Page last updated: 2024-10-20

urea and HIV

urea has been researched along with HIV in 16 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Research Excerpts

ExcerptRelevanceReference
"We have discovered that nonsymmetrical cyclic ureas containing a 3-aminoindazole P2 group are potent inhibitors of HIV protease with excellent oral bioavailability."7.70Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. ( Anderson, PS; Bacheler, LT; Chang, CH; Cordova, B; Erickson-Viitanen, S; Garber, S; Johnson, BL; Klabe, RM; Ko, SS; Lam, PY; Li, R; Reid, C; Rodgers, JD; Ru, Y; Seitz, SP; Trainor, GL; Wang, H; Wright, MR, 1998)
"Two series of cyclic ureas modified at the P1/P1' residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity."7.70The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: modifications of the P1/P1' residues. ( Bacheler, LT; Cordova, BC; Erickson-Viitanen, S; Klabe, RM; Patel, M; Rayner, MM; Seitz, SP, 1998)
"3 h in rats and the absolute oral bioavailability ranged from 18 to 100%."5.29A pharmacokinetic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs. ( Burcham, DL; Erickson-Viitanen, S; Grubb, MF; Huang, SM; Quon, CY; Saxton, PL; Wong, YN, 1994)
" The Population Council has developed a prototype intravaginal ring (IVR) releasing the non-nucleoside reverse transcriptase inhibitor (NNRTI) MIV-150 (M), zinc acetate (ZA), carrageenan (CG) and levonorgestrel (LNG) (MZCL IVR) to protect against HIV, HSV-2, HPV and unintended pregnancy."3.83A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo. ( Blanchard, J; Calenda, G; Cooney, ML; Fernández-Romero, JA; Gettie, A; Kizima, L; Mizenina, O; Robbiani, M; Teleshova, N; Ugaonkar, S; Villegas, G; Zhang, S; Zydowsky, TM, 2016)
"We have discovered that nonsymmetrical cyclic ureas containing a 3-aminoindazole P2 group are potent inhibitors of HIV protease with excellent oral bioavailability."3.70Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. ( Anderson, PS; Bacheler, LT; Chang, CH; Cordova, B; Erickson-Viitanen, S; Garber, S; Johnson, BL; Klabe, RM; Ko, SS; Lam, PY; Li, R; Reid, C; Rodgers, JD; Ru, Y; Seitz, SP; Trainor, GL; Wang, H; Wright, MR, 1998)
"Two series of cyclic ureas modified at the P1/P1' residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity."3.70The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: modifications of the P1/P1' residues. ( Bacheler, LT; Cordova, BC; Erickson-Viitanen, S; Klabe, RM; Patel, M; Rayner, MM; Seitz, SP, 1998)
"SC-52151 is a potent, selective, tight-binding human immunodeficiency virus (HIV) protease inhibitor containing the novel (R)-(hydroxyethyl) urea isostere."3.69SC-52151, a novel inhibitor of the human immunodeficiency virus protease. ( Bryant, M; Clare, M; DeCrescenzo, G; Dillard, R; Getman, D; Heintz, R; Houseman, K; Lansky, D; Marr, J; Smidt, M, 1995)
" While the use of currently approved HIV protease inhibitors in concert with drugs that target the reverse transcriptase has dramatically ameliorated the disease state for many individuals, highly-structured dosing regimens accompanied by adverse side-effect profiles have led to a significant level of patient non-compliance."2.42Non-peptidic HIV protease inhibitors. ( Chrusciel, RA; Strohbach, JW, 2004)
"Mollecarbamates 1-4 are a family of compounds that possess repeating o-carboxyphenethylamide units and a carbamate moiety, while the molleureas 5-8 contain tetra- and penta-repeating carboxyphenethylamide units and a urea bridge in different positions."1.46Mollecarbamates, Molleureas, and Molledihydroisoquinolone, o-Carboxyphenethylamide Metabolites of the Ascidian Didemnum molle Collected in Madagascar. ( Aknin, M; Barrows, LR; Carmeli, S; Gauvin-Bialecki, A; Issac, M; Kashman, Y; Pond, CD, 2017)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's6 (37.50)18.2507
2000's4 (25.00)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Issac, M1
Aknin, M1
Gauvin-Bialecki, A1
Pond, CD1
Barrows, LR1
Kashman, Y1
Carmeli, S1
Pang, X1
Liu, Z1
Zhai, G1
Chen, J1
Poddar, NK1
Tauzin, LJ1
Cooper, D1
Kolomeisky, AB1
Landes, CF1
Villegas, G1
Calenda, G1
Ugaonkar, S1
Zhang, S1
Kizima, L1
Mizenina, O1
Gettie, A2
Blanchard, J2
Cooney, ML1
Robbiani, M2
Fernández-Romero, JA1
Zydowsky, TM2
Teleshova, N1
Pessoa-E-Silva, R1
Mendonça Trajano-Silva, LA1
Lopes da Silva, MA1
da Cunha Gonçalves-de-Albuquerque, S1
de Goes, TC1
Silva de Morais, RC1
Lopes de Melo, F1
de Paiva-Cavalcanti, M1
Crostarosa, F1
Aravantinou, M1
Akpogheneta, OJ1
Jasny, E1
Shaw, A1
Kenney, J1
Piatak, M1
Lifson, JD1
Teitelbaum, A1
Hu, L1
Chudolij, A1
Kaltenbach, RF1
Patel, M2
Waltermire, RE1
Harris, GD1
Stone, BR1
Klabe, RM3
Garber, S2
Bacheler, LT3
Cordova, BC2
Logue, K1
Wright, MR2
Erickson-Viitanen, S4
Trainor, GL2
Chrusciel, RA1
Strohbach, JW1
Struga, M1
Kossakowski, J1
Kedzierska, E1
Fidecka, S1
Stefańska, J1
Delwart, EL1
Herring, B1
Rodrigo, AG1
Mullins, JI1
Wong, YN1
Burcham, DL1
Saxton, PL1
Grubb, MF1
Quon, CY1
Huang, SM1
Bryant, M1
Getman, D1
Smidt, M1
Marr, J1
Clare, M1
Dillard, R1
Lansky, D1
DeCrescenzo, G1
Heintz, R1
Houseman, K1
Rayner, MM2
Cordova, B2
Jackson, DA1
Rodgers, JD1
Lam, PY1
Johnson, BL1
Wang, H1
Li, R1
Ru, Y1
Ko, SS1
Seitz, SP2
Anderson, PS1
Reid, C1
Chang, CH1
Dormont, D1
Vaslin, B1
Dubeaux, D1
Boussin, F1
Maillard, F1
Deslys, JP1

Reviews

2 reviews available for urea and HIV

ArticleYear
Advances in non-peptidomimetic HIV protease inhibitors.
    Current medicinal chemistry, 2014, Volume: 21, Issue:17

    Topics: Drug Design; Drug Resistance, Viral; Fullerenes; HIV; HIV Infections; HIV Protease; HIV Protease Inh

2014
Non-peptidic HIV protease inhibitors.
    Current topics in medicinal chemistry, 2004, Volume: 4, Issue:10

    Topics: Anti-HIV Agents; Disulfides; Drug Resistance, Viral; Furans; Heterocyclic Compounds, 4 or More Rings

2004

Other Studies

14 other studies available for urea and HIV

ArticleYear
Mollecarbamates, Molleureas, and Molledihydroisoquinolone, o-Carboxyphenethylamide Metabolites of the Ascidian Didemnum molle Collected in Madagascar.
    Journal of natural products, 2017, 06-23, Volume: 80, Issue:6

    Topics: Animals; Carbamates; HIV; Humans; Isoquinolines; Madagascar; Microbial Sensitivity Tests; Molecular

2017
Single-molecule FRET studies of HIV TAR-DNA hairpin unfolding dynamics.
    The journal of physical chemistry. B, 2014, Oct-23, Volume: 118, Issue:42

    Topics: Base Sequence; Coloring Agents; DNA, Viral; Fluorescence Resonance Energy Transfer; HIV; Inverted Re

2014
A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Animals; Anti-Infective Agents; Carrageenan; Contraceptive Agents, Female; Contraceptive Devices, Fe

2016
Evaluation of urine for Leishmania infantum DNA detection by real-time quantitative PCR.
    Journal of microbiological methods, 2016, Volume: 131

    Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Brazil; Child; Creatinine; DNA, Kinetop

2016
A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy.
    PloS one, 2009, Nov-30, Volume: 4, Issue:11

    Topics: Animals; Anti-Infective Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chlorocebus

2009
Synthesis, antiviral activity and pharmacokinetics of P1/P1' substituted 3-aminoindazole cyclic urea HIV protease inhibitors.
    Bioorganic & medicinal chemistry letters, 2003, Feb-24, Volume: 13, Issue:4

    Topics: Administration, Oral; Animals; Biological Availability; Dogs; Drug Resistance; Heterocyclic Compound

2003
Synthesis and pharmacological activity of urea and thiourea derivatives of 4-azatricyclo[5.2.2.0(2,6)]undec-8-ene-3,5-dione.
    Chemical & pharmaceutical bulletin, 2007, Volume: 55, Issue:5

    Topics: Animals; Anti-HIV Agents; Anti-Infective Agents; Anticonvulsants; Antineoplastic Agents; Behavior, A

2007
Genetic subtyping of human immunodeficiency virus using a heteroduplex mobility assay.
    PCR methods and applications, 1995, Volume: 4, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Base Sequence; DNA Primers; DNA, Single-Stranded; DNA, Viral; El

1995
A pharmacokinetic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs.
    Biopharmaceutics & drug disposition, 1994, Volume: 15, Issue:7

    Topics: Administration, Oral; Animals; Biological Availability; Chromatography, High Pressure Liquid; Comput

1994
SC-52151, a novel inhibitor of the human immunodeficiency virus protease.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:10

    Topics: Amino Acid Sequence; Animals; Antiviral Agents; Dogs; Drug Synergism; HIV; HIV Protease Inhibitors;

1995
Population dynamics studies of wild-type and drug-resistant mutant HIV in mixed infections.
    Virology, 1997, Sep-15, Volume: 236, Issue:1

    Topics: Alkynes; Azepines; Benzoxazines; Cyclopropanes; Drug Resistance, Microbial; HIV; HIV Infections; HIV

1997
Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors.
    Chemistry & biology, 1998, Volume: 5, Issue:10

    Topics: Animals; Anti-HIV Agents; Crystallography, X-Ray; Dogs; Drug Design; HIV; HIV Protease Inhibitors; M

1998
The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: modifications of the P1/P1' residues.
    Bioorganic & medicinal chemistry letters, 1998, Apr-07, Volume: 8, Issue:7

    Topics: Antiviral Agents; Azepines; HIV; HIV Protease; HIV Protease Inhibitors; Indicators and Reagents; Kin

1998
Inactivation of human immunodeficiency virus during human growth hormone production.
    Archives of virology, 1988, Volume: 100, Issue:1-2

    Topics: Antiviral Agents; Cells, Cultured; Drug Contamination; Ethanol; Growth Hormone; HIV; Humans; Hydroge

1988