urea has been researched along with Cancer of Gastrointestinal Tract in 21 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Excerpt | Relevance | Reference |
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"Patients with GI tumors or breast cancer treated with capecitabine were included in this randomized phase III study." | 9.20 | Mapisal Versus Urea Cream as Prophylaxis for Capecitabine-Associated Hand-Foot Syndrome: A Randomized Phase III Trial of the AIO Quality of Life Working Group. ( Al-Batran, SE; Bolz, G; Gencer, D; Hegewisch-Becker, S; Hofheinz, RD; Kronawitter, U; Loeffler, LM; Potenberg, J; Schneeweiss, A; Schulz, H; Stahl, M; Tauchert, F, 2015) |
"Patients with GI tumors or breast cancer treated with capecitabine were included in this randomized phase III study." | 5.20 | Mapisal Versus Urea Cream as Prophylaxis for Capecitabine-Associated Hand-Foot Syndrome: A Randomized Phase III Trial of the AIO Quality of Life Working Group. ( Al-Batran, SE; Bolz, G; Gencer, D; Hegewisch-Becker, S; Hofheinz, RD; Kronawitter, U; Loeffler, LM; Potenberg, J; Schneeweiss, A; Schulz, H; Stahl, M; Tauchert, F, 2015) |
"In advanced gastrointestinal stromal tumor (GIST), there is an unmet need for therapies that target both primary and secondary mutations of pathogenic KIT/PDGFRA oncoproteins." | 2.94 | Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib. ( Abdul Razak, AR; Chi, P; Ganjoo, K; Gelderblom, H; George, S; Gordon, M; Heinrich, MC; Hu, S; Janku, F; Jones, RL; Rosen, O; Ruiz-Soto, R; Somaiah, N; Su, Y; Trent, J; von Mehren, M, 2020) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (42.86) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (4.76) | 24.3611 |
2020's | 11 (52.38) | 2.80 |
Authors | Studies |
---|---|
Symcox, M | 1 |
Somaiah, N | 2 |
Lemaître, J | 1 |
Watson, S | 1 |
Goggin, C | 1 |
Stansfeld, A | 1 |
Mahalingam, P | 1 |
Thway, K | 1 |
Smith, MJ | 1 |
Huang, P | 1 |
Jones, RL | 2 |
Napolitano, A | 1 |
Schwartz, GK | 1 |
Nemunaitis, J | 1 |
Bauer, S | 1 |
Blay, JY | 2 |
Choucair, K | 1 |
Gelderblom, H | 2 |
George, S | 2 |
Schöffski, P | 1 |
Mehren, MV | 1 |
Zalcberg, J | 1 |
Achour, H | 1 |
Ruiz-Soto, R | 2 |
Heinrich, MC | 2 |
Janku, F | 1 |
Abdul Razak, AR | 1 |
Chi, P | 1 |
von Mehren, M | 2 |
Ganjoo, K | 1 |
Trent, J | 1 |
Hu, S | 1 |
Rosen, O | 1 |
Su, Y | 1 |
Gordon, M | 1 |
Nguépy Keubo, FR | 1 |
Mboua, PC | 1 |
Djifack Tadongfack, T | 1 |
Fokouong Tchoffo, E | 1 |
Tasson Tatang, C | 1 |
Ide Zeuna, J | 1 |
Noupoue, EM | 1 |
Tsoplifack, CB | 1 |
Folefack, GO | 1 |
Kettani, M | 1 |
Bandelier, P | 1 |
Huo, J | 1 |
Li, H | 4 |
Yu, D | 1 |
Arulsamy, N | 1 |
AlAbbad, S | 1 |
Sardot, T | 1 |
Lekashvili, O | 1 |
Decato, D | 1 |
Lelj, F | 1 |
Alexander Ross, JB | 1 |
Rosenberg, E | 1 |
Nazir, H | 1 |
Muthuswamy, N | 1 |
Louis, C | 1 |
Jose, S | 1 |
Prakash, J | 1 |
Buan, MEM | 1 |
Flox, C | 1 |
Chavan, S | 1 |
Shi, X | 1 |
Kauranen, P | 1 |
Kallio, T | 1 |
Maia, G | 1 |
Tammeveski, K | 1 |
Lymperopoulos, N | 1 |
Carcadea, E | 1 |
Veziroglu, E | 1 |
Iranzo, A | 1 |
M Kannan, A | 1 |
Arunamata, A | 1 |
Tacy, TA | 1 |
Kache, S | 1 |
Mainwaring, RD | 1 |
Ma, M | 1 |
Maeda, K | 1 |
Punn, R | 1 |
Noguchi, S | 1 |
Hahn, S | 3 |
Iwasa, Y | 3 |
Ling, J | 2 |
Voccio, JP | 2 |
Kim, Y | 3 |
Song, J | 3 |
Bascuñán, J | 2 |
Chu, Y | 1 |
Tomita, M | 1 |
Cazorla, M | 1 |
Herrera, E | 1 |
Palomeque, E | 1 |
Saud, N | 1 |
Hoplock, LB | 1 |
Lobchuk, MM | 1 |
Lemoine, J | 1 |
Li, X | 10 |
Henson, MA | 1 |
Unsihuay, D | 1 |
Qiu, J | 1 |
Swaroop, S | 1 |
Nagornov, KO | 1 |
Kozhinov, AN | 1 |
Tsybin, YO | 1 |
Kuang, S | 1 |
Laskin, J | 1 |
Zin, NNINM | 1 |
Mohamad, MN | 1 |
Roslan, K | 1 |
Abdul Wafi, S | 1 |
Abdul Moin, NI | 1 |
Alias, A | 1 |
Zakaria, Y | 1 |
Abu-Bakar, N | 1 |
Naveed, A | 1 |
Jilani, K | 1 |
Siddique, AB | 1 |
Akbar, M | 1 |
Riaz, M | 1 |
Mushtaq, Z | 1 |
Sikandar, M | 1 |
Ilyas, S | 1 |
Bibi, I | 1 |
Asghar, A | 1 |
Rasool, G | 1 |
Irfan, M | 1 |
Li, XY | 1 |
Zhao, S | 1 |
Fan, XH | 1 |
Chen, KP | 1 |
Hua, W | 1 |
Liu, ZM | 1 |
Xue, XD | 1 |
Zhou, B | 1 |
Zhang, S | 2 |
Xing, YL | 1 |
Chen, MA | 1 |
Sun, Y | 1 |
Neradilek, MB | 1 |
Wu, XT | 1 |
Zhang, D | 2 |
Huang, W | 1 |
Cui, Y | 1 |
Yang, QQ | 1 |
Li, HW | 1 |
Zhao, XQ | 1 |
Hossein Rashidi, B | 1 |
Tarafdari, A | 1 |
Ghazimirsaeed, ST | 1 |
Shahrokh Tehraninezhad, E | 1 |
Keikha, F | 1 |
Eslami, B | 1 |
Ghazimirsaeed, SM | 1 |
Jafarabadi, M | 1 |
Silvani, Y | 1 |
Lovita, AND | 1 |
Maharani, A | 1 |
Wiyasa, IWA | 1 |
Sujuti, H | 1 |
Ratnawati, R | 1 |
Raras, TYM | 1 |
Lemin, AS | 1 |
Rahman, MM | 1 |
Pangarah, CA | 1 |
Kiyu, A | 1 |
Zeng, C | 2 |
Du, H | 1 |
Lin, D | 1 |
Jalan, D | 1 |
Rubagumya, F | 1 |
Hopman, WM | 1 |
Vanderpuye, V | 1 |
Lopes, G | 1 |
Seruga, B | 1 |
Booth, CM | 1 |
Berry, S | 1 |
Hammad, N | 1 |
Sajo, EA | 1 |
Okunade, KS | 1 |
Olorunfemi, G | 1 |
Rabiu, KA | 1 |
Anorlu, RI | 1 |
Xu, C | 2 |
Xiang, Y | 1 |
Xu, X | 1 |
Zhou, L | 2 |
Dong, X | 1 |
Tang, S | 1 |
Gao, XC | 1 |
Wei, CH | 1 |
Zhang, RG | 1 |
Cai, Q | 1 |
He, Y | 1 |
Tong, F | 1 |
Dong, JH | 1 |
Wu, G | 1 |
Dong, XR | 1 |
Tang, X | 1 |
Tao, F | 1 |
Xiang, W | 1 |
Zhao, Y | 2 |
Jin, L | 1 |
Tao, H | 1 |
Lei, Y | 1 |
Gan, H | 1 |
Huang, Y | 1 |
Chen, Y | 3 |
Chen, L | 3 |
Shan, A | 1 |
Zhao, H | 2 |
Wu, M | 2 |
Ma, Q | 1 |
Wang, J | 4 |
Zhang, E | 1 |
Zhang, J | 4 |
Li, Y | 5 |
Xue, F | 1 |
Deng, L | 1 |
Liu, L | 2 |
Yan, Z | 2 |
Wang, Y | 2 |
Meng, J | 1 |
Chen, G | 2 |
Anastassiadou, M | 1 |
Bernasconi, G | 1 |
Brancato, A | 1 |
Carrasco Cabrera, L | 1 |
Greco, L | 1 |
Jarrah, S | 1 |
Kazocina, A | 1 |
Leuschner, R | 1 |
Magrans, JO | 1 |
Miron, I | 1 |
Nave, S | 1 |
Pedersen, R | 1 |
Reich, H | 1 |
Rojas, A | 1 |
Sacchi, A | 1 |
Santos, M | 1 |
Theobald, A | 1 |
Vagenende, B | 1 |
Verani, A | 1 |
Du, L | 1 |
Liu, X | 1 |
Ren, Y | 1 |
Li, J | 7 |
Li, P | 1 |
Jiao, Q | 1 |
Meng, P | 1 |
Wang, F | 2 |
Wang, YS | 1 |
Wang, C | 3 |
Zhou, X | 2 |
Wang, W | 1 |
Wang, S | 2 |
Hou, J | 1 |
Zhang, A | 1 |
Lv, B | 1 |
Gao, C | 1 |
Pang, D | 1 |
Lu, K | 1 |
Ahmad, NH | 1 |
Wang, L | 1 |
Zhu, J | 2 |
Zhang, L | 2 |
Zhuang, T | 1 |
Tu, J | 1 |
Zhao, Z | 1 |
Qu, Y | 1 |
Yao, H | 1 |
Wang, X | 5 |
Lee, DF | 1 |
Shen, J | 3 |
Wen, L | 1 |
Huang, G | 2 |
Xie, X | 1 |
Zhao, Q | 1 |
Hu, W | 1 |
Zhang, Y | 4 |
Wu, X | 2 |
Lu, J | 2 |
Li, M | 1 |
Li, W | 2 |
Wu, W | 1 |
Du, F | 1 |
Ji, H | 1 |
Yang, X | 2 |
Xu, Z | 1 |
Wan, L | 1 |
Wen, Q | 1 |
Cho, CH | 1 |
Zou, C | 1 |
Xiao, Z | 1 |
Liao, J | 1 |
Su, X | 1 |
Bi, Z | 1 |
Su, Q | 1 |
Huang, H | 1 |
Wei, Y | 2 |
Gao, Y | 2 |
Na, KJ | 1 |
Choi, H | 1 |
Oh, HR | 1 |
Kim, YH | 1 |
Lee, SB | 1 |
Jung, YJ | 1 |
Koh, J | 1 |
Park, S | 1 |
Lee, HJ | 1 |
Jeon, YK | 1 |
Chung, DH | 1 |
Paeng, JC | 1 |
Park, IK | 1 |
Kang, CH | 1 |
Cheon, GJ | 1 |
Kang, KW | 1 |
Lee, DS | 1 |
Kim, YT | 1 |
Pajuelo-Lozano, N | 1 |
Alcalá, S | 1 |
Sainz, B | 1 |
Perona, R | 1 |
Sanchez-Perez, I | 1 |
Logotheti, S | 1 |
Marquardt, S | 1 |
Gupta, SK | 1 |
Richter, C | 1 |
Edelhäuser, BAH | 1 |
Engelmann, D | 1 |
Brenmoehl, J | 1 |
Söhnchen, C | 1 |
Murr, N | 1 |
Alpers, M | 1 |
Singh, KP | 1 |
Wolkenhauer, O | 1 |
Heckl, D | 1 |
Spitschak, A | 1 |
Pützer, BM | 1 |
Liao, Y | 1 |
Cheng, J | 1 |
Kong, X | 1 |
Li, S | 1 |
Zhang, M | 4 |
Zhang, H | 1 |
Yang, T | 2 |
Dong, Y | 1 |
Xu, Y | 1 |
Yuan, Z | 1 |
Cao, J | 1 |
Zheng, Y | 1 |
Luo, Z | 1 |
Mei, Z | 1 |
Yao, Y | 1 |
Liu, Z | 2 |
Liang, C | 1 |
Yang, H | 1 |
Song, Y | 1 |
Yu, K | 1 |
Zhu, C | 1 |
Huang, Z | 1 |
Qian, J | 1 |
Ge, J | 1 |
Hu, J | 2 |
Wang, H | 2 |
Liu, Y | 4 |
Mi, Y | 1 |
Kong, H | 1 |
Xi, D | 1 |
Yan, W | 1 |
Luo, X | 1 |
Ning, Q | 1 |
Chang, X | 2 |
Zhang, T | 2 |
Wang, Q | 2 |
Rathore, MG | 1 |
Reddy, K | 1 |
Chen, H | 1 |
Shin, SH | 1 |
Ma, WY | 1 |
Bode, AM | 1 |
Dong, Z | 1 |
Mu, W | 1 |
Liu, C | 3 |
Gao, F | 1 |
Qi, Y | 1 |
Lu, H | 1 |
Zhang, X | 4 |
Cai, X | 1 |
Ji, RY | 1 |
Hou, Y | 3 |
Tian, J | 2 |
Shi, Y | 1 |
Ying, S | 1 |
Tan, M | 1 |
Feng, G | 1 |
Kuang, Y | 1 |
Chen, D | 1 |
Wu, D | 3 |
Zhu, ZQ | 1 |
Tang, HX | 1 |
Shi, ZE | 1 |
Kang, J | 1 |
Liu, Q | 1 |
Qi, J | 2 |
Mu, J | 1 |
Cong, Z | 1 |
Chen, S | 2 |
Fu, D | 1 |
Li, Z | 2 |
Celestrin, CP | 1 |
Rocha, GZ | 1 |
Stein, AM | 1 |
Guadagnini, D | 1 |
Tadelle, RM | 1 |
Saad, MJA | 1 |
Oliveira, AG | 1 |
Bianconi, V | 1 |
Bronzo, P | 1 |
Banach, M | 1 |
Sahebkar, A | 1 |
Mannarino, MR | 1 |
Pirro, M | 1 |
Patsourakos, NG | 1 |
Kouvari, M | 1 |
Kotidis, A | 1 |
Kalantzi, KI | 1 |
Tsoumani, ME | 1 |
Anastasiadis, F | 1 |
Andronikos, P | 1 |
Aslanidou, T | 1 |
Efraimidis, P | 1 |
Georgiopoulos, A | 1 |
Gerakiou, K | 1 |
Grigoriadou-Skouta, E | 1 |
Grigoropoulos, P | 1 |
Hatzopoulos, D | 1 |
Kartalis, A | 1 |
Lyras, A | 1 |
Markatos, G | 1 |
Mikrogeorgiou, A | 1 |
Myroforou, I | 1 |
Orkopoulos, A | 1 |
Pavlidis, P | 1 |
Petras, C | 1 |
Riga, M | 1 |
Skouloudi, M | 1 |
Smyrnioudis, N | 1 |
Thomaidis, K | 1 |
Tsikouri, GE | 1 |
Tsikouris, EI | 1 |
Zisimos, K | 1 |
Vavoulis, P | 1 |
Vitali, MG | 1 |
Vitsas, G | 1 |
Vogiatzidis, C | 1 |
Chantanis, S | 1 |
Fousas, S | 1 |
Panagiotakos, DB | 1 |
Tselepis, AD | 1 |
Jungen, C | 1 |
Alken, FA | 1 |
Eickholt, C | 1 |
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Kuklik, P | 1 |
Klatt, N | 1 |
Schwarzl, J | 1 |
Moser, J | 1 |
Jularic, M | 1 |
Akbulak, RO | 1 |
Schaeffer, B | 1 |
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Meyer, C | 1 |
Nowak, JK | 1 |
Szczepanik, M | 1 |
Trypuć, M | 1 |
Pogorzelski, A | 1 |
Bobkowski, W | 1 |
Grytczuk, M | 1 |
Minarowska, A | 1 |
Wójciak, R | 1 |
Walkowiak, J | 1 |
Lu, Y | 1 |
Xi, J | 1 |
Li, C | 1 |
Chen, W | 2 |
Hu, X | 1 |
Zhang, F | 1 |
Wei, H | 1 |
Wang, Z | 1 |
Gurzu, S | 1 |
Jung, I | 1 |
Sugimura, H | 2 |
Stefan-van Staden, RI | 1 |
Yamada, H | 1 |
Natsume, H | 1 |
Iwashita, Y | 1 |
Szodorai, R | 1 |
Szederjesi, J | 1 |
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Langroudi, FH | 1 |
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Huang, J | 1 |
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Khosla, N | 1 |
Govindasamy, V | 1 |
Saini, A | 1 |
Annapurna, K | 1 |
Dhakate, SR | 1 |
Akkaya, Ö | 1 |
Chandgude, AL | 1 |
Dömling, A | 1 |
Harnett, J | 1 |
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Leach, M | 1 |
Brown, D | 1 |
Cramer, H | 1 |
Pinder, TA | 1 |
Steel, A | 1 |
Anheyer, D | 1 |
Cantu, J | 1 |
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Flores, K | 1 |
Gonzalez, D | 1 |
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Padilla, V | 1 |
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de Oliveira, PD | 1 |
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Martens, C | 1 |
Goplen, FK | 1 |
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Nordfalk, KF | 1 |
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Patel, PR | 2 |
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Fennell, TR | 1 |
Gal, RL | 1 |
Cohen, NJ | 1 |
Kruger, D | 1 |
Beck, RW | 1 |
Bergenstal, RM | 1 |
Calhoun, P | 1 |
Cushman, T | 1 |
Haban, A | 1 |
Hood, K | 1 |
Johnson, ML | 1 |
McArthur, T | 1 |
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Weinstock, RS | 1 |
Oser, SM | 1 |
Oser, TK | 1 |
Bugielski, B | 1 |
Strayer, H | 1 |
Aleppo, G | 1 |
Maruyama, H | 1 |
Hirayama, K | 1 |
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Ohgi, K | 1 |
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Shimohata, H | 1 |
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Fluharty, FL | 1 |
Moeller, SJ | 1 |
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Shah, PD | 1 |
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Brown, DN | 1 |
Won, HH | 1 |
Li, BT | 1 |
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Jhaveri, K | 1 |
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Zamora, S | 1 |
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Singh, A | 1 |
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Wang, XW | 1 |
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Yang, Y | 1 |
Chen, WF | 1 |
Luo, R | 1 |
Yang, K | 1 |
Amarasiri, SS | 1 |
Attanayake, AP | 1 |
Arawwawala, LDAM | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Phase 3, INterVentional, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of DCC-2618 In Patients With AdvanCed Gastrointestinal Stromal TUmorS Who Have Received Treatment With Prior Anticancer Therapies[NCT03353753] | Phase 3 | 129 participants (Actual) | Interventional | 2018-02-27 | Completed | ||
A Phase 3, Interventional, Randomized, Multicenter, Open-Label Study of DCC-2618 vs Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumors After Treatment With Imatinib[NCT03673501] | Phase 3 | 426 participants (Anticipated) | Interventional | 2019-02-11 | Active, not recruiting | ||
A Multicenter Phase 1, Open-Label Study of DCC-2618 to Assess Safety, Tolerability, Efficacy, and Pharmacokinetics in Patients With Advanced Malignancies[NCT02571036] | Phase 1 | 282 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
Ripretinib Combined With Surgery in Advanced Gastrointestinal Stromal Tumors That Have Failed Imatinib Therapy: A Multicenter,Observational Study[NCT05354388] | 30 participants (Anticipated) | Observational | 2021-10-01 | Recruiting | |||
A Phase II, Randomised Controlled Trial to Evaluate the Efficacy and Safety of Moisturising Creams With or Without Palm-oil-derived Vitamin E Concentrate in Addition to Urea-based Cream or Urea-based Cream Alone in Capecitabine-associated Palmar-Plantar E[NCT05939726] | 90 participants (Anticipated) | Interventional | 2023-05-16 | Recruiting | |||
A Randomized, Open-label Phase III Trial of Mapisal® Versus an Urea Hand-foot Cream as Prophylaxis for Capecitabine-induced Hand-foot Syndrome in Patients With Gastrointestinal Tumors or Breast Cancer[NCT01626781] | 0 participants | Expanded Access | No longer available | ||||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
The percentage of patients with a confirmed complete response or PR (CR: Disappearance of all target lesions and non-target lesions (if present at baseline); all lymph nodes must be non-pathological in size) or partial response (PR: >=30% decrease in the Sum of Diameters of target lesions and non-target lesions non-PD or NE or none at baseline; or target lesions CR and non-target lesions non-CR/Non-PD or NE) based on the independent radiologic review and during the initially assigned study treatment. To be assigned a status of a CR or PR, changes in tumor measurements must be confirmed by repeat CT or MRI assessments that must be performed at least 4 weeks after the criteria for response are first met. (NCT03353753)
Timeframe: From date of randomization to the earliest date of disease progression or death from any cause [through database cutoff 31-May-2019 (up to approximately 15 months)].
Intervention | Percentage of Participants (Number) |
---|---|
Ripretinib | 9.4 |
Placebo | 0 |
Overall Survival (OS) was defined as the interval between the date of randomization until the date of death or the date of last follow-up. (NCT03353753)
Timeframe: From the date of randomization to the date of death from any cause [through database cutoff 31-May-2019 (up to approximately 15 months)].
Intervention | weeks (Median) |
---|---|
Ripretinib | 65.6 |
Placebo | 28.6 |
PFS was defined as the time interval between the date of randomization and the earliest documented evidence of the first disease progression based on the independent radiologic review or death due to any cause on initially assigned study treatment, whichever comes earlier, assessed at 26, 39, and 52 weeks. (NCT03353753)
Timeframe: From date of randomization to the earliest date of disease progression or death from any cause [through database cutoff 31-May-2019 (up to approximately 15 months)].
Intervention | Weeks (Median) |
---|---|
Ripretinib | 27.6 |
Placebo | 4.1 |
Changes from baseline in European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for Cancer 30-item - Role Functioning. For the ripretinib arm the minimum and maximum for the outcome were -67 to 67; the placebo arm had a range of -83 to 67. The higher value represents a higher quality of life in disease-related symptoms. (NCT03353753)
Timeframe: From the date of randomization (Baseline) to Cycle 2 Day 1 (Month 2)
Intervention | units on a scale (Mean) |
---|---|
Ripretinib | 3.5 |
Placebo | -17.1 |
Change from baseline in EuroQol Visual Analogue Scale. For the ripretinib arm the minimum and maximum for the outcome were -43 to 91; the placebo arm had a range of -68 to 23. The higher value represents a higher quality of life in disease-related symptoms. (NCT03353753)
Timeframe: From the date of randomization (Baseline) to Cycle 2 Day 1 (Month 2)
Intervention | Units on a Scale (Mean) |
---|---|
Ripretinib | 3.7 |
Placebo | -8.9 |
Changes from baseline in European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for Cancer 30-Item - Physical Functioning. For the ripretinib arm, the minimum and maximum for the outcome were -33 to 53; the placebo arm had a range of -47 to 20. The higher value represents a higher quality of life in disease-related symptoms. (NCT03353753)
Timeframe: From the date of randomization (Baseline) to Cycle 2 Day 1 (Month 2)
Intervention | units on a scale (Mean) |
---|---|
Ripretinib | 1.6 |
Placebo | -8.9 |
TTP is defined as the interval between the date of randomization and the earliest documented evidence of disease progression based on the independent radiologic review. (NCT03353753)
Timeframe: From date of randomization to the earliest date of disease progression [through database cutoff 31-May-2019 (up to approximately 15 months)].
Intervention | Weeks (Median) |
---|---|
Ripretinib | 28 |
Placebo | 4.1 |
4 reviews available for urea and Cancer of Gastrointestinal Tract
Article | Year |
---|---|
Ripretinib in advanced gastrointestinal stromal tumors: an overview of current evidence and drug approval.
Topics: Antineoplastic Agents; Drug Approval; Drug Resistance, Neoplasm; Gastrointestinal Neoplasms; Gastroi | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Gastrointestinal stromal tumours.
Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Gastrointestinal Neoplasms; Gastrointestinal Strom | 2021 |
New treatments in advanced gastrointestinal stromal tumor.
Topics: Antineoplastic Agents; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Naphthyr | 2021 |
5 trials available for urea and Cancer of Gastrointestinal Tract
Article | Year |
---|---|
Intrigue: Phase III study of ripretinib versus sunitinib in advanced gastrointestinal stromal tumor after imatinib.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Res | 2020 |
Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Gastrointestinal Neoplasms; Gastr | 2020 |
Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Gastrointestinal Neoplasms; Gastr | 2020 |
Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Gastrointestinal Neoplasms; Gastr | 2020 |
Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Gastrointestinal Neoplasms; Gastr | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Mapisal Versus Urea Cream as Prophylaxis for Capecitabine-Associated Hand-Foot Syndrome: A Randomized Phase III Trial of the AIO Quality of Life Working Group.
Topics: Administration, Cutaneous; Adult; Aged; Antimetabolites, Antineoplastic; Antioxidants; Breast Neopla | 2015 |
Mapisal Versus Urea Cream as Prophylaxis for Capecitabine-Associated Hand-Foot Syndrome: A Randomized Phase III Trial of the AIO Quality of Life Working Group.
Topics: Administration, Cutaneous; Adult; Aged; Antimetabolites, Antineoplastic; Antioxidants; Breast Neopla | 2015 |
Mapisal Versus Urea Cream as Prophylaxis for Capecitabine-Associated Hand-Foot Syndrome: A Randomized Phase III Trial of the AIO Quality of Life Working Group.
Topics: Administration, Cutaneous; Adult; Aged; Antimetabolites, Antineoplastic; Antioxidants; Breast Neopla | 2015 |
Mapisal Versus Urea Cream as Prophylaxis for Capecitabine-Associated Hand-Foot Syndrome: A Randomized Phase III Trial of the AIO Quality of Life Working Group.
Topics: Administration, Cutaneous; Adult; Aged; Antimetabolites, Antineoplastic; Antioxidants; Breast Neopla | 2015 |
Treatment of Hodgkin's disease and other cancers with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962).
Topics: Adenocarcinoma; Adenoma, Islet Cell; Adolescent; Adrenal Gland Neoplasms; Adult; Alkylating Agents; | 1971 |
13 other studies available for urea and Cancer of Gastrointestinal Tract
Article | Year |
---|---|
Ripretinib for advanced gastrointestinal stromal tumor: Plain language summary of the INVICTUS study.
Topics: Adult; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Language; Naphthyridines | 2021 |
[New drug approvals: Ripretinib for advanced gastrointestinal stromal tumors (GIST) in fourth or later-line therapy].
Topics: Antineoplastic Agents; Drug Approval; Drug Resistance, Neoplasm; Gastrointestinal Neoplasms; Gastroi | 2022 |
Ripretinib and the Failure to Advance GI Stromal Tumor Therapy in the Age of Precision Medicine.
Topics: Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Naphthyridines; Precision Medic | 2022 |
Ripretinib (Qinlock) for GIST.
Topics: Antineoplastic Agents; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Molecula | 2021 |
Ripretinib in treatment of repeatedly relapsing rectal gastrointestinal stromal tumor: a case report.
Topics: Antineoplastic Agents; China; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; N | 2021 |
Influence of high caloric parenteral nutrition on catabolism and cellular immune competence in carcinoma patients.
Topics: Amino Acids; Diet; Energy Intake; Gastrointestinal Neoplasms; Humans; Immunity, Cellular; Immunoglob | 1982 |
Glucose and urea kinetics in patients with early and advanced gastrointestinal cancer: the response to glucose infusion, parenteral feeding, and surgical resection.
Topics: Aged; Blood Glucose; Calorimetry, Indirect; Carbon Radioisotopes; Female; Gastrointestinal Neoplasms | 1987 |
A phase II study of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC79037) in the palliative management of advanced gastrointestinal cancer.
Topics: Aged; Anemia; Blood Platelet Disorders; Cyclohexanes; Female; Gastrointestinal Neoplasms; Humans; Le | 1972 |
Combination chemotherapy in gastrointestinal cancer.
Topics: Adenocarcinoma; Adult; Alopecia; Appendiceal Neoplasms; Diarrhea; Drug Eruptions; Fluorouracil; Gall | 1970 |
Carcinogenicity of a single administration of N-nitrosomethylurea: a comparison between newborn and 5-week-old mice and rats.
Topics: Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Female; Gastrointestinal | 1970 |
Clinical evaluation of routine measurement of liver and bone alkaline phosphatases in human serum. Differential inhibition by L-phenylalanine and carbamide (urea) on the LKB 8600 reaction rate analyzer.
Topics: Alkaline Phosphatase; Autoanalysis; Bone and Bones; Bone Diseases; Colitis, Ulcerative; Evaluation S | 1974 |
Sequential 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) and 5-fluorouracil (NSC 19893) therapy of gastrointestinal cancer.
Topics: Cyclohexanes; Fluorouracil; Gastrointestinal Neoplasms; Humans; Leukopenia; Nitroso Compounds; Nitro | 1972 |
Phase II study of strepozotocin (NSC-85998) in the treatment of advanced gastrointestinal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Bile Duct Neoplasms; Bilirubin; Blood Gluc | 1971 |