Page last updated: 2024-10-21

urea and Compensatory Hyperinsulinemia

urea has been researched along with Compensatory Hyperinsulinemia in 12 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.

Research Excerpts

ExcerptRelevanceReference
" We hypothesized that this syndrome of hyperinsulinism and hyperammonemia was caused by excessive activity of glutamate dehydrogenase, which oxidizes glutamate to alpha-ketoglutarate and which is a potential regulator of insulin secretion in pancreatic beta cells and of ureagenesis in the liver."3.70Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. ( Burlina, AB; Greenberg, CR; Hopwood, NJ; Hsu, BY; Lieu, YK; Perlman, K; Poncz, M; Rich, BH; Stanley, CA; Zammarchi, E, 1998)
"Hypoglycemia in man induces a marked increase in hepatic amino- to urea-N clearance."3.70Hepatic amino- to urea-N clearance and forearm amino-N exchange during hypoglycemic and euglycemic hyperinsulinemia in normal man. ( Grøfte, T; Jørgensen, JO; Møller, N; Poulsen, PL; Vilstrup, H; Wolthers, T, 1999)
"It suggests that the HFS diet-induced hyperinsulinemia is responsible for the decrease in the circulating levels of urea, creatinine, and many amino acids, despite an increase in serum glucose levels."1.39Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats. ( de la Garza, AL; Etxeberria, U; Martínez, JA; Milagro, FI, 2013)
"In addition to the hyperinsulinemia previously reported to occur in nonhyperphagic VMH-lesioned rats, this study showed an increased glucagon secretion from perfused pancreases of these animals."1.26Nitrogen handling in adult hypothalamic obese rats. ( Hustvedt, BE; Jeanrenaud, B; Karakash, C; Rohner-Jeanrenaud, F, 1980)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19904 (33.33)18.7374
1990's4 (33.33)18.2507
2000's0 (0.00)29.6817
2010's3 (25.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Espinosa, A1
Ross, A1
Dovale-Rosabal, G1
Pino-de la Fuente, F1
Uribe-Oporto, E1
Sacristán, C1
Ruiz, P1
Valenzuela, R1
Romero, N1
Aubourg, SP1
Rodríguez, A1
Shim, CY1
Kim, S1
Chadderdon, S1
Wu, M1
Qi, Y1
Xie, A1
Alkayed, NJ1
Davidson, BP1
Lindner, JR1
Walker, V1
Etxeberria, U1
de la Garza, AL1
Martínez, JA1
Milagro, FI1
VOELKEL, A1
Karakash, C1
Rohner-Jeanrenaud, F1
Hustvedt, BE1
Jeanrenaud, B1
Ang, BC1
Halliday, D1
Powell-Tuck, J1
Hamberg, O1
Vilstrup, H2
Stanley, CA1
Lieu, YK1
Hsu, BY1
Burlina, AB1
Greenberg, CR1
Hopwood, NJ1
Perlman, K1
Rich, BH1
Zammarchi, E1
Poncz, M1
Grøfte, T1
Wolthers, T1
Jørgensen, JO1
Poulsen, PL1
Møller, N1
Tappy, L1
Owen, OE1
Boden, G1
Devlin, JT1
Horton, ES1

Reviews

1 review available for urea and Compensatory Hyperinsulinemia

ArticleYear
Ammonia metabolism and hyperammonemic disorders.
    Advances in clinical chemistry, 2014, Volume: 67

    Topics: Ammonia; Animals; Arginine; Biological Transport; Brain; Cell Membrane; Humans; Hyperammonemia; Hype

2014

Trials

2 trials available for urea and Compensatory Hyperinsulinemia

ArticleYear
Whole-body protein turnover in response to hyperinsulinemia in humans postabsorptively with [15N]glycine as tracer.
    The American journal of clinical nutrition, 1995, Volume: 61, Issue:5

    Topics: Adult; Ammonia; Blood Glucose; Carbon Isotopes; Cross-Over Studies; Female; Glucose Clamp Technique;

1995
Effects of insulin and glucose on urea synthesis in normal man, independent of pancreatic hormone secretion.
    Journal of hepatology, 1994, Volume: 21, Issue:3

    Topics: Adult; Alanine; Amino Acids; Blood Glucose; Female; Glucagon; Glucose; Humans; Hyperglycemia; Hyperi

1994

Other Studies

9 other studies available for urea and Compensatory Hyperinsulinemia

ArticleYear
EPA/DHA Concentrate by Urea Complexation Decreases Hyperinsulinemia and Increases Plin5 in the Liver of Mice Fed a High-Fat Diet.
    Molecules (Basel, Switzerland), 2020, Jul-20, Volume: 25, Issue:14

    Topics: Analysis of Variance; Animals; Body Weight; Diet, High-Fat; Docosahexaenoic Acids; Eicosapentaenoic

2020
Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume.
    American journal of physiology. Endocrinology and metabolism, 2014, Dec-15, Volume: 307, Issue:12

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Benzoates; Blood Volume; Epoxide Hydrolases; Hyperinsulinism;

2014
Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats.
    Journal of physiology and biochemistry, 2013, Volume: 69, Issue:3

    Topics: Amino Acids; Animals; Creatinine; Diet, High-Fat; Fatty Acids, Unsaturated; Hyperglycemia; Hyperinsu

2013
[First experience with an insulin-nadisan combination for hypoglycemia therapy in psychoses; preliminary report].
    Klinische Wochenschrift, 1956, Feb-15, Volume: 34, Issue:7-8

    Topics: Convulsive Therapy; Electroconvulsive Therapy; Humans; Hyperinsulinism; Hypoglycemia; Insulin; Psych

1956
Nitrogen handling in adult hypothalamic obese rats.
    The American journal of physiology, 1980, Volume: 238, Issue:1

    Topics: Amino Acids; Animals; Female; Glucagon; Hyperinsulinism; Hypothalamus; Hypothalamus, Middle; Lipid M

1980
Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene.
    The New England journal of medicine, 1998, May-07, Volume: 338, Issue:19

    Topics: Ammonia; Child; Child, Preschool; DNA Mutational Analysis; Female; Glutamate Dehydrogenase; Humans;

1998
Hepatic amino- to urea-N clearance and forearm amino-N exchange during hypoglycemic and euglycemic hyperinsulinemia in normal man.
    Journal of hepatology, 1999, Volume: 30, Issue:5

    Topics: Adult; Alanine; Amino Acids; Blood Glucose; Forearm; Glucagon; Glucose Clamp Technique; Humans; Hype

1999
Effect of hyperinsulinemia on urea pool size and substrate oxidation rates.
    Diabetes, 1988, Volume: 37, Issue:9

    Topics: Adult; Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Humans; Hyperinsulinism; Insulin; Kinetic

1988
Effects of prior high-intensity exercise on glucose metabolism in normal and insulin-resistant men.
    Diabetes, 1985, Volume: 34, Issue:10

    Topics: Adult; Blood Glucose; C-Peptide; Glucose; Glucose Tolerance Test; Glycogen; Glycogen Synthase; Human

1985