urea has been researched along with Hand Dermatoses in 23 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Hand Dermatoses: Skin diseases involving the HANDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hand-foot syndrome (HFS) is a dose-limiting toxicity of capecitabine for which no effective preventative treatment has been definitively demonstrated." | 9.14 | Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. ( Berenberg, JL; Christian, D; Delaune, R; Loprinzi, CL; Menon, SP; Pajon, ER; Qin, R; Rowland, KM; Satele, DV; Thomas, S; Wolf, SL, 2010) |
| "A parallel-group double-blind study was carried out which compared the efficacy of chemical avulsion of affected nail by urea 40% and bifonazole 1% cream alone with that of the same local therapy combined with short-term oral griseofulvin in onychomycosis." | 9.08 | Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin. ( Bergman, R; Bitterman, O; Cohen, A; Friedman-Birnbaum, R; Shemer, A; Stettendorf, S, 1997) |
| "20 patients with distal onychomycosis were given daily application of an ointment containing 2% tolnaftate and an ointment containing 20% urea under ODT." | 9.05 | Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment. ( Asai, Y; Hamada, T; Ishii, M, 1983) |
| "13 patients with distal subungual onychomycosis in a total of 48 dermatophyte-infected nails were treated with chemomechanical, partial nail avulsion followed by topical miconazole for 8 weeks." | 7.66 | Treatment of onychomycosis by partial nail avulsion and topical miconazole. ( Rollman, O, 1982) |
| "Hand-foot syndrome (HFS) is a dose-limiting toxicity of capecitabine for which no effective preventative treatment has been definitively demonstrated." | 5.14 | Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5. ( Berenberg, JL; Christian, D; Delaune, R; Loprinzi, CL; Menon, SP; Pajon, ER; Qin, R; Rowland, KM; Satele, DV; Thomas, S; Wolf, SL, 2010) |
| "A parallel-group double-blind study was carried out which compared the efficacy of chemical avulsion of affected nail by urea 40% and bifonazole 1% cream alone with that of the same local therapy combined with short-term oral griseofulvin in onychomycosis." | 5.08 | Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin. ( Bergman, R; Bitterman, O; Cohen, A; Friedman-Birnbaum, R; Shemer, A; Stettendorf, S, 1997) |
| "20 patients with distal onychomycosis were given daily application of an ointment containing 2% tolnaftate and an ointment containing 20% urea under ODT." | 5.05 | Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment. ( Asai, Y; Hamada, T; Ishii, M, 1983) |
| "Formaldehyde and formaldehyde-releasers are common causes of allergic contact dermatitis." | 3.77 | Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009). ( Borrego, L; Fernández-Redondo, V; García-Bravo, B; Giménez-Arnau, AM; Latorre, N; Sánchez, J; Silvestre, JF, 2011) |
| "Preparations containing urea were found to be effective in the treatment of ichthyosis vulgaris and so we were encouraged to test their use in other dry skin conditions." | 3.67 | [Urea as a single drug in dry skin]. ( Swanbeck, G, 1989) |
| "13 patients with distal subungual onychomycosis in a total of 48 dermatophyte-infected nails were treated with chemomechanical, partial nail avulsion followed by topical miconazole for 8 weeks." | 3.66 | Treatment of onychomycosis by partial nail avulsion and topical miconazole. ( Rollman, O, 1982) |
| "Allergic contact dermatitis is a frequent cause of hand dermatitis." | 2.45 | Hand dermatitis: a focus on allergic contact dermatitis to biocides. ( Bhutani, T; Jacob, SE; Lampel, HP; Maier, LE, 2009) |
| "Salicylic acid ointment was applied on one and carbamide ointment on the other back of the hand." | 1.28 | [Water content of the skin following salicylic acid and urea treatment]. ( Jakab, E; Rácz, I; Soós, G, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (56.52) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Apfelbacher, CJ | 1 |
| Ofenloch, RF | 1 |
| Weisshaar, E | 1 |
| Molin, S | 1 |
| Bauer, A | 1 |
| Mahler, V | 1 |
| Heinrich, A | 1 |
| von Kiedrowski, R | 1 |
| Schmitt, J | 1 |
| Elsner, P | 1 |
| Diepgen, TL | 1 |
| Lindh, JD | 1 |
| Bradley, M | 1 |
| Lacouture, ME | 1 |
| Reilly, LM | 1 |
| Gerami, P | 1 |
| Guitart, J | 1 |
| Maier, LE | 1 |
| Lampel, HP | 1 |
| Bhutani, T | 1 |
| Jacob, SE | 1 |
| Lodén, M | 1 |
| Wirén, K | 1 |
| Smerud, K | 1 |
| Meland, N | 1 |
| Hønnås, H | 1 |
| Mørk, G | 1 |
| Lützow-Holm, C | 1 |
| Funk, J | 1 |
| Meding, B | 1 |
| Wolf, SL | 1 |
| Qin, R | 1 |
| Menon, SP | 1 |
| Rowland, KM | 1 |
| Thomas, S | 1 |
| Delaune, R | 1 |
| Christian, D | 1 |
| Pajon, ER | 1 |
| Satele, DV | 1 |
| Berenberg, JL | 1 |
| Loprinzi, CL | 1 |
| Latorre, N | 1 |
| Borrego, L | 1 |
| Fernández-Redondo, V | 1 |
| García-Bravo, B | 1 |
| Giménez-Arnau, AM | 1 |
| Sánchez, J | 1 |
| Silvestre, JF | 1 |
| Onder, M | 1 |
| Oztas, M | 1 |
| Arnavut, O | 1 |
| Baran, R | 1 |
| Rollman, O | 1 |
| Ishii, M | 1 |
| Hamada, T | 1 |
| Asai, Y | 1 |
| Schubert, H | 1 |
| Würbach, G | 1 |
| Godenschweger, K | 1 |
| Schröder, W | 1 |
| Friedman-Birnbaum, R | 1 |
| Cohen, A | 1 |
| Shemer, A | 1 |
| Bitterman, O | 1 |
| Bergman, R | 1 |
| Stettendorf, S | 1 |
| Nolting, S | 1 |
| Swanbeck, G | 1 |
| Rácz, I | 1 |
| Soós, G | 1 |
| Jakab, E | 1 |
| Wang, DB | 1 |
| Yang, YT | 1 |
| Cao, RL | 1 |
| Cui, SY | 1 |
| Cao, ZR | 1 |
| Hay, RJ | 1 |
| Roberts, DT | 1 |
| Doherty, VR | 1 |
| Richardson, MD | 1 |
| Midgley, G | 1 |
| Ruslanov, DV | 1 |
| Hersle, K | 1 |
| Gisslén, H | 1 |
| Hindson, TC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II, Randomised Controlled Trial to Evaluate the Efficacy and Safety of Moisturising Creams With or Without Palm-oil-derived Vitamin E Concentrate in Addition to Urea-based Cream or Urea-based Cream Alone in Capecitabine-associated Palmar-Plantar E[NCT05939726] | 90 participants (Anticipated) | Interventional | 2023-05-16 | Recruiting | |||
| A Phase III Randomized, Placebo-controlled, Double-blind Trial to Determine the Effectiveness of a Urea/Lactic Acid-Based Topical Keratolytic Agent and Vitamin B-6 for Prevention of Capecitabine-Induced Hand and Foot Syndrome[NCT00296036] | Phase 3 | 137 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A patient self-reported hand-foot syndrome (HFSD), also known as palmar-plantar erythrodysesthesia, was completed daily while applying the cream. Patients rated skin severity symptoms individually in their hands and in their feet. Definitions of symptoms, which were based on Common Terminology Criteria for Adverse Events (CTCAE) v3.0, were provided to patients. The number of patients reporting moderate to severe symptoms in either hands or feet were tabulated and percentages are reported. (NCT00296036)
Timeframe: First 3 weeks of treatment
| Intervention | percentage of participants (Number) |
|---|---|
| Urea/Lactic Acid Cream | 13.6 |
| Placebo Cream | 10.2 |
Frequency and severity of adverse events reported by patients in weekly diary and evaluated through clinical assessment by NCI CTCAE v3.0. The number of patients reporting grade 3 or higher events are reported in this outcome measure. For a full list of all events, please refer to the Adverse Events section of this report. (NCT00296036)
Timeframe: Up to 4, 21-day cycles
| Intervention | participants (Number) | |
|---|---|---|
| Grade 3+ Adverse Event | Grade 4+ Adverse Event | |
| Placebo Cream | 18 | 3 |
| Urea/Lactic Acid Cream | 21 | 3 |
3 reviews available for urea and Hand Dermatoses
| Article | Year |
|---|---|
Clinical Effectiveness of Moisturizers in Atopic Dermatitis and Related Disorders: A Systematic Review.
Topics: Dermatitis, Atopic; Dermatitis, Irritant; Emollients; Epidermis; Glycerol; Hand Dermatoses; Humans; | 2015 |
Hand dermatitis: a focus on allergic contact dermatitis to biocides.
Topics: Allergens; Carbamates; Dermatitis, Allergic Contact; Dermatitis, Occupational; Dermatology; Disinfec | 2009 |
Nail fungal infections and treatment.
Topics: Bandages; Hand Dermatoses; Humans; Nails; Ointments; Onychomycosis; Urea | 2002 |
7 trials available for urea and Hand Dermatoses
| Article | Year |
|---|---|
Treatment with a barrier-strengthening moisturizer prevents relapse of hand-eczema. An open, randomized, prospective, parallel group study.
Topics: Administration, Cutaneous; Adult; Aged; Eczema; Emollients; Female; Hand Dermatoses; Humans; Male; M | 2010 |
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind | 2010 |
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind | 2010 |
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind | 2010 |
Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced hand-foot syndrome: North Central Cancer Treatment Group Study N05C5.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Double-Blind | 2010 |
Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment.
Topics: Administration, Oral; Adult; Clinical Trials as Topic; Drug Therapy, Combination; Female; Foot Derma | 1983 |
Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Antifungal Agents; Double-Bl | 1997 |
The topical treatment of onychomycosis using a new combined urea/imidazole preparation.
Topics: Administration, Topical; Adult; Aged; Antifungal Agents; Clinical Trials as Topic; Drug Combinations | 1988 |
[Calmurid HC ointment--a new principle in the treatment chronic traumiterative hand eczema].
Topics: Chronic Disease; Clinical Trials as Topic; Eczema; Female; Fluprednisolone; Hand Dermatoses; Humans; | 1972 |
Carbamide in hyperkeratosis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Trials as Topic; Dermatitis, Atopic; Eval | 1973 |
13 other studies available for urea and Hand Dermatoses
| Article | Year |
|---|---|
Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry.
Topics: Acitretin; Administration, Cutaneous; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and | 2019 |
Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib.
Topics: Administration, Topical; Aged; Aged, 80 and over; Antineoplastic Agents; Benzenesulfonates; Carcinom | 2008 |
Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009).
Topics: Adult; Allergens; Dermatitis, Allergic Contact; Dermatitis, Occupational; Facial Dermatoses; Formald | 2011 |
Nargile (Hubble-Bubble) smoking-induced hand eczema.
Topics: Adrenal Cortex Hormones; Aged; Eczema; Equipment Design; Hand Dermatoses; Humans; Male; Ointments; P | 2002 |
Treatment of onychomycosis by partial nail avulsion and topical miconazole.
Topics: Administration, Topical; Adult; Aged; Drug Therapy, Combination; Foot Dermatoses; Hand Dermatoses; H | 1982 |
[Effectiveness of hand-protective salves in urea contamination].
Topics: Dermatitis, Occupational; Germany, West; Hand Dermatoses; Humans; Ointments; Urea | 1984 |
[Urea and its therapeutic possibilities].
Topics: Adult; Foot Dermatoses; Hand Dermatoses; Humans; Male; Middle Aged; Scalp Dermatoses; Skin Diseases; | 1983 |
[Onychomycoses and their successful therapy].
Topics: Administration, Topical; Antifungal Agents; Drug Therapy, Combination; Foot Dermatoses; Hand Dermato | 1989 |
[Urea as a single drug in dry skin].
Topics: Administration, Topical; Dermatologic Agents; Drug Therapy, Combination; Eczema; Hand Dermatoses; Hu | 1989 |
[Water content of the skin following salicylic acid and urea treatment].
Topics: Administration, Topical; Adult; Body Water; Dermatologic Agents; Female; Hand Dermatoses; Humans; Ic | 1989 |
Urea plaster for softening diseased nails in the treatment of tinea unguium.
Topics: Foot Dermatoses; Hand Dermatoses; Humans; Ointments; Onychomycosis; Urea | 1986 |
[Basis and comparative evaluation of the combined therapy of patients with foot and hand mycoses].
Topics: Antibody Formation; Dermatomycoses; Dimethyl Sulfoxide; Drug Therapy, Combination; Foot Dermatoses; | 1985 |
Urea in the topical treatment of atopic eczema.
Topics: Adult; Betamethasone; Child; Child, Preschool; Chronic Disease; Dermatologic Agents; Eczema; Foot De | 1971 |