urea has been researched along with Endotoxemia in 18 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we investigated whether landiolol hydrochloride, an ultra-short-acting beta-blocker, can play an important role in ameliorating levels of LPS-induced up-regulation of renal HIF-1α-ET-1 system and inflammatory cytokines in a rat model of endotoxemia." | 7.80 | Potential amelioration of upregulated renal HIF-1alpha-endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia. ( Hagiya, K; Islam, MM; Jesmin, S; Kamiyama, J; Kawano, S; Khatun, T; Mizutani, T; Ogura, Y; Oki, M; Sakuramoto, H; Shimojo, N; Yamaguchi, N, 2014) |
| "Isoflurane is a common anesthetic agent used in human surgery and in animal models of sepsis." | 5.37 | The effects of isoflurane anesthesia and mechanical ventilation on renal function during endotoxemia. ( Eriksson, S; Fenhammar, J; Frithiof, R; Hjelmqvist, H; Lindbom, L; Rundgren, M; Soehnlein, O, 2011) |
| "Urea plays an important role in the urinary concentrating mechanism and expression of the urea transporters UT-A1, UT-A2, UT-A3, UT-A4, and UT-B is essential for tubular urea reabsorption." | 5.34 | Cytokine-mediated regulation of urea transporters during experimental endotoxemia. ( Bucher, M; Höcherl, K; Schmidt, C, 2007) |
| "LPS increased HR and landiolol decreased HR, with similar effects in each endotoxemia stage." | 3.85 | Use of a Short-Acting β1 Blocker During Endotoxemia May Reduce Cerebral Tissue Oxygenation if Hemodynamics are Depressed by a Decrease in Heart Rate. ( Kawashima, S; Kurita, T; Morita, K; Nakajima, Y, 2017) |
| " Here, we investigated whether landiolol hydrochloride, an ultra-short-acting beta-blocker, can play an important role in ameliorating levels of LPS-induced up-regulation of renal HIF-1α-ET-1 system and inflammatory cytokines in a rat model of endotoxemia." | 3.80 | Potential amelioration of upregulated renal HIF-1alpha-endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia. ( Hagiya, K; Islam, MM; Jesmin, S; Kamiyama, J; Kawano, S; Khatun, T; Mizutani, T; Ogura, Y; Oki, M; Sakuramoto, H; Shimojo, N; Yamaguchi, N, 2014) |
| "Arginine deficiency may underlie the cellular immune depression after surgery in obstructive jaundice, which is associated with gut-derived endotoxemia." | 3.69 | Arginine deficiency in bile duct-ligated rats after surgery: the role of plasma arginase and gut endotoxin restriction. ( Houdijk, AP; Teerlink, T; van Lambalgen, AA; van Leeuwen, PA; Visser, JJ, 1997) |
| "Inflammation is catabolic and causes muscle loss." | 2.82 | Amino acid supplementation is anabolic during the acute phase of endotoxin-induced inflammation: A human randomized crossover trial. ( Bach, E; Jessen, N; Johannsen, M; Jørgensen, JO; Møller, N; Richelsen, B; Rittig, N; Thomsen, HH, 2016) |
| "Isoflurane is a common anesthetic agent used in human surgery and in animal models of sepsis." | 1.37 | The effects of isoflurane anesthesia and mechanical ventilation on renal function during endotoxemia. ( Eriksson, S; Fenhammar, J; Frithiof, R; Hjelmqvist, H; Lindbom, L; Rundgren, M; Soehnlein, O, 2011) |
| "Endotoxemia was associated with hemoconcentration, protein extravasation, and arterial hypotension." | 1.36 | Renal effects of saline-based 10% pentastarch versus 6% tetrastarch infusion in ovine endotoxemic shock. ( Ellger, B; Erren, M; Ertmer, C; Fischer, LG; Köhler, G; Lange, M; Morelli, A; Pinto, BB; Rehberg, S; Rübig, E; Van Aken, H; Westphal, M, 2010) |
| "Urea plays an important role in the urinary concentrating mechanism and expression of the urea transporters UT-A1, UT-A2, UT-A3, UT-A4, and UT-B is essential for tubular urea reabsorption." | 1.34 | Cytokine-mediated regulation of urea transporters during experimental endotoxemia. ( Bucher, M; Höcherl, K; Schmidt, C, 2007) |
| " Twenty-four hours after LPS dosing in vivo, the mortality rate was 15%, while CsA pretreatment increased mortality rate to 30% and reduced hepatocyte viability, increased ALT leakage and reduced urea synthesis." | 1.31 | Inhibition of endotoxemia-induced nitric oxide synthase expression by cyclosporin A enhances hepatocyte injury in rats: amelioration by NO donors. ( Canová, N; Farghali, H; Gaier, N; Kmonicková, E; Lincová, D; Masek, K; Strestíková, P, 2002) |
| "Gentamicin (3 mg/kg, iv) was administered 24 hours after an endotoxin challenge (5 mg/kg, ip)." | 1.30 | Effect of endotoxin on gentamicin pharmacokinetics in old and young adult rats. ( Ali, BH; Bashir, AK; Tanira, MO, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kurita, T | 1 |
| Kawashima, S | 1 |
| Morita, K | 1 |
| Nakajima, Y | 1 |
| Vaziri, ND | 1 |
| Yuan, J | 1 |
| Khazaeli, M | 1 |
| Masuda, Y | 1 |
| Ichii, H | 1 |
| Liu, S | 1 |
| Ogura, Y | 1 |
| Jesmin, S | 1 |
| Yamaguchi, N | 1 |
| Oki, M | 1 |
| Shimojo, N | 1 |
| Islam, MM | 1 |
| Khatun, T | 1 |
| Kamiyama, J | 1 |
| Sakuramoto, H | 1 |
| Hagiya, K | 1 |
| Kawano, S | 1 |
| Mizutani, T | 1 |
| Rittig, N | 1 |
| Bach, E | 1 |
| Thomsen, HH | 1 |
| Johannsen, M | 1 |
| Jørgensen, JO | 1 |
| Richelsen, B | 1 |
| Jessen, N | 1 |
| Møller, N | 1 |
| Gasanov, MD | 1 |
| Cichy, MC | 1 |
| Rocha, FG | 1 |
| Tristão, VR | 1 |
| Pessoa, EA | 1 |
| Cenedeze, MA | 1 |
| Nürmberg Junior, R | 1 |
| Schor, N | 1 |
| Bellini, MH | 1 |
| Ertmer, C | 1 |
| Köhler, G | 1 |
| Rehberg, S | 1 |
| Morelli, A | 1 |
| Lange, M | 1 |
| Ellger, B | 1 |
| Pinto, BB | 1 |
| Rübig, E | 1 |
| Erren, M | 1 |
| Fischer, LG | 1 |
| Van Aken, H | 1 |
| Westphal, M | 1 |
| Frithiof, R | 1 |
| Soehnlein, O | 1 |
| Eriksson, S | 1 |
| Fenhammar, J | 1 |
| Hjelmqvist, H | 1 |
| Lindbom, L | 1 |
| Rundgren, M | 1 |
| Tripatara, P | 1 |
| Onlamul, W | 1 |
| Booranasubkajorn, S | 1 |
| Wattanarangsan, J | 1 |
| Huabprasert, S | 1 |
| Lumlerdkij, N | 1 |
| Akarasereenont, P | 1 |
| Laohapand, T | 1 |
| Bito, R | 1 |
| Shikano, T | 1 |
| Kawabata, H | 1 |
| ESSMAN, WB | 1 |
| Schmidt, C | 1 |
| Höcherl, K | 1 |
| Bucher, M | 1 |
| Gupta, A | 1 |
| Rhodes, GJ | 1 |
| Berg, DT | 1 |
| Gerlitz, B | 1 |
| Molitoris, BA | 1 |
| Grinnell, BW | 1 |
| Ruetten, H | 1 |
| Thiemermann, C | 1 |
| Tanira, MO | 1 |
| Ali, BH | 1 |
| Bashir, AK | 1 |
| Houdijk, AP | 1 |
| Teerlink, T | 1 |
| Visser, JJ | 1 |
| van Lambalgen, AA | 1 |
| van Leeuwen, PA | 1 |
| Hallemeesch, MM | 1 |
| Soeters, PB | 1 |
| Deutz, NE | 1 |
| Farghali, H | 1 |
| Canová, N | 1 |
| Gaier, N | 1 |
| Lincová, D | 1 |
| Kmonicková, E | 1 |
| Strestíková, P | 1 |
| Masek, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metabolic Effects of Endotoxin Induced Acute Inflammation in Healthy Young Men With and Without Supplement of Amino Acids.[NCT01705782] | 8 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for urea and Endotoxemia
| Article | Year |
|---|---|
Amino acid supplementation is anabolic during the acute phase of endotoxin-induced inflammation: A human randomized crossover trial.
Topics: Adaptor Proteins, Signal Transducing; Adult; Amino Acids; Body Mass Index; Cell Cycle Proteins; Cros | 2016 |
17 other studies available for urea and Endotoxemia
| Article | Year |
|---|---|
Use of a Short-Acting β1 Blocker During Endotoxemia May Reduce Cerebral Tissue Oxygenation if Hemodynamics are Depressed by a Decrease in Heart Rate.
Topics: Adrenergic beta-Antagonists; Animals; Blood Gas Analysis; Blood Pressure; Cardiac Output; Endotoxemi | 2017 |
Oral activated charcoal adsorbent (AST-120) ameliorates chronic kidney disease-induced intestinal epithelial barrier disruption.
Topics: Administration, Oral; Adsorption; Animals; Carbon; Claudin-1; Endotoxemia; Endotoxins; Gastrointesti | 2013 |
Potential amelioration of upregulated renal HIF-1alpha-endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia.
Topics: Animals; Biomarkers; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Endothelin-1; Endot | 2014 |
[Рformation of algorithms to determine the severity of endotoxemia in peritonitis].
Topics: Abdominal Cavity; Adult; Algorithms; Drainage; Endotoxemia; Female; Humans; Male; Malondialdehyde; P | 2015 |
Collagen XVIII/endostatin expression in experimental endotoxemic acute renal failure.
Topics: Acute Kidney Injury; Animals; Blotting, Western; Collagen Type XVIII; Creatinine; Endostatins; Endot | 2009 |
Renal effects of saline-based 10% pentastarch versus 6% tetrastarch infusion in ovine endotoxemic shock.
Topics: Animals; Body Weight; Creatinine; Diuresis; Endotoxemia; Endotoxins; Female; Hemodynamics; Hydroxyet | 2010 |
The effects of isoflurane anesthesia and mechanical ventilation on renal function during endotoxemia.
Topics: Anesthetics, Inhalation; Angiotensin II; Animals; Arginine Vasopressin; Cell Migration Assays, Leuko | 2011 |
The safety of Homnawakod herbal formula containing Aristolochia tagala Cham. in Wistar rats.
Topics: Animals; Aristolochia; Aristolochic Acids; Blood Pressure; Chemical and Drug Induced Liver Injury; C | 2012 |
Isolation and characterization of denatured serum albumin from rats with endotoxicosis.
Topics: Animals; Blotting, Western; Chromatography, Ion Exchange; Circular Dichroism; Electrophoresis, Polya | 2003 |
BEHAVIORAL BIOASSAY FOR EXPERIMENTALLY INDUCED UREMIC ENDOTOXEMIA IN RATS.
Topics: Acute Kidney Injury; Animals; Behavior, Animal; Biological Assay; Blood Urea Nitrogen; Endotoxemia; | 1965 |
Cytokine-mediated regulation of urea transporters during experimental endotoxemia.
Topics: Animals; Cytokines; Dexamethasone; Diuresis; Dose-Response Relationship, Drug; Endotoxemia; Gene Exp | 2007 |
Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Blood Urea Nitrogen; Cell Adhesion; Down-Regulation; E | 2007 |
Effect of selective blockade of endothelin ETB receptors on the liver dysfunction and injury caused by endotoxaemia in the rat.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Azepines; Blood Pr | 1996 |
Effect of endotoxin on gentamicin pharmacokinetics in old and young adult rats.
Topics: Aging; Animals; Anti-Bacterial Agents; Blood Glucose; Blood Proteins; Body Weight; Creatinine; Eatin | 1997 |
Arginine deficiency in bile duct-ligated rats after surgery: the role of plasma arginase and gut endotoxin restriction.
Topics: Animals; Arginase; Arginine; Cholestasis; Cholestyramine Resin; Common Bile Duct; Endotoxemia; Hemat | 1997 |
Renal arginine and protein synthesis are increased during early endotoxemia in mice.
Topics: Amino Acids; Ammonia; Animals; Arginine; Citrulline; Endotoxemia; Female; Kidney; Lipopolysaccharide | 2002 |
Inhibition of endotoxemia-induced nitric oxide synthase expression by cyclosporin A enhances hepatocyte injury in rats: amelioration by NO donors.
Topics: Alanine Transaminase; Animals; Cell Separation; Cells, Immobilized; Chromatography, Agarose; Cold Te | 2002 |