urea has been researched along with Adrenocortical Carcinoma in 3 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Results 63 patients with metastatic ACC, all of whom had previously failed systemic chemotherapy and only 2 of whom were mitotane-naïve, were dosed with oral nevanimibe at doses ranging from 1." | 2.94 | A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma. ( Chugh, R; Fassnacht, M; Habra, MA; Ijzerman, MM; Jafarinasabian, P; Kebebew, E; Kroiss, M; Lin, VH; Mohideen, P; Naing, A; Schneider, BJ; Smith, DC, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Laha, D | 1 |
| Grant, RRC | 1 |
| Mishra, P | 1 |
| Boufraqech, M | 1 |
| Shen, M | 1 |
| Zhang, YQ | 1 |
| Hall, MD | 1 |
| Quezado, M | 1 |
| De Melo, MS | 1 |
| Del Rivero, J | 1 |
| Zeiger, M | 1 |
| Nilubol, N | 1 |
| Smith, DC | 1 |
| Kroiss, M | 1 |
| Kebebew, E | 1 |
| Habra, MA | 1 |
| Chugh, R | 1 |
| Schneider, BJ | 1 |
| Fassnacht, M | 1 |
| Jafarinasabian, P | 1 |
| Ijzerman, MM | 1 |
| Lin, VH | 1 |
| Mohideen, P | 1 |
| Naing, A | 1 |
| Chang, X | 1 |
| Zhao, Y | 1 |
| Ju, S | 1 |
| Guo, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1 Study of the Safety and Tolerability of ATR-101 in Adrenocortical Carcinoma[NCT01898715] | Phase 1 | 63 participants (Actual) | Interventional | 2013-08-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for urea and Adrenocortical Carcinoma
| Article | Year |
|---|---|
A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Female; Humans; Male; Middle Aged; | 2020 |
2 other studies available for urea and Adrenocortical Carcinoma
| Article | Year |
|---|---|
Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Animals; Apoptosis; beta Catenin; Caspase 3; Cel | 2022 |
Orexin-A stimulates 3β-hydroxysteroid dehydrogenase expression and cortisol production in H295R human adrenocortical cells through the AKT pathway.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenocortical Carcinoma; Benzoxazoles; Blotting, Western; Cell Lin | 2014 |