Page last updated: 2024-10-20

urea and Ductus Arteriosus, Patent

urea has been researched along with Ductus Arteriosus, Patent in 3 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Ductus Arteriosus, Patent: A congenital heart defect characterized by the persistent opening of fetal DUCTUS ARTERIOSUS that connects the PULMONARY ARTERY to the descending aorta (AORTA, DESCENDING) allowing unoxygenated blood to bypass the lung and flow to the PLACENTA. Normally, the ductus is closed shortly after birth.

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	1 (33.33)	24.3611
2020's	1 (33.33)	2.80

Authors

Authors	Studies
Giretti, I	1
Correani, A	1
Antognoli, L	1
Monachesi, C	1
Marchionni, P	1
Biagetti, C	1
Bellagamba, MP	1
Cogo, P	1
D'Ascenzo, R	1
Burattini, I	1
Carnielli, VP	1
Merino, JL	1
Espejo, B	1
Ferreiro, P	1
Bueno, B	1
Paraíso, V	1
Gawlowski, Z	1
Aladangady, N	1
Coen, PG	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Early Sodium Intake in Preterm Newborns; Randomized Clinical Trial[NCT04035564]			Phase 4	52 participants (Actual)	Interventional	2018-03-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

% Weight Change

The difference between initial weight and 72hrs weight, expressed in percentage of birth weight. (NCT04035564)
Timeframe: Initial weight (baseline) vs 72 hours

Intervention	% of birth weight (Mean)
Sodium < 1mEq/kg/Day	-9.206
Sodium 5mEq/kg/Day	-6.345

Change in Serum Sodium

The difference between current serum sodium and initial serum sodium (NCT04035564)
Timeframe: Initial serum sodium (baseline) vs 72 hours

Intervention	mEq/L (Mean)
Sodium < 1mEq/kg/Day	1.921
Sodium 5mEq/kg/Day	5.71

Hypernatremia

serum sodium >150mEq/L (NCT04035564)
Timeframe: 72 hours

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	1
Sodium 5mEq/kg/Day	1

Hyponatremia

serum sodium <130mEq/L (NCT04035564)
Timeframe: 72 hours

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	6
Sodium 5mEq/kg/Day	1

Mortality

Death during hospitalization. (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	5
Sodium 5mEq/kg/Day	2

Number of Participants With Intraventricular Hemorrhage

Bleeding into the brain´s ventricular system (intracranial ultrasound). (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	6
Sodium 5mEq/kg/Day	4

Number of Participants With Late-onset Sepsis

Positive blood culture and/or 5 days of continuous antimicrobial therapy (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	8
Sodium 5mEq/kg/Day	5

Number of Participants With Necrotizing Enterocolitis

"Number of patients with Bell stage II or greater necrotizing enterocolitis~Bell's Staging:~Stage II A:~Gastrointestinal signs: Increasing gastric aspirates, mild abdominal distention, fecal occult blood, absent bowel sounds.~Systemic signs: Temperature instability, apnea, bradycardia, lethargy. Radiological findings: Intestinal dilatation, ileus, pneumatosis intestinalis.~Stage II B:~Gastrointestinal signs: As stage IIA plus abdominal tenderness. Systemic signs: As stage IIA plus metabolic acidosis and thrombocytopenia. Radiological findings: As stage IIA plus portal vein gas and ascites.~Stage III A:~Gastrointestinal signs: As stage IIB plus marked abdominal tenderness and generalised peritonitis.~Systemic signs: As stage IIB plus hypotension and severe apnea. Radiological findings: As stage IIB~Stage III B:~Gastrointestinal signs: As stage IIIA As stage IIIA As stage IIIA plus pneumoperitoneum" (NCT04035564)
Timeframe: Patients will be followed during hospitalization, an expected average of 3 months of age

Intervention	Participants (Count of Participants)
Sodium < 1mEq/kg/Day	2
Sodium 5mEq/kg/Day	2

Weight Change

The difference between current weight and initial weight (NCT04035564)
Timeframe: Initial weight (baseline) vs 72 hours

Intervention	Grams (Mean)
Sodium < 1mEq/kg/Day	-135.43
Sodium 5mEq/kg/Day	-96.05

Other Studies

3 other studies available for urea and Ductus Arteriosus, Patent

Article	Year
Blood urea in preterm infants on routine parenteral nutrition: A multiple linear regression analysis. Clinical nutrition (Edinburgh, Scotland), 2021, Volume: 40, Issue:1 Topics: Amino Acids; Birth Weight; Creatinine; Ductus Arteriosus, Patent; Eating; Female; Gestational Age; H	2021
[Pregnancy and advanced chronic kidney disease]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2010, Volume: 30, Issue:3 Topics: Ductus Arteriosus, Patent; Epilepsy; Female; Fetal Growth Retardation; Humans; Hyaline Membrane Dise	2010
Hypernatraemia in preterm infants born at less than 27 weeks gestation. Journal of paediatrics and child health, 2006, Volume: 42, Issue:12 Topics: Birth Weight; Creatine; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Female; Fluid Therapy	2006