Page last updated: 2024-10-20

urea and Hand Dermatoses

urea has been researched along with Hand Dermatoses in 23 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Hand Dermatoses: Skin diseases involving the HANDS.

Research Excerpts

ExcerptRelevanceReference
"Hand-foot syndrome (HFS) is a dose-limiting toxicity of capecitabine for which no effective preventative treatment has been definitively demonstrated."9.14Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. ( Berenberg, JL; Christian, D; Delaune, R; Loprinzi, CL; Menon, SP; Pajon, ER; Qin, R; Rowland, KM; Satele, DV; Thomas, S; Wolf, SL, 2010)
"A parallel-group double-blind study was carried out which compared the efficacy of chemical avulsion of affected nail by urea 40% and bifonazole 1% cream alone with that of the same local therapy combined with short-term oral griseofulvin in onychomycosis."9.08Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin. ( Bergman, R; Bitterman, O; Cohen, A; Friedman-Birnbaum, R; Shemer, A; Stettendorf, S, 1997)
"20 patients with distal onychomycosis were given daily application of an ointment containing 2% tolnaftate and an ointment containing 20% urea under ODT."9.05Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment. ( Asai, Y; Hamada, T; Ishii, M, 1983)
"13 patients with distal subungual onychomycosis in a total of 48 dermatophyte-infected nails were treated with chemomechanical, partial nail avulsion followed by topical miconazole for 8 weeks."7.66Treatment of onychomycosis by partial nail avulsion and topical miconazole. ( Rollman, O, 1982)
"Hand-foot syndrome (HFS) is a dose-limiting toxicity of capecitabine for which no effective preventative treatment has been definitively demonstrated."5.14Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. ( Berenberg, JL; Christian, D; Delaune, R; Loprinzi, CL; Menon, SP; Pajon, ER; Qin, R; Rowland, KM; Satele, DV; Thomas, S; Wolf, SL, 2010)
"A parallel-group double-blind study was carried out which compared the efficacy of chemical avulsion of affected nail by urea 40% and bifonazole 1% cream alone with that of the same local therapy combined with short-term oral griseofulvin in onychomycosis."5.08Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin. ( Bergman, R; Bitterman, O; Cohen, A; Friedman-Birnbaum, R; Shemer, A; Stettendorf, S, 1997)
"20 patients with distal onychomycosis were given daily application of an ointment containing 2% tolnaftate and an ointment containing 20% urea under ODT."5.05Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment. ( Asai, Y; Hamada, T; Ishii, M, 1983)
"Formaldehyde and formaldehyde-releasers are common causes of allergic contact dermatitis."3.77Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009). ( Borrego, L; Fernández-Redondo, V; García-Bravo, B; Giménez-Arnau, AM; Latorre, N; Sánchez, J; Silvestre, JF, 2011)
"Preparations containing urea were found to be effective in the treatment of ichthyosis vulgaris and so we were encouraged to test their use in other dry skin conditions."3.67[Urea as a single drug in dry skin]. ( Swanbeck, G, 1989)
"13 patients with distal subungual onychomycosis in a total of 48 dermatophyte-infected nails were treated with chemomechanical, partial nail avulsion followed by topical miconazole for 8 weeks."3.66Treatment of onychomycosis by partial nail avulsion and topical miconazole. ( Rollman, O, 1982)
"Allergic contact dermatitis is a frequent cause of hand dermatitis."2.45Hand dermatitis: a focus on allergic contact dermatitis to biocides. ( Bhutani, T; Jacob, SE; Lampel, HP; Maier, LE, 2009)
"Salicylic acid ointment was applied on one and carbamide ointment on the other back of the hand."1.28[Water content of the skin following salicylic acid and urea treatment]. ( Jakab, E; Rácz, I; Soós, G, 1989)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199013 (56.52)18.7374
1990's1 (4.35)18.2507
2000's4 (17.39)29.6817
2010's5 (21.74)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Apfelbacher, CJ1
Ofenloch, RF1
Weisshaar, E1
Molin, S1
Bauer, A1
Mahler, V1
Heinrich, A1
von Kiedrowski, R1
Schmitt, J1
Elsner, P1
Diepgen, TL1
Lindh, JD1
Bradley, M1
Lacouture, ME1
Reilly, LM1
Gerami, P1
Guitart, J1
Maier, LE1
Lampel, HP1
Bhutani, T1
Jacob, SE1
Lodén, M1
Wirén, K1
Smerud, K1
Meland, N1
Hønnås, H1
Mørk, G1
Lützow-Holm, C1
Funk, J1
Meding, B1
Wolf, SL1
Qin, R1
Menon, SP1
Rowland, KM1
Thomas, S1
Delaune, R1
Christian, D1
Pajon, ER1
Satele, DV1
Berenberg, JL1
Loprinzi, CL1
Latorre, N1
Borrego, L1
Fernández-Redondo, V1
García-Bravo, B1
Giménez-Arnau, AM1
Sánchez, J1
Silvestre, JF1
Onder, M1
Oztas, M1
Arnavut, O1
Baran, R1
Rollman, O1
Ishii, M1
Hamada, T1
Asai, Y1
Schubert, H1
Würbach, G1
Godenschweger, K1
Schröder, W1
Friedman-Birnbaum, R1
Cohen, A1
Shemer, A1
Bitterman, O1
Bergman, R1
Stettendorf, S1
Nolting, S1
Swanbeck, G1
Rácz, I1
Soós, G1
Jakab, E1
Wang, DB1
Yang, YT1
Cao, RL1
Cui, SY1
Cao, ZR1
Hay, RJ1
Roberts, DT1
Doherty, VR1
Richardson, MD1
Midgley, G1
Ruslanov, DV1
Hersle, K1
Gisslén, H1
Hindson, TC1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II, Randomised Controlled Trial to Evaluate the Efficacy and Safety of Moisturising Creams With or Without Palm-oil-derived Vitamin E Concentrate in Addition to Urea-based Cream or Urea-based Cream Alone in Capecitabine-associated Palmar-Plantar E[NCT05939726]90 participants (Anticipated)Interventional2023-05-16Recruiting
A Phase III Randomized, Placebo-controlled, Double-blind Trial to Determine the Effectiveness of a Urea/Lactic Acid-Based Topical Keratolytic Agent and Vitamin B-6 for Prevention of Capecitabine-Induced Hand and Foot Syndrome[NCT00296036]Phase 3137 participants (Actual)Interventional2006-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

To Determine Whether the Prophylactic Use of a Topical Urea/Lactic Acid Cream Can Decrease the Incidence/Severity of Capecitabine-caused Palmar-plantar Erythrodysesthesia

A patient self-reported hand-foot syndrome (HFSD), also known as palmar-plantar erythrodysesthesia, was completed daily while applying the cream. Patients rated skin severity symptoms individually in their hands and in their feet. Definitions of symptoms, which were based on Common Terminology Criteria for Adverse Events (CTCAE) v3.0, were provided to patients. The number of patients reporting moderate to severe symptoms in either hands or feet were tabulated and percentages are reported. (NCT00296036)
Timeframe: First 3 weeks of treatment

Interventionpercentage of participants (Number)
Urea/Lactic Acid Cream13.6
Placebo Cream10.2

To Evaluate the Potential Toxicity of Urea/Lactic Acid Cream

Frequency and severity of adverse events reported by patients in weekly diary and evaluated through clinical assessment by NCI CTCAE v3.0. The number of patients reporting grade 3 or higher events are reported in this outcome measure. For a full list of all events, please refer to the Adverse Events section of this report. (NCT00296036)
Timeframe: Up to 4, 21-day cycles

,
Interventionparticipants (Number)
Grade 3+ Adverse EventGrade 4+ Adverse Event
Placebo Cream183
Urea/Lactic Acid Cream213

Reviews

3 reviews available for urea and Hand Dermatoses

ArticleYear
Clinical Effectiveness of Moisturizers in Atopic Dermatitis and Related Disorders: A Systematic Review.
    American journal of clinical dermatology, 2015, Volume: 16, Issue:5

    Topics: Dermatitis, Atopic; Dermatitis, Irritant; Emollients; Epidermis; Glycerol; Hand Dermatoses; Humans;

2015
Hand dermatitis: a focus on allergic contact dermatitis to biocides.
    Dermatologic clinics, 2009, Volume: 27, Issue:3

    Topics: Allergens; Carbamates; Dermatitis, Allergic Contact; Dermatitis, Occupational; Dermatology; Disinfec

2009
Nail fungal infections and treatment.
    Hand clinics, 2002, Volume: 18, Issue:4

    Topics: Bandages; Hand Dermatoses; Humans; Nails; Ointments; Onychomycosis; Urea

2002

Trials

7 trials available for urea and Hand Dermatoses

ArticleYear
Treatment with a barrier-strengthening moisturizer prevents relapse of hand-eczema. An open, randomized, prospective, parallel group study.
    Acta dermato-venereologica, 2010, Volume: 90, Issue:6

    Topics: Administration, Cutaneous; Adult; Aged; Eczema; Emollients; Female; Hand Dermatoses; Humans; Male; M

2010
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35

    Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind

2010
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35

    Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind

2010
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35

    Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind

2010
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-10, Volume: 28, Issue:35

    Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind

2010
Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment.
    Dermatologica, 1983, Volume: 167, Issue:5

    Topics: Administration, Oral; Adult; Clinical Trials as Topic; Drug Therapy, Combination; Female; Foot Derma

1983
Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin.
    International journal of dermatology, 1997, Volume: 36, Issue:1

    Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Antifungal Agents; Double-Bl

1997
The topical treatment of onychomycosis using a new combined urea/imidazole preparation.
    Clinical and experimental dermatology, 1988, Volume: 13, Issue:3

    Topics: Administration, Topical; Adult; Aged; Antifungal Agents; Clinical Trials as Topic; Drug Combinations

1988
[Calmurid HC ointment--a new principle in the treatment chronic traumiterative hand eczema].
    Zeitschrift fur Haut- und Geschlechtskrankheiten, 1972, Jul-01, Volume: 47, Issue:13

    Topics: Chronic Disease; Clinical Trials as Topic; Eczema; Female; Fluprednisolone; Hand Dermatoses; Humans;

1972
Carbamide in hyperkeratosis.
    The Practitioner, 1973, Volume: 210, Issue:256

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Trials as Topic; Dermatitis, Atopic; Eval

1973

Other Studies

13 other studies available for urea and Hand Dermatoses

ArticleYear
Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry.
    Contact dermatitis, 2019, Volume: 80, Issue:1

    Topics: Acitretin; Administration, Cutaneous; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and

2019
Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:11

    Topics: Administration, Topical; Aged; Aged, 80 and over; Antineoplastic Agents; Benzenesulfonates; Carcinom

2008
Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009).
    Contact dermatitis, 2011, Volume: 65, Issue:5

    Topics: Adult; Allergens; Dermatitis, Allergic Contact; Dermatitis, Occupational; Facial Dermatoses; Formald

2011
Nargile (Hubble-Bubble) smoking-induced hand eczema.
    International journal of dermatology, 2002, Volume: 41, Issue:11

    Topics: Adrenal Cortex Hormones; Aged; Eczema; Equipment Design; Hand Dermatoses; Humans; Male; Ointments; P

2002
Treatment of onychomycosis by partial nail avulsion and topical miconazole.
    Dermatologica, 1982, Volume: 165, Issue:1

    Topics: Administration, Topical; Adult; Aged; Drug Therapy, Combination; Foot Dermatoses; Hand Dermatoses; H

1982
[Effectiveness of hand-protective salves in urea contamination].
    Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete, 1984, Volume: 30, Issue:9

    Topics: Dermatitis, Occupational; Germany, West; Hand Dermatoses; Humans; Ointments; Urea

1984
[Urea and its therapeutic possibilities].
    Fortschritte der Medizin, 1983, Mar-24, Volume: 101, Issue:11

    Topics: Adult; Foot Dermatoses; Hand Dermatoses; Humans; Male; Middle Aged; Scalp Dermatoses; Skin Diseases;

1983
[Onychomycoses and their successful therapy].
    Wiener medizinische Wochenschrift (1946), 1989, Aug-31, Volume: 139, Issue:15-16

    Topics: Administration, Topical; Antifungal Agents; Drug Therapy, Combination; Foot Dermatoses; Hand Dermato

1989
[Urea as a single drug in dry skin].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1989, Volume: 40 Suppl 9

    Topics: Administration, Topical; Dermatologic Agents; Drug Therapy, Combination; Eczema; Hand Dermatoses; Hu

1989
[Water content of the skin following salicylic acid and urea treatment].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1989, Volume: 40 Suppl 9

    Topics: Administration, Topical; Adult; Body Water; Dermatologic Agents; Female; Hand Dermatoses; Humans; Ic

1989
Urea plaster for softening diseased nails in the treatment of tinea unguium.
    Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao, 1986, Volume: 1, Issue:3

    Topics: Foot Dermatoses; Hand Dermatoses; Humans; Ointments; Onychomycosis; Urea

1986
[Basis and comparative evaluation of the combined therapy of patients with foot and hand mycoses].
    Vestnik dermatologii i venerologii, 1985, Issue:9

    Topics: Antibody Formation; Dermatomycoses; Dimethyl Sulfoxide; Drug Therapy, Combination; Foot Dermatoses;

1985
Urea in the topical treatment of atopic eczema.
    Archives of dermatology, 1971, Volume: 104, Issue:3

    Topics: Adult; Betamethasone; Child; Child, Preschool; Chronic Disease; Dermatologic Agents; Eczema; Foot De

1971