranial hypertension, and as a prognostic indicator in circulatory shock." | 2.39 | The serum osmole gap. ( Cadnapaphornchai, P; Kruse, JA, 1994) |
| "Future research into the treatment of SIADH must be directed at developing effective antagonists of ADH." | 2.37 | Management of the syndrome of inappropriate secretion of antidiuretic hormone. ( Kinzie, BJ, 1987) |
| "Hyponatremia is a state of an osmole-free water excess compared to the amounts of solutes and clinical management of hyponatremic patients requires pathophysiology-oriented approaches to select appropriate treatments." | 1.62 | [Hyponatremia - causes, diagnostic evaluation and treatment]. ( Kettritz, R, 2021) |
| "In hospitalised patients with a serum sodium level ≤ 129 mmol/l due to SIADH, urea in a dosage of 0." | 1.56 | Urea for hyponatraemia due to the syndrome of inappropriate antidiuretic hormone secretion. ( de Boer, MP; Hempenius, L; van Roon, EN; Woudstra, J, 2020) |
| "This hyponatremia is saline-responsive, but relapse can be frequently observed." | 1.51 | Hyponatremia secondary to transient renal salt wasting (TRSW): A not so uncommon observation in the elderly . ( Decaux, G; Musch, W, 2019) |
| "Urea was used on 78 occasions in 69 patients." | 1.51 | Urea treatment in fluid restriction-refractory hyponatraemia. ( Berkman, KE; Dimeski, G; Inder, WJ; Lockett, J; Russell, AW, 2019) |
| "Oral urea was utilized in 5 SIADH patients where Na failed to increase with fluid restriction alone." | 1.48 | Investigation and management of moderate to severe inpatient hyponatraemia in an Australian tertiary hospital. ( Berkman, K; Dimeski, G; Haigh, K; Inder, WJ; Li, L; Lockett, J; Russell, A, 2018) |
| "We report the approach to the treatment of hyponatremia and its unique challenges in infancy." | 1.42 | Approach to the treatment of the infant with hyponatremia. ( Greenberg, JH; Marsenic, O; Tufro, A, 2015) |
| "Hyponatremia is a common electrolyte disorder that carries significant morbidity and mortality." | 1.42 | Urea minimizes brain complications following rapid correction of chronic hyponatremia compared with vasopressin antagonist or hypertonic saline. ( Couturier, BS; Decaux, G; Gankam Kengne, F; Soupart, A, 2015) |
| "Hyponatremia is the main complication of inappropriate antidiuretic hormone secretion (SIADH), sometimes fatal." | 1.38 | Inappropriate antidiuretic hormone secretion: long-term successful urea treatment. ( Cachat, F; Chehade, H; Girardin, E; Rosato, L, 2012) |
| "Hyponatremia was induced in male Sprague-Dawley rats by water loading and subcutaneous infusion of 1-deamino-8-D-arginine vasopressin (dDAVP)." | 1.33 | BSC1 inhibition complements effects of vasopressin V2 receptor antagonist on hyponatremia in SIADH rats. ( Arata, T; Ejima, Y; Hatano, R; Kazama, I; Matsubara, M; Michimata, M; Miyama, N; Sasaki, S; Sato, A; Satomi, S; Suzuki, K; Suzuki, M, 2005) |
| "Myoinositol-treated animals had significantly fewer demyelinating lesions than mannitol (2." | 1.33 | Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. ( Rojiani, AM; Schroeder, BM; Silver, SM; Sterns, RH, 2006) |
| "Aldosterone levels were much lower in ACTH deficiency patients during the hyponatremic state (33 +/- 40 pg/ml) when compared with the nonendocrine SIADH (120 +/- 60 pg/ml; P < 0." | 1.32 | Low plasma bicarbonate level in hyponatremia related to adrenocorticotropin deficiency. ( Decaux, G; Musch, W; Penninckx, R; Soupart, A, 2003) |
| "Ra urea was 5." | 1.30 | Effect of liver disease and transplantation on urea synthesis in humans: relationship to acid-base status. ( Jahoor, F; Shangraw, RE, 1999) |
| "Treatment with enalapril (n = 7) during pacing reduced the decrease in aortic flow by 33% and prevented changes in plasma urea, potassium, and sodium." | 1.28 | Converting enzyme inhibition by enalapril in experimental heart failure. ( Bassenge, E; Holtz, J; Munzel, T; Sommer, O, 1990) |
| "Reported successes in the treatment of hyponatremia due to SIADH by administration of urea and normal saline led to the authors' routine use of this therapy for hyponatremic neurosurgical patients." | 1.28 | Administration of intravenous urea and normal saline for the treatment of hyponatremia in neurosurgical patients. ( Harbaugh, RE; Reeder, RF, 1989) |
| "Urea treatment also induced a persistent osmotic diuresis, allowing a normal daily intake of water despite SIADH." | 1.26 | Treatment of the syndrome of inappropriate secretion of antidiuretic hormone by urea. ( Brimioulle, S; Decaux, G; Genette, F; Mockel, J, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (30.08) | 18.7374 |
| 1990's | 18 (13.53) | 18.2507 |
| 2000's | 28 (21.05) | 29.6817 |
| 2010's | 32 (24.06) | 24.3611 |
| 2020's | 15 (11.28) | 2.80 |
| Authors | Studies |
|---|---|
| Martínez, Á | 1 |
| Rodríguez, A | 1 |
| Corral, M | 1 |
| Reyes, E | 1 |
| Rodríguez, S | 1 |
| Klhůfek, J | 1 |
| Šálek, T | 1 |
| Bozkurt Babuş, S | 1 |
| Köse, A | 1 |
| Erdoğan, S | 1 |
| Kiraz, M | 1 |
| İyikesici, F | 1 |
| Adrogué, HJ | 1 |
| Tucker, BM | 1 |
| Madias, NE | 2 |
| Cui, J | 3 |
| Halpin, K | 3 |
| Paprocki, E | 3 |
| Bioletto, F | 1 |
| Varaldo, E | 1 |
| Prencipe, N | 1 |
| Benso, A | 1 |
| Berton, AM | 1 |
| Veligratli, F | 1 |
| Alexandrou, D | 1 |
| Shah, S | 1 |
| Amin, R | 1 |
| Dattani, M | 1 |
| Gan, HW | 1 |
| Famuboni, A | 1 |
| Lopez-Garcia, C | 1 |
| Trompeter, R | 1 |
| Bockenhauer, D | 1 |
| Li, P | 1 |
| Kuo, N | 1 |
| Patel, R | 1 |
| Omary, MB | 1 |
| Monnerat, S | 1 |
| Atila, C | 1 |
| Baur, F | 1 |
| Santos de Jesus, J | 1 |
| Refardt, J | 1 |
| Dickenmann, M | 1 |
| Christ-Crain, M | 2 |
| Colombo, F | 1 |
| Milani, M | 1 |
| Rondon-Berrios, H | 1 |
| Woudstra, J | 1 |
| de Boer, MP | 1 |
| Hempenius, L | 1 |
| van Roon, EN | 1 |
| Decaux, G | 33 |
| Gankam Kengne, F | 3 |
| González Pannia, P | 1 |
| Balboa, R | 1 |
| Navarro, R | 1 |
| Nocita, MF | 1 |
| Ferraro, M | 1 |
| Mannucci, C | 1 |
| Kettritz, R | 1 |
| Cailleaux, A | 1 |
| Mahieu, F | 1 |
| Heinrichs, C | 2 |
| Adams, B | 1 |
| Ismaili, K | 1 |
| Brachet, C | 2 |
| Baldrighi, M | 1 |
| Castello, LM | 1 |
| Bartoli, E | 1 |
| Bardanzellu, F | 1 |
| Pintus, MC | 1 |
| Masile, V | 1 |
| Fanos, V | 2 |
| Marcialis, MA | 2 |
| Musch, W | 9 |
| Berkman, K | 1 |
| Haigh, K | 1 |
| Li, L | 1 |
| Lockett, J | 2 |
| Dimeski, G | 2 |
| Russell, A | 1 |
| Inder, WJ | 2 |
| Berkman, KE | 1 |
| Russell, AW | 1 |
| Nervo, A | 1 |
| D'Angelo, V | 1 |
| Rosso, D | 1 |
| Castellana, E | 1 |
| Cattel, F | 1 |
| Arvat, E | 1 |
| Grossi, E | 1 |
| Hoorn, EJ | 1 |
| Spasovski, G | 1 |
| Salah, K | 1 |
| Stienen, S | 1 |
| Moons, AHM | 1 |
| Bakx, ALM | 1 |
| van Pol, PE | 1 |
| Kortz, RAM | 1 |
| Ferreira, JP | 1 |
| Marques, I | 1 |
| Schroeder-Tanka, JM | 1 |
| Keijer, JT | 1 |
| Bayes-Genis, A | 1 |
| Pinto, YM | 1 |
| Tijssen, JG | 1 |
| Kok, WE | 1 |
| Shchekochikhin, D | 1 |
| Tkachenko, O | 1 |
| Schrier, RW | 1 |
| de Solà-Morales, O | 1 |
| Riera, M | 1 |
| Al Wakeel, JS | 1 |
| Couturier, BS | 1 |
| Soupart, A | 14 |
| Frenkel, NJ | 1 |
| Vogt, L | 1 |
| De Rooij, SE | 1 |
| Trimpert, C | 1 |
| Levi, MM | 1 |
| Deen, PM | 1 |
| van den Born, BJ | 1 |
| Greenberg, JH | 1 |
| Tufro, A | 1 |
| Marsenic, O | 1 |
| Santiago Pérez, A | 1 |
| Runkle de la Vega, I | 1 |
| Peña Pedrosa, JA | 1 |
| Arias Fernández, ML | 1 |
| Sterns, RH | 3 |
| Silver, SM | 3 |
| Hix, JK | 1 |
| Cairns, RS | 1 |
| Hew-Butler, T | 1 |
| Cuesta, M | 1 |
| Hannon, MJ | 1 |
| Thompson, CJ | 1 |
| Annoni, F | 1 |
| Fontana, V | 1 |
| Brimioulle, S | 3 |
| Creteur, J | 1 |
| Vincent, JL | 1 |
| Taccone, FS | 1 |
| Nigro, N | 1 |
| Winzeler, B | 1 |
| Suter-Widmer, I | 1 |
| Schuetz, P | 1 |
| Arici, B | 1 |
| Bally, M | 1 |
| Blum, CA | 1 |
| Nickel, CH | 1 |
| Bingisser, R | 1 |
| Bock, A | 1 |
| Huber, A | 1 |
| Müller, B | 1 |
| Kawai, N | 1 |
| Ishikawa, K | 1 |
| Nemoto, K | 1 |
| Katano, T | 1 |
| Takahashi, S | 1 |
| Hori, T | 1 |
| Asada, T | 1 |
| Dessì, A | 1 |
| Contu, S | 1 |
| Field, MJ | 1 |
| Andres, C | 1 |
| Varsavsky, M | 1 |
| Quesada Charneco, M | 1 |
| Rozas Moreno, P | 1 |
| Lichtwarck-Aschoff, M | 1 |
| Pippi, A | 1 |
| Dietrich, B | 1 |
| Hensen, J | 1 |
| Chehade, H | 1 |
| Rosato, L | 1 |
| Girardin, E | 1 |
| Cachat, F | 1 |
| Coussement, J | 1 |
| Danguy, C | 1 |
| Zouaoui-Boudjeltia, K | 1 |
| Defrance, P | 1 |
| Bankir, L | 1 |
| Biston, P | 1 |
| Piagnerelli, M | 1 |
| Coffernils, M | 2 |
| Couturier, B | 1 |
| Gankam-Kengne, F | 1 |
| Vandergheynst, F | 1 |
| Berl, T | 1 |
| Edoute, Y | 1 |
| Davids, MR | 1 |
| Johnston, C | 1 |
| Halperin, ML | 1 |
| BATT, RE | 1 |
| CIRKSENA, WJ | 1 |
| LEBHERZ, TB | 1 |
| WEIL, WB | 1 |
| WALLACE, WM | 1 |
| WILSON, JD | 1 |
| CAMPION, DS | 1 |
| NORTH, JD | 1 |
| PAMPIGLIONE, G | 1 |
| Penninckx, R | 1 |
| Hedeshi, A | 1 |
| Kazama, I | 1 |
| Hatano, R | 1 |
| Michimata, M | 1 |
| Suzuki, K | 1 |
| Arata, T | 1 |
| Suzuki, M | 1 |
| Miyama, N | 1 |
| Sato, A | 1 |
| Satomi, S | 1 |
| Ejima, Y | 1 |
| Sasaki, S | 1 |
| Matsubara, M | 1 |
| Gupta, BD | 1 |
| Sharma, P | 1 |
| Bagla, J | 1 |
| Parakh, M | 1 |
| Soni, JP | 1 |
| Schroeder, BM | 1 |
| Rojiani, AM | 1 |
| Verhoeven, A | 1 |
| Huang, EA | 1 |
| Feldman, BJ | 1 |
| Schwartz, ID | 1 |
| Geller, DH | 1 |
| Rosenthal, SM | 1 |
| Gitelman, SE | 1 |
| Gawlowski, Z | 1 |
| Aladangady, N | 1 |
| Coen, PG | 1 |
| Barcia, RE | 1 |
| Castiglia, NI | 1 |
| Villaverde, ME | 1 |
| Lanosa, GA | 1 |
| Ujeda Mantello, CJ | 1 |
| Aguirre, M | 1 |
| Borello, GJ | 1 |
| Caisson, AM | 1 |
| Schroëder, B | 1 |
| Liamis, G | 1 |
| Christidis, D | 1 |
| Alexandridis, G | 1 |
| Bairaktari, E | 1 |
| Elisaf, M | 1 |
| Leblanc, PE | 1 |
| Cheisson, G | 1 |
| Geeraerts, T | 1 |
| Tazarourte, K | 1 |
| Duranteau, J | 1 |
| Vigué, B | 1 |
| Issa, VS | 1 |
| Bacal, F | 1 |
| Mangini, S | 1 |
| Carneiro, RM | 1 |
| Azevedo, CH | 1 |
| Chizzola, PR | 1 |
| Ferreira, SM | 1 |
| Bocchi, EA | 1 |
| Renneboog, B | 1 |
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| Aviram, A | 1 |
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| Czaczkes, JW | 1 |
| Ullmann, TD | 1 |
| Knapp, MS | 1 |
| Bhagat, CI | 1 |
| Garcia-Webb, P | 1 |
| Fletcher, E | 1 |
| Beilby, JP | 1 |
| Kamm, DE | 1 |
| Genin, M | 1 |
| Kuchmy, B | 1 |
| Hollander, J | 1 |
| Genette, F | 2 |
| Mockel, J | 3 |
| Wallerstedt, S | 1 |
| Unger, J | 1 |
| Thimpont, J | 1 |
| Vandervelde, D | 1 |
| Verhaeverbeke, I | 1 |
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| Prospert, F | 4 |
| Namias, B | 2 |
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| Poon, WS | 1 |
| Lolin, YI | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Urea for Chronic Hyponatremia: A Pilot Study[NCT04588207] | Phase 2 | 2 participants (Actual) | Interventional | 2021-12-28 | Terminated (stopped due to Unable to recruit participants) | ||
| Hypotonic Hyponatremia: Criteria for the Correct Classification of Its Etiology and of Patient Volume Status at the Access in the Emergency Department and at the Subsequent Re-evaluation in Hospital Wards[NCT04402190] | 123 participants (Actual) | Observational | 2018-06-01 | Completed | |||
| Research Project: Pilot Study on Oral Urea Use in Patients at High Risk of Kidney Stone Recurrence[NCT04727606] | Phase 2 | 0 participants (Actual) | Interventional | 2023-01-15 | Withdrawn (stopped due to We never got Health Canada approval) | ||
| Early Sodium Intake in Preterm Newborns; Randomized Clinical Trial[NCT04035564] | Phase 4 | 52 participants (Actual) | Interventional | 2018-03-30 | Completed | ||
| Hypertonic Saline Solution in Decompensated Heart Failure[NCT00555685] | Phase 2 | 34 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| [NCT00541944] | 120 participants (Anticipated) | Observational | 2007-04-30 | Recruiting | |||
| Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia[NCT04744987] | 122 participants (Actual) | Observational | 2019-07-30 | Completed | |||
| Post-Operative Water Load Following Transsphenoidal Pituitary Surgery[NCT02727686] | 30 participants (Actual) | Interventional | 2016-03-07 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The difference between initial weight and 72hrs weight, expressed in percentage of birth weight. (NCT04035564)
Timeframe: Initial weight (baseline) vs 72 hours
| Intervention | % of birth weight (Mean) |
|---|---|
| Sodium < 1mEq/kg/Day | -9.206 |
| Sodium 5mEq/kg/Day | -6.345 |
The difference between current serum sodium and initial serum sodium (NCT04035564)
Timeframe: Initial serum sodium (baseline) vs 72 hours
| Intervention | mEq/L (Mean) |
|---|---|
| Sodium < 1mEq/kg/Day | 1.921 |
| Sodium 5mEq/kg/Day | 5.71 |
serum sodium >150mEq/L (NCT04035564)
Timeframe: 72 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Sodium < 1mEq/kg/Day | 1 |
| Sodium 5mEq/kg/Day | 1 |
serum sodium <130mEq/L (NCT04035564)
Timeframe: 72 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Sodium < 1mEq/kg/Day | 6 |
| Sodium 5mEq/kg/Day | 1 |
Death during hospitalization. (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age
| Intervention | Participants (Count of Participants) |
|---|---|
| Sodium < 1mEq/kg/Day | 5 |
| Sodium 5mEq/kg/Day | 2 |
Bleeding into the brain´s ventricular system (intracranial ultrasound). (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age
| Intervention | Participants (Count of Participants) |
|---|---|
| Sodium < 1mEq/kg/Day | 6 |
| Sodium 5mEq/kg/Day | 4 |
Positive blood culture and/or 5 days of continuous antimicrobial therapy (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age
| Intervention | Participants (Count of Participants) |
|---|---|
| Sodium < 1mEq/kg/Day | 8 |
| Sodium 5mEq/kg/Day | 5 |
"Number of patients with Bell stage II or greater necrotizing enterocolitis~Bell's Staging:~Stage II A:~Gastrointestinal signs: Increasing gastric aspirates, mild abdominal distention, fecal occult blood, absent bowel sounds.~Systemic signs: Temperature instability, apnea, bradycardia, lethargy. Radiological findings: Intestinal dilatation, ileus, pneumatosis intestinalis.~Stage II B:~Gastrointestinal signs: As stage IIA plus abdominal tenderness. Systemic signs: As stage IIA plus metabolic acidosis and thrombocytopenia. Radiological findings: As stage IIA plus portal vein gas and ascites.~Stage III A:~Gastrointestinal signs: As stage IIB plus marked abdominal tenderness and generalised peritonitis.~Systemic signs: As stage IIB plus hypotension and severe apnea. Radiological findings: As stage IIB~Stage III B:~Gastrointestinal signs: As stage IIIA As stage IIIA As stage IIIA plus pneumoperitoneum" (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age
| Intervention | Participants (Count of Participants) |
|---|---|
| Sodium < 1mEq/kg/Day | 2 |
| Sodium 5mEq/kg/Day | 2 |
The difference between current weight and initial weight (NCT04035564)
Timeframe: Initial weight (baseline) vs 72 hours
| Intervention | Grams (Mean) |
|---|---|
| Sodium < 1mEq/kg/Day | -135.43 |
| Sodium 5mEq/kg/Day | -96.05 |
23 reviews available for urea and Hyponatremia
| Article | Year |
|---|---|
Diagnosis and Management of Hyponatremia: A Review.
Topics: Coma; Heart Failure; Humans; Hyponatremia; Hypovolemia; Inappropriate ADH Syndrome; Prospective Stud | 2022 |
Long-term efficacy of empagliflozin as an add-on treatment for chronic SIAD: a case report and literature review.
Topics: Aged; Diabetes Mellitus, Type 2; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Sodium; Ure | 2023 |
Tolvaptan and urea in paediatric hyponatraemia.
Topics: Antidiuretic Hormone Receptor Antagonists; Benzazepines; Child; Humans; Hyponatremia; Inappropriate | 2024 |
Urea for Chronic Hyponatremia.
Topics: Chronic Disease; Diuretics; Humans; Hyponatremia; Urea | 2020 |
Hypertonic saline, isotonic saline, water restriction, long loops diuretics, urea or vaptans to treat hyponatremia.
Topics: Acute Disease; Antidiuretic Hormone Receptor Antagonists; Bicarbonates; Chronic Disease; Drinking; H | 2020 |
Focus on neonatal and infantile onset of nephrogenic syndrome of inappropriate antidiuresis: 12 years later.
Topics: Age of Onset; Antidiuretic Hormone Receptor Antagonists; Clinical Trials as Topic; Diuretics, Osmoti | 2019 |
Recent developments in the management of acute and chronic hyponatremia.
Topics: Acute Disease; Antidiuretic Hormone Receptor Antagonists; Chronic Disease; Fluid Therapy; Humans; Hy | 2019 |
Hyponatremia: an update on current pharmacotherapy.
Topics: Aged; Antidiuretic Hormone Receptor Antagonists; Brain Edema; Chronic Disease; Clinical Trials as To | 2013 |
Urea for management of the syndrome of inappropriate secretion of ADH: A systematic review.
Topics: Disease Management; Drug Evaluation; Evidence-Based Medicine; Humans; Hypernatremia; Hypokalemia; Hy | 2014 |
Diagnosis and treatment of hyponatraemia in neurosurgical patients.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Antidiuretic Hormone Receptor Antagonists; Brain | 2016 |
Nephrogenic syndrome of inappropriate antidiuresis: a novel cause of euvolemic hypotonic hyponatremia in newborns. Diagnosis and practical management.
Topics: Administration, Oral; Diabetes Insipidus, Nephrogenic; Female; Fluid Therapy; Humans; Hyponatremia; | 2009 |
[Treatment of hyponatremia: new developments and controversies].
Topics: Antidiuretic Hormone Receptor Antagonists; Benzazepines; Blood Volume; Drinking; Humans; Hyponatremi | 2011 |
Long-term treatment of hyponatremic patients with nephrogenic syndrome of inappropriate antidiuresis: personal experience and review of published case reports.
Topics: Adult; Aged; Diuretics; Furosemide; Genetic Diseases, X-Linked; Humans; Hyponatremia; Inappropriate | 2012 |
An elderly patient with chronic hyponatremia.
Topics: Age Factors; Aged; Antidiuretic Hormone Receptor Antagonists; Biomarkers; Chronic Disease; Demeclocy | 2013 |
Treatment of symptomatic hyponatremia.
Topics: Brain; Humans; Hyponatremia; Risk Factors; Saline Solution, Hypertonic; Urea | 2003 |
Brain volume regulation in response to hypo-osmolality and its correction.
Topics: Acute Disease; Animals; Brain; Brain Edema; Chronic Disease; Demyelinating Diseases; Humans; Hyponat | 2006 |
[Does cerebral salt wasting syndrome exist?].
Topics: Adrenal Cortex Hormones; Blood Pressure; Brain Diseases; Diagnosis, Differential; Humans; Hyponatrem | 2007 |
Clinical laboratory evaluation of the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Acid-Base Equilibrium; Bicarbonates; Biomarkers; Clinical Laboratory Techniques; Creatinine; Diagnos | 2008 |
The serum osmole gap.
Topics: Alcoholic Intoxication; Blood Glucose; Ethylene Glycols; Humans; Hyponatremia; Methanol; Osmolar Con | 1994 |
[Treatment of severe hyponatremia (<120mEq/l)].
Topics: Acute Disease; Chronic Disease; Demyelinating Diseases; Humans; Hyponatremia; Postoperative Complica | 2001 |
Management of the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Demeclocycline; Drug-Related Side Effects and Adverse Reactions; Humans; Hyponatremia; Inappropriate | 1987 |
Hepatic encephalopathy.
Topics: Acetazolamide; Ammonia; Constipation; Diet Therapy; Electroencephalography; Gastrointestinal Hemorrh | 1973 |
The pathophysiology of the dialysis disequilibrium syndrome.
Topics: Acute Kidney Injury; Animals; Brain Edema; Calcium; Carbon Dioxide; Cerebrospinal Fluid; Electroence | 1969 |
7 trials available for urea and Hyponatremia
| Article | Year |
|---|---|
Effect of protein supplementation on plasma sodium levels in the syndrome of inappropriate antidiuresis: a monocentric, open-label, proof-of-concept study-the TREASURE study.
Topics: Creatinine; Dietary Supplements; Humans; Hyponatremia; Inappropriate ADH Syndrome; Powders; Sodium; | 2023 |
Palatability of two different formulations of urea for the treatment of hyponatremia: A double-blind, randomized, cross-over study.
Topics: Cross-Over Studies; Female; Humans; Hyponatremia; Male; Middle Aged; Taste Perception; Urea | 2023 |
Oral urea treatment for polydipsia-hyponatremia syndrome in patients with schizophrenia.
Topics: Administration, Oral; Adult; Humans; Hyponatremia; Male; Middle Aged; Schizophrenia; Syndrome; Thirs | 2009 |
Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antidiuretic Hormone Receptor Antagonists; Ben | 2012 |
Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antidiuretic Hormone Receptor Antagonists; Ben | 2012 |
Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antidiuretic Hormone Receptor Antagonists; Ben | 2012 |
Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antidiuretic Hormone Receptor Antagonists; Ben | 2012 |
Treatment of the polydipsia-hyponatremia syndrome with urea.
Topics: Administration, Oral; Adult; Aged; Body Weight; Circadian Rhythm; Comorbidity; Creatine; Drinking; D | 2005 |
Hypertonic saline solution for renal failure prevention in patients with decompensated heart failure.
Topics: Biomarkers; Cardiotonic Agents; Creatinine; Diuretics; Dobutamine; Female; Furosemide; Heart Failure | 2007 |
Difference in solute excretion during correction of hyponatremic patients with cirrhosis or syndrome of inappropriate secretion of antidiuretic hormone by oral vasopressin V2 receptor antagonist VPA-985.
Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Diuresis; Humans; Hyponatremia; Ina | 2001 |
103 other studies available for urea and Hyponatremia
| Article | Year |
|---|---|
Hyponatremia treatment with oral urea in heart failure.
Topics: Heart Failure; Humans; Hyponatremia; Urea | 2022 |
Thiazide-associated hyponatremia in internal medicine patients: analysis of epidemiological and biochemical profiles.
Topics: Anorexia; Creatinine; Female; Furosemide; Humans; Hyponatremia; Hypovolemia; Internal Medicine; Male | 2022 |
Risk factors and mortality in elderly patients with severe hyponatremia admitted to the emergency department.
Topics: Aged; C-Reactive Protein; Emergency Service, Hospital; Humans; Hyponatremia; Liver Cirrhosis; Retros | 2023 |
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1.
Topics: Child; Humans; Hyponatremia; Inappropriate ADH Syndrome; Incisor; Infant; Neurofibromatosis 1; Urea; | 2023 |
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1.
Topics: Child; Humans; Hyponatremia; Inappropriate ADH Syndrome; Incisor; Infant; Neurofibromatosis 1; Urea; | 2023 |
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1.
Topics: Child; Humans; Hyponatremia; Inappropriate ADH Syndrome; Incisor; Infant; Neurofibromatosis 1; Urea; | 2023 |
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1.
Topics: Child; Humans; Hyponatremia; Inappropriate ADH Syndrome; Incisor; Infant; Neurofibromatosis 1; Urea; | 2023 |
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1.
Topics: Child; Humans; Hyponatremia; Inappropriate ADH Syndrome; Incisor; Infant; Neurofibromatosis 1; Urea; | 2023 |
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1.
Topics: Child; Humans; Hyponatremia; Inappropriate ADH Syndrome; Incisor; Infant; Neurofibromatosis 1; Urea; | 2023 |
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1.
Topics: Child; Humans; Hyponatremia; Inappropriate ADH Syndrome; Incisor; Infant; Neurofibromatosis 1; Urea; | 2023 |
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1.
Topics: Child; Humans; Hyponatremia; Inappropriate ADH Syndrome; Incisor; Infant; Neurofibromatosis 1; Urea; | 2023 |
Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1.
Topics: Child; Humans; Hyponatremia; Inappropriate ADH Syndrome; Incisor; Infant; Neurofibromatosis 1; Urea; | 2023 |
Hypoosmosis alters hepatocyte mitochondrial morphology and induces selective release of carbamoyl phosphate synthetase 1.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Cytochromes c; Hepatocytes; Hyp | 2023 |
Urea for hyponatraemia due to the syndrome of inappropriate antidiuretic hormone secretion.
Topics: Aged; Aged, 80 and over; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Middle Aged | 2020 |
Prevalence of cerebral edema among diabetic ketoacidosis patients.
Topics: Adolescent; Argentina; Brain Edema; Child; Child, Preschool; Cross-Sectional Studies; Diabetic Ketoa | 2020 |
[Hyponatremia - causes, diagnostic evaluation and treatment].
Topics: Humans; Hyponatremia; Sodium; Sodium-Glucose Transporter 2 Inhibitors; Urea | 2021 |
[Nephrogenic syndrome of inappropriate antidiuresis: Early diagnosis avoids severe hyponatremia complications].
Topics: Early Diagnosis; Genetic Diseases, X-Linked; Humans; Hyponatremia; Inappropriate ADH Syndrome; Infan | 2017 |
Comment on "Mild water restriction with or without urea for the longterm treatment of SIADH: Can urine osmolality help the choice?" by Decaux et al.
Topics: Humans; Hyponatremia; Inappropriate ADH Syndrome; Osmolar Concentration; Urea; Water | 2018 |
High fractional potassium excretion in symptomatic hyponatremia.
Topics: Aged; Diuretics; Humans; Hyponatremia; Inappropriate ADH Syndrome; Middle Aged; Polydipsia; Potassiu | 2019 |
Investigation and management of moderate to severe inpatient hyponatraemia in an Australian tertiary hospital.
Topics: Aged; Cohort Studies; Disease Management; Female; Fluid Therapy; Hospitalization; Humans; Hyponatrem | 2018 |
Urea treatment in fluid restriction-refractory hyponatraemia.
Topics: Aged; Female; Humans; Hyponatremia; Male; Middle Aged; Sodium; Tertiary Care Centers; Treatment Outc | 2019 |
Urea in cancer patients with chronic SIAD-induced hyponatremia: Old drug, new evidence.
Topics: Aged; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Middle Aged; Neoplasms; Retros | 2019 |
Hyponatremia secondary to transient renal salt wasting (TRSW): A not so uncommon observation in the elderly
.
Topics: Aged; Aged, 80 and over; Calcium; Diuresis; Diuretics; Female; Fluid Therapy; Humans; Hyponatremia; | 2019 |
External Validation of the ELAN-HF Score, Predicting 6-Month All-Cause Mortality in Patients Hospitalized for Acute Decompensated Heart Failure.
Topics: Acute Disease; Age Factors; Aged; Blood Pressure; Cause of Death; Edema; Female; Heart Failure; Hosp | 2019 |
Kidney function and metabolic profile of chronic kidney disease and hemodialysis patients during Ramadan fasting.
Topics: Adult; Aged; Blood Pressure; Blood Urea Nitrogen; Body Weight; Creatinine; Erythrocyte Count; Fastin | 2014 |
Urea minimizes brain complications following rapid correction of chronic hyponatremia compared with vasopressin antagonist or hypertonic saline.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Astrocytes; Benzamides; Blood-Brain Barrier; Bra | 2015 |
Thiazide-induced hyponatraemia is associated with increased water intake and impaired urea-mediated water excretion at low plasma antidiuretic hormone and urine aquaporin-2.
Topics: Aged; Aged, 80 and over; Aquaporin 2; Drinking; Electrolytes; Female; Humans; Hydrochlorothiazide; H | 2015 |
Approach to the treatment of the infant with hyponatremia.
Topics: Humans; Hyponatremia; Infant; Male; Sodium; Treatment Outcome; Urea | 2015 |
[Response to clinical case report: treatment with urea as an alternative to tolvaptan for the syndrome of inappropriate secretion of antidiuretic hormone].
Topics: Humans; Hyponatremia; Inappropriate ADH Syndrome; Urea; Vasopressins | 2014 |
Urea for hyponatremia?
Topics: Animals; Hyponatremia; Male; Urea | 2015 |
Proof of concept: hypovolemic hyponatremia may precede and augment creatine kinase elevations during an ultramarathon.
Topics: Adult; Creatine Kinase; Humans; Hyponatremia; Hypovolemia; Male; Middle Aged; Physical Exertion; Rha | 2016 |
Early Effects of Enteral Urea on Intracranial Pressure in Patients With Acute Brain Injury and Hyponatremia.
Topics: Acute Disease; Adult; Aged; APACHE; Brain Injuries; Female; Humans; Hyponatremia; Inappropriate ADH | 2017 |
Evaluation of copeptin and commonly used laboratory parameters for the differential diagnosis of profound hyponatraemia in hospitalized patients: 'The Co-MED Study'.
Topics: Aged; Aged, 80 and over; Diagnosis, Differential; Glycopeptides; Hospitalization; Humans; Hydrocorti | 2017 |
Comment on "Does 'asymptomatic hyponatremia' exist?".
Topics: Humans; Hyponatremia; Terminology as Topic; Urea | 2010 |
Treatment of euvolemic hyponatremia in the intensive care unit by urea.
Topics: Aged; Aged, 80 and over; Female; Humans; Hyponatremia; Intensive Care Units; Male; Middle Aged; Retr | 2010 |
[Urea as therapeutic option for the treatment of the syndrome of inappropriate antidiuretic hormone secretion].
Topics: Amitriptyline; Carbamazepine; Comorbidity; Demeclocycline; Diabetic Neuropathies; Diuretics; Furosem | 2011 |
[Supplement to continuing medical education article "Dysnatremia in intensive care patients"].
Topics: Critical Care; Humans; Hyponatremia; Inappropriate ADH Syndrome; Osmolar Concentration; Urea; Vasopr | 2011 |
Inappropriate antidiuretic hormone secretion: long-term successful urea treatment.
Topics: Child, Preschool; Chronic Disease; Diuretics, Osmotic; Female; Humans; Hyponatremia; Inappropriate A | 2012 |
Treatment of the syndrome of inappropriate secretion of antidiuretic hormone with urea in critically ill patients.
Topics: Adult; Aged; Critical Illness; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Middl | 2012 |
An integrative physiological approach to polyuria and hyponatraemia: a 'double-take' on the diagnosis and therapy in a patient with schizophrenia.
Topics: Adult; Diabetes Insipidus; Diagnosis, Differential; Diuresis; Humans; Hyponatremia; Male; Polyuria; | 2003 |
GOUT AND SALT-WASTING RENAL DISEASE DURING PREGNANCY; DIAGNOSIS, MANAGEMENT, AND FOLLOW-UP.
Topics: Blood Chemical Analysis; Colchicine; Diet Therapy; Diet, Sodium-Restricted; Female; Follow-Up Studie | 1963 |
FLUID THERAPY IN RENAL DISEASE.
Topics: Acute Kidney Injury; Child; Diuresis; Fluid Therapy; Glomerulonephritis; Humans; Hyperkalemia; Hypoc | 1964 |
PERITONEAL DIALYSIS AND RENAL FAILURE.
Topics: Acute Kidney Injury; Anuria; Blood; Creatine; Creatinine; Dialysis; Glomerulonephritis; Heart Failur | 1965 |
ELECTROENCEPHALOGRAPHIC AND METABOLIC CHANGES AFTER SURGICAL OPERATIONS.
Topics: Bicarbonates; Blood; Child; Chlorides; Electroencephalography; Humans; Hypokalemia; Hyponatremia; Me | 1965 |
Low plasma bicarbonate level in hyponatremia related to adrenocorticotropin deficiency.
Topics: Adrenocorticotropic Hormone; Aged; Aged, 80 and over; Aldosterone; Bicarbonates; Carbon Dioxide; Dia | 2003 |
Low sodium excretion in SIADH patients with low diuresis.
Topics: Aged; Alcohol Withdrawal Seizures; Alcoholism; Creatinine; Diagnosis, Differential; Diuresis; Duoden | 2004 |
BSC1 inhibition complements effects of vasopressin V2 receptor antagonist on hyponatremia in SIADH rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Aquaporins; Benzazepines; Deamino A | 2005 |
Renal failure in asphyxiated neonates.
Topics: Acute Kidney Injury; Apgar Score; Asphyxia Neonatorum; Birth Weight; Case-Control Studies; Causality | 2005 |
Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats.
Topics: Animals; Arginine Vasopressin; Behavior, Animal; Blood Glucose; Brain; Demyelinating Diseases; Disea | 2006 |
Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children.
Topics: Administration, Oral; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Hyponatremi | 2006 |
Urea treatment for exercise-associated hyponatremia.
Topics: Administration, Oral; Exercise; Humans; Hyponatremia; Infusions, Intravenous; Urea | 2006 |
Hypernatraemia in preterm infants born at less than 27 weeks gestation.
Topics: Birth Weight; Creatine; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Female; Fluid Therapy | 2006 |
[Hyponatremia as a risk factor of death in patients with community-acquired pneumonia requiring hospitalization].
Topics: Adult; APACHE; Argentina; Cerebrovascular Disorders; Community-Acquired Infections; Epidemiologic Me | 2006 |
Treatment of hyponatraemia by urea decreases risks of brain complications in rats. Brain osmolyte contents analysis.
Topics: Animals; Betaine; Body Water; Brain; Brain Diseases; Demyelinating Diseases; Electrolytes; Hyponatre | 2007 |
Uric acid homeostasis in the evaluation of diuretic-induced hyponatremia.
Topics: Aged; Creatinine; Diagnosis, Differential; Diuretics; Edema; Female; Humans; Hyponatremia; Hypovolem | 2007 |
Idiopathic hyponatremia in a young patient: look at the sinus.
Topics: Adult; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Neuroblastoma; Radiography; Urea | 2008 |
Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics.
Topics: Aged; Diagnosis, Differential; Diuretics; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; | 2008 |
Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics.
Topics: Aged; Diagnosis, Differential; Diuretics; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; | 2008 |
Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics.
Topics: Aged; Diagnosis, Differential; Diuretics; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; | 2008 |
Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics.
Topics: Aged; Diagnosis, Differential; Diuretics; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; | 2008 |
Hyperosmolality with hyponatremia, caused by inappropriate administration of mannitol.
Topics: Acute Kidney Injury; Aged; Blood Chemical Analysis; Body Weight; Humans; Hyponatremia; Iatrogenic Di | 1967 |
Saline depletion, pre-renal failure and acute renal failure.
Topics: Acute Kidney Injury; Adolescent; Calcium; Creatinine; Female; Humans; Hypernatremia; Hyponatremia; P | 1984 |
Calculated vs measured plasma osmolalities revisited.
Topics: Blood Chemical Analysis; Blood Glucose; Diabetes Mellitus; Humans; Hypernatremia; Hyponatremia; Kidn | 1984 |
Diuretic-induced azotemia: unmasking the role of increased peripheral catabolism through evisceration-hepatectomy.
Topics: Amino Acids; Animals; Furosemide; Hepatectomy; Hyponatremia; Intestines; Metabolic Clearance Rate; M | 1983 |
Hypouremia in the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Humans; Hyponatremia; Inappropriate ADH Syndrome; Urea; Vasopressins | 1980 |
[Hyponatremia in clinical practice].
Topics: Humans; Hyponatremia; Inappropriate ADH Syndrome; Urea | 1981 |
Treatment of the syndrome of inappropriate secretion of antidiuretic hormone by urea.
Topics: Adult; Aged; Body Weight; Diuresis; Drinking; Humans; Hyponatremia; Inappropriate ADH Syndrome; Kidn | 1980 |
Urea therapy for inappropriate antidiuretic hormone secretion from tuberculous meningitis.
Topics: Brain Edema; Diuresis; Humans; Hypertension; Hyponatremia; Inappropriate ADH Syndrome; Intracranial | 1980 |
Combined fractional excretion of sodium and urea better predicts response to saline in hyponatremia than do usual clinical and biochemical parameters.
Topics: Aged; Aged, 80 and over; Aldosterone; Creatinine; Diuretics; Drinking Behavior; Extracellular Space; | 1995 |
Delayed hyponatremia after transsphenoidal surgery for pituitary adenoma. Report of nine cases.
Topics: Adenoma; Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Humans; Hyponatremia; Male; Midd | 1995 |
Uric acid, anion gap and urea concentration in the diagnostic approach to hyponatremia.
Topics: Acid-Base Equilibrium; Diuretics; Heart Failure; Humans; Hyponatremia; Hypopituitarism; Inappropriat | 1994 |
Effect of urea and indomethacin intake on solute excretion in the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Aged; Chlorides; Humans; Hyponatremia; Inappropriate ADH Syndrome; Indomethacin; Middle Aged; Natriu | 1993 |
The influence of polydipsia on water excretion in hyponatremic, polydipsic, schizophrenic patients.
Topics: Adult; Blood Glucose; Blood Pressure; Creatinine; Female; Humans; Hyponatremia; Male; Middle Aged; P | 1996 |
Water and sodium disorders following surgical excision of pituitary region tumours.
Topics: Adolescent; Adult; Aged; Atrial Natriuretic Factor; Child; Creatinine; Deamino Arginine Vasopressin; | 1996 |
Exercise-associated hyponatremia in Alaskan sled dogs: urinary and hormonal responses.
Topics: Animals; Body Weight; Diet; Diuresis; Dogs; Eating; Energy Metabolism; Female; Hormones; Hyponatremi | 1997 |
[Clinical case of the month. Acute renal insufficiency following ethylene glycol poisoning].
Topics: Acute Kidney Injury; Anuria; Calcium Oxalate; Creatinine; Ethylene Glycol; Humans; Hyponatremia; Kid | 1997 |
Creatinine, electrolytes and urea--do I hear much groaning?
Topics: Creatinine; Humans; Hyperkalemia; Hypernatremia; Hypokalemia; Hyponatremia; Urea | 1999 |
Effect of liver disease and transplantation on urea synthesis in humans: relationship to acid-base status.
Topics: Acid-Base Equilibrium; Adult; Arteries; Bicarbonates; Carbon Dioxide; Female; Humans; Hydrogen-Ion C | 1999 |
The biochemistry of runners in a 1600 km ultramarathon.
Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blo | 1999 |
Evidence that chronicity of hyponatremia contributes to the high urate clearance observed in the syndrome of inappropriate antidiuretic hormone secretion.
Topics: Adult; Aged; Case-Control Studies; Chronic Disease; Glomerular Filtration Rate; Humans; Hyponatremia | 2000 |
Re: hyponatremia.
Topics: Drug Administration Schedule; Humans; Hyponatremia; Saline Solution, Hypertonic; Urea | 2001 |
Utility and limitations of biochemical parameters in the evaluation of hyponatremia in the elderly.
Topics: Aged; Aged, 80 and over; Aldosterone; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Isot | 2001 |
Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia.
Topics: Animals; Body Water; Brain; Chronic Disease; Hyponatremia; Inositol; Male; Mercuric Chloride; Potass | 2002 |
Hyponatraemia in patients with head injury.
Topics: Adult; Craniocerebral Trauma; Extracellular Space; Female; Humans; Hyponatremia; Male; Sodium; Urea; | 1979 |
Sodium losing renal disease: Two cases and a review of the literature.
Topics: Adult; Drinking; Humans; Hyponatremia; Kidney Diseases; Male; Middle Aged; Sodium; Urea; Urinary Bla | 1978 |
Prognostic value of spontaneous hyponatremia in cirrhosis with ascites.
Topics: Bilirubin; Diuresis; Humans; Hyponatremia; Kidney Function Tests; Liver Cirrhosis; Prognosis; Serum | 1976 |
Mechanism of low serum sodium levels in Mediterranean spotted fever.
Topics: Adolescent; Adult; Aged; Boutonneuse Fever; Chlorides; Creatinine; Female; Hematuria; Humans; Hypona | 1991 |
The electrolytes in hyponatremia.
Topics: Adaptation, Physiological; Animals; Atrial Natriuretic Factor; Bicarbonates; Extracellular Space; Hu | 1991 |
Limits of brain tolerance to daily increments in serum sodium in chronically hyponatraemic rats treated with hypertonic saline or urea: advantages of urea.
Topics: Animals; Brain; Chronic Disease; Demyelinating Diseases; Hyponatremia; Male; Rats; Rats, Inbred Stra | 1991 |
Dissociation between uric acid and urea clearances in the syndrome of inappropriate secretion of antidiuretic hormone related to salt excretion.
Topics: Adult; Humans; Hyponatremia; Inappropriate ADH Syndrome; Middle Aged; Osmolar Concentration; Prospec | 1990 |
Diuretics and electrolyte disturbances in 1000 consecutive geriatric admissions.
Topics: Age Factors; Aged; Amiloride; Diuretics; Drug Combinations; Drug Prescriptions; Humans; Hydrochlorot | 1990 |
Converting enzyme inhibition by enalapril in experimental heart failure.
Topics: Administration, Oral; Animals; Cardiac Output, Low; Cardiac Pacing, Artificial; Creatinine; Dogs; En | 1990 |
Intravenous urea and saline for hyponatremia.
Topics: Humans; Hyponatremia; Sodium Chloride; Urea | 1989 |
Rapid correction of hyponatraemia with urea may protect against brain damage in rats.
Topics: Animals; Brain; Brain Diseases; Hyponatremia; Male; Rats; Rats, Inbred Strains; Saline Solution, Hyp | 1989 |
Hyponatremia treatment by urea and saline.
Topics: Humans; Hyponatremia; Sodium Chloride; Urea | 1989 |
Administration of intravenous urea and normal saline for the treatment of hyponatremia in neurosurgical patients.
Topics: Blood Urea Nitrogen; Humans; Hyponatremia; Inappropriate ADH Syndrome; Injections, Intravenous; Nerv | 1989 |
Influence of converting enzyme inhibition on the hormonal and renal adaptation to hyper- and hyponatraemic dehydration.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Dehydrati | 1986 |
Intrapartum fluid administration and sodium concentration in maternal and umbilical cord plasma.
Topics: Female; Fetal Blood; Glucose; Humans; Hyponatremia; Labor, Obstetric; Oxytocin; Pharmaceutical Vehic | 1987 |
Urea treatment for water retention in hyponatremic congestive heart failure.
Topics: Aged; Drug Therapy, Combination; Furosemide; Heart Failure; Humans; Hyponatremia; Male; Urea | 1987 |
Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea.
Topics: Adult; Ascites; Body Weight; Creatinine; Drug Therapy, Combination; Edema; Furosemide; Humans; Hypon | 1986 |
Biochemical and clinical correlates of diuretic therapy in the elderly.
Topics: Aged; Airway Obstruction; Coronary Disease; Creatinine; Diuretics; Heart Failure; Humans; Hypokalemi | 1986 |
Use of urea for treatment of water retention in hyponatraemic cirrhosis with ascites resistant to diuretics.
Topics: Diuretics; Edema; Female; Humans; Hyponatremia; Liver Cirrhosis, Alcoholic; Middle Aged; Urea | 1985 |
Salt wasting, raised plasma-renin activity, and normal or high plasma-aldosterone: a form of pseudohypoaldosteronism.
Topics: Acidosis; Aldosterone; Bicarbonates; Blood Urea Nitrogen; Carbon Dioxide; Child; Child, Preschool; D | 1973 |
Letter: Hyponatraemia.
Topics: Blood Glucose; Cell Membrane Permeability; Humans; Hydrogen-Ion Concentration; Hyponatremia; Osmolar | 1974 |
Amiloride ('MK 870') in patients with ascites due to cirrhosis of the liver.
Topics: Adult; Ascites; Bicarbonates; Creatinine; Diuretics; Ethacrynic Acid; Furosemide; Guanidines; Humans | 1968 |
Inappropriate antidiuretic hormone secretion in oat-cell carcinoma of bronchus. Aggravation of hyponatraemia by intravenous cyclophosphamide.
Topics: Adult; Autopsy; Bicarbonates; Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Small Cell; C | 1972 |
Hyponatraemia syndrome in acute myeloid leukaemia.
Topics: Adult; Ampicillin; Blood Cell Count; Body Weight; Bone Marrow Cells; Chlorides; Cloxacillin; Cytarab | 1974 |
Renal papillary necrosis in infancy.
Topics: Acidosis; Acute Disease; Anuria; Bicarbonates; Body Weight; Dehydration; Humans; Hyponatremia; Infan | 1973 |
Electrolyte disturbances in Liberian children with kwashiorkor.
Topics: Alkalies; Alkalosis; Arteries; Blood; Calcium; Child; Child, Preschool; Chlorides; Chloroquine; Cult | 1973 |
Transplantation of cadaveric kidneys from patients with hepatorenal syndrome. Evidence for the functionalnature of renal failure in advanced liver disease.
Topics: Adult; Anuria; Blood Urea Nitrogen; Cadaver; Creatinine; Diuresis; Female; Humans; Hyponatremia; Kid | 1969 |
Sodium depletion in chronic renal failure.
Topics: Blood Pressure Determination; Blood Proteins; Glomerular Filtration Rate; Hemoglobins; Humans; Hypon | 1971 |
Syndrome of cellular agony--biochemical characterization.
Topics: Autopsy; Child; Death; Gastroenteritis; Humans; Hyperglycemia; Hyperkalemia; Hyponatremia; Kwashiork | 1969 |
Body fluid composition and sodium excretion under osmotic diuresis.
Topics: Adult; Body Fluids; Diuresis; Diuretics; Electrolytes; Extracellular Space; Female; Humans; Hypernat | 1970 |
Role of blood urea and serum sodium concentrations in the pathogenesis of the dialysis dysequilibrium syndrome.
Topics: Animals; Brain Chemistry; Cerebrospinal Fluid; Dogs; Electroencephalography; Hemodynamics; Humans; H | 1968 |