urea has been researched along with Cocaine-Related Disorders in 10 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent evidence suggests that blockade of the hypocretin receptor 1 may act as a useful pharmacotherapy for cocaine abuse." | 3.81 | Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep. ( Bernstein, DL; Brodnik, ZD; España, RA; Prince, CD, 2015) |
| "Based on the known sex differences in cocaine addiction, in the current study we examined orexin-mediated cocaine seeking during self-administration, extinction, and reinstatement in age-matched male (initial weight 250-300 g) and female (initial weight 175-225 g) Sprague-Dawley rats by using the orexin-1 receptor (OX1R) antagonist 1-(2-methylbenzoxazol-6-yl)-3-[1,5]naphthyridin-4-yl urea (SB-334867) (10-30 mg/kg)." | 1.38 | Orexin-1 receptor mediation of cocaine seeking in male and female rats. ( Cameron, MD; Chan, C; Ghee, SM; Kenny, PJ; Lin, L; See, RE; Zhou, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amato, RJ | 1 |
| Felts, AS | 1 |
| Rodriguez, AL | 1 |
| Venable, DF | 1 |
| Morrison, RD | 1 |
| Byers, FW | 1 |
| Daniels, JS | 1 |
| Niswender, CM | 1 |
| Conn, PJ | 1 |
| Lindsley, CW | 1 |
| Jones, CK | 1 |
| Emmitte, KA | 1 |
| Martin-Fardon, R | 2 |
| Weiss, F | 1 |
| Bentzley, BS | 1 |
| Aston-Jones, G | 3 |
| Brodnik, ZD | 1 |
| Bernstein, DL | 1 |
| Prince, CD | 1 |
| España, RA | 1 |
| Smith, RJ | 2 |
| Tahsili-Fahadan, P | 1 |
| See, RE | 2 |
| Borgland, SL | 1 |
| Chang, SJ | 1 |
| Bowers, MS | 1 |
| Thompson, JL | 1 |
| Vittoz, N | 1 |
| Floresco, SB | 1 |
| Chou, J | 1 |
| Chen, BT | 1 |
| Bonci, A | 1 |
| James, MH | 1 |
| Charnley, JL | 1 |
| Levi, EM | 1 |
| Jones, E | 1 |
| Yeoh, JW | 1 |
| Smith, DW | 1 |
| Dayas, CV | 1 |
| Zhou, L | 1 |
| Ghee, SM | 1 |
| Chan, C | 1 |
| Lin, L | 1 |
| Cameron, MD | 1 |
| Kenny, PJ | 2 |
| Boutrel, B | 1 |
| Specio, SE | 1 |
| Markou, A | 1 |
| Koob, GF | 1 |
| de Lecea, L | 1 |
10 other studies available for urea and Cocaine-Related Disorders
| Article | Year |
|---|---|
Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.
Topics: Allosteric Regulation; Aminopyridines; Animals; Brain; Cocaine-Related Disorders; Disease Models, An | 2013 |
Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking: comparison with natural reward seeking.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Benzoxazoles; Cocaine; Cocaine-Related Disorders; | 2014 |
Orexin-1 receptor signaling increases motivation for cocaine-associated cues.
Topics: Animals; Benzoxazoles; Cocaine-Related Disorders; Cues; Male; Motivation; Naphthyridines; Orexin Rec | 2015 |
Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep.
Topics: Animals; Appetitive Behavior; Benzoxazoles; Brain; Cocaine; Cocaine-Related Disorders; Disease Model | 2015 |
Orexin/hypocretin is necessary for context-driven cocaine-seeking.
Topics: Analysis of Variance; Animals; Benzoxazoles; Cocaine; Cocaine-Related Disorders; Conditioning, Opera | 2010 |
Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking.
Topics: Animals; Behavior, Addictive; Benzoxazoles; Brain; Cocaine; Cocaine-Related Disorders; Cues; Dopamin | 2009 |
Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers.
Topics: Animals; Benzoxazoles; Choice Behavior; Cocaine-Related Disorders; Dietary Fats; Intracellular Signa | 2009 |
Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking.
Topics: Animals; Benzoxazoles; Cocaine; Cocaine-Related Disorders; Cues; Dopamine Uptake Inhibitors; Extinct | 2011 |
Orexin-1 receptor mediation of cocaine seeking in male and female rats.
Topics: Animals; Benzoxazoles; Cocaine-Related Disorders; Cues; Extinction, Psychological; Female; Male; Mot | 2012 |
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
Topics: Analysis of Variance; Animals; Behavior, Addictive; Benzoxazoles; Brain; Cocaine; Cocaine-Related Di | 2005 |