urea and Critical Illness studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Research Excerpts

Excerpt	Relevance	Reference
"The use of landiolol hydrochloride for HR control of non-arrhythmic tachycardia in critically ill infants is well tolerated."	8.31	Heart rate control with landiolol hydrochloride in infants with ventricular dysfunction and pulmonary hypertension. ( Ackerl, J; Dresbach, T; Kipfmueller, F; Monno, P; Mueller, A; Schmitt, J; Schroeder, L; Shatilova, O; Unger, M, 2023)
" Objective of this work was to determine predictive and diagnostic value of urinary malondialdehyde (UMDA) as a marker for acute kidney injury (AKI) in critically sick full-term newborns."	7.88	URINARY MALONDIALDEHYDE AS A PREDICTIVE AND DIAGNOSTIC MARKER FOR NEONATAL ACUTE KIDNEY INJURY. ( Agafonova, L; Babintseva, A; Frunza, A; Hodovanets, Y; Makarova, O, 2018)
"To evaluate the performance of fractional excretion of urea (FeU) for differentiating transient (T) from persistent (P) acute kidney injury (AKI) and to assess performance of FeU in predicting AKI in patients admitted to the ICU."	7.80	Transient versus persistent acute kidney injury and the diagnostic performance of fractional excretion of urea in critically ill patients. ( Abu-Hanna, A; Bouman, CS; Hofstra, LS; Kuiper, MA; Royakkers, AA; Schultz, MJ; Spronk, PE; Wlodzimirow, KA, 2014)
"Hypernatremia is a common electrolyte problem at the intensive care setting, with a prevalence that can reach up to 25%."	6.66	The role of urea-induced osmotic diuresis and hypernatremia in a critically ill patient: case report and literature review. ( Distenhreft, JIQ; Luchi, WM; Ramos, JM; Scopel, GS; Seguro, AC; Vianna, JGP, 2020)
"Reanalysis of multicenter randomized trial of glutamine supplementation in critical illness (REducing Deaths due to OXidative Stress [REDOXS])."	5.51	Catabolism in Critical Illness: A Reanalysis of the REducing Deaths due to OXidative Stress (REDOXS) Trial. ( Day, A; Flower, L; Fowler, AJ; Haines, RW; Heyland, DK; Pearse, RM; Prowle, JR; Puthucheary, Z; Wan, YI, 2022)
"The super-selective β1-antagonist landiolol may increase inotropy and may be associated with positive outcomes in critically ill patients with acute decompensated heart failure or sepsis."	5.41	Mechanisms of landiolol-mediated positive inotropy in critical care settings. ( Chalkias, A; O'Donnell, EP, 2023)
"FeUrea was 39% (28 to 40) in the no-AKI group, 41% (29 to 54) in the transient AKI group and 32% (22 to 51) in the persistent AKI group (P = 0."	5.37	Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study. ( Bernardin, G; Brochard, L; Cohen, Y; Darmon, M; Das, V; Dellamonica, J; Gonzalez, F; Schlemmer, B; Schortgen, F; Vincent, F; Zeni, F, 2011)
"Most often, urea cycle disorders have been described as acute onset hyperammonemia in the newborn period; however, there is a growing awareness that urea cycle disorders can present at almost any age, frequently in the critical care setting."	4.82	Unmasked adult-onset urea cycle disorders in the critical care setting. ( Barr, F; Christman, BW; Dawling, S; Lee, B; Rhead, WJ; Singh, RH; Smith, W; Sniderman King, L; Summar, ML, 2005)
"The use of landiolol hydrochloride for HR control of non-arrhythmic tachycardia in critically ill infants is well tolerated."	4.31	Heart rate control with landiolol hydrochloride in infants with ventricular dysfunction and pulmonary hypertension. ( Ackerl, J; Dresbach, T; Kipfmueller, F; Monno, P; Mueller, A; Schmitt, J; Schroeder, L; Shatilova, O; Unger, M, 2023)
" Objective of this work was to determine predictive and diagnostic value of urinary malondialdehyde (UMDA) as a marker for acute kidney injury (AKI) in critically sick full-term newborns."	3.88	URINARY MALONDIALDEHYDE AS A PREDICTIVE AND DIAGNOSTIC MARKER FOR NEONATAL ACUTE KIDNEY INJURY. ( Agafonova, L; Babintseva, A; Frunza, A; Hodovanets, Y; Makarova, O, 2018)
"To evaluate the performance of fractional excretion of urea (FeU) for differentiating transient (T) from persistent (P) acute kidney injury (AKI) and to assess performance of FeU in predicting AKI in patients admitted to the ICU."	3.80	Transient versus persistent acute kidney injury and the diagnostic performance of fractional excretion of urea in critically ill patients. ( Abu-Hanna, A; Bouman, CS; Hofstra, LS; Kuiper, MA; Royakkers, AA; Schultz, MJ; Spronk, PE; Wlodzimirow, KA, 2014)
"Urea administration appears useful for the treatment of SIADH-associated hyponatremia in critically ill patients."	3.78	Treatment of the syndrome of inappropriate secretion of antidiuretic hormone with urea in critically ill patients. ( Bankir, L; Biston, P; Coussement, J; Danguy, C; Defrance, P; Piagnerelli, M; Zouaoui-Boudjeltia, K, 2012)
"To evaluate the Kt assessed through ionic dializance (KtOCM) in UCI patients undergoing renal replacement therapy for acute kidney injury, comparing the results with those obtained through the urea removal rate method determined by dialyzate collection (Kturea)."	3.76	[Measuring Kt by ionic dialysance is a useful tool for assessing dialysis dose in critical patients]. ( Algranati, S; Bevione, P; Bonfanti, W; Bratti, G; Crucelegui, MS; Giannasi, S; Greloni, G; Heguilen, R; Rosa Díez, GJ; San Román, E; Varela, F, 2010)
"Secondly, to identify when during critical illness catabolism might decrease, such that targeted nutritional strategies may logically be initiated."	2.90	Exploration of muscle loss and metabolic state during prolonged critical illness: Implications for intervention? ( Bountziouka, V; Brett, SJ; Frost, GS; Hickson, M; Wandrag, L, 2019)
"In prolonged critical illness, increased bone resorption and osteoblast dysfunction have been reported facing low 25 hydroxy vitamin D [25(OH)D] concentrations."	2.71	Bone turnover in prolonged critical illness: effect of vitamin D. ( Bouillon, R; De Pourcq, L; Van den Berghe, G; Van Roosbroeck, D; Vanhove, P; Wouters, PJ, 2003)
"Survived days free of acute renal failure treatment were fewer for the IHDF (4."	2.70	Intermittent hemodiafiltration in acute renal failure in critically ill patients. ( Pettilä, V; Tiula, E, 2001)
"Hypernatremia is a common electrolyte problem at the intensive care setting, with a prevalence that can reach up to 25%."	2.66	The role of urea-induced osmotic diuresis and hypernatremia in a critically ill patient: case report and literature review. ( Distenhreft, JIQ; Luchi, WM; Ramos, JM; Scopel, GS; Seguro, AC; Vianna, JGP, 2020)
"We propose an adaptation of a maintenance dialysis parameter (standard Kt/V) as a benchmark to supplement effluent-based dosing of CRRT."	2.55	Quantification and Dosing of Renal Replacement Therapy in Acute Kidney Injury: A Reappraisal. ( Clark, WR; Leblanc, M; Ricci, Z; Ronco, C, 2017)
"There is no consensus definition of acute renal failure (ARF) in critically ill patients."	2.42	Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. ( Bellomo, R; Kellum, JA; Mehta, RL; Palevsky, P; Ronco, C, 2004)
"Hypernatremia is common in critical care, especially in severely burned patients."	1.56	The Link between Hypermetabolism and Hypernatremia in Severely Burned Patients. ( Kreutziger, J; Rugg, C; Schmid, S; Ströhle, M, 2020)
"ICU patients admitted with influenza infection without bacterial co-infection."	1.48	Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection. ( Barahona, D; Bodí, M; Díaz, E; Guardiola, J; Martín-Loeches, I; Monclou, J; Restrepo, MI; Reyes, LF; Rodríguez, A; Sirgo, G; Solé-Violán, J; Suberviola, B, 2018)
"Sepsis is the most common trigger for acute kidney injury (AKI) in critically ill patients."	1.38	A prospective evaluation of urine microscopy in septic and non-septic acute kidney injury. ( Bagshaw, SM; Bellomo, R; Bennett, M; Devarajan, P; Haase, M; Haase-Fielitz, A, 2012)
"FeUrea was 39% (28 to 40) in the no-AKI group, 41% (29 to 54) in the transient AKI group and 32% (22 to 51) in the persistent AKI group (P = 0."	1.37	Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study. ( Bernardin, G; Brochard, L; Cohen, Y; Darmon, M; Das, V; Dellamonica, J; Gonzalez, F; Schlemmer, B; Schortgen, F; Vincent, F; Zeni, F, 2011)
"Hyperammonemia is encountered frequently in acutely ill children presenting for emergency care with altered levels of consciousness (ALOC)."	1.36	Hyperammonemia in the pediatric emergency care setting. ( Dabnon, M; Fouad, HM; Galal, NM; Saied, A, 2010)
"Blood-side dosing methods may overestimate urea removal in comparison to dialysate-side measurements during intermittent HD (IHD) for acute renal failure (ARF)."	1.35	Dosing intermittent haemodialysis in the intensive care unit patient with acute renal failure--estimation of urea removal and evidence for the regional blood flow model. ( Daugirdas, JT; Depner, TA; Greene, T; Kanagasundaram, NS; Larive, AB; Paganini, EP, 2008)
"Critically ill patients with acute renal failure are traditionally treated with low-protein diets to help control uremia."	1.30	A prospective comparative study of moderate versus high protein intake for critically ill patients with acute renal failure. ( Bellomo, R; Boyce, N; Daskalakis, M; Farmer, M; Parkin, G; Seacombe, J; Wright, C, 1997)

Research

Studies (74)

Authors

Clinical Trials (19)

Trial Overview

Trial Outcomes

Urine Volume

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	13 (17.57)	18.2507
2000's	17 (22.97)	29.6817
2010's	34 (45.95)	24.3611
2020's	10 (13.51)	2.80

Authors	Studies
Flower, L	2
Haines, RW	2
McNelly, A	1
Bear, DE	1
Koelfat, K	1
Damink, SO	1
Hart, N	1
Montgomery, H	1
Prowle, JR	2
Puthucheary, Z	2
Fowler, AJ	1
Wan, YI	1
Heyland, DK	1
Day, A	1
Pearse, RM	1
Delles, C	1
Rossitto, G	1
Schroeder, L	1
Monno, P	1
Unger, M	1
Ackerl, J	1
Shatilova, O	1
Schmitt, J	1
Dresbach, T	1
Mueller, A	1
Kipfmueller, F	1
Shiri, S	2
Naik, NM	2
Av, L	2
Vasudevan, A	2
Chalkias, A	1
O'Donnell, EP	1
Gassanov, N	1
Er, F	1
de Jong, LAA	1
Otten-Helmers, AG	1
Spronk, PE	2
van Kan, HJM	1
Gunst, J	1
Kashani, KB	1
Hermans, G	1
Wandrag, L	1
Brett, SJ	1
Frost, GS	1
Bountziouka, V	1
Hickson, M	1
Rugg, C	1
Ströhle, M	1
Schmid, S	1
Kreutziger, J	1
Weidhase, L	1
de Fallois, J	1
Haußig, E	1
Kaiser, T	1
Mende, M	1
Petros, S	1
Hariri, G	1
Urbina, T	1
Mazerand, S	1
Bige, N	1
Baudel, JL	1
Ait-Oufella, H	1
Clark, WR	2
Leblanc, M	2
Ricci, Z	3
Ronco, C	6
Poveda-Jaramillo, R	1
Monaco, F	1
Zangrillo, A	1
Landoni, G	1
Rodríguez, A	1
Reyes, LF	1
Monclou, J	1
Suberviola, B	1
Bodí, M	1
Sirgo, G	1
Solé-Violán, J	1
Guardiola, J	1
Barahona, D	1
Díaz, E	1
Martín-Loeches, I	1
Restrepo, MI	1
Fealy, N	2
Aitken, L	1
du Toit, E	1
Bailey, M	1
Baldwin, I	3
Villa, G	1
Neri, M	1
Cerdá, J	1
Hodovanets, Y	1
Babintseva, A	1
Agafonova, L	1
Makarova, O	1
Frunza, A	1
Schiffl, H	3
Arabi, YM	1
Al-Dorzi, HM	1
Mehta, S	1
Tamim, HM	1
Haddad, SH	1
Jones, G	1
McIntyre, L	1
Solaiman, O	1
Sakkijha, MH	1
Sadat, M	1
Afesh, L	1
Kumar, A	1
Bagshaw, SM	5
Aldawood, AS	1
Lund, A	1
Damholt, MB	1
Wiis, J	1
Kelsen, J	1
Strange, DG	1
Møller, K	1
Liang, KV	1
Zhang, JH	1
Palevsky, PM	1
Distenhreft, JIQ	1
Vianna, JGP	1
Scopel, GS	1
Ramos, JM	1
Seguro, AC	1
Luchi, WM	1
Fischer, R	1
Lang, SM	1
Wlodzimirow, KA	1
Abu-Hanna, A	1
Royakkers, AA	1
Hofstra, LS	1
Kuiper, MA	1
Schultz, MJ	1
Bouman, CS	1
Palli, E	1
Makris, D	1
Papanikolaou, J	1
Garoufalis, G	1
Zakynthinos, E	1
Oppert, M	1
Aniort, J	1
Ait Hssain, A	1
Pereira, B	1
Coupez, E	1
Pioche, PA	1
Leroy, C	1
Heng, AE	1
Souweine, B	1
Lautrette, A	1
Balsorano, P	1
Romagnoli, S	1
Evans, SK	1
De Gaudio, AR	1
Ferrando-Vivas, P	1
Jones, A	1
Rowan, KM	1
Harrison, DA	1
Zingerenko, VB	1
Rosa Díez, GJ	1
Bevione, P	1
Crucelegui, MS	1
Bratti, G	1
Bonfanti, W	1
Varela, F	1
Algranati, S	1
Giannasi, S	1
San Román, E	1
Heguilen, R	1
Greloni, G	1
Serra Cabañas, N	1
Barros Freiría, X	1
Garro Martínez, J	1
Blasco Pelícano, M	1
Maduell Canals, F	1
Torras Rabasa, A	1
Poch López de Briñas, E	1
Baird, JS	1
Galal, NM	1
Fouad, HM	1
Saied, A	1
Dabnon, M	1
Haase, M	1
Haase-Fielitz, A	1
Bennett, M	2
Devarajan, P	2
Bellomo, R	8
Darmon, M	1
Vincent, F	1
Dellamonica, J	1
Schortgen, F	1
Gonzalez, F	1
Das, V	1
Zeni, F	1
Brochard, L	1
Bernardin, G	1
Cohen, Y	1
Schlemmer, B	1
Lindner, G	1
Schwarz, C	1
Funk, GC	1
Lyndon, WD	1
Wille, KM	1
Tolwani, AJ	1
Coussement, J	1
Danguy, C	1
Zouaoui-Boudjeltia, K	1
Defrance, P	1
Bankir, L	1
Biston, P	1
Piagnerelli, M	1
Claure-Del Granado, R	1
Macedo, E	1
Chertow, GM	1
Soroko, S	1
Himmelfarb, J	1
Ikizler, TA	1
Paganini, EP	3
Mehta, RL	2
Prowle, J	1
Kim, JC	1
Cruz, D	1
Garzotto, F	1
Kaushik, M	1
Teixeria, C	1
Baldwin, M	1
Nalesso, F	1
Kim, JH	1
Kang, E	1
Kim, HC	1
Uchino, S	1
Morimatsu, H	1
Van den Berghe, G	1
Van Roosbroeck, D	1
Vanhove, P	1
Wouters, PJ	1
De Pourcq, L	1
Bouillon, R	1
Casino, FG	1
Marshall, MR	2
Kellum, JA	1
Palevsky, P	1
Graves, C	1
Saffle, J	1
Morris, S	1
Summar, ML	1
Barr, F	1
Dawling, S	1
Smith, W	1
Lee, B	1
Singh, RH	1
Rhead, WJ	1
Sniderman King, L	1
Christman, BW	1
Fuller, HD	1
Bachetoni, A	1
D'amico, G	1
Rossi, S	1
Alessandri, E	1
Rocco, M	1
Pietropaoli, P	1
Kanagasundaram, NS	3
Greene, T	2
Larive, AB	1
Daugirdas, JT	1
Depner, TA	1
Gibney, RT	1
Pinsky, MR	1
Brophy, P	1
Padilla, J	1
Paganini, E	1
Pannu, N	1
van Bommel, EF	1
Bouvy, ND	1
So, KL	1
Vincent, HH	1
Zietse, R	1
Bruining, HA	1
Weimar, W	1
Ensinger, H	1
Träger, K	1
Geisser, W	1
Anhäupl, T	1
Ahnefeld, FW	1
Vogt, J	1
Georgieff, M	1
Parkin, G	3
Boyce, N	3
Love, J	1
Brocklehurst, IC	1
Thomas, AN	1
Kishen, R	1
Guy, JM	1
Seacombe, J	1
Daskalakis, M	1
Farmer, M	1
Wright, C	1
Dahn, MS	2
Lange, MP	2
Fletcher, SJ	1
Slaymaker, AE	1
Bodenham, AR	1
Vucevic, M	1
Benn, S	1
Brunet, S	1
Geadah, D	1
Parent, D	1
Courteau, S	1
Cardinal, J	1
Dehne, MG	1
Mühling, J	1
Papke, G	1
Nopens, H	1
Kuntzsch, U	1
Hempelmann, G	1
Larive, B	1
Pettilä, V	1
Tiula, E	1
Golper, TA	1
Shaver, MJ	1
Alam, MG	1
Chatoth, DK	1
Gallagher, HG	1
Phelan, DM	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effects of Medical High Protein Nutrition on the Muscle Mass in Adult ICU Patients[NCT06168136]		84 participants (Anticipated)	Interventional	2024-01-01	Not yet recruiting
A Multicenter Randomized Controlled Clinical Study With WeiYuan Tai (a Nutritional Supplement) on Nutritional Support of Enhanced Protein in Severe Patients(Tai Shan)[NCT04177446]		180 participants (Anticipated)	Interventional	2019-12-25	Not yet recruiting
Daily Urinary Urea Excretion to Guide Renal Replacement Therapy Weaning in Intensive Care Units[NCT03763188]		260 participants (Actual)	Observational	2016-09-01	Completed
Continuous Renal Replacement Therapy With Anticoagulation-free Regimen in Bleeding-risk Patients Using oXiris Membrane - CARROM Study[NCT01779635]		20 participants (Actual)	Interventional	2013-08-31	Completed
Cerebral Oximetry and Perioperative Outcome in Non-Cardiac Surgery[NCT01838733]		200 participants (Anticipated)	Observational	2014-04-30	Recruiting
The Role of Serum Neutrophil Gelatinase Associated Lipocalin in Predicting Acute Kidney Injury in Patients With Coronary Artery Disease[NCT03266367]		45 participants (Anticipated)	Observational	2017-09-15	Not yet recruiting
Retrospective Analysis of Aminoglycoside-associated Acute Renal Injury in Septic Critically Ill Patients[NCT01932814]		317 participants (Actual)	Observational	2012-09-30	Completed
"Early and Late Timing Indication for Starting Renal Replacement Therapy in Acute Renal Failure After Cardiac Surgery: a Prospective, Controlled, Interventional, Single-center Trial"[NCT01961999]		1,800 participants (Actual)	Interventional	2011-07-31	Completed
Impact of a Continuous Dialysis Technique Associated With Adsorption Capacity Membranes in Patients With Sepsis Associated - Acute Kidney Injury.[NCT01790620]		110 participants (Actual)	Interventional	2013-05-31	Completed
ACTION-1: ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair, a Randomised Trial.[NCT04061798]	Phase 4	750 participants (Anticipated)	Interventional	2020-03-02	Recruiting
Predicted Long Term Renal Outcome After Medical or Postcardiotomy Refractory Cardiogenic Shock Requiring Renal Replacement Therapy Concomitant With Venoarterial Extracorporeal Membrane Oxygenation[NCT05788211]		100 participants (Anticipated)	Observational	2022-01-01	Recruiting
Soluble Urokinase Plasminogen Activator Receptor (suPAR) in the Early Diagnosis of Acute Kidney Injury After On-Pump Cardiac Surgery[NCT02921113]		105 participants (Actual)	Observational	2016-04-30	Completed
Evaluating the Role of Cystatin C and Creatinine as Markers of Renal Recovery in Critically Ill Patients After Acute Kidney Injury.[NCT02894164]		336 participants (Actual)	Observational [Patient Registry]	2008-01-31	Completed
Multi-Drug Resistant Organism Network - MDRO Network[NCT03646227]		6,496 participants (Actual)	Observational	2016-06-16	Completed
Acute Kidney Injury and Nonsteroidal Anti-inflammatory Drugs in Patients Undergoing High-risk Abdominal or Thoracic Surgery[NCT02553174]		50 participants (Actual)	Observational	2016-06-01	Terminated (stopped due to unable to recruit sufficient patients to satisfy study protocols)
Vancomycin De-escalation Therapy in Patients With Pneumonia and Negative MRSA Nasal Swab[NCT03586362]		278 participants (Anticipated)	Observational	2018-02-08	Active, not recruiting
Protocol to Assess the Severity of Acute Kidney Injury[NCT00673244]		77 participants (Actual)	Interventional	2008-04-30	Completed
Influence of Elevated Baseline Serum Creatinine and Body Composition on Acute Kidney Injury in Cardiac Surgery - The InCreAS Trial[NCT02598271]		200 participants (Actual)	Observational	2016-10-31	Completed
Local Assessment of Ventilatory Management During General Anesthesia for Surgery - a Prospective Observational Multi-center Cohort Study[NCT01601223]		10,690 participants (Actual)	Observational	2013-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Urine output measured in ml/hr for first 6 hours after furosemide administration (NCT00673244)
Timeframe: Time from furosemide administration to 6 hours after furosemide administration

Intervention	ml (Mean)
	Urine Volume - Hour 1	Urine Volume - Hour 2	Urine Volume - Hour 3	Urine Volume - Hour 4	Urine Volume - Hour 5	Urine Volume - Hour 6
Did Not Progress to AKIN Stage-III	329	392	311	265	219	194
Progressed to AKIN Stage III	89	96	109	88	83	75

Article	Year
Catabolism in Critical Illness: A Reanalysis of the REducing Deaths due to OXidative Stress (REDOXS) Trial. Critical care medicine, 2022, 07-01, Volume: 50, Issue:7 Topics: Bayes Theorem; Creatinine; Critical Illness; Glutamine; Humans; Oxidative Stress; Urea	2022
Exploration of muscle loss and metabolic state during prolonged critical illness: Implications for intervention? PloS one, 2019, Volume: 14, Issue:11 Topics: Adult; Aged; C-Reactive Protein; Critical Illness; Cytidine; Female; Humans; Length of Stay; Male; M	2019
Myoglobin clearance with continuous veno-venous hemodialysis using high cutoff dialyzer versus continuous veno-venous hemodiafiltration using high-flux dialyzer: a prospective randomized controlled trial. Critical care (London, England), 2020, 11-11, Volume: 24, Issue:1 Topics: Aged; Creatinine; Critical Illness; Female; Humans; Kaplan-Meier Estimate; Male; Metabolic Clearance	2020
Evaluation of urea and creatinine change during continuous renal replacement therapy: effect of blood flow rate. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2018, Volume: 20, Issue:1 Topics: Acute Kidney Injury; Adult; Blood Flow Velocity; Creatinine; Critical Illness; Humans; Prospective S	2018
Association of protein intake with the outcomes of critically ill patients: a post hoc analysis of the PermiT trial. The American journal of clinical nutrition, 2018, 11-01, Volume: 108, Issue:5 Topics: Adult; Aged; Biomarkers; Critical Care; Critical Illness; Dietary Proteins; Energy Intake; Enteral N	2018
Urea reduction ratio may be a simpler approach for measurement of adequacy of intermittent hemodialysis in acute kidney injury. BMC nephrology, 2019, 03-06, Volume: 20, Issue:1 Topics: Acute Kidney Injury; Aged; Biomarkers; Critical Illness; Female; Humans; Male; Middle Aged; Renal Di	2019
Solute clearance in CRRT: prescribed dose versus actual delivered dose. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:3 Topics: Acute Kidney Injury; Blood Urea Nitrogen; Creatinine; Critical Illness; Female; Hemodiafiltration; H	2012
Bone turnover in prolonged critical illness: effect of vitamin D. The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:10 Topics: Acute Disease; Adult; Aged; Bone Resorption; C-Reactive Protein; Calcitriol; Calcium; Creatinine; Cr	2003
Urine colour as an index of hydration in critically ill patients. Anaesthesia, 1999, Volume: 54, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Central Venous Pressure; Critical Illness; Dehydration;	1999
Intermittent hemodiafiltration in acute renal failure in critically ill patients. Clinical nephrology, 2001, Volume: 56, Issue:4 Topics: Acute Kidney Injury; Adult; Aged; Calcium; Creatinine; Critical Illness; Female; Hemodiafiltration;	2001

Article	Year
Effect of intermittent or continuous feeding and amino acid concentration on urea-to-creatinine ratio in critical illness. JPEN. Journal of parenteral and enteral nutrition, 2022, Volume: 46, Issue:4 Topics: Amino Acids; Amino Acids, Essential; Creatinine; Critical Care; Critical Illness; Humans; Urea	2022
Of Snails, Earthworms, and Men: Insights into Strategies to Preserve Water. Function (Oxford, England), 2022, Volume: 3, Issue:1 Topics: Animals; Critical Illness; Humans; Iatrogenic Disease; Male; Oligochaeta; Urea; Water	2022
Heart rate control with landiolol hydrochloride in infants with ventricular dysfunction and pulmonary hypertension. ESC heart failure, 2023, Volume: 10, Issue:1 Topics: Child; Critical Illness; Female; Heart Rate; Humans; Hypertension, Pulmonary; Infant; Infant, Newbor	2023
Sustained Low Efficiency Dialysis in Critically Ill Children With Acute Kidney Injury: Single-Center Observational Cohort in a Resource-Limited Setting. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2023, 03-01, Volume: 24, Issue:3 Topics: Acute Kidney Injury; Child; Cohort Studies; Critical Illness; Humans; Hybrid Renal Replacement Thera	2023
Sustained Low Efficiency Dialysis in Critically Ill Children With Acute Kidney Injury: Single-Center Observational Cohort in a Resource-Limited Setting. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2023, 03-01, Volume: 24, Issue:3 Topics: Acute Kidney Injury; Child; Cohort Studies; Critical Illness; Humans; Hybrid Renal Replacement Thera	2023
Sustained Low Efficiency Dialysis in Critically Ill Children With Acute Kidney Injury: Single-Center Observational Cohort in a Resource-Limited Setting. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2023, 03-01, Volume: 24, Issue:3 Topics: Acute Kidney Injury; Child; Cohort Studies; Critical Illness; Humans; Hybrid Renal Replacement Thera	2023
Sustained Low Efficiency Dialysis in Critically Ill Children With Acute Kidney Injury: Single-Center Observational Cohort in a Resource-Limited Setting. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2023, 03-01, Volume: 24, Issue:3 Topics: Acute Kidney Injury; Child; Cohort Studies; Critical Illness; Humans; Hybrid Renal Replacement Thera	2023
Bioelectrical Impedance Measurements for Assessment of Kidney Function in Critically Ill Patients. Critical care medicine, 2019, Volume: 47, Issue:12 Topics: Aged; Creatinine; Critical Illness; Electric Impedance; Female; Humans; Kidney; Kidney Function Test	2019
The urea-creatinine ratio as a novel biomarker of critical illness-associated catabolism. Intensive care medicine, 2019, Volume: 45, Issue:12 Topics: Biomarkers; Creatinine; Critical Illness; Humans; Muscles; Urea	2019
The Link between Hypermetabolism and Hypernatremia in Severely Burned Patients. Nutrients, 2020, Mar-15, Volume: 12, Issue:3 Topics: Adult; Burns; Creatinine; Critical Illness; Diuresis; Electrolytes; Female; Humans; Hypernatremia; I	2020
Rate control in atrial fibrillation using Landiolol is safe in critically ill Covid-19 patients. Critical care (London, England), 2021, 01-22, Volume: 25, Issue:1 Topics: Aged; Atrial Fibrillation; COVID-19 Drug Treatment; Critical Illness; Female; Heart Rate; Hospitaliz	2021
Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection. Medicina intensiva, 2018, Volume: 42, Issue:7 Topics: Acute Kidney Injury; Adult; Bacterial Infections; Biomarkers; Calcitonin; Coinfection; Comorbidity;	2018
Prescription and Delivery of the Right Continuous Renal Replacement Therapies Dose. Contributions to nephrology, 2018, Volume: 194 Topics: Acute Kidney Injury; Critical Illness; Hemodialysis Solutions; Humans; Prescriptions; Renal Replacem	2018
URINARY MALONDIALDEHYDE AS A PREDICTIVE AND DIAGNOSTIC MARKER FOR NEONATAL ACUTE KIDNEY INJURY. Georgian medical news, 2018, Issue:278 Topics: Acute Kidney Injury; Biomarkers; Blood Urea Nitrogen; Case-Control Studies; Creatinine; Critical Ill	2018
Intracranial pressure during hemodialysis in patients with acute brain injury. Acta anaesthesiologica Scandinavica, 2019, Volume: 63, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Area Under Curve; Blood-Brain Barrier; Brain Edema; Brain In	2019
Assessment of dialysis dose in critically ill maintenance dialysis patients. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2014, Volume: 18, Issue:5 Topics: Aged; Aged, 80 and over; APACHE; Critical Illness; Dialysis Solutions; Female; Hospital Mortality; H	2014
Transient versus persistent acute kidney injury and the diagnostic performance of fractional excretion of urea in critically ill patients. Nephron. Clinical practice, 2014, Volume: 126, Issue:1 Topics: Acute Kidney Injury; Adult; Aged; Area Under Curve; Biomarkers; Critical Care; Critical Illness; Fem	2014
Contrast-induced nephropathy in aged critically ill patients. Oxidative medicine and cellular longevity, 2014, Volume: 2014 Topics: Adult; Aging; Contrast Media; Creatinine; Critical Illness; Dinoprost; Female; Humans; Kidney Diseas	2014
Daily urinary urea excretion to guide intermittent hemodialysis weaning in critically ill patients. Critical care (London, England), 2016, Feb-19, Volume: 20 Topics: Acute Kidney Injury; Aged; Biomarkers; Cohort Studies; Critical Care; Critical Illness; Female; Huma	2016
Urinary Strong Ion Difference as a Marker of Renal Dysfunction. A Retrospective Analysis. PloS one, 2016, Volume: 11, Issue:6 Topics: Acute Kidney Injury; Aged; Biomarkers; Calcium; Chlorides; Creatinine; Critical Illness; Female; Hum	2016
Development and validation of the new ICNARC model for prediction of acute hospital mortality in adult critical care. Journal of critical care, 2017, Volume: 38 Topics: Adult; Age Factors; Aged; Blood Glucose; Cardiopulmonary Resuscitation; Chronic Disease; Creatinine;	2017
[Measuring Kt by ionic dialysance is a useful tool for assessing dialysis dose in critical patients]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2010, Volume: 30, Issue:2 Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Algorithms; Automation; Critical Illness; Femal	2010
[The monitoring of dialysis dose by ionic dialysance-based Kt reveals less dialysis adequacy than the Kt/V(UREA)-based measurement in critically ill patients with acute renal failure]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2010, Volume: 30, Issue:2 Topics: Acute Kidney Injury; Aged; Algorithms; Automation; Critical Illness; Female; Hemodialysis Solutions;	2010
The sieving coefficient and clearance of vasopressin during continuous renal replacement therapy in critically ill children. Journal of critical care, 2010, Volume: 25, Issue:4 Topics: Adolescent; beta 2-Microglobulin; Child; Child, Preschool; Critical Care; Critical Illness; Hemodiaf	2010
Hyperammonemia in the pediatric emergency care setting. Pediatric emergency care, 2010, Volume: 26, Issue:12 Topics: Ammonia; Brain Damage, Chronic; Child; Child, Preschool; Consciousness Disorders; Critical Illness;	2010
A prospective evaluation of urine microscopy in septic and non-septic acute kidney injury. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:2 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Cohort Studies; Creatinine; Critical Illness; Disease	2012
Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study. Critical care (London, England), 2011, Jul-27, Volume: 15, Issue:4 Topics: Acute Kidney Injury; Aged; Biomarkers; Cohort Studies; Critical Illness; Diuretics; Female; Hemodyna	2011
Osmotic diuresis due to urea as the cause of hypernatraemia in critically ill patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:3 Topics: Critical Illness; Diuresis; Female; Humans; Hypernatremia; Intensive Care Units; Male; Middle Aged;	2012
Treatment of the syndrome of inappropriate secretion of antidiuretic hormone with urea in critically ill patients. American journal of nephrology, 2012, Volume: 35, Issue:3 Topics: Adult; Aged; Critical Illness; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Middl	2012
Toward the optimal dose metric in continuous renal replacement therapy. The International journal of artificial organs, 2012, Volume: 35, Issue:6 Topics: Acute Kidney Injury; Adult; Biomarkers; Blood Urea Nitrogen; Creatinine; Critical Illness; Dialysis	2012
Urine biochemistry in septic and non-septic acute kidney injury: a prospective observational study. Journal of critical care, 2013, Volume: 28, Issue:4 Topics: Acute Kidney Injury; Acute-Phase Proteins; Aged; APACHE; Area Under Curve; Biomarkers; Chi-Square Di	2013
Effects of dialysate flow configurations in continuous renal replacement therapy on solute removal: computational modeling. Blood purification, 2013, Volume: 35, Issue:1-3 Topics: Acute Kidney Injury; Computer Simulation; Convection; Critical Illness; Diffusion; Hemodialysis Solu	2013
Continuous is not continuous: the incidence and impact of circuit "down-time" on uraemic control during continuous veno-venous haemofiltration. Intensive care medicine, 2003, Volume: 29, Issue:4 Topics: Aged; Creatinine; Critical Illness; Female; Hemofiltration; Humans; Male; Middle Aged; Prospective S	2003
Simple and accurate quantification of dialysis in acute renal failure patients during either urea non-steady state or treatment with irregular or continuous schedules. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:6 Topics: Acute Kidney Injury; Critical Illness; Humans; Kinetics; Metabolic Clearance Rate; Renal Dialysis; U	2004
Comparison of urine urea nitrogen collection times in critically ill patients. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2005, Volume: 20, Issue:2 Topics: Adolescent; Adult; Aged; Critical Care; Critical Illness; Enteral Nutrition; Female; Humans; Intensi	2005
The contribution of blood chemistry to the electrical resistance of blood: an in vitro model. Acta physiologica Hungarica, 2005, Volume: 92, Issue:2 Topics: Adult; Aged; Bicarbonates; Blood Chemical Analysis; Blood Glucose; Blood Proteins; Cardiac Output; C	2005
Solute removal during continuous renal replacement therapy in critically ill patients: convection versus diffusion. Critical care (London, England), 2006, Volume: 10, Issue:2 Topics: Adult; Aged; Convection; Creatinine; Critical Illness; Cross-Over Studies; Diffusion; Female; Humans	2006
Utility of urea kinetic modelling for prescription of adequate intermittent dialysis in critically ill maintenance dialysis patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:7 Topics: Critical Illness; Humans; Kidney Failure, Chronic; Kinetics; Models, Biological; Prescriptions; Rena	2007
Prescription of an intermittent haemodialysis dose using urea kinetic modelling is feasible in the critically ill patient. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:3 Topics: Acute Kidney Injury; Body Water; Critical Illness; Humans; Kidney Failure, Chronic; Models, Biologic	2008
Dosing intermittent haemodialysis in the intensive care unit patient with acute renal failure--estimation of urea removal and evidence for the regional blood flow model. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:7 Topics: Acute Kidney Injury; Aged; Blood Urea Nitrogen; Cardiac Output; Critical Illness; Female; Humans; In	2008
High-risk surgical acute renal failure treated by continuous arteriovenous hemodiafiltration: metabolic control and outcome in sixty patients. Nephron, 1995, Volume: 70, Issue:2 Topics: Acidosis; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; APACHE; Creatinine; Criti	1995
Glucose and urea production and leucine, ketoisocaproate and alanine fluxes at supraphysiological plasma adrenaline concentrations in volunteers. Intensive care medicine, 1994, Volume: 20, Issue:2 Topics: Adult; Alanine; Amino Acids; Blood Glucose; C-Peptide; Caproates; Critical Illness; Epinephrine; Gas	1994
Acute renal failure in the critically ill: management by continuous veno-venous hemodiafiltration. Journal of critical care, 1993, Volume: 8, Issue:3 Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Cost of Illness; Creatinine; Critical Illness;	1993
A prospective comparative study of continuous arteriovenous hemodiafiltration and continuous venovenous hemodiafiltration in critically ill patients. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1993, Volume: 21, Issue:4 Topics: Chi-Square Distribution; Creatinine; Critical Care; Critical Illness; Female; Hemofiltration; Humans	1993
Creatinine and urea clearance during continuous veno-venous haemofiltration in critically ill patients. Anaesthesia, 1996, Volume: 51, Issue:6 Topics: Acute Kidney Injury; Adult; Aged; Creatinine; Critical Illness; Female; Hemofiltration; Humans; Male	1996
A prospective comparative study of moderate versus high protein intake for critically ill patients with acute renal failure. Renal failure, 1997, Volume: 19, Issue:1 Topics: Acute Kidney Injury; Amino Acids; Combined Modality Therapy; Critical Illness; Dietary Proteins; Dos	1997
Systemic and splanchnic metabolic response to exogenous human growth hormone. Surgery, 1998, Volume: 123, Issue:5 Topics: APACHE; C-Peptide; C-Reactive Protein; Critical Illness; Energy Intake; Hemodynamics; Human Growth H	1998
The influence of hepatic venous oxygen saturation on the liver's synthetic response to metabolic stress. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1999, Volume: 221, Issue:1 Topics: Albumins; Animals; Critical Illness; Glucose; Hepatic Veins; Humans; In Vitro Techniques; Liver; Liv	1999
Diffusive and convective solute clearances during continuous renal replacement therapy at various dialysate and ultrafiltration flow rates. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1999, Volume: 34, Issue:3 Topics: Acute Kidney Injury; Adult; Aged; beta 2-Microglobulin; Blood Flow Velocity; Creatinine; Critical Il	1999
Unrecognized renal damage in critically ill patients. Renal failure, 1999, Volume: 21, Issue:6 Topics: Acute Kidney Injury; Case-Control Studies; Creatine; Critical Illness; Humans; Kidney; Kidney Functi	1999
Urea kinetics during sustained low-efficiency dialysis in critically ill patients requiring renal replacement therapy. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 39, Issue:3 Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Blood Urea Nitrogen; Critical Illness; Female;	2002
Oral rehydration therapy: a Third World solution applied to intensive care. Intensive care medicine, 1992, Volume: 18, Issue:1 Topics: Aged; Creatinine; Critical Care; Critical Illness; Diarrhea; Electrolytes; Fluid Therapy; Humans; Ma	1992

urea and Critical Illness