urea has been researched along with Cancer of Pancreas in 35 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Whether perioperative change of urea to creatinine ratio (CUCR) can reflect muscle wasting and predict postoperative complications have not been investigated." | 8.02 | Change in urea to creatinine ratio is associated with postoperative complications and skeletal muscle wasting in pancreatic cancer patients following pancreatoduodenectomy. ( Duan, K; Feng, B; Gao, X; Gong, M; Wei, L; Zhou, J; Zhu, D, 2021) |
| " Whether perioperative change of urea to creatinine ratio (CUCR) can reflect muscle wasting and predict postoperative complications have not been investigated." | 4.02 | Change in urea to creatinine ratio is associated with postoperative complications and skeletal muscle wasting in pancreatic cancer patients following pancreatoduodenectomy. ( Duan, K; Feng, B; Gao, X; Gong, M; Wei, L; Zhou, J; Zhu, D, 2021) |
| " The enzyme has been demonstrated histochemically in a carcinoma of the pancreas and also in an islet cell tumour and the tumour enzyme has been shown to be unique, not only electrophoretically, but in being remarkably heat sensitive and in being activated by low molarities of urea." | 3.65 | Pancreatic alkaline phosphatase and a tumour variant. ( Hine, P; Kay, G; Timperley, WR; Warnes, TW, 1972) |
| " Pharmacokinetic analysis revealed that oral dosing of t-CUPM resulted in higher blood levels than that of sorafenib throughout the complete time course (48 h)." | 1.43 | Inhibition of mutant KrasG12D-initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM. ( Hammock, BD; Hwang, SH; Li, H; Liao, J; Liu, JY; Wecksler, AT; Yang, GY; Yang, J; Yang, Y, 2016) |
| "Pancreatic cancer is obstinate and resistant to gemcitabine, a standard chemotherapeutic agent for the disease." | 1.38 | Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine. ( Ishigaki, Y; Kawakami, K; Kitano, A; Minamoto, T; Motoo, Y; Nakajima, H; Nakamura, Y; Nakaya, N; Sato, I; Shimasaki, T; Takata, T; Takegami, T; Tanaka, T; Tomosugi, N; Zhao, X, 2012) |
| " To maximize the likelihood of their clinical success, it is essential to optimize drug scheduling as well as pharmacodynamic biomarkers in preclinical models." | 1.37 | Assessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition. ( Arumugarajah, S; Brown, JL; Gross, M; Hassan, MC; Hylander-Gans, L; Lawrence, TS; Maybaum, J; Morgan, MA; Morosini, D; Parsels, JD; Parsels, LA; Qian, Y; Simeone, DM; Tanska, DM; Zabludoff, SD; Zhao, L, 2011) |
| "Herein, we show that pancreatic cancer cells contain a pool of active GSK-3beta and that pharmacologic inhibition of GSK-3 kinase activity using small molecule inhibitors or genetic depletion of GSK-3beta by RNA interference leads to decreased cancer cell proliferation and survival." | 1.33 | Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. ( Billadeau, DD; Fernandez-Zapico, ME; Ougolkov, AV; Savoy, DN; Urrutia, RA, 2005) |
| "A woman with exocrine pancreatic cancer presented a syndrome of humoral hypercalcemia of malignancy (HHM)." | 1.27 | Enhancement of cyclic adenosine monophosphate content in bone cells by the factor extracted from a pancreatic cancer associated with hypercalcemia. ( Akatsu, T; Fuse, Y; Kinoshita, T; Kosano, H; Kugai, N; Maemura, M; Nagata, N; Shimauchi, T; Takatani, O; Tsuda, H, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (48.57) | 18.7374 |
| 1990's | 1 (2.86) | 18.2507 |
| 2000's | 5 (14.29) | 29.6817 |
| 2010's | 8 (22.86) | 24.3611 |
| 2020's | 4 (11.43) | 2.80 |
| Authors | Studies |
|---|---|
| Duan, K | 1 |
| Gong, M | 1 |
| Gao, X | 1 |
| Wei, L | 1 |
| Feng, B | 1 |
| Zhou, J | 1 |
| Zhu, D | 1 |
| Belvedere, R | 1 |
| Morretta, E | 1 |
| Novizio, N | 1 |
| Morello, S | 1 |
| Bruno, O | 1 |
| Brullo, C | 1 |
| Petrella, A | 1 |
| Lu, Y | 1 |
| Li, C | 1 |
| Sagar, S | 1 |
| Singh, S | 1 |
| Mallareddy, JR | 1 |
| Sonawane, YA | 1 |
| Napoleon, JV | 1 |
| Rana, S | 1 |
| Contreras, JI | 1 |
| Rajesh, C | 1 |
| Ezell, EL | 1 |
| Kizhake, S | 1 |
| Garrison, JC | 1 |
| Radhakrishnan, P | 1 |
| Natarajan, A | 1 |
| Kunnimalaiyaan, S | 1 |
| Gamblin, TC | 1 |
| Kunnimalaiyaan, M | 1 |
| Liao, J | 1 |
| Hwang, SH | 1 |
| Li, H | 1 |
| Yang, Y | 1 |
| Yang, J | 1 |
| Wecksler, AT | 1 |
| Liu, JY | 1 |
| Hammock, BD | 1 |
| Yang, GY | 1 |
| Parsels, LA | 4 |
| Tanska, DM | 2 |
| Parsels, JD | 4 |
| Zabludoff, SD | 3 |
| Cuneo, KC | 1 |
| Lawrence, TS | 4 |
| Maybaum, J | 4 |
| Morgan, MA | 4 |
| Holst, JJ | 1 |
| Wewer Albrechtsen, NJ | 1 |
| Pedersen, J | 1 |
| Knop, FK | 1 |
| Wilson, W | 1 |
| Baldwin, AS | 1 |
| Zhao, L | 3 |
| Davis, MA | 1 |
| Hassan, MC | 2 |
| Arumugarajah, S | 2 |
| Hylander-Gans, L | 2 |
| Morosini, D | 2 |
| Simeone, DM | 2 |
| Canman, CE | 1 |
| Normolle, DP | 1 |
| Qian, Y | 1 |
| Gross, M | 1 |
| Brown, JL | 2 |
| Shimasaki, T | 1 |
| Ishigaki, Y | 1 |
| Nakamura, Y | 1 |
| Takata, T | 1 |
| Nakaya, N | 1 |
| Nakajima, H | 1 |
| Sato, I | 1 |
| Zhao, X | 1 |
| Kitano, A | 1 |
| Kawakami, K | 1 |
| Tanaka, T | 1 |
| Takegami, T | 1 |
| Tomosugi, N | 1 |
| Minamoto, T | 1 |
| Motoo, Y | 1 |
| Vance, S | 1 |
| Liu, E | 1 |
| TICKTIN, HE | 1 |
| TRUJILLO, NP | 1 |
| EVANS, PF | 1 |
| ROE, JH | 1 |
| Sakai, H | 1 |
| Igarashi, K | 1 |
| Imai, M | 1 |
| Miura, K | 1 |
| Kanai, M | 1 |
| Okazaki, A | 1 |
| Ougolkov, AV | 2 |
| Fernandez-Zapico, ME | 2 |
| Savoy, DN | 1 |
| Urrutia, RA | 1 |
| Billadeau, DD | 2 |
| Bilim, VN | 1 |
| Smyrk, TC | 1 |
| Chari, ST | 1 |
| Ong, SL | 1 |
| Garcea, G | 1 |
| Thomasset, SC | 1 |
| Mann, CD | 1 |
| Neal, CP | 1 |
| Abu Amara, M | 1 |
| Dennison, AR | 1 |
| Berry, DP | 1 |
| Dimitrov, D | 1 |
| Viiachki, I | 1 |
| Lambreva, L | 1 |
| Krŭstev, M | 1 |
| Gerber, AC | 1 |
| Kozdrowski, I | 1 |
| Wyss, SR | 1 |
| Berger, EG | 1 |
| Beischer, W | 1 |
| Melani, F | 1 |
| Keller, L | 1 |
| Pfeiffer, EF | 1 |
| Almdal, TP | 1 |
| Heindorff, H | 1 |
| Bardram, L | 1 |
| Vilstrup, H | 1 |
| Malaisse, WJ | 1 |
| Blachier, F | 1 |
| Mourtada, A | 1 |
| Camara, J | 1 |
| Albor, A | 1 |
| Valverde, I | 1 |
| Sener, A | 1 |
| Nagata, N | 1 |
| Kugai, N | 1 |
| Maemura, M | 1 |
| Akatsu, T | 1 |
| Shimauchi, T | 1 |
| Kinoshita, T | 1 |
| Kosano, H | 1 |
| Takatani, O | 1 |
| Tsuda, H | 1 |
| Fuse, Y | 1 |
| Druckrey, H | 1 |
| Ivankovic, S | 1 |
| Bücheler, J | 1 |
| Preussmann, R | 1 |
| Thomas, C | 1 |
| Reitemeier, RJ | 2 |
| Moertel, CG | 2 |
| Hahn, RG | 2 |
| Kofstad, J | 1 |
| Froyshov, I | 1 |
| Gjone, E | 1 |
| Blix, S | 1 |
| Vogel, TT | 1 |
| Sadoff, L | 1 |
| Rudas, B | 1 |
| Warnes, TW | 1 |
| Timperley, WR | 1 |
| Hine, P | 1 |
| Kay, G | 1 |
| Schutt, AJ | 1 |
| Thomas, JP | 1 |
| Shields, R | 1 |
| Boeckl, O | 1 |
1 review available for urea and Cancer of Pancreas
| Article | Year |
|---|---|
[Streptozotocin].
Topics: Adenoma, Islet Cell; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Diabetes Mellitus; | 1972 |
1 trial available for urea and Cancer of Pancreas
| Article | Year |
|---|---|
Nephrotoxicity of streptozotocin (NSC-85998).
Topics: Adenoma, Islet Cell; Antibiotics, Antineoplastic; Carcinoma, Bronchogenic; Clinical Trials as Topic; | 1970 |
33 other studies available for urea and Cancer of Pancreas
| Article | Year |
|---|---|
Change in urea to creatinine ratio is associated with postoperative complications and skeletal muscle wasting in pancreatic cancer patients following pancreatoduodenectomy.
Topics: Creatinine; Humans; Muscle, Skeletal; Pancreatic Neoplasms; Pancreaticoduodenectomy; Postoperative C | 2021 |
The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs.
Topics: Annexin A1; Calcium; Cell Line, Tumor; Cell Membrane; Cell Movement; Down-Regulation; Extracellular | 2021 |
Incidental Findings of Coexisting Metastatic Pancreatic Cancer in Patients With Prostate Cancer on 18 F-Prostate-Specific Membrane Antigen PET/CT.
Topics: Aged; Gallium Radioisotopes; Humans; Incidental Findings; Lysine; Male; Pancreatic Neoplasms; Positr | 2022 |
Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Dr | 2021 |
Glycogen synthase kinase-3 inhibitor AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Glycogen Synthase | 2015 |
Inhibition of mutant KrasG12D-initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzoates; Carcinoma, Pancreatic Ductal; Cell | 2016 |
Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry.
Topics: Antimetabolites, Antineoplastic; Cell Cycle Checkpoints; Cell Line, Tumor; Checkpoint Kinase 1; Cycl | 2016 |
Glucagon and Amino Acids Are Linked in a Mutual Feedback Cycle: The Liver-α-Cell Axis.
Topics: Amino Acids; Animals; Feedback; Glucagon; Glucagon-Secreting Cells; Glucagonoma; Glucose; Humans; Li | 2017 |
Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer.
Topics: Cell Proliferation; Cell Survival; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase | 2008 |
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.
Topics: Adenocarcinoma; Animals; Blotting, Western; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase | 2010 |
Assessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition.
Topics: Animals; Biomarkers; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 1; Deoxycytidine; DNA Damage | 2011 |
Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Deoxyc | 2012 |
Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.
Topics: Analysis of Variance; Cell Cycle Checkpoints; Checkpoint Kinase 1; DNA Repair; Drug Combinations; Fl | 2011 |
DIAGNOSTIC VALUE OF A NEW SERUM LIPASE METHOD.
Topics: Amylases; Blood; Clinical Enzyme Tests; Diagnosis; Humans; Kidney Diseases; Lipase; Liver Diseases; | 1965 |
[Perioperative heart rate control with landiolol for a patient with rapid atrial fibrillation complicated with low cardiac function].
Topics: Anesthesia, Epidural; Anesthesia, General; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardi | 2004 |
Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells.
Topics: Apoptosis; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neopl | 2005 |
Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Proli | 2006 |
Surrogate markers of resectability in patients undergoing exploration of potentially resectable pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Biopsy; CA-19-9 Antigen; Decision | 2008 |
[Changes in the laboratory indices of patients with cancer of the head of the pancreas before and after surgery].
Topics: Adult; Aged; Blood Proteins; Creatinine; Electrolytes; Erythrocytes; Female; Humans; Male; Middle Ag | 1982 |
The charge heterogeneity of soluble human galactosyltransferases isolated from milk, amniotic fluid and malignant ascites.
Topics: Amino Acids; Amniotic Fluid; Ascites; Female; Galactosyltransferases; Humans; Hydrogen-Ion Concentra | 1979 |
Chromatographic heterogeneity of insulin extracted from insulomas.
Topics: Adenoma, Islet Cell; Chromatography, Gel; Humans; Hydrogen-Ion Concentration; Insulin; Molecular Wei | 1975 |
Increased amino acid clearance and urea synthesis in a patient with glucagonoma.
Topics: Adenoma, Islet Cell; Amino Acids; Female; Glucagonoma; Humans; Middle Aged; Pancreatic Neoplasms; Ur | 1990 |
Stimulus-secretion coupling of arginine-induced insulin release: metabolism of L-arginine and L-ornithine in tumoral islet cells.
Topics: Adenoma, Islet Cell; Animals; Arginase; Arginine; Biogenic Amines; Insulin; Insulin Secretion; Islet | 1989 |
Enhancement of cyclic adenosine monophosphate content in bone cells by the factor extracted from a pancreatic cancer associated with hypercalcemia.
Topics: Animals; Bone and Bones; Calcitonin; Cells, Cultured; Chromatography, Gel; Cyclic AMP; Ethanol; Fema | 1986 |
[Production of stomach and pancreatic cancer in the guinea pig using methylnitroso-urea and methylnitroso-urethane].
Topics: Animals; Body Weight; Carcinoma; Ear Neoplasms; Guinea Pigs; Laryngeal Neoplasms; Leukemia; Lung Neo | 1968 |
Combination chemotherapy in gastrointestinal cancer.
Topics: Adenocarcinoma; Adult; Alopecia; Appendiceal Neoplasms; Diarrhea; Drug Eruptions; Fluorouracil; Gall | 1970 |
A case of pyrexia of undetermined origin demonstrated at the Royal College of Physicians of London.
Topics: Aged; Anemia; Arthroplasty; Back Pain; Blood Pressure; Blood Sedimentation; Complement Fixation Test | 1974 |
Pancreatic tumor with intractable watery diarrhea, hypokalemia and hypercalcemia electrolyte balance studies.
Topics: Adenoma, Islet Cell; Alkaline Phosphatase; Bicarbonates; Calcium; Creatinine; Diarrhea; Humans; Hype | 1967 |
Notes on streptozotocin in metastatic insulinoma.
Topics: Adenoma, Islet Cell; Adult; Antibiotics, Antineoplastic; Autopsy; Blood Glucose; Bone Marrow; Brain; | 1971 |
Pancreatic alkaline phosphatase and a tumour variant.
Topics: Adenocarcinoma; Adenoma, Islet Cell; Alkaline Phosphatase; Bone and Bones; Carcinoma; Electrophoresi | 1972 |
Phase II study of strepozotocin (NSC-85998) in the treatment of advanced gastrointestinal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Bile Duct Neoplasms; Bilirubin; Blood Gluc | 1971 |
Associated autonomic dysfunction and carcinoma of the pancreas.
Topics: Adenocarcinoma; Aged; Blood Volume; Creatinine; Dysautonomia, Familial; Hematocrit; Humans; Male; Pa | 1970 |
[Heterologous liver perfusion. A possibility of temporary liver substitution].
Topics: Alkaline Phosphatase; Animals; Bile; Bilirubin; Blood; Blood Gas Analysis; Cholestasis; Cholesterol; | 1968 |