urea has been researched along with Experimental Neoplasms in 157 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
| Excerpt | Relevance | Reference |
|---|---|---|
| " implanted murine radiation induced fibrosarcomas (RIF-1) display narrow resonances assignable to betaine and other trimethylamines and broad resonances due to amino acids and peptides." | 7.68 | In vivo 14N nuclear magnetic resonance spectroscopy of tumors: detection of ammonium and trimethylamine metabolites in the murine radiation induced fibrosarcoma 1. ( Constantinidis, I; Gamcsik, MP; Glickson, JD, 1991) |
| "Lung adenomas were induced in strain A mice by chronic treatment with N-nitroso compounds (given in drinking water) and with amines or ureas in food plus NaNO2 in drinking water." | 7.65 | Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine. ( Cardesa, A; Mirvish, SS; Shubik, P; Wallcave, L, 1975) |
| " Experiments in 214 DS carcinosarcoma bearing Wistar rats have shown that BA 1, at a dosage of only about 12 percent LD50 (150 mg kg) and negligible lethality (1." | 5.25 | [Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a ( Ardenne, M; Reitnauer, PG, 1975) |
| "Excessive urea excretion associated with a negative nitrogen balance and massive loss of skeletal muscle mass (cachexia) is a frequent life threatening complication in malignancies and HIV infection." | 3.69 | Abnormal glutathione and sulfate levels after interleukin 6 treatment and in tumor-induced cachexia. ( Berke, G; Bockstette, M; Dröge, W; Fiers, W; Gross, A; Hack, V; Kinscherf, R, 1996) |
| " implanted murine radiation induced fibrosarcomas (RIF-1) display narrow resonances assignable to betaine and other trimethylamines and broad resonances due to amino acids and peptides." | 3.68 | In vivo 14N nuclear magnetic resonance spectroscopy of tumors: detection of ammonium and trimethylamine metabolites in the murine radiation induced fibrosarcoma 1. ( Constantinidis, I; Gamcsik, MP; Glickson, JD, 1991) |
| "Four simultaneous dosages of the ethylnitrosourea precursors, ethylurea and sodium nitrite, were administered intragastrically to pregnant hamsters at 100 mg/kg and 50 mg/kg respectively, from the 12-15th days of pregnancy." | 3.65 | Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters. ( Rustia, M; Schenken, J, 1976) |
| "The rates of urea synthesis in rat liver and in a series of rat liver neoplasms with widely different growth rates and degree of differentiation were investigated using tissue slices incubated in a Krebs-Ringer bicarbonate buffer." | 3.65 | Urea synthesis in Novikoff and Morris hepatomas. ( Lawson, D; Morris, HP; Paik, WK; Weinhouse, S, 1977) |
| "Lymphoma L5178Y cells were treated with neuraminidase of Vibrio cholerae, potassium iodine, dithiotreitol (DTT), mercaptoethanol, glutaraldehyde, iodoacetamide, merthiolate, sodium periodate, urea, papaine, trypsine and EDTA, to increase immunoreaction in tumor cells." | 3.65 | [Immunogenicity of L5178Y cells modified by different reagents]. ( Arellano-Blanco, J; Becerril-Meza, G; Fernández-Quintero, P; Gómez-Estrada, H; López-de la Rosa, LM, 1977) |
| "Lung adenomas were induced in strain A mice by chronic treatment with N-nitroso compounds (given in drinking water) and with amines or ureas in food plus NaNO2 in drinking water." | 3.65 | Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine. ( Cardesa, A; Mirvish, SS; Shubik, P; Wallcave, L, 1975) |
| " Preclinical pharmacokinetics conducted in several species were predictive for the observed pharmacokinetic behavior of 12 in cancer patients." | 1.43 | Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). ( Albert, E; Bacqué, E; Bonche, F; Calvet, L; Capdevila, C; Delaisi, C; Egile, C; Goulaouic, H; Grapinet, S; Houtmann, J; Kenigsberg, M; Khider, J; Lowinski, M; Martinet, N; Nemecek, C; Rak, A; Roesner, M; Schio, L; Semiond, D; Ugolini, A; Vallée, F, 2016) |
| "PSMA is upregulated in prostate cancer epithelia and in the neovasculature of most solid tumors." | 1.37 | 2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer. ( Byun, Y; Chen, Y; Foss, CA; Mease, RC; Nimmagadda, S; Pomper, MG; Pullambhatla, M; Senthamizhchelvan, S; Sgouros, G, 2011) |
| "Cancer cachexia is characterized by loss of lean body mass." | 1.30 | Hepatic amino acid and protein metabolism in non-anorectic, moderately cachectic tumor-bearing rats. ( Boers, W; de Blaauw, I; Deutz, NE; von Meyenfeldt, MF, 1997) |
| "Lentinan was also denatured by NaOH and the transition of [alpha]D values and optical rotatory dispersion curves were seen in the manner of two concentration-dependent phases." | 1.27 | Denaturation and renaturation of a beta-1,6;1,3-glucan, lentinan, associated with expression of T-cell-mediated responses. ( Chihara, C; Maeda, YY; Rokutanda, M; Watanabe, ST, 1988) |
| "The lead-induced renal neoplasms were histologically similar to those which occur spontaneously in man and, therefore, may serve as an animal model to study human disease." | 1.27 | Neoplasia induced in male rats fed lead acetate, ethyl urea, and sodium nitrite. ( Exon, JH; Kerkvliet, NI; Koller, LD, 1985) |
| " Experiments in 214 DS carcinosarcoma bearing Wistar rats have shown that BA 1, at a dosage of only about 12 percent LD50 (150 mg kg) and negligible lethality (1." | 1.25 | [Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a ( Ardenne, M; Reitnauer, PG, 1975) |
| "Faster growing hepatomas also have greater quantities of sulfhydryls and disulfides." | 1.25 | Sulfhydryl group quantitation of hepatoma and liver microsomal fractions. ( Hochberg, AA; Morris, HP; Stratman, FW; Zahlten, RN, 1975) |
| "Peracetic acid was a potent tumor promoter and a weak complete carcinogen on the skin of female ICR Swiss mice." | 1.25 | Cocarcinogenic activity of peroxy compounds. ( Bock, FG; Fox, HW; Myers, HK, 1975) |
| "In the hepatomas, evidence was obtained for the preexistence of considerable amounts of the smaller, RNase-containing subunits in the cell." | 1.24 | Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas. ( Roth, JS; Utsunomiya, T, 1966) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 138 (87.90) | 18.7374 |
| 1990's | 5 (3.18) | 18.2507 |
| 2000's | 2 (1.27) | 29.6817 |
| 2010's | 11 (7.01) | 24.3611 |
| 2020's | 1 (0.64) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, CF | 1 |
| Wang, QC | 1 |
| Chen, R | 1 |
| Zhou, HL | 1 |
| Wu, TT | 1 |
| Du, Y | 1 |
| Zhang, NN | 1 |
| Zhang, HM | 1 |
| Fan, ZY | 1 |
| Wang, LL | 1 |
| Hu, CJ | 1 |
| Sang, ZP | 1 |
| Li, HL | 1 |
| Wang, L | 1 |
| Tang, L | 1 |
| Zhang, JQ | 1 |
| Milshteyn, E | 1 |
| von Morze, C | 2 |
| Reed, GD | 1 |
| Shang, H | 1 |
| Shin, PJ | 1 |
| Larson, PEZ | 1 |
| Vigneron, DB | 2 |
| Yang, W | 1 |
| Chen, Y | 2 |
| Zhou, X | 1 |
| Gu, Y | 1 |
| Qian, W | 1 |
| Zhang, F | 1 |
| Han, W | 1 |
| Lu, T | 1 |
| Tang, W | 1 |
| Zuo, SJ | 1 |
| Zhang, S | 1 |
| Mao, S | 1 |
| Xie, XX | 1 |
| Xiao, X | 1 |
| Xin, MH | 1 |
| Xuan, W | 1 |
| He, YY | 1 |
| Cao, YX | 1 |
| Zhang, SQ | 1 |
| Long, D | 1 |
| Mao, J | 1 |
| Liu, T | 1 |
| Fu, C | 1 |
| Tan, L | 1 |
| Ren, X | 1 |
| Shi, H | 1 |
| Su, H | 1 |
| Ren, J | 1 |
| Meng, X | 1 |
| Lim, J | 1 |
| Kelley, EH | 1 |
| Methot, JL | 1 |
| Zhou, H | 1 |
| Petrocchi, A | 1 |
| Chen, H | 1 |
| Hill, SE | 1 |
| Hinton, MC | 1 |
| Hruza, A | 1 |
| Jung, JO | 1 |
| Maclean, JK | 1 |
| Mansueto, M | 1 |
| Naumov, GN | 1 |
| Philippar, U | 1 |
| Raut, S | 1 |
| Spacciapoli, P | 1 |
| Sun, D | 1 |
| Siliphaivanh, P | 1 |
| Ugolini, A | 1 |
| Kenigsberg, M | 1 |
| Rak, A | 1 |
| Vallée, F | 1 |
| Houtmann, J | 1 |
| Lowinski, M | 1 |
| Capdevila, C | 1 |
| Khider, J | 1 |
| Albert, E | 1 |
| Martinet, N | 1 |
| Nemecek, C | 1 |
| Grapinet, S | 1 |
| Bacqué, E | 1 |
| Roesner, M | 1 |
| Delaisi, C | 1 |
| Calvet, L | 1 |
| Bonche, F | 1 |
| Semiond, D | 1 |
| Egile, C | 1 |
| Goulaouic, H | 1 |
| Schio, L | 1 |
| Kakadiya, R | 1 |
| Dong, H | 1 |
| Kumar, A | 1 |
| Narsinh, D | 1 |
| Zhang, X | 1 |
| Chou, TC | 1 |
| Lee, TC | 1 |
| Shah, A | 1 |
| Su, TL | 1 |
| Tanaka, R | 1 |
| Squires, MS | 1 |
| Kimura, S | 1 |
| Yokota, A | 1 |
| Nagao, R | 1 |
| Yamauchi, T | 1 |
| Takeuchi, M | 1 |
| Yao, H | 1 |
| Reule, M | 1 |
| Smyth, T | 1 |
| Lyons, JF | 1 |
| Thompson, NT | 1 |
| Ashihara, E | 1 |
| Ottmann, OG | 1 |
| Maekawa, T | 1 |
| Schroeder, MA | 1 |
| Clarke, K | 1 |
| Neubauer, S | 1 |
| Tyler, DJ | 1 |
| Pullambhatla, M | 1 |
| Foss, CA | 1 |
| Byun, Y | 1 |
| Nimmagadda, S | 1 |
| Senthamizhchelvan, S | 1 |
| Sgouros, G | 1 |
| Mease, RC | 1 |
| Pomper, MG | 1 |
| Larson, PE | 1 |
| Hu, S | 1 |
| Yoshihara, HA | 1 |
| Bok, RA | 1 |
| Goga, A | 1 |
| Ardenkjaer-Larsen, JH | 1 |
| MOHLER, WC | 1 |
| WEITZEL, G | 1 |
| SCHNEIDER, F | 1 |
| FRETZDORFF, AM | 1 |
| SEYNSCHE, K | 1 |
| FINGER, H | 1 |
| ENDO, H | 1 |
| TADA, M | 1 |
| YOUNG, CW | 1 |
| HODAS, S | 1 |
| WILSON, JR | 1 |
| MERRICK, H | 1 |
| VOGEL, SD | 1 |
| WOODWARD, ER | 1 |
| PASSEN, S | 1 |
| SCHULTZ, RB | 1 |
| Beebe, JS | 1 |
| Jani, JP | 1 |
| Knauth, E | 1 |
| Goodwin, P | 1 |
| Higdon, C | 1 |
| Rossi, AM | 1 |
| Emerson, E | 1 |
| Finkelstein, M | 1 |
| Floyd, E | 1 |
| Harriman, S | 1 |
| Atherton, J | 1 |
| Hillerman, S | 1 |
| Soderstrom, C | 1 |
| Kou, K | 1 |
| Gant, T | 1 |
| Noe, MC | 1 |
| Foster, B | 1 |
| Rastinejad, F | 1 |
| Marx, MA | 1 |
| Schaeffer, T | 1 |
| Whalen, PM | 1 |
| Roberts, WG | 1 |
| Polycarpe, E | 1 |
| Arnould, L | 1 |
| Schmitt, E | 1 |
| Duvillard, L | 1 |
| Ferrant, E | 1 |
| Isambert, N | 1 |
| Duvillard, C | 1 |
| Beltramo, JL | 1 |
| Chevet, D | 1 |
| Chauffert, B | 1 |
| Nelson, HG | 1 |
| Shelton, FJ | 1 |
| Wetzel, WH | 1 |
| Yarbro, JW | 1 |
| Jobst, K | 2 |
| Skipper, HE | 1 |
| Yurchenco, PD | 1 |
| Furthmayr, H | 1 |
| Rieber, M | 1 |
| Rieber, MS | 1 |
| von Ardenne, M | 1 |
| Reitnauer, PG | 2 |
| Krüger, W | 1 |
| Hack, V | 1 |
| Gross, A | 1 |
| Kinscherf, R | 1 |
| Bockstette, M | 1 |
| Fiers, W | 1 |
| Berke, G | 1 |
| Dröge, W | 1 |
| de Blaauw, I | 1 |
| Deutz, NE | 1 |
| Boers, W | 1 |
| von Meyenfeldt, MF | 1 |
| Bozhenko, VK | 1 |
| Beridze, AD | 1 |
| Shishkin, AM | 1 |
| Guslistyĭ, VP | 1 |
| Carter, CA | 1 |
| Waud, WR | 1 |
| Li, LH | 1 |
| DeKoning, TF | 1 |
| McGovren, JP | 1 |
| Plowman, J | 1 |
| Ardenne, M | 1 |
| Ballal, NR | 1 |
| Goldberg, DA | 1 |
| Busch, H | 2 |
| Stratman, FW | 1 |
| Hochberg, AA | 1 |
| Zahlten, RN | 1 |
| Morris, HP | 3 |
| Rustia, M | 5 |
| Schenken, J | 1 |
| Lawson, D | 1 |
| Paik, WK | 1 |
| Weinhouse, S | 1 |
| Lea, MA | 1 |
| Kock, MR | 1 |
| Nagao, M | 1 |
| Suzuki, E | 1 |
| Yasuo, K | 1 |
| Yahagi, T | 1 |
| Seino, Y | 1 |
| Gómez-Estrada, H | 1 |
| López-de la Rosa, LM | 1 |
| Becerril-Meza, G | 1 |
| Arellano-Blanco, J | 1 |
| Fernández-Quintero, P | 1 |
| Nixon, JE | 1 |
| Koller, LD | 2 |
| Exon, JH | 2 |
| Bock, FG | 1 |
| Myers, HK | 1 |
| Fox, HW | 1 |
| Maekawa, A | 1 |
| Ishiwata, H | 1 |
| Odashima, S | 1 |
| Ecanow, B | 1 |
| Gold, BH | 1 |
| McCreery, JW | 1 |
| Yaneva, M | 1 |
| Dessev, G | 1 |
| Mirvish, SS | 3 |
| Cardesa, A | 1 |
| Wallcave, L | 1 |
| Shubik, P | 2 |
| Afanas'ev, GG | 1 |
| Pelevina, II | 1 |
| Koestner, A | 2 |
| Denlinger, RH | 1 |
| Gamcsik, MP | 1 |
| Constantinidis, I | 1 |
| Glickson, JD | 1 |
| Maeda, YY | 1 |
| Watanabe, ST | 1 |
| Chihara, C | 1 |
| Rokutanda, M | 1 |
| Brown, LF | 1 |
| Van de Water, L | 1 |
| Harvey, VS | 1 |
| Dvorak, HF | 1 |
| Chance, WT | 1 |
| Muggia-Sullam, M | 1 |
| Chen, MH | 1 |
| Murphy, RF | 1 |
| Fischer, JE | 1 |
| Harrap, KR | 1 |
| Kerkvliet, NI | 1 |
| Kleihues, P | 1 |
| Zülch, KJ | 2 |
| Matsumoto, S | 1 |
| Radke, U | 1 |
| Zeller, WJ | 1 |
| Ivankovic, S | 6 |
| Albrecht, C | 1 |
| Van Zyl, IM | 1 |
| Richardson, UI | 1 |
| Snodgrass, PJ | 1 |
| Nuzum, CT | 1 |
| Tashjian, AH | 1 |
| Stavrou, D | 2 |
| Dahme, E | 1 |
| Carruthers, C | 5 |
| Bhattacharaya, M | 2 |
| Georgsson, G | 1 |
| Wessel, W | 2 |
| Thomas, C | 3 |
| Druckrey, H | 5 |
| Preussmann, R | 4 |
| Krüger, FW | 1 |
| Osswald, H | 1 |
| Walker, G | 1 |
| Schelten, E | 1 |
| Shapiro, WR | 3 |
| Landschïtz, C | 1 |
| Hadjiolov, D | 1 |
| Hafen, P | 1 |
| Koblitz, V | 1 |
| Atzeroth, R | 1 |
| von Kreybig, T | 1 |
| McLean, P | 1 |
| Reid, E | 1 |
| Gurney, MW | 1 |
| Utsunomiya, T | 1 |
| Roth, JS | 1 |
| Higashi, K | 1 |
| Della Porta, G | 1 |
| Schreiber, D | 8 |
| Jänisch, W | 5 |
| Scholtze, P | 3 |
| Tausch, H | 2 |
| Millar, FK | 1 |
| Brooks, RH | 1 |
| White, J | 1 |
| Bollmann, R | 1 |
| Enish, VA | 1 |
| Shreĭber, D | 1 |
| Vartsok, R | 1 |
| Warzok, R | 5 |
| Rubenstein, B | 1 |
| Frei, JV | 3 |
| Terracini, B | 1 |
| Testa, MC | 1 |
| Kupfer, M | 2 |
| Kupfer, G | 2 |
| Zintzsch, I | 1 |
| Juhls, H | 1 |
| Ehrentraut, W | 1 |
| Schagen, B | 1 |
| Matsuyama, A | 1 |
| Tagashira, Y | 1 |
| Nagata, C | 1 |
| Gorbacheva, LB | 1 |
| Kukushkina, GV | 1 |
| Landschütz, C | 1 |
| Thomson, JM | 1 |
| Maruyama, Y | 1 |
| Schwartz, S | 1 |
| Hahn, E | 1 |
| Swenberg, JA | 1 |
| Wechsler, W | 2 |
| Citoler, P | 1 |
| Batka, H | 3 |
| Schneider, J | 2 |
| Balhorn, R | 1 |
| Oliver, D | 1 |
| Hohmann, P | 1 |
| Chalkley, R | 1 |
| Granner, D | 1 |
| Moyer, GH | 1 |
| Pitot, HC | 1 |
| Quentin, E | 1 |
| Lageman, A | 3 |
| Geyer, M | 1 |
| Holmberg, B | 1 |
| Chang, TM | 1 |
| Tekeli, S | 1 |
| Biava, CG | 1 |
| Price, JM | 1 |
| Teller, MN | 1 |
| Bowie, M | 1 |
| Mountain, IM | 1 |
| Stock, CC | 1 |
| Hoffmann, F | 1 |
| Graffi, A | 1 |
| Benda, P | 1 |
| Lightbody, J | 1 |
| Sato, G | 1 |
| Levine, L | 1 |
| Sweet, W | 1 |
| Carter, SK | 1 |
| Newman, JW | 1 |
| Dietz, W | 1 |
| Burnett, JB | 1 |
| Lijinsky, W | 1 |
| Garcia, H | 1 |
| Keefer, L | 1 |
| Loo, J | 1 |
| Ross, AE | 1 |
| Greenblatt, M | 1 |
| Kommineni, VR | 1 |
| Hicks, RM | 1 |
| Wakefield, JS | 1 |
| Mayo, JG | 1 |
| Laster, WR | 1 |
| Andrews, CM | 1 |
| Schabel, FM | 1 |
| Hiraki, S | 2 |
| Osske, G | 1 |
| Zabel-Langhennig, R | 1 |
| Kolesnichenko, TS | 1 |
| Ramadan, MA | 1 |
| Takizawa, S | 1 |
| Nishihara, H | 1 |
| Hosokawa, M | 1 |
| Gotoda, E | 1 |
| Kobayashi, H | 1 |
| Matsuyama, M | 1 |
| Suzuki, H | 1 |
| Swann, PF | 2 |
| Magee, PN | 2 |
| Eckert, H | 1 |
| Seidler, E | 1 |
| Lantos, PL | 1 |
| Sugiura, K | 1 |
| Tarnowski, GS | 2 |
| Cappuccino, JG | 2 |
| Schmid, FA | 2 |
| Reyes, P | 1 |
| Huennekens, FM | 1 |
| Herrold, KM | 3 |
| Mizuno, NS | 1 |
| Humphrey, EW | 1 |
| Bilalov, FI | 1 |
| Sander, J | 1 |
| Ausman, JI | 1 |
| Rall, DP | 1 |
| Schmidek, HH | 1 |
| Nielsen, SL | 1 |
| Schiller, AL | 1 |
| Messer, J | 1 |
| Jones, EL | 1 |
| Smith, WT | 1 |
| Searle, CE | 1 |
| Killington, RA | 1 |
| Williams, AE | 1 |
| Ratcliffe, NA | 1 |
| Whitehead, TP | 1 |
| Smith, H | 1 |
| Valeriote, FA | 1 |
| Bruce, WR | 1 |
| Meeker, BE | 1 |
| Pery, P | 1 |
| Fougereau, M | 1 |
| Poroshenko, GG | 1 |
| Gor'kova, SN | 1 |
| Evseenko, LS | 1 |
| Leaver, DD | 1 |
| Marytnova, RP | 1 |
| Ronichevskaia, GM | 1 |
| Sekirov, BA | 1 |
| Givelber, HM | 1 |
| DiPaolo, JA | 1 |
| de Sousa, CP | 1 |
| Boyland, E | 1 |
| Nery, R | 1 |
| Kreis, W | 1 |
| Burchenal, JH | 1 |
| Green, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Molecular Imaging of Prostate Cancer Using Radiofluorinated PSMA Ligand[NCT04266392] | Early Phase 1 | 20 participants (Actual) | Interventional | 2019-12-16 | Completed | ||
| A Multi-center, Open-label, Single Arm Phase III Clinical Trial for the Diagnostic Efficacy Assessment and Safety Evaluation by [18F]Florastamin PET/CT Imaging Examination in Patients With Suspected Recurrent or Metastatic Prostate Cancer[NCT05936658] | Phase 3 | 89 participants (Anticipated) | Interventional | 2023-05-08 | Recruiting | ||
| 18F-DCFPyL PET/CT in High Risk and Recurrent Prostate Cancer[NCT03181867] | Phase 2 | 330 participants (Anticipated) | Interventional | 2017-08-03 | Enrolling by invitation | ||
| Evaluation of 18F-DCFPyL PSMA- Versus 18F-NaF-PET Imaging for Detection of Metastatic Prostate Cancer[NCT03173924] | Phase 2 | 180 participants (Anticipated) | Interventional | 2017-06-06 | Enrolling by invitation | ||
| 09.017 - A Phase I Study of Tolfenamic Acid With Gemcitabine and Radiation in Patients With Locally Advanced or Metastatic Pancreatic Cancer Requiring Definitive or Palliative Radiation Therapy[NCT02159248] | Phase 1 | 0 participants (Actual) | Interventional | 2014-03-31 | Withdrawn (stopped due to The study closed prior to enrolling any participants.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for urea and Experimental Neoplasms
| Article | Year |
|---|---|
Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease.
Topics: Animals; Bicarbonates; Carbon Isotopes; Cardiomyopathies; Cardiovascular Diseases; Diagnostic Techni | 2011 |
Blocking the formation of N-nitroso compounds with ascorbic acid in vitro and in vivo.
Topics: Adenoma; Amines; Aminopyrine; Animals; Ascorbic Acid; Dimethylnitrosamine; Female; Liver; Lung Neopl | 1975 |
Use of newborn and infant animals in carcinogenicity testing.
Topics: Age Factors; Animals; Animals, Newborn; Anthracenes; Carcinogens; Carcinoma, Hepatocellular; Hydroca | 1968 |
[Chemical factors and cancer of the bladder].
Topics: Amines; Aniline Compounds; Animals; Benzopyrenes; Coffee; Cyclamates; Female; Guinea Pigs; Humans; H | 1974 |
Immobilization of enzymes, adsorbents, or both within semipermeable microcapsules (artificial cells) for clinical and experimental treatment of metabolite-related disorders.
Topics: Acatalasia; Administration, Oral; Animals; Asparaginase; Asparagine; Catalase; Disease Models, Anima | 1973 |
1 trial available for urea and Experimental Neoplasms
| Article | Year |
|---|---|
Nitrosoureas: 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962; BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037; CCNU)--clinical brochure.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Dogs; Humans; Mice; Neoplasms; Neoplasms, | 1968 |
151 other studies available for urea and Experimental Neoplasms
| Article | Year |
|---|---|
Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasm | 2022 |
Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized
Topics: Algorithms; Animals; Computer Simulation; Image Processing, Computer-Assisted; Lactic Acid; Magnetic | 2018 |
Design, synthesis and biological evaluation of bis-aryl ureas and amides based on 2-amino-3-purinylpyridine scaffold as DFG-out B-Raf kinase inhibitors.
Topics: Amides; Animals; Benzamides; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; | 2015 |
Combination of 4-anilinoquinazoline, arylurea and tertiary amine moiety to discover novel anticancer agents.
Topics: Amines; Aniline Compounds; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dis | 2016 |
Highly stable microwave susceptible agents via encapsulation of Ti-mineral superfine powders in urea-formaldehyde resin microcapsules for tumor hyperthermia therapy.
Topics: Animals; Capsules; Female; Formaldehyde; Hep G2 Cells; Humans; Hyperthermia, Induced; Mice; Mice, In | 2016 |
Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Dose-R | 2016 |
Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844).
Topics: Animals; Benzothiazoles; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Dru | 2016 |
Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard-quinoline conjugates having a urea or hydrazinecarboxamide linker.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Proliferation; DNA; Drug Screening Assays, Antitumo | 2010 |
Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells.
Topics: Animals; Antineoplastic Agents; Benzamides; Benzimidazoles; Cell Proliferation; Drug Delivery System | 2010 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Fluorine Radioisotopes; Glutamate Carboxypeptidase II; | 2011 |
Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea.
Topics: Animals; Carbon Isotopes; Contrast Media; Cyclopropanes; Disease Models, Animal; Imaging, Three-Dime | 2012 |
CYTOTOXICITY OF HYDROXYUREA (NSC-32065) REVERSIBLE BY PYRIMIDINE DEOXYRIBOSIDES IN A MAMMALIAN CELL LINE GROWN IN VITRO.
Topics: Antimetabolites; Cell Line; Cricetinae; Hydroxyurea; In Vitro Techniques; Neoplasms; Neoplasms, Expe | 1964 |
[ADDITIONAL CLASSES OF COMPOUNDS INHIBITING TUMORS. I. CYTOSTATIC EFFECTS OF N- AND S-HYDROXYMETHYL COMPOUNDS].
Topics: Amides; Animals; Antineoplastic Agents; Benzimidazoles; Carbohydrate Metabolism; Carcinoma, Ehrlich | 1963 |
EXPERIMENTAL STUDIES ON THE ANTITUMOR EFFECT OF BIURET DERIVATIVES.
Topics: Animals; Antineoplastic Agents; Biuret; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Rese | 1964 |
HYDROXYUREA: INHIBITORY EFFECT ON DNA METABOLISM.
Topics: Antineoplastic Agents; Cytosine Nucleotides; DNA; DNA, Neoplasm; Guanine Nucleotides; HeLa Cells; Hu | 1964 |
HYPERPARATHYROID-LIKE STATE IN RABBITS WITH THE VX-2 CARCINOMA: FURTHER STUDIES.
Topics: Animals; Blood; Blood Urea Nitrogen; Hypercalcemia; Hyperparathyroidism; Neoplasm Transplantation; N | 1965 |
USE OF THE SHOPE PAPILLOMA VIRUS-INDUCED ARGINASE AS A BIOCHEMICAL MARKER IN VITRO.
Topics: Animals; Arginase; Biological Assay; Biomarkers; Cottontail rabbit papillomavirus; In Vitro Techniqu | 1965 |
Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy.
Topics: Animals; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Kinetics; Male; Mice; Mice, Inbre | 2003 |
Low urine osmolarity as a determinant of cisplatin-induced nephrotoxicity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cisplatin; Colonic Neoplasms; Creatinine; In Situ Nick-En | 2004 |
Potential carcinostatic agents. I. Derivatives and analogs of 1-(2-hydroxyethyl)-3-(4-tolyl)urea.
Topics: Animals; Carcinoma; Chemistry, Organic; Leukemia L1210; Lung Neoplasms; Mice; Neoplasms, Experimenta | 1967 |
The effect of deoxyribonucleoside and ribonucleoside addition on the inhibitory effect of hydroxyurea on deoxyribonucleic acid synthesis.
Topics: Animals; DNA; Drug Antagonism; Injections, Intraperitoneal; Mice; Neoplasms, Experimental; Nucleosid | 1967 |
Teratogenous changes and tumors in rats following treatment with methylnitroso-urea (MNU).
Topics: Animals; Brain; Bronchial Neoplasms; Carcinogens; Female; Kidney Neoplasms; Male; Mammary Neoplasms, | 1967 |
Criteria associated with destruction of leukemia and solid tumor cells in animals.
Topics: Animals; Cricetinae; Cyclophosphamide; Cytarabine; Leukemia L1210; Methotrexate; Mice; Neoplasm Tran | 1967 |
Self-assembly of basement membrane collagen.
Topics: Animals; Basement Membrane; Collagen; Gels; Hydrogen-Ion Concentration; Kinetics; Macromolecular Sub | 1984 |
Metastatic potential correlates with cell-surface protein alterations in B16 melanoma variants.
Topics: Animals; Cell Line; Cytoskeleton; Melanoma; Membrane Proteins; Mice; Molecular Weight; Neoplasm Meta | 1981 |
2-Cyanoethyl urea and its derivatives as potential immunostimulants in experimental cancer therapy.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Neoplasm; Antibody Formation; Antibody-Producing Cells; | 1981 |
Abnormal glutathione and sulfate levels after interleukin 6 treatment and in tumor-induced cachexia.
Topics: Animals; Cachexia; Cysteine; Female; Fibrosarcoma; Glutamate-Cysteine Ligase; Glutathione; Interleuk | 1996 |
Hepatic amino acid and protein metabolism in non-anorectic, moderately cachectic tumor-bearing rats.
Topics: Amino Acids; Animals; Cachexia; Female; Gluconeogenesis; Liver; Liver Circulation; Neoplasms, Experi | 1997 |
[Use of multivariate methods in the analysis of laboratory indicators of blood].
Topics: Animals; Blood Chemical Analysis; Blood Glucose; Blood Proteins; Cholesterol; Cluster Analysis; Crea | 1997 |
Preclinical antitumor activity of bizelesin in mice.
Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Drug Administration Schedule; Drug Resistan | 1996 |
[Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a
Topics: Animals; Antineoplastic Agents; Carcinosarcoma; Cyclophosphamide; Drug Evaluation, Preclinical; Drug | 1975 |
Dissociation and reconstitution of chromatin without appreciable degradation of the proteins.
Topics: Animals; Carcinoma, Hepatocellular; Chromatin; DNA-Directed RNA Polymerases; Electrophoresis, Polyac | 1975 |
Sulfhydryl group quantitation of hepatoma and liver microsomal fractions.
Topics: Age Factors; Animals; Carcinoma, Hepatocellular; Cell Fractionation; Disulfides; Edetic Acid; Endopl | 1975 |
Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters.
Topics: Animals; Cricetinae; Estrogens; Ethylnitrosourea; Female; Male; Maternal-Fetal Exchange; Mesocricetu | 1976 |
Urea synthesis in Novikoff and Morris hepatomas.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Carcinoma, Hepatocellular; Fasting; Liver; Liver Ne | 1977 |
Nuclear protein changes in rat hepatomas correlating with growth rate.
Topics: Acetates; Animals; Carcinoma, Hepatocellular; Chick Embryo; Densitometry; Electrophoresis, Polyacryl | 1975 |
Mutagenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine, a bladder carcinogen, and related compounds.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinogens; Hydroxylation; In Vitro Techniques; Microsomes, | 1977 |
[Immunogenicity of L5178Y cells modified by different reagents].
Topics: Animals; Antibody Formation; Dithiothreitol; Glutaral; Immunity, Cellular; Iodoacetamide; Lymphoma; | 1977 |
Effect of methylmercury chloride on transplacental tumors induced by sodium nitrite and ethylurea in rats.
Topics: Animals; Cocarcinogenesis; Female; Male; Maternal-Fetal Exchange; Methylmercury Compounds; Neoplasms | 1979 |
Cocarcinogenic activity of peroxy compounds.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetates; Animals; Benzoates; Carcinogens; Drug Synergism; Female; | 1975 |
Transplacental carcinogenesis and chemical determination of 1-butyl-1-nitrosourea in stomach content after simultaneous oral administration of 1-butylurea and sodium nitrite to ACI/N rats.
Topics: Animals; Brain Neoplasms; Female; Gastric Mucosa; Glioma; Male; Maternal-Fetal Exchange; Neoplasms, | 1977 |
Tumour matrix destruction by the use of hydrophobic bond breakers: a preliminary report.
Topics: Animals; Chemical Phenomena; Chemistry; Cricetinae; Extracellular Space; Hyperthermia, Induced; Neop | 1977 |
Persistence of the ten-nucleotide repeat in chromatin unfolded in urea, as revealed by digestion with deoxyribonuclease i.
Topics: Base Sequence; Chromatin; Deoxyribonucleases; DNA; DNA, Neoplasm; Liver; Micrococcal Nuclease; Neopl | 1976 |
Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine.
Topics: Adenoma; Amines; Animals; Ascorbic Acid; Caffeine; Dose-Response Relationship, Drug; Gallic Acid; Lu | 1975 |
[Combined action of oxyurea and irradiation on solid experimental lymphosarcoma].
Topics: Animals; DNA; Lymphoma, Non-Hodgkin; Mice; Neoplasms, Experimental; Time Factors; Urea | 1975 |
Induction of neurogenic and lymphoid neoplasms by the feeding of threshold levels of methyl- and ethylnitrousourea precursors to adult rats.
Topics: Animals; Brain Neoplasms; Ethylnitrosourea; Female; Lymphoma; Mammary Neoplasms, Experimental; Methy | 1975 |
Inhibitory effect of sodium ascorbate on ethylurea and sodium nitrite carcinogensis and negative findings in progeny after intestinal inoculation of precursors into pregnant hamsters.
Topics: Animals; Ascorbic Acid; Astrocytoma; Brain Neoplasms; Cecum; Cricetinae; Ethylnitrosourea; Female; I | 1975 |
The effect of gonadal ablation on transplacentally induced neurogenic tumors in hamsters.
Topics: Adrenal Cortex; Animals; Brain Neoplasms; Brain Stem; Castration; Cricetinae; Female; Gonads; Hyperp | 1976 |
In vivo 14N nuclear magnetic resonance spectroscopy of tumors: detection of ammonium and trimethylamine metabolites in the murine radiation induced fibrosarcoma 1.
Topics: Ammonia; Animals; Fibrosarcoma; Magnetic Resonance Spectroscopy; Methylamines; Mice; Neoplasms, Expe | 1991 |
Denaturation and renaturation of a beta-1,6;1,3-glucan, lentinan, associated with expression of T-cell-mediated responses.
Topics: Acute-Phase Proteins; Animals; Dimethyl Sulfoxide; Female; Hemorrhage; Immunity, Cellular; Immunothe | 1988 |
Fibrinogen influx and accumulation of cross-linked fibrin in healing wounds and in tumor stroma.
Topics: Animals; Autoradiography; Fibrin; Fibrinogen; Guinea Pigs; Immunosorbent Techniques; Neoplasms, Expe | 1988 |
Reversal of tumor-induced biochemical abnormalities by insulin treatment in rats.
Topics: Amino Acids; Animals; Anorexia; Blood Glucose; Body Weight; Eating; Glucagon; Gluconeogenesis; Insul | 1986 |
Preclinical studies identifying carboplatin as a viable cisplatin alternative.
Topics: Animals; Antineoplastic Agents; Blood; Body Weight; Carboplatin; Cisplatin; Drug Evaluation, Preclin | 1985 |
Neoplasia induced in male rats fed lead acetate, ethyl urea, and sodium nitrite.
Topics: Animals; Disease Models, Animal; Kidney Neoplasms; Lead; Male; Neoplasms, Experimental; Nitrites; Or | 1985 |
Morphology of malignant gliomas induced in rabbits by systemic application of N-methyl-N-nitrosourea.
Topics: Animals; Cerebral Ventricle Neoplasms; Ependymoma; Female; Glioma; Injections, Intravenous; Neoplasm | 1970 |
[Carcinogenic action of a single subcutaneous administration of n-butyl-nitrosourea to new born rats. A simple model for neuro-oncological studies].
Topics: Animals; Brain Neoplasms; Carcinogens; Ependymoma; Female; Glioma; Male; Neoplasms, Experimental; Ne | 1972 |
A comparative study of the protein components of ribonucleoprotein particles isolated from rat liver and hepatoma nuclei.
Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleus; Electrophoresis, Polyacrylamide Gel; Liver; Liver | 1973 |
Establishment of a clonal strain of hepatoma cells which maintain in culture the five enzymes of the urea cycle.
Topics: Ammonia; Animals; Arginase; Arginine; Bucladesine; Carbamates; Carcinoma, Hepatocellular; Chromosome | 1974 |
[Enzyme histochemistry of experimental brain tumours in rabbits].
Topics: Animals; Brain Neoplasms; Esterases; Glioblastoma; Glioma; Glycoside Hydrolases; Histocytochemistry; | 1969 |
Differences in the urea-extracted proteins of mouse epidermis and squamous cell carcinomata determined by fluorescence microscopy.
Topics: Absorption; Animals; Antigens, Neoplasm; Carcinoma, Squamous Cell; Fluorescent Antibody Technique; I | 1973 |
Antigenic differences between normal mouse epidermis and methylcholanthrene-induced squamous-cell carcinomas.
Topics: Animals; Antigens, Neoplasm; Carcinoma, Squamous Cell; Cross Reactions; Immunodiffusion; Immunoglobu | 1972 |
[The ultrastructure of experimental nerve tumours].
Topics: Animals; Carcinogens; Endoplasmic Reticulum; Female; Microscopy, Electron; Mitochondria; Neoplasms, | 1969 |
[Morphology and histochemistry of experimental brain tumours in rabbits].
Topics: Alkaline Phosphatase; Animals; Brain Neoplasms; Cerebral Ventricle Neoplasms; Ependymoma; Esterases; | 1969 |
[Selective induction of carcinomas of the glandular stomach by N-methyl-N-nitroso-N'-acetylurea(AcMNU) in rats].
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Neoplasms, Experimental; Nitroso Compounds; Rats; S | 1970 |
[The organotropy of alkylating activity of dimethylnitrosamine (DMNA) and nitrosomethyl urea (NMH) in vivo].
Topics: Alkylating Agents; Animals; Body Weight; Carbon Isotopes; Female; Formates; Guanine; Hepatectomy; In | 1970 |
Studies on the chemotherapy of experimental brain tumors: evaluation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, vincristine, and 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Ependymom | 1971 |
[Induction of stomach cancer and neurogenic malignoma by oral administration of methyl-nitrosobiuret (MNB) in rats].
Topics: Adenocarcinoma; Animals; Brain Neoplasms; Carcinogens; Intubation, Gastrointestinal; Methods; Neopla | 1971 |
Thymic lymphoma and myeloid leukemia in the rat induced with ethylnitrosourea.
Topics: Animals; Leukemia, Experimental; Leukemia, Myeloid; Lymphoma, Non-Hodgkin; Male; Neoplasms, Experime | 1972 |
[Endogenous nitrosation of n-alkyl-ureas and n-alkyl-carbonamides as teratogenic factor in rat and mouse (author's transl)].
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Amides; Animals; Carbon Dioxide; Female; Head; Hemor | 1973 |
Effect of azo-dye carcinogenesis on enzymes concerned with urea synthesis in rat liver.
Topics: Animals; Arginase; Carcinogens; Carcinoma, Hepatocellular; Glucosephosphate Dehydrogenase; Ligases; | 1964 |
Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Edetic Acid; Hydrogen-Ion Conc | 1966 |
Stability of nucleolar 45-S RNA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleolus; Centrifugation, Density Gradient; Hydrogen-Ion C | 1967 |
[Experimental tumors of the central nervous system].
Topics: Abdominal Neoplasms; Animals; Astrocytoma; Brain Neoplasms; Carcinogens; Central Nervous System; Fem | 1968 |
Energy expenditure and nitrogen metabolism of rats bearing a transplantable anterior pituitary tumor.
Topics: Adrenocorticotropic Hormone; Allantoin; Animals; Electrophoresis; Growth Hormone; Immunoelectrophore | 1969 |
[Studies on the organotropism of the carcinogenic effect of N-nitroso-N-methylurea (NMU) in rats].
Topics: Age Factors; Animals; Brain Neoplasms; Carcinogens; Esophageal Neoplasms; Hydrogen-Ion Concentration | 1969 |
[Experimental tumors of the central nervous system in rabbits].
Topics: Animals; Astrocytoma; Brain Neoplasms; Female; Glioblastoma; Male; Neoplasms, Experimental; Nitroso | 1968 |
[Induction of brain and spinal cord tumors in rabbits with N-methyl-N-nitrosourea].
Topics: Animals; Brain; Brain Neoplasms; Carcinogens; Female; Glioblastoma; Injections, Intravenous; Intesti | 1969 |
(Mg2+ Na+ K+)-ATPase activity of liver from tumor bearing rats.
Topics: Adenosine Triphosphatases; Animals; Binding Sites; Carcinoma, Hepatocellular; Enzyme Activation; Hyd | 1969 |
Toxicity, tissue changes, and tumor induction in inbred Swiss mice by methylnitrosamine and -amide compounds.
Topics: Adenoma; Animals; Animals, Newborn; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Carcinoma, Hep | 1970 |
The newest development of experimental induced tumors of the central nervous system.
Topics: Age Factors; Animals; Brain Neoplasms; Carcinogens; Humans; Methods; Mice; Neoplasms; Neoplasms, Exp | 1969 |
Carcinogenicity of a single administration of N-nitrosomethylurea: a comparison between newborn and 5-week-old mice and rats.
Topics: Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Female; Gastrointestinal | 1970 |
[Skin deformity tumors in young pigs induced by transplancental action of ethyl-nitroso-urea. Genesis of hidradenoma].
Topics: Adenoma, Sweat Gland; Animals; Carcinogens; Female; Fetus; Hamartoma; Maternal-Fetal Exchange; Neopl | 1969 |
[Induction of neurogenic malignancies by one single dose of ethyl-nitrosourea (ENU) given to newborn and juvenile BD IX-strain rats].
Topics: Administration, Oral; Age Factors; Animals; Animals, Newborn; Body Weight; Carcinogens; Disease Mode | 1970 |
A circular dichroism study on the conformation of DNA in rat liver chromatin.
Topics: Animals; Ascitic Fluid; Carcinoma, Hepatocellular; Cell Line; Chemical Phenomena; Chemistry; Chromos | 1971 |
Some aspects of the mechanism of action of 1-propyl-1-nitrosourea.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular | 1970 |
[Transplacental and neonatal carcinogenesis by ethylnitrosobiuret (ENBU) in BD IX-rats].
Topics: Adenocarcinoma; Animals; Ependymoma; Female; Fetus; Gestational Age; Glioma; Heart Neoplasms; Neopla | 1971 |
Effect of chemotherapy and-or head irradiation on survival of mice with intracranial glioma.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Copper; Cytarabine; Disease Models, Animal; Ependym | 1971 |
The induction of tumors of the nervous system with intravenous methylnitrosourea.
Topics: Animals; Astrocytoma; Brain Neoplasms; Carcinogens; Female; Germ-Free Life; Glioma; Male; Microscopy | 1972 |
[Histochemical, electronmicroscopical and autoradiographical studies on experimentally induced nephroblastomas].
Topics: Angiography; Animals; Autoradiography; Cell Transformation, Neoplastic; Cytoplasm; Female; Kidney Ne | 1972 |
[Tumors of the nervous system in rats following intraperitoneal injections of methylnitrosourea].
Topics: Animals; Carcinogens; Castration; Female; Injections, Intraperitoneal; Male; Neoplasms, Experimental | 1972 |
[Transplacental induction of nervous system tumors. Comparison of effectivity of methyl- and ethylnitrosourea].
Topics: Animals; Brain Neoplasms; Carcinogens; Cerebral Ventricle Neoplasms; Female; Glioma; Injections, Int | 1972 |
Turnover of deoxyribonucleic acid, histones, and lysine-rich histone phosphate in hepatoma tissue culture cells.
Topics: Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Electrophoresis, Polyacrylamide Gel; Half-Life; | 1972 |
Protein turnover in microsomal subfractions of liver and Morris hepatomas 7800 and 9618A.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Cholesterol; | 1973 |
Differences in the urea-extracted or fibrous proteins of mouse epidermis at various stages of malignant transformation.
Topics: Adenocarcinoma, Scirrhous; Animals; Antigens, Neoplasm; Carcinoma, Squamous Cell; Cell Transformatio | 1974 |
Multiple carcinogenic effects of the ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters.
Topics: Age Factors; Animals; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Female; Liver Neoplasms; Ma | 1974 |
[Induction of heart tumors in rats using methylnitrosourea].
Topics: Animals; Carcinogens; Castration; Female; Fibrosarcoma; Heart Neoplasms; Heart Ventricles; Injection | 1972 |
[Induction of small intestine carcinomas in rabbits using methylnitrosourea].
Topics: Adenocarcinoma; Animals; Carcinogens; Female; Injections, Intravenous; Intestinal Neoplasms; Intesti | 1972 |
[The spectrum of extra neural tumors in rats following N-methyl-N-nitroso urea treatment].
Topics: Abdominal Neoplasms; Animals; Castration; Female; Heart Neoplasms; Hypoxia; Injections, Intraperiton | 1972 |
Antigenic changes in mouse epidermis at various stages of neoplastic transformation.
Topics: Animals; Antigens, Neoplasm; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Epithelium; | 1972 |
The carcinogenic activity of 3-hydroxymethyl-1-((3-(5-nitro-2-furyl)allydidene)amino)-hydantoin in rats.
Topics: Adenocarcinoma; Adenoma; Allyl Compounds; Animals; Carcinogens; Diet; Female; Hydantoins; Kidney; Ki | 1973 |
Prenatal induction of neurogenic tumors in hamsters by precursors ethylurea and sodium nitrite.
Topics: Animals; Cricetinae; Female; Fetus; Gestational Age; Male; Maternal-Fetal Exchange; Neoplasms, Exper | 1974 |
Combination chemotherapy of advanced murine myeloma and subsequent resistance to tumor cell challenge.
Topics: Allyl Compounds; Aniline Compounds; Animals; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, | 1974 |
[Histological changes in the mouse skin during the cancerogenic action of N-methyl-N-nitrosourea].
Topics: Animals; Carcinoma, Squamous Cell; Histological Techniques; Male; Mice; Neoplasms, Experimental; Nit | 1966 |
Differentiated rat glial cell strain in tissue culture.
Topics: Animals; Brain Neoplasms; Cell Differentiation; Clone Cells; Culture Techniques; Glioma; Microscopy, | 1968 |
[Experimental nerve tumors induced in rats by use of N-methyl-N-nitrososurea. 3. Electron microscopic findings].
Topics: Animals; Basement Membrane; Histocytochemistry; Histological Techniques; Microscopy, Electron; Neopl | 1970 |
Urea-extractable antigens in normal, benign, and neoplastic mouse epidermis.
Topics: Animals; Antigens; Blood Proteins; Carcinoma, Squamous Cell; Immune Sera; Immunodiffusion; Mice; Neo | 1970 |
The tyrosinases of mouse melanoma. Isolation and molecular properties.
Topics: Acrylates; Alcohols; Amino Acids; Animals; Catechol Oxidase; Chemical Phenomena; Chemistry; Chlorpro | 1971 |
Carcinogenesis and alkylation of rat liver nucleic acids by nitrosomethylurea and nitrosoethylurea administered by intraportal injection.
Topics: Alkylating Agents; Animals; Carcinogens; Chromatography, Ion Exchange; Deuterium; DNA; DNA, Neoplasm | 1972 |
Nitrosamide formation in vivo: induction of lung adenomas in Swiss mice by concurrent feeding of nitrite and methylurea or ethylurea.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Female; Kinetics; Lung Neoplasms; Lymphoma; Male; Mic | 1972 |
Rapid induction of bladder cancer in rats with N-methyl-N-nitrosourea. I. Histology.
Topics: Animals; Epithelium; Female; Hyperplasia; Male; Necrosis; Neoplasms, Experimental; Nitroso Compounds | 1972 |
Success and failure in the treatment of solid tumors. 3. "Cure" of metastatic Lewis lung carcinoma with methyl-CCNU (NSC-95442) and surgery-chemotherapy.
Topics: Animals; Antineoplastic Agents; Carcinoma; Carmustine; Cell Line; Cyclohexanes; Cyclophosphamide; Lu | 1972 |
Carcinogenic effect on N,N'-dimethylnitrosourea on syrian hamsters.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Female; Injections, Subc | 1971 |
[Studies on the histogenesis of experimentally induced brain tumors. I. Light microscopic findings].
Topics: Animals; Brain Neoplasms; Cell Transformation, Neoplastic; Cytogenetics; Glioma; Methods; Neoplasm T | 1971 |
Induction of malignant lymphomas by N,N'-dimethylnitrosourea in adult mice.
Topics: Animals; Carcinogens; Female; Lymphatic Metastasis; Lymphoma; Male; Methylation; Methylnitrosourea; | 1971 |
[Connective tissue changes in organ cultures of embryonic rat lung following the transplacental action of nitrosomethyl urea].
Topics: Animals; Connective Tissue; Female; Lung; Lung Neoplasms; Maternal-Fetal Exchange; Neoplasms, Experi | 1971 |
Ethylnitrosourea-induced transplantable tumors of the peripheral nervous system in inbred rats.
Topics: Animals; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds | 1971 |
Induction of tumors in the brain, kidney, and other extra-mammary gland organs by a continuous oral administration of N-nitrosobutylurea in Wistar-Furth rats.
Topics: Administration, Oral; Animals; Brain Neoplasms; Carcinogens; Castration; Duodenal Neoplasms; Ear Neo | 1971 |
Leukemia and mammary tumor in rats administered N-nitrosobutylurea.
Topics: Administration, Oral; Animals; Carcinogens; Female; Leukemia; Male; Mammary Neoplasms, Experimental; | 1971 |
Induction of neurosarcoma by injections of N-nitrosobutylurea in suckling Syrian golden hamsters.
Topics: Abdominal Neoplasms; Age Factors; Animals; Cricetinae; Fibrosarcoma; Lung Neoplasms; Lymphatic Metas | 1971 |
Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate.
Topics: Alkanes; Alkylation; Animals; Brain Chemistry; Carbon Isotopes; Carcinogens; Chromatography, Ion Exc | 1971 |
Tumour induction by low molecular weight alkylating agents.
Topics: Adenoma; Alkanes; Alkylating Agents; Animals; Carcinogens; DNA Replication; DNA, Neoplasm; Guanine; | 1971 |
[Carcinogenic effect of methylnitrosourea in the mouse].
Topics: Adenoma; Administration, Oral; Animals; Bronchial Neoplasms; Carcinogens; Injections, Intravenous; M | 1971 |
Fine-structural changes of reacting glial cells by experimental brain tumours induced transplacentally by N-ethyl-N-nitrosourea in rats.
Topics: Animals; Axons; Brain Neoplasms; Female; Golgi Apparatus; Macrophages; Maternal-Fetal Exchange; Neop | 1971 |
Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and two related compounds on a spectrum of tumors.
Topics: Adenocarcinoma; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Fibrosarcoma; Glioma; Hydroxy | 1967 |
Effect of 1, 3-diallylurea and related compounds on growth of transplanted animal tumors.
Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Female; | 1967 |
Ion-dependent activation of dihydrofolate reductase from L1210 cells.
Topics: Animals; Binding Sites; Bromine; Chlorine; Folic Acid Antagonists; Hydrogen-Ion Concentration; Ions; | 1967 |
[Various effects of N-methyl-N-nitrosourea in rats. I. Tumors].
Topics: Animals; Brain Neoplasms; Carcinogens; Glioma; Neoplasms, Experimental; Neurilemmoma; Neurofibroma; | 1971 |
Adenocarcinomas of the intestine induced in Syrian hamsters by N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Carcinogens; Cricetinae; Intestinal Neoplasms; Intestine, Large; Intestine, | 1969 |
Effect of combined therapy with cytosine arabinoside (NSC-63878) and l,3-bis-(2-chloroethyl)-1-nitrosourea (NSC-409962) on sarcoma 180 and L1210 in vivo.
Topics: Animals; Cytarabine; DNA, Neoplasm; Drug Synergism; Female; Leukemia L1210; Mice; Neoplasms, Experim | 1969 |
[Various low-molecular nitrogen compounds in experimental brain tumors in white mice].
Topics: Aminobutyrates; Ammonia; Animals; Aspartic Acid; Brain; Brain Neoplasms; Glutamates; Mice; Neoplasms | 1970 |
[Induction of malignant tumors in rats by oral administration of N,N'-dimethylurea and nitrite].
Topics: Animals; Brain Neoplasms; Carcinogens; Female; Heart Neoplasms; Kidney Neoplasms; Neoplasms, Experim | 1970 |
Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-l-nitrosourea, cyclophosphamide, mithramycin, and methotrexate.
Topics: Animals; Antibiotics, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Diseas | 1970 |
Upper respiratory tract tumors induced in Syrian hamsters by N-methyl-N-nitrosourea.
Topics: Animals; Bronchial Neoplasms; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Esophageal Neoplasm | 1970 |
[Transplacental formation of malignant tumors after oral administration of ethylurea and nitrite to rats].
Topics: Administration, Oral; Animals; Female; Leukemia, Experimental; Maternal-Fetal Exchange; Neoplasms, E | 1970 |
Further studies on chemotherapy of experimental brain tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Ependymoma; Fluorouracil; Glioma; Mice; Neoplasms, | 1970 |
Morphological studies of rat brain tumors induced by N-nitrosomethylurea.
Topics: Animals; Animals, Newborn; Astrocytoma; Brain Neoplasms; Cell Line; Culture Techniques; Disease Mode | 1971 |
Tissue-dependent differences in DNA methylation products of mice treated with methyl-labelled methylnitrosourea.
Topics: Adenine; Adenoma; Animals; Bone Marrow; Carbon Isotopes; DNA, Neoplasm; Guanine; Kidney; Liver; Lung | 1971 |
Experimental tumour induction in the rat nervous system by N-ethyl N-nitrosourea.
Topics: Animals; Brain Neoplasms; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds; Periphe | 1971 |
Hypoglycaemia and malignancy differences of closely related sublines of a rat tumour.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Blood Glucose; Calcium; Chole | 1971 |
Synergistic action of cyclophosphamide and 1,3-bis(2-chloroethyl)-1-nitrosourea on a transplanted murine lymphoma.
Topics: Animals; Cyclophosphamide; Drug Synergism; Injections, Intraperitoneal; Lymphoma; Mice; Neoplasm Tra | 1968 |
[Enzymatic reoxidation of Fab fragments of completely reduced gamma globulin immunoglobulins].
Topics: Animals; Centrifugation, Density Gradient; Guanidines; Humans; Immunoglobulin G; Iodine Isotopes; Mi | 1968 |
[A strain of ascitic tumor NK-Ly, resistant to nitrosomethylurea].
Topics: Alkylating Agents; Animals; Chromosomes; Mice; Neoplasms, Experimental; Nitroso Compounds; Polyploid | 1968 |
The induction of tumours in the rat by a single oral dose of N-nitrosomethylurea.
Topics: Animals; Female; Gastric Mucosa; Intestinal Neoplasms; Intestines; Jaw Neoplasms; Keratoacanthoma; K | 1969 |
On the DNA and histone content of N-nitrosomethylurea induced rat tumours.
Topics: Adenoma; Aneuploidy; Animals; Brain Neoplasms; Bronchial Neoplasms; Carcinoma; DNA; DNA, Neoplasm; F | 1969 |
[The effect of various doses of nitrosomethyl (ethyl) urea on the development of spontaneous leukosis and tumors in mice].
Topics: Animals; Antineoplastic Agents; Carcinogens; Leukemia, Experimental; Mammary Neoplasms, Experimental | 1969 |
Teratogenic effects of N-ethyl-N-nitrosourea in the Syrian hamster.
Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; Female; Injections, Intraperitoneal; Neoplasms, Ex | 1969 |
Inhibition of Shope fibroma virus with N-hydroxyurethane and related compounds.
Topics: Animals; Antiviral Agents; Fibroma; In Vitro Techniques; Kidney; Neoplasms, Experimental; Oncogenic | 1965 |
Effect of hydroxylamine (NSC-26250) and related compounds on growth of transplanted animal tumors.
Topics: Animals; Female; Hydroxylamines; Leukemia, Experimental; Male; Mice; Neoplasms, Experimental; Rats; | 1966 |
The effect of 1, 3-bis(2-chloroethyl)-nitrosourea on nicotinamide adenine dinucleotide glycohydrolase of mouse and rat neoplastic and normal tissues.
Topics: Animals; Brain; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Intestines; Kidney; Liver; Lung; Mi | 1966 |
Carcinogenic effect of N-methyl-N-nitrosourea administered subcutaneously to Syrian hamsters.
Topics: Animals; Carcinogens; Cricetinae; Hematopoietic System; Hyperplasia; Injections, Subcutaneous; Lung | 1966 |
[Production of neurogenic tumors in descendants following a single injection of ethylnitrosourea to pregnant rats].
Topics: Animals; Animals, Newborn; Brachial Plexus; Brain Neoplasms; Carcinogens; Cauda Equina; Female; Femo | 1966 |