urea has been researched along with Colorectal Cancer in 21 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dysregulation of the urea cycle (UC) has been detected in colorectal cancer (CRC)." | 8.84 | Association between serum urea concentrations and the risk of colorectal cancer, particularly in individuals with type 2 diabetes: A cohort study. ( Chen, X; Gao, P; Jiang, Y; Liu, Z; Mei, Z; Suo, C; Xu, K; Yuan, H; Zhang, T; Zhao, R; Zhu, D, 2024) |
| "Urea cycle activity in colorectal cancer is associated with the absence of ureolytic gut bacteria." | 8.31 | Microbiome Imbalance Promotes Colorectal Cancer via Urea Cycle Activation. ( , 2023) |
| "Here, we show that colorectal cancers (CRCs) display negligible expression of OTC and, in subset of cases, ASS1 proteins." | 5.48 | Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes. ( Al-Aqbi, SS; Alexandrou, C; Andreadi, C; Blades, M; Boyle, W; Brown, K; Cheng, PN; Higgins, JA; Howells, LM; Karmokar, A; Luo, JL; Moore, DA; Murray, GI; Rufini, A; Thomas, A; Viskaduraki, M, 2018) |
| "Irinotecan (Campto, Rhône-Poulenc Rorer) is probably the most studied drug used as second-line treatment for colorectal cancer." | 5.09 | Colorectal cancer: dilemmas regarding patient selection and toxicity prediction. ( Jelic, S; Nikolic-Tomasevic, Z; Popov, I; Radosavljevic, D, 2000) |
| "Dysregulation of the urea cycle (UC) has been detected in colorectal cancer (CRC)." | 4.84 | Association between serum urea concentrations and the risk of colorectal cancer, particularly in individuals with type 2 diabetes: A cohort study. ( Chen, X; Gao, P; Jiang, Y; Liu, Z; Mei, Z; Suo, C; Xu, K; Yuan, H; Zhang, T; Zhao, R; Zhu, D, 2024) |
| "Urea cycle activity in colorectal cancer is associated with the absence of ureolytic gut bacteria." | 4.31 | Microbiome Imbalance Promotes Colorectal Cancer via Urea Cycle Activation. ( , 2023) |
| "Finally, several agents may prevent colorectal cancer through prevention of the formation of colorectal polyps (eg, cyclooxygenase inhibitors)." | 2.40 | Promising new agents for treatment of patients with colorectal cancer. ( Von Hoff, DD, 1998) |
| "Here, we show that colorectal cancers (CRCs) display negligible expression of OTC and, in subset of cases, ASS1 proteins." | 1.48 | Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes. ( Al-Aqbi, SS; Alexandrou, C; Andreadi, C; Blades, M; Boyle, W; Brown, K; Cheng, PN; Higgins, JA; Howells, LM; Karmokar, A; Luo, JL; Moore, DA; Murray, GI; Rufini, A; Thomas, A; Viskaduraki, M, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 9 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, Q | 1 |
| Pan, X | 1 |
| Wang, D | 1 |
| Rong, Q | 1 |
| Ma, B | 1 |
| Xie, X | 2 |
| Zhang, Y | 3 |
| Wang, J | 1 |
| Hu, L | 2 |
| Wu, CF | 1 |
| Wang, QC | 1 |
| Chen, R | 1 |
| Zhou, HL | 1 |
| Wu, TT | 1 |
| Du, Y | 1 |
| Zhang, NN | 1 |
| Zhang, HM | 1 |
| Fan, ZY | 1 |
| Wang, LL | 1 |
| Hu, CJ | 1 |
| Sang, ZP | 1 |
| Li, HL | 1 |
| Wang, L | 1 |
| Tang, L | 1 |
| Zhang, JQ | 1 |
| Meng, X | 1 |
| Peng, J | 1 |
| Yu, F | 1 |
| Wang, W | 1 |
| Pan, Q | 1 |
| Jin, H | 1 |
| Huang, X | 1 |
| Yu, H | 1 |
| Li, S | 1 |
| Feng, D | 1 |
| Liu, Q | 1 |
| Fang, L | 1 |
| Lee, MH | 1 |
| Brezmes, J | 1 |
| Llambrich, M | 1 |
| Cumeras, R | 1 |
| Gumà, J | 1 |
| Gao, P | 1 |
| Mei, Z | 1 |
| Liu, Z | 1 |
| Zhu, D | 1 |
| Yuan, H | 1 |
| Zhao, R | 1 |
| Xu, K | 1 |
| Zhang, T | 2 |
| Jiang, Y | 1 |
| Suo, C | 1 |
| Chen, X | 1 |
| Torrente, L | 1 |
| Maan, G | 1 |
| Oumkaltoum Rezig, A | 1 |
| Quinn, J | 1 |
| Jackson, A | 1 |
| Grilli, A | 1 |
| Casares, L | 1 |
| Kulesskiy, E | 1 |
| Saarela, J | 1 |
| Bicciato, S | 1 |
| Edwards, J | 1 |
| Dinkova-Kostova, AT | 1 |
| de la Vega, L | 1 |
| Tang, JF | 1 |
| Xu, H | 1 |
| Tian, K | 1 |
| Wu, MN | 1 |
| Huang, SY | 1 |
| Du, YM | 1 |
| Zhou, P | 1 |
| Lu, RJ | 1 |
| He, S | 1 |
| Xu, JM | 1 |
| Si, JJ | 1 |
| Li, J | 1 |
| Chen, DL | 1 |
| Ran, JH | 1 |
| Long, Y | 1 |
| Sanchez-Espiridion, B | 1 |
| Lin, M | 1 |
| White, L | 1 |
| Mishra, L | 1 |
| Raju, GS | 1 |
| Kopetz, S | 1 |
| Eng, C | 1 |
| Hildebrandt, MAT | 1 |
| Chang, DW | 1 |
| Ye, Y | 1 |
| Liang, D | 1 |
| Wu, X | 1 |
| Alexandrou, C | 1 |
| Al-Aqbi, SS | 1 |
| Higgins, JA | 1 |
| Boyle, W | 1 |
| Karmokar, A | 1 |
| Andreadi, C | 1 |
| Luo, JL | 1 |
| Moore, DA | 1 |
| Viskaduraki, M | 1 |
| Blades, M | 1 |
| Murray, GI | 1 |
| Howells, LM | 1 |
| Thomas, A | 1 |
| Brown, K | 1 |
| Cheng, PN | 1 |
| Rufini, A | 1 |
| Li, L | 1 |
| Chen, Q | 1 |
| Yu, Y | 1 |
| Chen, H | 1 |
| Lu, M | 1 |
| Huang, Y | 1 |
| Li, P | 1 |
| Chang, H | 1 |
| Tan, B | 1 |
| Qiu, Y | 2 |
| Zou, X | 1 |
| Chen, T | 2 |
| Xie, G | 1 |
| Cheng, Y | 1 |
| Dong, T | 1 |
| Zhao, L | 1 |
| Feng, B | 1 |
| Hu, X | 1 |
| Xu, LX | 2 |
| Zhao, A | 2 |
| Zhang, M | 1 |
| Cai, G | 2 |
| Cai, S | 2 |
| Zhou, Z | 1 |
| Zheng, M | 1 |
| Jia, W | 2 |
| Zhang, B | 1 |
| Dong, S | 1 |
| Zhu, R | 1 |
| Hu, C | 1 |
| Hou, J | 1 |
| Li, Y | 1 |
| Zhao, Q | 1 |
| Shao, X | 1 |
| Bu, Q | 1 |
| Li, H | 1 |
| Wu, Y | 1 |
| Cen, X | 1 |
| Zhao, Y | 1 |
| Su, M | 1 |
| Zheng, X | 1 |
| Xu, Y | 1 |
| Ni, Y | 1 |
| Farooq, N | 1 |
| Patterson, AJ | 1 |
| Walsh, SR | 1 |
| Prytherch, DR | 1 |
| Justin, TA | 1 |
| Tang, TY | 1 |
| Lauwaet, T | 1 |
| Oliveira, MJ | 1 |
| Callewaert, B | 1 |
| De Bruyne, G | 1 |
| Saelens, X | 1 |
| Ankri, S | 1 |
| Vandenabeele, P | 1 |
| Mirelman, D | 1 |
| Mareel, M | 1 |
| Leroy, A | 1 |
| Chen, YL | 1 |
| Jong, YJ | 1 |
| Ferrance, J | 1 |
| Hsien, JS | 1 |
| Shih, CJ | 1 |
| Feng, CH | 1 |
| Wu, MT | 1 |
| Wu, SM | 1 |
| Deehan, DJ | 1 |
| Heys, SD | 1 |
| Broom, J | 1 |
| Eremin, O | 1 |
| Whiting, PH | 1 |
| Von Hoff, DD | 1 |
| Nikolic-Tomasevic, Z | 1 |
| Jelic, S | 1 |
| Popov, I | 1 |
| Radosavljevic, D | 1 |
| del Ara, RM | 1 |
| González-Polo, RA | 1 |
| Caro, A | 1 |
| del Amo, E | 1 |
| Palomo, L | 1 |
| Hernández, E | 1 |
| Soler, G | 1 |
| Fuentes, JM | 1 |
2 reviews available for urea and Colorectal Cancer
| Article | Year |
|---|---|
Urine NMR Metabolomics for Precision Oncology in Colorectal Cancer.
Topics: Acetates; Acetone; Biomarkers; Carnitine; Colorectal Neoplasms; Creatinine; Glucose; Humans; Lysine; | 2022 |
Promising new agents for treatment of patients with colorectal cancer.
Topics: Adenoviridae; Antineoplastic Agents; Benzofurans; Colorectal Neoplasms; Drug Screening Assays, Antit | 1998 |
2 trials available for urea and Colorectal Cancer
| Article | Year |
|---|---|
Renal impairment associated with the pre-operative administration of recombinant interleukin-2.
Topics: Acetylglucosaminidase; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Creatinine; Female; gam | 1994 |
Colorectal cancer: dilemmas regarding patient selection and toxicity prediction.
Topics: Adult; Antineoplastic Agents, Phytogenic; Blood Proteins; Camptothecin; Colorectal Neoplasms; Creati | 2000 |
17 other studies available for urea and Colorectal Cancer
| Article | Year |
|---|---|
Discovery of (
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Line, Tumor; Chemotaxis; Colorectal Neopl | 2021 |
Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasm | 2022 |
Roles of lncRNA LVBU in regulating urea cycle/polyamine synthesis axis to promote colorectal carcinoma progression.
Topics: Animals; Colorectal Neoplasms; Humans; MicroRNAs; Polyamines; RNA, Long Noncoding; Tumor Suppressor | 2022 |
Microbiome Imbalance Promotes Colorectal Cancer via Urea Cycle Activation.
Topics: Bacteria; Colorectal Neoplasms; Humans; Microbiota; Urea | 2023 |
Association between serum urea concentrations and the risk of colorectal cancer, particularly in individuals with type 2 diabetes: A cohort study.
Topics: Cohort Studies; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Humans; Risk Factors; Urea | 2024 |
High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro.
Topics: Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Drug Eval | 2020 |
Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines.
Topics: Animals; Biomarkers; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colorectal Neopla | 2021 |
Global and targeted serum metabolic profiling of colorectal cancer progression.
Topics: Adenoma; Adult; Aged; Caffeine; Case-Control Studies; Chromatography, Liquid; Colonic Polyps; Colore | 2017 |
Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes.
Topics: Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Arginase; Arginine; Argininosuccinate | 2018 |
RKI-1447 suppresses colorectal carcinoma cell growth via disrupting cellular bioenergetics and mitochondrial dynamics.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasm | 2020 |
Metabonomics identifies serum metabolite markers of colorectal cancer.
Topics: Adult; Aged; Biomarkers, Tumor; Carcinoembryonic Antigen; Case-Control Studies; Citric Acid Cycle; C | 2013 |
Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3.
Topics: Animals; Arginine; Cell Proliferation; Colorectal Neoplasms; Female; Gene Knockdown Techniques; HCT1 | 2015 |
Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS.
Topics: Adult; Aged; Amino Acids; Colorectal Neoplasms; Female; Gas Chromatography-Mass Spectrometry; Humans | 2009 |
Predicting outcome following colorectal cancer surgery using a colorectal biochemical and haematological outcome model (Colorectal BHOM).
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Forecasting; Humans; Logi | 2011 |
Proteolysis of enteric cell villin by Entamoeba histolytica cysteine proteinases.
Topics: Animals; Carrier Proteins; Cell Adhesion; Coculture Techniques; Colorectal Neoplasms; Cysteine Endop | 2003 |
Single nucleotide polymorphism detection in the hMSH2 gene using conformation-sensitive CE.
Topics: Base Sequence; Case-Control Studies; Colorectal Neoplasms; DNA Primers; DNA, Neoplasm; Electrophores | 2008 |
Diagnostic performance of arginase activity in colorectal cancer.
Topics: Arginase; Biological Assay; Biomarkers, Tumor; Biopsy; Carcinoma; Colorectal Neoplasms; Enzyme Stabi | 2002 |