urea has been researched along with Adrenal Hyperplasia, Congenital in 6 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nevanimibe hydrochloride (ATR-101), which selectively inhibits adrenal cortex function, might reduce androgen excess independent of ACTH and thus allow for lower glucocorticoid dosing in CAH." | 2.94 | A Phase 2, Multicenter Study of Nevanimibe for the Treatment of Congenital Adrenal Hyperplasia. ( Auchus, RJ; Chang, AY; El-Maouche, D; Joyal, EG; Lin, VH; Merke, DP; Mohideen, P; Plaunt, MR; Turcu, AF; Vogiatzi, MG; Weintraub, L, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| El-Maouche, D | 1 |
| Merke, DP | 1 |
| Vogiatzi, MG | 1 |
| Chang, AY | 1 |
| Turcu, AF | 1 |
| Joyal, EG | 1 |
| Lin, VH | 1 |
| Weintraub, L | 1 |
| Plaunt, MR | 1 |
| Mohideen, P | 1 |
| Auchus, RJ | 1 |
| Speiser, PW | 1 |
| Honour, JW | 1 |
| Anderson, JM | 1 |
| Shackleton, CH | 1 |
| Bose, HS | 1 |
| Baldwin, MA | 1 |
| Miller, WL | 1 |
| Omenn, GS | 1 |
| Plöchl, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2, Multicenter Study of ATR-101 for the Treatment of Congenital Adrenal Hyperplasia[NCT02804178] | Phase 2 | 10 participants (Actual) | Interventional | 2016-05-18 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17-hydroxyprogesterone was measured predose in the morning at the beginning and end of each dose level. (NCT02804178)
Timeframe: Evaluated at baseline and day 15 of each dose level. Each subject will have up to 5 dose levels.
| Intervention | Participants (Count of Participants) |
|---|---|
| ATR-101 | 2 |
2 reviews available for urea and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Inborn errors of metabolism: clues to understanding human behavioral disorders.
Topics: Adrenal Hyperplasia, Congenital; Brain; Galactosemias; Glycine; Hepatolenticular Degeneration; Heter | 1976 |
[Diseases of newborn infants based on inborn anomalies of metabolism. 1. Theoretical principles].
Topics: Adrenal Hyperplasia, Congenital; Amino Acid Metabolism, Inborn Errors; Amino Acids; Carbohydrate Met | 1970 |
1 trial available for urea and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
A Phase 2, Multicenter Study of Nevanimibe for the Treatment of Congenital Adrenal Hyperplasia.
Topics: 17-alpha-Hydroxyprogesterone; Administration, Oral; Adolescent; Adrenal Cortex; Adrenal Hyperplasia, | 2020 |
3 other studies available for urea and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Invited Commentary: A Phase 2, Multicenter Study of Nevanimibe for the Treatment of Congenital Adrenal Hyperplasia.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Hyperplasia, Congenital; Humans; Urea | 2020 |
Difficulties in the diagnosis of congenital adrenal hyperplasia in early infancy: the 11 beta-hydroxylase defect.
Topics: Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital; Adult; Chromatography, Gel; Creatinine; El | 1983 |
Incorrect folding of steroidogenic acute regulatory protein (StAR) in congenital lipoid adrenal hyperplasia.
Topics: Adrenal Hyperplasia, Congenital; Circular Dichroism; Escherichia coli; Guanidine; Hot Temperature; H | 1998 |