urea and Diabetes Insipidus studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Diabetes Insipidus: A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.

Research Excerpts

Excerpt	Relevance	Reference
" The effect of arginine vasopressin (AVP) administration on mRNA expression of these three transporters was examined in Brattleboro rats with diabetes insipidus."	3.70	Renal tubular and vascular urea transporters: influence of antidiuretic hormone on messenger RNA expression in Brattleboro rats. ( Bankir, L; Hu, MC; Promeneur, D; Trinh-Trang-Tan, MM, 1998)
"sec) and 14C-urea permeability (Pu x 10(-5) cm/sec) in the middle and distal inner medullary collecting duct (IMCD) obtained from acutely water-loaded Wistar rats and rats homozygous for diabetes insipidus (DI)."	3.68	Effect of chlorpropamide on water and urea transport in the inner medullary collecting duct. ( Kudo, LH; Ping, WC; Rocha, AS, 1991)
" In this study we examined the concentrations and contents of total solute, urea, and nonurea solute in tissue from cortex to papillary tip of DI rats before and after dehydration for 12, 24, and 48 h."	3.67	Compositional changes of the corticopapillary osmotic gradient during dehydration in the absence of vasopressin. ( Edwards, BR; Williamson, GL, 1984)
"During the onset of malignant hypertension (MH) in rats treated with deoxycorticosterone trimethylacetate (DOC), plasma arginine vasopressin (AVP) concentrations increase tenfold as a consequence of hypovolemia and hyperosmolality."	3.65	Vasopressor role of ADH in the pathogenesis of malignant DOC hypertension. ( Haack, D; Möhring, B; Möhring, J; Petri, M, 1977)
" Although some evidence of damage to the gastrinsecreting cells was obtained, the fasting plasma gastrin was not significantly altered and the patient died from a perforated duodenal ulcer."	3.65	Further studies on streptozotocin therapy for a multiple-hormone-producing islet cell carcinoma. ( Cassar, J; Coulson, R; Edwards, JC; Ganguli, PC; Murray-Lyon, IM; Taylor, KW; Williams, R, 1971)
"Under these conditions, when dehydration was superimposed for 72 hr, urine osmolality did not increase markedly."	1.25	The effect of vasopressin (Pitressin) administration and dehydration on the concentration of solutes in renal fluids of rats with and without hereditary hypothalamic diabetes insipidus. ( Lee, J; Williams, PG, 1972)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (92.45)	18.7374
1990's	3 (5.66)	18.2507
2000's	1 (1.89)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Edoute, Y	1
Davids, MR	1
Johnston, C	1
Halperin, ML	1
ZATUCHNI, J	1
ARMENTO, DF	1
MENZEL, PH	1
APPELBOOM, JW	1
BRODSKY, WA	1
SCOTT, WN	1
Fraser, AG	1
Cowie, JF	1
Lambie, AT	1
Robson, JS	1
Ganeval, D	1
Grünfeld, JP	1
Eloy, L	1
Lacour, B	1
Russo-Marie, F	1
Noël, LH	1
Anagnostopoulos, T	1
Michajlovskij, N	1
Ponec, J	1
Dzurba, A	1
Lichardus, B	1
Guiol, C	2
Prevost, MC	2
Montastruc, P	2
López Gastón, O	1
Jorge, M	1
Fernández, E	1
Malvino, E	1
Quiroga, E	1
Williamson, GL	2
Edwards, BR	2
Stoff, JS	1
Rosa, RM	1
Silva, P	1
Epstein, FH	1
Promeneur, D	1
Bankir, L	1
Hu, MC	1
Trinh-Trang-Tan, MM	1
Skopková, J	1
Schück, O	1
Cort, JH	1
Bleich, HL	1
Boro, ES	1
Konrads, A	1
Hofbauer, KG	1
Bauereiss, K	1
Möhring, J	3
Gross, F	1
De Groot, CA	1
Tijssen, AM	1
Giovannelli, G	1
Kohrs, G	1
Möhring, B	2
Petri, M	2
Homsy, E	1
Haack, D	2
Balment, RJ	1
Henderson, IW	1
Jones, IC	1
Mosley, W	1
Tisher, CC	1
Yarger, WE	1
Peck, JW	1
Blass, EM	1
Baum, N	1
Anhalt, M	1
Carlton, CE	1
Scott, R	1
Fernández-Repollet, E	1
Opava-Stitzer, S	1
Martínez-Maldonado, M	2
Rocha, AS	1
Ping, WC	1
Kudo, LH	1
Comtois, R	1
Bertrand, S	1
Beauregard, H	1
Vinay, P	1
Meinders, AE	1
Touber, JL	1
de Vries, LA	1
Jones, NF	3
Barraclough, MA	3
Perreiello, VA	1
Marsden, CD	1
Thurau, K	1
Valtin, H	4
Schnermann, J	1
Murray-Lyon, IM	1
Cassar, J	1
Coulson, R	1
Williams, R	1
Ganguli, PC	1
Edwards, JC	1
Taylor, KW	1
Barnes, N	1
Cottom, DG	1
Stavroulaki-Tsapara, A	1
Haley, D	1
Eknoyan, G	1
Loew, D	1
Meng, K	1
Pennell, JP	1
Lacy, FB	1
Jamison, RL	1
Kettyle, WM	1
Laycock, JF	1
Williams, PG	3
Koçak, N	1
Lee, J	2
Harrington, AR	2
Joppich, R	1
Deetjen, P	1
Kauker, M	1
Hare, R	1
Hare, K	2
Uhlich, E	1
Eigler, J	1
Tryzna, G	1
Finke, K	1
Winkelmann, W	1
Buchborn, E	1
Morgan, T	1
Nitschke, U	1
Levine, RA	1
Plöchl, E	1
Stur, O	1
Urakabe, S	1
Orita, Y	1
Furukawa, T	1
Abe, H	1
Goldblatt, EL	1
Kauker, ML	1
Hare, RS	1
Schröder, R	1
Buschmann, HJ	1
Ehrental, K	1

Article	Year
An integrative physiological approach to polyuria and hyponatraemia: a 'double-take' on the diagnosis and therapy in a patient with schizophrenia. QJM : monthly journal of the Association of Physicians, 2003, Volume: 96, Issue:7 Topics: Adult; Diabetes Insipidus; Diagnosis, Differential; Diuresis; Humans; Hyponatremia; Male; Polyuria;	2003
PITRESSIN-RESISTANT DIABETES INSIPIDUS AND DIABETES MELLITUS AND BILATERAL HYDRONEPHROSIS. The American journal of the medical sciences, 1964, Volume: 247 Topics: Blood Chemical Analysis; Carbon Dioxide; Chlorides; Diabetes Insipidus; Diabetes Mellitus; Glucose T	1964
EFFECT OF OSMOTIC DIURESIS ON INTRARENAL SOLUTES IN DIABETES INSIPIDUS AND HYDROPENIA. The American journal of physiology, 1965, Volume: 208 Topics: Dehydration; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diuresis; Dogs; Mannitol; Osmosis;	1965
The effects of furosemide on the osmolality of the urine and the composition of renal tissue. The Journal of pharmacology and experimental therapeutics, 1967, Volume: 158, Issue:3 Topics: Adult; Animals; Biological Transport; Cell Membrane Permeability; Creatinine; Dehydration; Diabetes	1967
Glaphenine-induced acute renal failure in the rat: a new experimental model. The American journal of physiology, 1982, Volume: 243, Issue:4 Topics: Acute Kidney Injury; Animals; Blood Pressure; Creatinine; Diabetes Insipidus; Disease Models, Animal	1982
[(Na-K) ATPase activity and corticopapillary osmotic gradient in the kidney of rats with hereditary hypothalamic diabetes insipudus after administration of 1-deamino-8-arginine-vasopressin (DDAVP)]. Bratislavske lekarske listy, 1980, Volume: 73, Issue:6 Topics: Animals; Arginine Vasopressin; Deamino Arginine Vasopressin; Diabetes Insipidus; Kidney; Kidney Cort	1980
Renal effect of clonidine during acute hypobaric pressure breathing in normal and diabetes insipidus rats. Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 270, Issue:1 Topics: Animals; Atmospheric Pressure; Clonidine; Creatinine; Diabetes Insipidus; Diuresis; Kidney; Male; Ra	1984
[Central diabetes insipidus in a case of prolonged brain death]. Medicina, 1983, Volume: 43, Issue:6 Pt 1 Topics: Adult; Brain Death; Diabetes Insipidus; Female; Humans; Osmolar Concentration; Polyuria; Sodium; Sod	1983
Compositional changes of the corticopapillary osmotic gradient during dehydration in the absence of vasopressin. Renal physiology, 1984, Volume: 7, Issue:1 Topics: Animals; Dehydration; Diabetes Insipidus; Female; Kidney Concentrating Ability; Kidney Cortex; Kidne	1984
Indomethacin impairs water diuresis in the DI rat: role of prostaglandins independent of ADH. The American journal of physiology, 1981, Volume: 241, Issue:3 Topics: Animals; Diabetes Insipidus; Dinoprostone; Diuresis; Indomethacin; Kidney; Kinetics; Meclofenamic Ac	1981
Changes in the corticopapillary osmotic gradient during prolonged dehydration of the Brattleboro rat. Annals of the New York Academy of Sciences, 1982, Volume: 394 Topics: Animals; Dehydration; Diabetes Insipidus; Female; Glomerular Filtration Rate; Kidney Concentrating A	1982
Renal tubular and vascular urea transporters: influence of antidiuretic hormone on messenger RNA expression in Brattleboro rats. Journal of the American Society of Nephrology : JASN, 1998, Volume: 9, Issue:8 Topics: Animals; Arginine Vasopressin; Carrier Proteins; Deamino Arginine Vasopressin; Diabetes Insipidus; G	1998
Oral urine recycling in diabetes insipidus (DI) rats--the role of the gut in absorption of some urinary components. Physiologia Bohemoslovaca, 1979, Volume: 28, Issue:3 Topics: Animals; Creatinine; Diabetes Insipidus; Drinking; Eating; Female; Intestinal Absorption; Intestinal	1979
Antidiuretic hormone. The New England journal of medicine, 1976, Sep-16, Volume: 295, Issue:12 Topics: Animals; Cell Membrane; Cell Membrane Permeability; Chlorpropamide; Cyclic AMP; Diabetes Insipidus;	1976
Glycerol-induced acute renal failure in Brattleboro rats with hypothalamic diabetes insipidus. Clinical science (London, England : 1979), 1979, Volume: 56, Issue:2 Topics: Acute Kidney Injury; Angiotensinogen; Animals; Blood; Blood Pressure; Diabetes Insipidus; Female; Gl	1979
The effects of long-term oral treatment with chlorothiazide or furosemide on hereditary diabetes insipidus in rats. Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 237, Issue:1 Topics: Animals; Chlorothiazide; Diabetes Insipidus; Diuresis; Electrolytes; Female; Furosemide; Natriuresis	1979
[Nephrogenic diabetes insipidus]. Minerva medica, 1979, Oct-13, Volume: 70, Issue:44 Topics: Adult; Child; Diabetes Insipidus; Female; Humans; Kidney Diseases; Male; Osmotic Pressure; Sodium Ch	1979
Effects of prolonged vasopressin treatment in Brattleboro rats with diabetes insipidus. The American journal of physiology, 1978, Volume: 234, Issue:2 Topics: Adrenal Glands; Aldosterone; Angiotensin II; Animals; Arginine Vasopressin; Corticosterone; Diabetes	1978
Vasopressor role of ADH in the pathogenesis of malignant DOC hypertension. The American journal of physiology, 1977, Volume: 232, Issue:3 Topics: Angiotensin II; Animals; Antibodies; Arginine Vasopressin; Blood Pressure; Body Weight; Desoxycortic	1977
Water and electrolyte balance in adrenalectomized rats with diabetes insipidus (Brattleboro strain) given antidiuretic hormone. General and comparative endocrinology, 1977, Volume: 33, Issue:3 Topics: Adrenalectomy; Animals; Body Weight; Calcium; Chlorides; Diabetes Insipidus; Drinking Behavior; Magn	1977
Lanthanum permeability of tight junctions along the collecting duct of the rat. Kidney international, 1975, Volume: 7, Issue:1 Topics: Animals; Blood; Diabetes Insipidus; Diuresis; Epithelial Cells; Epithelium; Female; Glomerular Filtr	1975
Localization of thirst and antidiuretic osmoreceptors by intracranial injections in rats. The American journal of physiology, 1975, Volume: 228, Issue:5 Topics: Angiotensin II; Animals; Brain Mapping; Carbachol; Chemoreceptor Cells; Diabetes Insipidus; Diuresis	1975
Post-obstructive diuresis. The Journal of urology, 1975, Volume: 114, Issue:1 Topics: Diabetes Insipidus; Diuresis; Humans; Kidney Tubules, Distal; Osmolar Concentration; Postoperative C	1975
Renal hemodynamics and urinary concentrating capacity in protein deprivation: role of antidiuretic hormone. The American journal of the medical sciences, 1992, Volume: 303, Issue:5 Topics: Animals; Diabetes Insipidus; Hemodynamics; Kidney; Kidney Concentrating Ability; Protein Deficiency;	1992
Effect of chlorpropamide on water and urea transport in the inner medullary collecting duct. Kidney international, 1991, Volume: 39, Issue:1 Topics: Animals; Biological Transport, Active; Chlorpropamide; Diabetes Insipidus; Diuresis; Kidney Tubules,	1991
Low serum urea level in dehydrated patients with central diabetes insipidus. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1988, Nov-15, Volume: 139, Issue:10 Topics: Adult; Creatinine; Dehydration; Diabetes Insipidus; Female; Fluid Therapy; Humans; Hypernatremia; Ma	1988
Renal effect of acute hypobaric pressure breathing in normal and diabetes insipidus rats. Journal de physiologie, 1986, Volume: 81, Issue:1 Topics: Air Pressure; Animals; Atmospheric Pressure; Blood Volume; Chlorine; Diabetes Insipidus; Disease Mod	1986
Chlorpropamide treatment in diabetes insipidus. Lancet (London, England), 1967, Sep-09, Volume: 2, Issue:7515 Topics: Adult; Aged; Chlorides; Chlorpropamide; Creatine; Diabetes Insipidus; Diuresis; Female; Humans; Male	1967
Further studies on streptozotocin therapy for a multiple-hormone-producing islet cell carcinoma. Gut, 1971, Volume: 12, Issue:9 Topics: Acetoacetates; Adenoma, Islet Cell; Antibiotics, Antineoplastic; Autopsy; Blood Glucose; Diabetes In	1971
Nephrogenic diabetes insipidus. Effects of 3,5, cyclic-adenosine monophosphate. Archives of disease in childhood, 1972, Volume: 47, Issue:255 Topics: Adolescent; Blood Pressure; Child; Creatinine; Cyclic AMP; Diabetes Insipidus; Glomerular Filtration	1972
Changes in electrolyte excretion following intraperitoneal injection of dibutyryl cyclic AMP in the brattleboro rat. Life sciences, 1974, May-16, Volume: 14, Issue:10 Topics: Adenosine Monophosphate; Animals; Bucladesine; Diabetes Insipidus; Fasting; Homozygote; Injections,	1974
[Acute renal failure after scalding of the rat (author's transl)]. Langenbecks Archiv fur Chirurgie, 1974, Volume: 335, Issue:4 Topics: Acute Kidney Injury; Aldosterone; Animals; Anuria; Burns; Diabetes Insipidus; Disease Models, Animal	1974
An in vivo study of the concentrating process in the descending limb of Henle's loop. Kidney international, 1974, Volume: 5, Issue:5 Topics: Animals; Diabetes Insipidus; Disease Models, Animal; Diuresis; Female; Kidney Concentrating Ability;	1974
Chemical and dimensional chracterization of the renal countercurrent system in mice. Kidney international, 1972, Volume: 1, Issue:3 Topics: Age Factors; Animals; Colorimetry; Diabetes Insipidus; Diuresis; Drug Resistance; Genotype; Kidney;	1972
The effect of vasopressin (Pitressin) administration on sodium, potassium and urea excretion in rats with and without diabetes insipidus (DI), with a note on the excretion of vasopressin in the DI rat. The Journal of endocrinology, 1973, Volume: 56, Issue:1 Topics: Animals; Biological Transport, Active; Diabetes Insipidus; Female; Injections, Subcutaneous; Kidney;	1973
[Kidney function in idiopathic diabetes insipidus]. Munchener medizinische Wochenschrift (1950), 1973, Aug-03, Volume: 115, Issue:31 Topics: Adolescent; Adult; Chlorides; Diabetes Insipidus; Female; Glomerular Filtration Rate; Glucose; Human	1973
The effect of vasopressin (Pitressin) administration and dehydration on the concentration of solutes in renal fluids of rats with and without hereditary hypothalamic diabetes insipidus. The Journal of physiology, 1972, Volume: 220, Issue:3 Topics: Ammonia; Animals; Centrifugation, Density Gradient; Creatinine; Dehydration; Diabetes Insipidus; Kid	1972
Hyponatremia due to sodium depletion in the absence of vasopressin. The American journal of physiology, 1972, Volume: 222, Issue:3 Topics: Animals; Body Weight; Depression, Chemical; Diabetes Insipidus; Diet; Feeding Behavior; Female; Furo	1972
The relation between the reabsorption of urea and of water in the distal tubule of the rat kidney. Pflugers Archiv : European journal of physiology, 1971, Volume: 329, Issue:2 Topics: Animals; Carbon Isotopes; Diabetes Insipidus; Dietary Proteins; Diuresis; Inulin; Kidney Function Te	1971
The effect of vasopressin on renal transport of urea and water in dogs with experimental diabetes insipidus. Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 185, Issue:1 Topics: Animals; Creatinine; Diabetes Insipidus; Diuresis; Dogs; Female; Glomerular Filtration Rate; Kidney;	1970
The effect of vasopressin on the reabsorption of sodium, potassium and urea by the renal tubules in man. Clinical science, 1970, Volume: 39, Issue:4 Topics: Adult; Creatinine; Diabetes Insipidus; Diuresis; Humans; Kidney Tubules; Male; Middle Aged; Potassiu	1970
[The mode of action of chlorpropamide in diabetes insipidus]. Klinische Wochenschrift, 1971, Mar-15, Volume: 49, Issue:6 Topics: Adolescent; Adult; Aged; Animals; Anura; Chlorpropamide; Diabetes Insipidus; Diuresis; Female; Human	1971
Sodium and urea concentrations in renal papillary fluid of rats, with dehydration and vasopressin (Pitressin) administration. The Journal of physiology, 1971, Volume: 215, Issue:1 Topics: Animals; Dehydration; Diabetes Insipidus; Kidney; Rats; Sodium; Urea; Vasopressins	1971
[Studies on the mechanism of action of vasopressin on kidney function]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1967, Oct-01, Volume: 22, Issue:19 Topics: Diabetes Insipidus; Humans; Infusions, Parenteral; Kidney; Kidney Concentrating Ability; Osmosis; Os	1967
Impaired urinary concentration after vasopressin and its gradual correction in hypothalamic diabetes insipidus. The Journal of clinical investigation, 1968, Volume: 47, Issue:3 Topics: Animals; Dehydration; Diabetes Insipidus; Diuresis; Hypothalamus; Kidney; Kidney Concentrating Abili	1968
Antiduretic responses to exogenous adenosine 3',5'-monophosphate in man. Clinical science, 1968, Volume: 34, Issue:2 Topics: Adenine Nucleotides; Adult; Blood Urea Nitrogen; Creatinine; Diabetes Insipidus; Diuresis; Female; G	1968
[Sweat studies in renal diabetes insipidus during treatment with saluretics]. Helvetica paediatrica acta, 1965, Volume: 20, Issue:4 Topics: Chlorides; Chlorthalidone; Diabetes Insipidus; Diuretics; Furosemide; Humans; Infant, Newborn; Infan	1965
Analysis of urea excretion with special reference to the influence of abrupt change in urine flow. Japanese circulation journal, 1965, Volume: 29, Issue:10 Topics: Adult; Animals; Chlorides; Chlorthalidone; Diabetes Insipidus; Diuresis; Female; Humans; Hydrochloro	1965
Sequestration of urea and nonurea solutes in renal tissues of rats with hereditary hypothalamic diabetes insipidus: effect of vasopressin and dehydration on the countercurrent mechanism. The Journal of clinical investigation, 1966, Volume: 45, Issue:3 Topics: Animals; Dehydration; Diabetes Insipidus; Electrolytes; Kidney; Rats; Urea; Vasopressins	1966
Effect of ethyleneimine on renal action of vasopressin. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1966, Volume: 123, Issue:3 Topics: Animals; Azirines; Diabetes Insipidus; Diuresis; Dogs; Drug Antagonism; Kidney Tubules; Urea; Vasopr	1966
[The effect of tonephin on the renal electrolyte and urea excretion following infusion of glucose and sterofundin]. Klinische Wochenschrift, 1966, Aug-15, Volume: 44, Issue:16 Topics: Chlorides; Diabetes Insipidus; Electrolytes; Glucose; Humans; Infusions, Parenteral; Inulin; Kidney	1966

urea and Diabetes Insipidus

Research Excerpts

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