urea has been researched along with Akinetic-Rigid Variant of Huntington Disease in 7 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
| Excerpt | Relevance | Reference |
|---|---|---|
| " ARG2 protein is not reduced in the prodromal stage, though enzyme activity is reduced, indicating that altered Mn bioavailability as a cofactor leads to the deficient enzymatic activity." | 1.46 | Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model. ( Aschner, M; Bichell, TJV; Bowman, AB; Bradley, EM; Bryan, M; Colbran, RJ; Di Pardo, A; Dudek, K; Fisher, N; Halbesma, T; Holt, HK; Horning, K; Kwakye, GF; Maglione, V; Neely, MD; Osmand, A; Stubbs, AD; Tidball, AM; Tipps, KG; Uhouse, MA; Umashanker, P; Wegrzynowicz, M, 2017) |
| "We conclude that Huntington's disease is not associated with a generalised disturbance of quinolinic acid metabolism, however, a local hyperproduction of quinolinic acid cannot be excluded from our results." | 1.27 | Normal excretion of quinolinic acid in Huntington's disease. ( Brown, RR; Garnett, ES; Heyes, MP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Handley, RR | 1 |
| Reid, SJ | 1 |
| Brauning, R | 1 |
| Maclean, P | 1 |
| Mears, ER | 1 |
| Fourie, I | 1 |
| Patassini, S | 1 |
| Cooper, GJS | 1 |
| Rudiger, SR | 1 |
| McLaughlan, CJ | 1 |
| Verma, PJ | 1 |
| Gusella, JF | 1 |
| MacDonald, ME | 1 |
| Waldvogel, HJ | 1 |
| Bawden, CS | 1 |
| Faull, RLM | 1 |
| Snell, RG | 1 |
| Chen, CM | 3 |
| Lin, YS | 1 |
| Wu, YR | 2 |
| Chen, P | 1 |
| Tsai, FJ | 2 |
| Yang, CL | 1 |
| Tsao, YT | 1 |
| Chang, W | 1 |
| Hsieh, IS | 1 |
| Chern, Y | 3 |
| Soong, BW | 2 |
| Bichell, TJV | 1 |
| Wegrzynowicz, M | 1 |
| Tipps, KG | 1 |
| Bradley, EM | 1 |
| Uhouse, MA | 1 |
| Bryan, M | 1 |
| Horning, K | 1 |
| Fisher, N | 1 |
| Dudek, K | 1 |
| Halbesma, T | 1 |
| Umashanker, P | 1 |
| Stubbs, AD | 1 |
| Holt, HK | 1 |
| Kwakye, GF | 1 |
| Tidball, AM | 1 |
| Colbran, RJ | 1 |
| Aschner, M | 1 |
| Neely, MD | 1 |
| Di Pardo, A | 1 |
| Maglione, V | 1 |
| Osmand, A | 1 |
| Bowman, AB | 1 |
| Chiang, MC | 2 |
| Chen, HM | 2 |
| Lai, HL | 1 |
| Chen, HW | 1 |
| Chou, SY | 1 |
| England, JL | 1 |
| Kaganovich, D | 1 |
| Lee, YH | 1 |
| Chang, HH | 1 |
| Wu, YC | 1 |
| Liu, CS | 1 |
| Niu, DM | 1 |
| Wu, JY | 1 |
| Chen, YT | 1 |
| Heyes, MP | 1 |
| Garnett, ES | 1 |
| Brown, RR | 1 |
7 other studies available for urea and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.
Topics: Adult; Animals; Animals, Genetically Modified; Corpus Striatum; Disease Models, Animal; Female; Huma | 2017 |
High Protein Diet and Huntington's Disease.
Topics: Adult; Citrulline; Dietary Proteins; Disease Progression; Female; Humans; Huntington Disease; Male; | 2015 |
Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.
Topics: Animals; Arginase; Corpus Striatum; Disease Models, Animal; Huntington Disease; Male; Manganese; Mic | 2017 |
The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Disease Models, Animal; Female; Hu | 2009 |
Polyglutamine shows a urea-like affinity for unfolded cytosolic protein.
Topics: Animals; Cell Line; Cytosol; Humans; Huntington Disease; Microscopy, Confocal; Peptides; Protein Den | 2011 |
Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.
Topics: Animals; Brain-Derived Neurotrophic Factor; CCAAT-Enhancer-Binding Protein-alpha; Citrulline; Diet; | 2007 |
Normal excretion of quinolinic acid in Huntington's disease.
Topics: Adolescent; Adult; Creatinine; Female; Humans; Huntington Disease; Male; Middle Aged; Pyridines; Qui | 1985 |