urea has been researched along with Dementias, Transmissible in 5 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Transmissible spongiform encephalopathies are associated with accumulation of PrP(Sc), a conformer of a cellular protein called PrP(C)." | 1.31 | Binding of disease-associated prion protein to plasminogen. ( Aguzzi, A; Fischer, MB; Parizek, P; Roeckl, C; Schwarz, HP, 2000) |
| "The main hypothesis for prion diseases proposes that the cellular protein (PrP(C)) can be altered into a misfolded, beta-sheet-rich isoform (PrP(Sc)), which in most cases undergoes aggregation." | 1.31 | DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation. ( Brentani, RR; Cordeiro, Y; Foguel, D; Juliano, L; Juliano, MA; Machado, F; Silva, JL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sweeting, B | 2 |
| Brown, E | 1 |
| Khan, MQ | 2 |
| Chakrabartty, A | 2 |
| Pai, EF | 2 |
| Mulligan, VK | 1 |
| Arslan, PE | 1 |
| Cashman, NR | 1 |
| Cordeiro, Y | 2 |
| Lima, LM | 1 |
| Gomes, MP | 1 |
| Foguel, D | 2 |
| Silva, JL | 2 |
| Fischer, MB | 1 |
| Roeckl, C | 1 |
| Parizek, P | 1 |
| Schwarz, HP | 1 |
| Aguzzi, A | 1 |
| Machado, F | 1 |
| Juliano, L | 1 |
| Juliano, MA | 1 |
| Brentani, RR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of the Coagulation Pathway at the Synapse in Prion Diseases[NCT02480725] | 50 participants (Anticipated) | Observational | 2015-06-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for urea and Dementias, Transmissible
| Article | Year |
|---|---|
N-terminal helix-cap in α-helix 2 modulates β-state misfolding in rabbit and hamster prion proteins.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Asparagine; Circular Dichroism; Cricetinae; Hydroge | 2013 |
Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP.
Topics: Amino Acid Motifs; Amino Acids; Animals; Cell Death; Circular Dichroism; Crystallography, X-Ray; Dis | 2010 |
Modulation of prion protein oligomerization, aggregation, and beta-sheet conversion by 4,4'-dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS).
Topics: Anilino Naphthalenesulfonates; Animals; Circular Dichroism; Cricetinae; Dose-Response Relationship, | 2004 |
Binding of disease-associated prion protein to plasminogen.
Topics: Animals; Blotting, Western; Guanidine; Humans; Magnetics; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2000 |
DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation.
Topics: Animals; Circular Dichroism; DNA; DNA-Binding Proteins; Humans; Nucleic Acid Conformation; Oligonucl | 2001 |