Page last updated: 2024-10-20

urea and Amyloidosis

urea has been researched along with Amyloidosis in 32 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.

Research Excerpts

ExcerptRelevanceReference
"Betaine was more effective than sorbitol."1.31Counteracting effects of renal solutes on amyloid fibril formation by immunoglobulin light chains. ( Cape, SP; Carpenter, JF; Chi, E; Kim, YS; Manning, MC; Raffen, R; Randolph, TW; Solomon, A; Stevens, FJ; Wilkins-Stevens, P, 2001)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199013 (40.63)18.7374
1990's1 (3.13)18.2507
2000's12 (37.50)29.6817
2010's4 (12.50)24.3611
2020's2 (6.25)2.80

Authors

AuthorsStudies
Nakagawa, M1
Obita, T1
Mizuguchi, M1
Qafary, M1
Khajeh, K1
Ramazzotti, M1
Moosavi-Movahedi, AA1
Chiti, F1
Martin, EB1
Williams, A1
Wooliver, C1
Heidel, RE1
Adams, S1
Dunlap, J1
Ramirez-Alvarado, M1
Blancas-Mejia, LM1
Lands, RH1
Kennel, SJ1
Wall, JS1
De Simone, E1
Di Micco, L1
La Manna, G1
Di Iorio, B1
Fortin, JS1
Benoit-Biancamano, MO1
C-Gaudreault, R1
Hurshman Babbes, AR1
Powers, ET1
Kelly, JW3
Smith, DP2
Radford, SE3
Ashcroft, AE1
ARAPAKIS, G1
TRIBE, CR1
BENDITT, EP2
ERIKSEN, N2
Ishii, E1
Ando, Y1
Kusano, E1
Isakozawa, Y1
Takesawa, S1
Paraskevas, KI1
Anagnostou, D1
Bouris, C1
Altland, K1
Benson, MD1
Costello, CE1
Ferlini, A1
Hazenberg, BP1
Hund, E1
Kristen, AV1
Linke, RP1
Merlini, G1
Salvi, F1
Saraiva, MJ1
Singer, R1
Skinner, M1
Winter, P1
Fry, AC1
Singh, DK1
Chandna, SM1
Farrington, K1
David, S1
Cambi, V1
Kim, YS1
Cape, SP1
Chi, E1
Raffen, R1
Wilkins-Stevens, P1
Stevens, FJ1
Manning, MC1
Randolph, TW1
Solomon, A1
Carpenter, JF1
Ratnaswamy, G1
Huff, ME1
Su, AI1
Rion, S1
Morgan, CJ1
Gelfand, M1
Atreya, C1
Miranker, AD1
Hammarström, P1
Jiang, X1
Deechongkit, S1
Kad, NM1
Thomson, NH1
Smith, DA1
McParland, VJ1
Kalverda, AP1
Homans, SW1
Srivastava, RN1
Mayekar, G1
Anand, R1
Choudhry, VP1
Ghai, OP1
Tandon, HD1
Nichols, RB1
Clamp, JR1
Bottomley, JP1
Bradley, J1
Whitehouse, GH1
Kennedy, AC1
Burton, JA1
Allison, ME1
Zòltowska, A1
Wrzolkowa, T1
Zalin, A1
Darby, A1
Vaughan, S1
Raftery, EB1
Zuckerberg, A1
Gazith, J1
Rimon, A1
Reshef, T1
Gafni, J1
Blagg, CR1
Kemble, F1
Taverner, D1
Dzúrik, R1
Brixová, E1
Gömöri, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multinational Prospective Study on the Duration of Steroid Therapy in Steroid Sensitive Nephrotic Syndrome[NCT03878914]Phase 434 participants (Actual)Interventional2019-08-06Terminated (stopped due to The study was terminated at all but one site because of the pandemic)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for urea and Amyloidosis

ArticleYear
[Protein carbamylation: what it is and why it concerns nephrologists].
    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2018, Volume: 35, Issue:3

    Topics: Alzheimer Disease; Amino Acids; Amyloidosis; Anemia, Sickle Cell; Animals; Cardiovascular Diseases;

2018
[The efficiency and duration of dialysis].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 5

    Topics: Amyloidosis; beta 2-Microglobulin; Biomarkers; Humans; Peritoneal Dialysis, Continuous Ambulatory; P

2004
[Hemofiltration (HF) and hemodiafiltration (HDF)--overview].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 5

    Topics: Amyloidosis; beta 2-Microglobulin; Creatinine; Dialysis Solutions; Endotoxins; Hemodiafiltration; He

2004
Anurea caused by primary amyloidosis of the lower third of the ureters, the ureterovesical junction and the urinary bladder: a case report and review of the literature.
    International urology and nephrology, 2004, Volume: 36, Issue:3

    Topics: Amyloidosis; Female; Humans; Metabolic Diseases; Middle Aged; Urea; Ureteral Diseases; Urinary Bladd

2004

Other Studies

28 other studies available for urea and Amyloidosis

ArticleYear
The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin.
    The Biochemical journal, 2022, 09-30, Volume: 479, Issue:18

    Topics: Amyloid; Amyloidosis; Animals; Humans; Hydrophobic and Hydrophilic Interactions; Mammals; Mice; Muta

2022
Urea titration of a lipase from Pseudomonas sp. reveals four different conformational states, with a stable partially folded state explaining its high aggregation propensity.
    International journal of biological macromolecules, 2021, Mar-31, Volume: 174

    Topics: Amyloid; Amyloidosis; Circular Dichroism; Hydrogen-Ion Concentration; Lipase; Protein Aggregates; Pr

2021
Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Amyloid; Amyloidogenic Proteins; Amyloidosis; Blotting, Western; Ele

2017
Discovery of ethyl urea derivatives as inhibitors of islet amyloid polypeptide fibrillization and cytotoxicity.
    Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:3

    Topics: Amyloid; Amyloidosis; Diabetes Mellitus, Type 2; Humans; Islet Amyloid Polypeptide; Islets of Langer

2016
Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.
    Biochemistry, 2008, Jul-01, Volume: 47, Issue:26

    Topics: Alternative Splicing; Amyloidosis; Cross-Linking Reagents; Prealbumin; Protein Denaturation; Protein

2008
Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Apr-13, Volume: 107, Issue:15

    Topics: Amyloid; Amyloidosis; beta 2-Microglobulin; Dimerization; Escherichia coli; Humans; Hydrogen-Ion Con

2010
AMYLOIDOSIS IN RHEUMATOID ARTHRITIS INVESTIGATED BY MEANS OF RECTAL BIOPSY.
    Annals of the rheumatic diseases, 1963, Volume: 22

    Topics: Amyloidosis; Arthritis; Arthritis, Rheumatoid; Biopsy; Blood Chemical Analysis; Geriatrics; Humans;

1963
AMYLOID. II. STARCH GEL ELECTROPHORETIC ANALYSIS OF SOME PROTEINS EXTRACTED FROM AMYLOID.
    Archives of pathology, 1964, Volume: 78

    Topics: Adolescent; Amyloid; Amyloidosis; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Bronchiecta

1964
Genetic microheterogeneity of human transthyretin detected by IEF.
    Electrophoresis, 2007, Volume: 28, Issue:12

    Topics: Amino Acid Substitution; Amyloidosis; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Conc

2007
Relative importance of residual renal function and convection in determining beta-2-microglobulin levels in high-flux haemodialysis and on-line haemodiafiltration.
    Blood purification, 2007, Volume: 25, Issue:3

    Topics: Adult; Aged; Amyloidosis; beta 2-Microglobulin; C-Reactive Protein; Convection; Female; Hemodiafiltr

2007
High-efficiency dialysis with PMMA dialyzers: treatment dose delivery and long-term results.
    Contributions to nephrology, 1999, Volume: 125

    Topics: Amyloidosis; beta 2-Microglobulin; Bicarbonates; Biocompatible Materials; Hemodialysis Solutions; Hu

1999
Counteracting effects of renal solutes on amyloid fibril formation by immunoglobulin light chains.
    The Journal of biological chemistry, 2001, Jan-12, Volume: 276, Issue:2

    Topics: Amyloid; Amyloidosis; Betaine; Chromatography, High Pressure Liquid; Guanidine; Humans; Immunoglobul

2001
Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Feb-27, Volume: 98, Issue:5

    Topics: Amyloidosis; Calcium; Circular Dichroism; Finland; Gelsolin; Genetic Predisposition to Disease; Huma

2001
Kidney dialysis-associated amyloidosis: a molecular role for copper in fiber formation.
    Journal of molecular biology, 2001, Jun-01, Volume: 309, Issue:2

    Topics: Amyloidosis; beta 2-Microglobulin; Cations, Divalent; Copper; Fluorescence; Humans; Hydrogen-Ion Con

2001
Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy.
    Biochemistry, 2001, Sep-25, Volume: 40, Issue:38

    Topics: Amino Acid Substitution; Amyloid; Amyloidosis; Anions; Binding Sites; Cross-Linking Reagents; Drug S

2001
Beta(2)-microglobulin and its deamidated variant, N17D form amyloid fibrils with a range of morphologies in vitro.
    Journal of molecular biology, 2001, Oct-26, Volume: 313, Issue:3

    Topics: Amino Acid Substitution; Amyloidosis; beta 2-Microglobulin; Circular Dichroism; Congo Red; Fluoresce

2001
Structural properties of an amyloid precursor of beta(2)-microglobulin.
    Nature structural biology, 2002, Volume: 9, Issue:5

    Topics: Amyloidosis; beta 2-Microglobulin; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectrosco

2002
Nephrotic syndrome in indian children.
    Archives of disease in childhood, 1975, Volume: 50, Issue:8

    Topics: Adolescent; Age Factors; Amyloidosis; Child; Child, Preschool; Edema; Female; Glomerulonephritis; He

1975
Investigation of glycoprotein material associated with hepatic amyloid.
    Clinica chimica acta; international journal of clinical chemistry, 1967, Volume: 17, Issue:3

    Topics: Amyloid; Amyloidosis; Carbohydrates; Chromatography; Electrophoresis; Glycoproteins; Hexoses; Humans

1967
Waldenstrom's macroglobulinaemia and amyloidosis with subcutaneous calcification and lymphographic appearances.
    The British journal of radiology, 1974, Volume: 47, Issue:556

    Topics: Amyloidosis; Biopsy; Bone Marrow Cells; Calcinosis; Calcium; Cardiomegaly; Cyclophosphamide; Hematoc

1974
Tuberculosis as a continuing cause of renal amyloidosis.
    British medical journal, 1974, Sep-28, Volume: 3, Issue:5934

    Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Amyloidosis; Arthritis, Rheumatoid; Autopsy; Biopsy; C

1974
Experimental amyloidosis in hamsters.
    The Journal of pathology, 1973, Volume: 109, Issue:2

    Topics: Amyloidosis; Animals; Blood Proteins; Cricetinae; Diphtheria Toxoid; Disease Models, Animal; Edema;

1973
Primary neuropathic amyloidosis in three brothers.
    British medical journal, 1974, Jan-12, Volume: 1, Issue:5897

    Topics: Aged; Amyloidosis; Biopsy; Blood Pressure; Constipation; Diarrhea; Electrocardiography; Erectile Dys

1974
Chemical similarity among amyloid substances associated with long standing inflammation.
    Laboratory investigation; a journal of technical methods and pathology, 1972, Volume: 26, Issue:6

    Topics: Acrylamides; Adult; Aged; Amino Acid Sequence; Amyloid; Amyloidosis; Arthritis, Juvenile; Arthritis,

1972
The structural subunit of amyloid. Isolation and characterization of a polypeptide capable of fibril formation.
    European journal of biochemistry, 1972, Jul-13, Volume: 28, Issue:2

    Topics: Amino Acids; Amyloid; Amyloidosis; Birefringence; Carbohydrates; Chromatography, Thin Layer; Congo R

1972
Nerve conduction velocity in relationship to the severity of renal disease.
    Nephron, 1968, Volume: 5, Issue:4

    Topics: Adult; Amyloidosis; Creatinine; Female; Glomerulonephritis; Humans; Hypertension, Renal; Kidney Calc

1968
Liver glycogen concentration in patients with chronic uremia.
    Experientia, 1968, Jun-15, Volume: 24, Issue:6

    Topics: Amyloidosis; Bicarbonates; Erythrocyte Count; Glomerulonephritis; Glucose Tolerance Test; Humans; Li

1968
[Intrarenal circulation in kidney diseases].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1966, Oct-01, Volume: 21, Issue:19

    Topics: Amyloidosis; Collagen Diseases; Creatinine; Diabetic Nephropathies; Glomerulonephritis; Humans; Hype

1966