urea and Acute Kidney Failure studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Research Excerpts

Excerpt	Relevance	Reference
"This study investigated the effect and mechanism of rosiglitazone on a rat model with contrast-induced acute kidney injury (CI-AKI)."	9.51	Rosiglitazone Alleviates Contrast-Induced Acute Kidney Injury in Rats via the PPAR ( Chen, E; Huang, J; Wu, J; Zheng, X, 2022)
"The effect of N-acetylcysteine (NAC) to prevent contrast nephropathy (CN) in patients with moderate to severe renal insufficiency undergoing coronary angiography or interventions is not clear."	9.11	Effect of N-acetylcysteine for prevention of contrast nephropathy in patients with moderate to severe renal insufficiency: a randomized trial. ( Chan, AK; Chan, JY; Chan, WW; Fung, JW; Kum, LC; Sanderson, JE; Szeto, CC; Wong, JT; Woo, KS; Wu, EB; Yip, GW; Yu, CM, 2004)
"Ifosfamide is metabolized into chloroacetaldehyde, which can cause acute kidney injury."	8.12	Ifosfamide-induced acute kidney injury in a patient with leiomyosarcoma: A case report. ( Boskabadi, J; Salehifar, E; Yousefi-Mazhin, E, 2022)
"To develop new anti-inflammatory drugs for the prevention and treatment of acute kidney injury, a series of novel glycyrrhetic ureas were designed, synthesized and evaluated for anti-inflammatory activity using RAW264."	8.02	Design and synthesis of novel glycyrrhetin ureas as anti-inflammatory agents for the treatment of acute kidney injury. ( Jiang, X; Shi, T; Tang, W; Wang, H; Wu, C; Yang, YA; Zha, L; Zuo, J, 2021)
" The objective of this study was to evaluate the association of: 1) age, 2) sex, 3) body weight and 4) serum creatinine and urea levels on serum SDMA concentrations."	7.96	Serum symmetric dimethylarginine concentration in healthy horses and horses with acute kidney injury. ( Niedzwiedz, A; Paslawska, U; Siwinska, N; Slowikowska, M; Zak, A, 2020)
" The NAG effect on rats with AKI caused a reduction of the mortality rate, an increase in diuresis, a reduction of proteinuria, an increase in creatinine and urea excretion, which indicates the normalization of the renal excretory function and nitrogen metabolism."	7.91	Nephroprotective effect of N-acetylglucosamine in rats with acute kidney injury. ( Shebeko, SK; Tarasenko, OO; Zupanets, IA, 2019)
"The mechanisms by which landiolol, an ultra-short-acting, selective β-1 blocker, could improve septic acute kidney injury and how inflammation might affect mitochondrial function and cause the renal injury were examined."	7.91	Effects of Landiolol in Lipopolysaccharide-Induced Acute Kidney Injury in Rats and In Vitro. ( Kanmura, Y; Kiyonaga, N; Moriyama, T, 2019)
" Objective of this work was to determine predictive and diagnostic value of urinary malondialdehyde (UMDA) as a marker for acute kidney injury (AKI) in critically sick full-term newborns."	7.88	URINARY MALONDIALDEHYDE AS A PREDICTIVE AND DIAGNOSTIC MARKER FOR NEONATAL ACUTE KIDNEY INJURY. ( Agafonova, L; Babintseva, A; Frunza, A; Hodovanets, Y; Makarova, O, 2018)
"The blood urea nitrogen to creatinine ratio (BCR) has been used since the early 1940s to help clinicians differentiate between prerenal acute kidney injury (PR AKI) and intrinsic AKI (I AKI)."	7.85	Diagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department. ( Bach-Ngohou, K; Batard, E; Manoeuvrier, G; Masson, D; Trewick, D, 2017)
" We investigated the role of hydrogen sulfide (H2S) in PHSML drainage in alleviating acute kidney injury (AKI) by administering D,L-propargylglycine (PPG) and sodium hydrosulfide hydrate (NaHS) to 12 specific pathogen-free male Wistar rats with PHSML drainage."	7.81	Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage alleviates kidney injury in rats. ( Han, B; Li, SG; Niu, CY; Zhang, LM; Zhao, ZG, 2015)
"Short-term administration of Galactosamine to experimental animals causes liver damage and acute liver failure (ALF), as well as acute renal failure in some cases."	7.81	D-Galactosamine Intoxication in Experimental Animals: Is it Only an Experimental Model of Acute Liver Failure? ( Brytan, M; Dyrla, P; Gil, J; Kade, G; Nowak, Z; Patera, J; Saracyn, M; Wańkowicz, Z; Zdanowski, R, 2015)
"To evaluate the performance of fractional excretion of urea (FeU) for differentiating transient (T) from persistent (P) acute kidney injury (AKI) and to assess performance of FeU in predicting AKI in patients admitted to the ICU."	7.80	Transient versus persistent acute kidney injury and the diagnostic performance of fractional excretion of urea in critically ill patients. ( Abu-Hanna, A; Bouman, CS; Hofstra, LS; Kuiper, MA; Royakkers, AA; Schultz, MJ; Spronk, PE; Wlodzimirow, KA, 2014)
"We measured SUN and blood urea nitrogen (BUN) in hospitalized patients diagnosed with AKI based on Acute Kidney Injury Network (AKIN)-criteria."	7.80	Saliva urea nitrogen dipstick - a novel bedside diagnostic tool for acute kidney injury. ( Calice-Silva, V; Callegari, J; Carter, M; Kotanko, P; Levin, NW; Pecoits-Filho, R; Raimann, JG; Vieira, MA, 2014)
"The study evaluates the effect of genistein, a soy isoflavone, on insulin sensitivity and renal functional and structural injury in rats rendered insulin-resistant by feeding on a high-fructose diet for 60 days."	7.74	Effect of genistein, a soy isoflavone, on whole body insulin sensitivity and renal damage induced by a high-fructose diet. ( Anuradha, CV; Palanisamy, N; Viswanathan, P, 2008)
"A 19-year-old woman with no history of renal or hematologic dysfunction developed methemoglobinemia, muscle damage, rhabdomyolysis and severe acute renal failure after an overdose of phenazopyridine hydrochloride (pyridium)."	7.67	Methemoglobinemia, muscle damage and renal failure complicating phenazopyridine overdose. ( Gavish, D; Gottehrer, N; Israeli, A; Kleinman, Y; Knobler, H, 1986)
"Since arginine is a precursor of urea and other guanidino derivatives, we have evaluated its metabolism in acute uremia using the isolated perfused rat liver."	7.65	Effect of acute uremia on arginine metabolism and urea and guanidino acid production by perfused rat liver. ( Owens, B; Perez, GO; Rietberg, B; Schiff, ER, 1977)
"Glycerol was used to induce RM-associated AKI in rats."	5.91	Protective effect of thymol on glycerol-induced acute kidney injury. ( Cheng, F; Liu, X; Qi, G; Wang, Q; Wang, R; Yang, X; Zhou, H, 2023)
"Edaravone was administered for two weeks before the induction of CI-AKI."	5.72	Exploring the effects of edaravone in rats with contrast-induced acute kidney injury. ( Al Tahrawi, AY; Alshogran, OY; Nusair, SD, 2022)
"Diquat is a herbicide that can have deleterious effects on the kidneys, liver, heart, lungs, and central nervous system on ingestion."	5.72	Case series: Diquat poisoning with acute kidney failure, myocardial damage, and rhabdomyolysis. ( Gao, Y; Jian, T; Jian, X; Kan, B; Li, Y; Shi, L; Wang, J; Yu, G; Zhao, L, 2022)
"This study investigated the effect and mechanism of rosiglitazone on a rat model with contrast-induced acute kidney injury (CI-AKI)."	5.51	Rosiglitazone Alleviates Contrast-Induced Acute Kidney Injury in Rats via the PPAR ( Chen, E; Huang, J; Wu, J; Zheng, X, 2022)
"FEUrea is a promising tool for the differential diagnosis of AKI in patients with cirrhosis."	5.48	Fractional excretion of urea: A simple tool for the differential diagnosis of acute kidney injury in cirrhosis. ( Bajaj, JS; Carl, D; Kang, L; Patidar, KR; Sanyal, AJ, 2018)
"Glycerol treatment produced significant renal structural abnormalities and functional impairment (increased urea and creatinine)."	5.46	Protective effect of quinacrine against glycerol-induced acute kidney injury in rats. ( Al Asmari, AK; Al Sadoon, KT; Obaid, AA; Tariq, M; Yesunayagam, D, 2017)
"FeUrea was 39% (28 to 40) in the no-AKI group, 41% (29 to 54) in the transient AKI group and 32% (22 to 51) in the persistent AKI group (P = 0."	5.37	Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study. ( Bernardin, G; Brochard, L; Cohen, Y; Darmon, M; Das, V; Dellamonica, J; Gonzalez, F; Schlemmer, B; Schortgen, F; Vincent, F; Zeni, F, 2011)
"The effect of N-acetylcysteine (NAC) to prevent contrast nephropathy (CN) in patients with moderate to severe renal insufficiency undergoing coronary angiography or interventions is not clear."	5.11	Effect of N-acetylcysteine for prevention of contrast nephropathy in patients with moderate to severe renal insufficiency: a randomized trial. ( Chan, AK; Chan, JY; Chan, WW; Fung, JW; Kum, LC; Sanderson, JE; Szeto, CC; Wong, JT; Woo, KS; Wu, EB; Yip, GW; Yu, CM, 2004)
" Increase of uNGAL in absence of clinical signs or alterations in creatinine, urea, or GFR might suggest that there is metabolic adaptation to endurance exercise, or possibly predisposition to acute kidney injury over time."	4.98	Quantification of NGAL in Urine of Endurance Cycling Athletes. ( Machado, JCQ; Nogueira-Machado, JA; Vasconcellos, LS; Volpe, CMO, 2018)
"The fractional excretion of urea (FEU) is a useful index for differentiating the main categories of causes of acute kidney injury, ie, prerenal causes and intrinsic causes."	4.88	Finding the cause of acute kidney injury: which index of fractional excretion is better? ( Gotfried, J; Nally, JV; Raina, R; Wiesen, J, 2012)
"Ifosfamide is metabolized into chloroacetaldehyde, which can cause acute kidney injury."	4.12	Ifosfamide-induced acute kidney injury in a patient with leiomyosarcoma: A case report. ( Boskabadi, J; Salehifar, E; Yousefi-Mazhin, E, 2022)
"Although paraquat (PQ) induces oxidative damage and inflammatory responses in the lungs, the mechanism underlying PQ-induced acute kidney injury in patients is unclear."	4.12	Immunosuppressive therapies attenuate paraquat-induced renal dysfunction by suppressing inflammatory responses and lipid peroxidation. ( Chang, CW; Fu, JF; Tsai, HR; Yen, HC; Yen, TH, 2022)
" In IRI and cisplatin-induced AKI, GSDMD-deficient mice exhibited hypersensitivity to injury as assessed by tubular damage, elevated markers of serum urea, and serum creatinine."	4.12	Gasdermin D-deficient mice are hypersensitive to acute kidney injury. ( Anders, HJ; Becker, JU; Beer, K; Belavgeni, A; Bornstein, SR; Brucker, A; Gembardt, F; Hoppenz, P; Hugo, C; Kusunoki, Y; Latk, M; Linkermann, A; Locke, S; Maremonti, F; Meyer, C; Shao, F; Tonnus, W; von Mässenhausen, A, 2022)
"To describe the management of dogs with acute kidney injury (AKI) by continuous renal replacement therapy (CRRT), and to investigate the relationship between a prescribed CRRT dose, the hourly urea reduction ratio (URR), and the overall efficacy."	4.12	Continuous renal replacement therapy is a safe and effective modality for the initial management of dogs with acute kidney injury. ( Chen, H; Kelmer, E; Klainbart, S; Segev, G, 2022)
" Biochemical evaluation was carried out by assessment of body weights and by estimating renal function tests (plasma urea, plasma creatinine and plasma uric acid), tissue antioxidant enzymes (catalase, SOD) and MDA level."	4.02	Protective role of salicylic acid in gentamicin induced nephrotoxicity. ( Fatimah, SN; Usman, SM, 2021)
"To develop new anti-inflammatory drugs for the prevention and treatment of acute kidney injury, a series of novel glycyrrhetic ureas were designed, synthesized and evaluated for anti-inflammatory activity using RAW264."	4.02	Design and synthesis of novel glycyrrhetin ureas as anti-inflammatory agents for the treatment of acute kidney injury. ( Jiang, X; Shi, T; Tang, W; Wang, H; Wu, C; Yang, YA; Zha, L; Zuo, J, 2021)
" The objective of this study was to evaluate the association of: 1) age, 2) sex, 3) body weight and 4) serum creatinine and urea levels on serum SDMA concentrations."	3.96	Serum symmetric dimethylarginine concentration in healthy horses and horses with acute kidney injury. ( Niedzwiedz, A; Paslawska, U; Siwinska, N; Slowikowska, M; Zak, A, 2020)
" The NAG effect on rats with AKI caused a reduction of the mortality rate, an increase in diuresis, a reduction of proteinuria, an increase in creatinine and urea excretion, which indicates the normalization of the renal excretory function and nitrogen metabolism."	3.91	Nephroprotective effect of N-acetylglucosamine in rats with acute kidney injury. ( Shebeko, SK; Tarasenko, OO; Zupanets, IA, 2019)
"The mechanisms by which landiolol, an ultra-short-acting, selective β-1 blocker, could improve septic acute kidney injury and how inflammation might affect mitochondrial function and cause the renal injury were examined."	3.91	Effects of Landiolol in Lipopolysaccharide-Induced Acute Kidney Injury in Rats and In Vitro. ( Kanmura, Y; Kiyonaga, N; Moriyama, T, 2019)
"We found that the levels of creatinine, urea, nitric oxide, alanine transaminase, aspartate aminotransferase, creatine kinase in serum samples, malondialdehyde, nitric oxide, inducible nitric oxide synthase, and endothelial nitric oxide synthase concentrations in renal tissue were increased in the myoglobinuric acute kidney injury group compared with the control group (p<0."	3.88	The Effects of Baicalin on Myoglobinuric Acute Renal Failure in Rats. ( Aydoğdu, N; Süt, N; Taştekin, E; Yalçınkaya Yavuz, Ö, 2018)
" Objective of this work was to determine predictive and diagnostic value of urinary malondialdehyde (UMDA) as a marker for acute kidney injury (AKI) in critically sick full-term newborns."	3.88	URINARY MALONDIALDEHYDE AS A PREDICTIVE AND DIAGNOSTIC MARKER FOR NEONATAL ACUTE KIDNEY INJURY. ( Agafonova, L; Babintseva, A; Frunza, A; Hodovanets, Y; Makarova, O, 2018)
"The blood urea nitrogen to creatinine ratio (BCR) has been used since the early 1940s to help clinicians differentiate between prerenal acute kidney injury (PR AKI) and intrinsic AKI (I AKI)."	3.85	Diagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department. ( Bach-Ngohou, K; Batard, E; Manoeuvrier, G; Masson, D; Trewick, D, 2017)
"In case of a ruptured bladder with urine leakage into the peritoneal cavity 'reversed autodialysis' can occur, in which urea and creatinine diffuse back into the bloodstream via the peritoneum."	3.83	[A patient with high creatinine levels but no renal failure: reversed autodialysis in a patient with a ruptured bladder]. ( Brussaard, C; De Mey, J; Raeymaeckers, S; Tosi, M; Van Bael, K, 2016)
"This study investigates the effects of zinc in acute kidney injury induced by gentamicin (Ge)."	3.83	The protective effects of zinc in experimental gentamicin induced acute renal failure in rats. ( Gales, C; Mititelu-Tartau, L; Nechifor, M; Pasca, AS; Saftencu, PM; Schiriac, CE; Teslariu, O, 2016)
"Renal ischemia for 10 minutes was sufficient to raise urine levels of protein, glucose, fractional excretion of potassium, urea, creatinine clearance, urine activity of gamma-glutamyltransferase and alkaline phosphatase enzymes in the first 24 hours, up to five days after reperfusion, which may indicate risk of acute kidney injury, according to the RIFLE classification."	3.81	Renal biomarkers of male and female Wistar rats (Rattus norvegicus) undergoing renal ischemia and reperfusion. ( Bazzano, T; Porfirio, LC; Restel, TI; Silva, IS; Souza, AS, 2015)
" We investigated the role of hydrogen sulfide (H2S) in PHSML drainage in alleviating acute kidney injury (AKI) by administering D,L-propargylglycine (PPG) and sodium hydrosulfide hydrate (NaHS) to 12 specific pathogen-free male Wistar rats with PHSML drainage."	3.81	Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage alleviates kidney injury in rats. ( Han, B; Li, SG; Niu, CY; Zhang, LM; Zhao, ZG, 2015)
"Short-term administration of Galactosamine to experimental animals causes liver damage and acute liver failure (ALF), as well as acute renal failure in some cases."	3.81	D-Galactosamine Intoxication in Experimental Animals: Is it Only an Experimental Model of Acute Liver Failure? ( Brytan, M; Dyrla, P; Gil, J; Kade, G; Nowak, Z; Patera, J; Saracyn, M; Wańkowicz, Z; Zdanowski, R, 2015)
" Serum and urine electrolytes, osmolality, urea nitrogen and creatinine were measured."	3.81	Hypervolemic hypernatremia is the most common type of hypernatremia in the intensive care unit. ( Ing, TS; Pouria, MM; Sam, R; Sarahian, S, 2015)
" The creatinine clearance, serum urea, uric acid, lactate dehydrogenase, potassium, fractional excretion of sodium, and microproteinuria were measured to assess kidney injury."	3.80	Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats. ( Arora, S; Brar, R; Kaur, T; Singh, AP; Singh, JP, 2014)
"To evaluate the performance of fractional excretion of urea (FeU) for differentiating transient (T) from persistent (P) acute kidney injury (AKI) and to assess performance of FeU in predicting AKI in patients admitted to the ICU."	3.80	Transient versus persistent acute kidney injury and the diagnostic performance of fractional excretion of urea in critically ill patients. ( Abu-Hanna, A; Bouman, CS; Hofstra, LS; Kuiper, MA; Royakkers, AA; Schultz, MJ; Spronk, PE; Wlodzimirow, KA, 2014)
" MR images were acquired on two mouse models of kidney injury: adenine-induced chronic kidney disease (CKD) and rhabdomyolysis-induced acute kidney injury (AKI)."	3.80	Assessment with unenhanced MRI techniques of renal morphology and hemodynamic changes during acute kidney injury and chronic kidney disease in mice. ( Abramovitch, R; Axelrod, JH; Heyman, SN; Milman, Z; Nachmansson, N, 2014)
" Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient's serums."	3.80	Oxidative status parameters in children with urinary tract infection. ( Bogavac-Stanojevic, N; Ivanisevic, I; Ivanisevic, J; Jelic-Ivanovic, Z; Kotur-Stevuljevic, J; Paripovic, D; Peco-Antic, A; Petrovic, S, 2014)
"Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e."	3.80	Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. ( Araújo, RC; Bacurau, RF; Câmara, NO; Estrela, GR; Malheiros, DM; Wasinski, F, 2014)
" Body weight, daily fluid and feed intakes, and serum levels of creatinine, urea, and electrolytes were monitored on a weekly basis, and renal histology was evaluated at the end of the study."	3.80	Costus afer ker gawl leaves against gentamicin-induced nephrotoxicity in rats. ( Ezejiofor, AN; Orisakwe, OE; Orish, CN, 2014)
"We measured SUN and blood urea nitrogen (BUN) in hospitalized patients diagnosed with AKI based on Acute Kidney Injury Network (AKIN)-criteria."	3.80	Saliva urea nitrogen dipstick - a novel bedside diagnostic tool for acute kidney injury. ( Calice-Silva, V; Callegari, J; Carter, M; Kotanko, P; Levin, NW; Pecoits-Filho, R; Raimann, JG; Vieira, MA, 2014)
"To evaluate the Kt assessed through ionic dializance (KtOCM) in UCI patients undergoing renal replacement therapy for acute kidney injury, comparing the results with those obtained through the urea removal rate method determined by dialyzate collection (Kturea)."	3.76	[Measuring Kt by ionic dialysance is a useful tool for assessing dialysis dose in critical patients]. ( Algranati, S; Bevione, P; Bonfanti, W; Bratti, G; Crucelegui, MS; Giannasi, S; Greloni, G; Heguilen, R; Rosa Díez, GJ; San Román, E; Varela, F, 2010)
" Univariate analysis documented age, ASA score, diabetes mellitus, chronic hypertension, the use of diuretics and NSAID, anemia, and an increased value of plasma urea as risk factors."	3.75	[Risk factors for renal dysfunction after total hip arthroplasty]. ( Aveline, C; Bonnet, F; Cognet, F; Le Hetet, H; Leroux, A; Vautier, P, 2009)
"The study evaluates the effect of genistein, a soy isoflavone, on insulin sensitivity and renal functional and structural injury in rats rendered insulin-resistant by feeding on a high-fructose diet for 60 days."	3.74	Effect of genistein, a soy isoflavone, on whole body insulin sensitivity and renal damage induced by a high-fructose diet. ( Anuradha, CV; Palanisamy, N; Viswanathan, P, 2008)
" Renal function and integrity were evaluated using serum urea and creatinine, serum electrolytes (sodium and potassium), fractional clearance of sodium (FcNa) and potassium (FcK), urine enzyme activity of gamma-glutamyl transpeptidase and alkaline phosphatase, urine protein:creatinine ratio, and urinalysis."	3.71	Renal involvement in dogs with babesiosis. ( Jacobson, LS; Lobetti, RG, 2001)
"During the initial phase of ARF in the course of rhabdomyolysis dynamic increases in serum urea and creatinine were observed, as well as a tendency to hyperkalemia."	3.71	Acute renal failure in patients with rhabdomyolysis. ( Kraśniak, A; Lonak, H; Miłkowski, A; Ochmański, W; Sułowicz, W; Sydor, A; Szumilak, D; Szymczakiewicz-Multanowska, A; Walatek, B; Wójcikiewicz, T, 2002)
" FA produced necrosis of the epithelial cells of the convoluted tubules as the detection of the beta-aminoisobutyric acid end product of DNA and thymine catabolism indicated."	3.70	DNA degradation in the kidney of folic acid-treated guinea pigs. ( Gourgiotis, D; Kavazarakis, E; Messaritaki, A; Moustaki, M; Nakopoulou, L; Nicolaidou, P; Tzaki, M; Zeis, MP; Zeis, PM, 2000)
" The animals were monitored daily for body weight, s-creatinine, s-urea and B-glucose."	3.70	High dosage growth hormone treatment and post-ischemic acute renal failure in the rat. ( Bengtsson, BA; Matejka, GL, 1998)
" By week 6, there was no difference in renal function, as assessed by animal survival, BUN, urea and inulin clearances, proteinuria, renal morphometry, or renal size, between EGF- and vehicle-treated rats."	3.68	Effect of epidermal growth factor in the rat 5/6 renal ablation model. ( Gillespie, KN; Lane, PH; Moskowitz, DW; Schmitz, PG; Schneider, AN, 1992)
" Glomerular damage caused by puromycin aminonucleoside did not induce aminoaciduria until marked proteinuria occurred (day 9), and even then amino acid excretion was much less than that caused by gentamicin."	3.68	Aminoaciduria is an earlier index of renal tubular damage than conventional renal disease markers in the gentamicin-rat model of acute renal failure. ( Goldberg, DM; Macpherson, NA; Moscarello, MA, 1991)
"Mannitol administered after renal ischemia ameliorates both functional and morphologic aspects of acute tubular injury despite dramatically increasing tubular aerobic work."	3.67	Effects of mannitol on the postischemic kidney. Biochemical, functional, and morphologic assessments. ( Mahan, J; Merola, AJ; Zager, RA, 1985)
"A 19-year-old woman with no history of renal or hematologic dysfunction developed methemoglobinemia, muscle damage, rhabdomyolysis and severe acute renal failure after an overdose of phenazopyridine hydrochloride (pyridium)."	3.67	Methemoglobinemia, muscle damage and renal failure complicating phenazopyridine overdose. ( Gavish, D; Gottehrer, N; Israeli, A; Kleinman, Y; Knobler, H, 1986)
" The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin."	3.66	Cefoxitin-associated renal failure. ( Bailey, RR; Reddy, J, 1981)
"The ability of large doses of exogenous angiotensin II to cause widespread multifocal microscopic myocardial necrosis in the rabbit has been confirmed."	3.65	Angiotensin- and norepinephrine-induced myocardial lesions: experimental and clinical studies in rabbits and man. ( Brown, JJ; Gavras, H; Gray, B; Kremer, D; Lever, AF; MacAdam, RF; medina, A; Morton, JJ; Robertson, JI, 1975)
"Since arginine is a precursor of urea and other guanidino derivatives, we have evaluated its metabolism in acute uremia using the isolated perfused rat liver."	3.65	Effect of acute uremia on arginine metabolism and urea and guanidino acid production by perfused rat liver. ( Owens, B; Perez, GO; Rietberg, B; Schiff, ER, 1977)
"8 patients suffering from acute renal failure (shock kidney) with anuria extending over 3 to 5 days, were treated with L-thyroxine for 5 to 9 days (5-6 mug per kg body weight per day orally)."	3.65	[Thyroxine treatment in acute renal failure (author's transl)]. ( Straub, E, 1975)
"High doses of colistin were used in the treatment of severely ill patients with refractory klebsiella chest and urinary tract infections."	3.65	Effects of large doses of colistin sulphomethate sodium on renal function. ( Graham, DI; Price, DJ, 1970)
"Seventeen patients with acute renal failure (ARF) were treated with separated continuous veno venous hemofiltration (CVVH) system conducted with the pre-dilution mode."	2.72	Efficacy of cellulose triacetate dialyzer and polysulfone synthetic hemofilter for continuous venovenous hemofiltration in acute renal failure. ( Eiam-ong, S; Leelahavanichkul, A; Pichaiwong, W, 2006)
"ICU patients with acute renal failure requiring continuous renal replacement therapy, without cirrhosis, severe coagulopathy, or known sensitivity to heparin."	2.71	Citrate vs. heparin for anticoagulation in continuous venovenous hemofiltration: a prospective randomized study. ( Berghmans, D; Canivet, JL; Damas, P; Dubois, B; Ledoux, D; Monchi, M, 2004)
"Ten pharmacokinetic profiles were measured."	2.70	Pharmacokinetics of ciprofloxacin in ICU patients on continuous veno-venous haemodiafiltration. ( Daley, PJ; Lipman, J; Mullany, DV; Rickard, CM; Wallis, SC, 2001)
"Survived days free of acute renal failure treatment were fewer for the IHDF (4."	2.70	Intermittent hemodiafiltration in acute renal failure in critically ill patients. ( Pettilä, V; Tiula, E, 2001)
" In summary, while the impact of delivered intermittent hemodialysis on the survival of patients with ARF remains to be determined, these results indicate that dialysis delivery is suboptimal in ARF, and empiric dosing should strongly consider factors related to lean body mass, including age and gender."	2.70	Correlates of urea kinetic modeling during hemodialysis in patients with acute renal failure. ( Balakrishnan, VS; Cendoroglo, M; Cunniff-Jaber, PJ; Jaber, BL; King, AJ; Pereira, BJ; Ruthazer, R, 2002)
"Urea clearance was determined at commencement of dialysis and then at 12 hour intervals up to 48 hours post commencement."	2.68	Comparative clearance performance of two dialyser units used in the CVVHD mode. ( Boyle, M; Jacobs, S; Torda, TA; Wyndham, K, 1995)
"Vancomycin clearance was appreciably greater with hemofiltration, which is consistent with a greater potential for convection-based therapy in the removal of uremic and other middle molecules."	2.67	A comparison of molecular clearance rates during continuous hemofiltration and hemodialysis with a novel volumetric continuous renal replacement system. ( Davison, AM; Goutcher, E; Jeffrey, RF; Khan, AA; Prabhu, P; Todd, N; Will, EJ, 1994)
"The furosemide dose was 20-60 mg."	2.64	The effect of prophylactic use of furosemide on renal function during open heart surgery. ( Hollmén, A; Nuutinen, L, 1976)
"We propose an adaptation of a maintenance dialysis parameter (standard Kt/V) as a benchmark to supplement effluent-based dosing of CRRT."	2.55	Quantification and Dosing of Renal Replacement Therapy in Acute Kidney Injury: A Reappraisal. ( Clark, WR; Leblanc, M; Ricci, Z; Ronco, C, 2017)
"The main pathomechanism of acute renal failure (ARF) is acute tubular necrosis (ATN) due to reduced perfusion of renal cortex resulting in ischemic injury."	2.44	[Acute renal failure: pathophysiology and clinical management]. ( Beige, J; Kreutz, R; Rothermund, L, 2007)
"There is no consensus definition of acute renal failure (ARF) in critically ill patients."	2.42	Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. ( Bellomo, R; Kellum, JA; Mehta, RL; Palevsky, P; Ronco, C, 2004)
"In the setting of acute renal failure, dialysis adequacy has been measured using both single-pool and double-pool urea kinetics, as well as blood-based and dialysate-based urea kinetic modeling."	2.40	Dialysis adequacy in patients with acute renal failure. ( Friedman, AN; Jaber, BL, 1999)
"Glycerol was used to induce RM-associated AKI in rats."	1.91	Protective effect of thymol on glycerol-induced acute kidney injury. ( Cheng, F; Liu, X; Qi, G; Wang, Q; Wang, R; Yang, X; Zhou, H, 2023)
"We report a case of bilateral ureteric calculi in an infant with diarrhoea disease and dehydration."	1.91	OBSTRUCTIVE UROPATHY FROM BILATERAL URETERIC CALCULI IN AN INFANT WITH DIARRHOEA DISEASE. ( Aliu, R; Asabe, I; Bello, A; Jalo, I; Olatoke, L, 2023)
"Acute liver failure was present in 4 (25%) and acute-on-chronic liver failure in 8 (75%)."	1.72	Ammonia Clearance with Different Continuous Renal Replacement Therapy Techniques in Patients with Liver Failure. ( Baldwin, I; Bellomo, R; Fealy, N; Fisher, C; Naorungroj, T, 2022)
" CP was given once intraperitoneally (10 mg/kg,) eliciting acute kidney injury as assured by several adverse histological changes; glomerulopathy, tubulopathy, and vasculopathy, an inflammatory response including elevated TNF-α, IL-6, and IL-1β."	1.72	TGF-β1, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: Comparative modulating role of Melatonin, Vit. E and Ozone. ( Abd El-Emam, MM; Abdel-Rahman Mohamed, A; Bin Emran, T; El-Shetry, ES; Khater, SI; Metwally, MMM; Mostafa-Hedeab, G; Nassan, MA, 2022)
"Edaravone was administered for two weeks before the induction of CI-AKI."	1.72	Exploring the effects of edaravone in rats with contrast-induced acute kidney injury. ( Al Tahrawi, AY; Alshogran, OY; Nusair, SD, 2022)
"Diquat is a herbicide that can have deleterious effects on the kidneys, liver, heart, lungs, and central nervous system on ingestion."	1.72	Case series: Diquat poisoning with acute kidney failure, myocardial damage, and rhabdomyolysis. ( Gao, Y; Jian, T; Jian, X; Kan, B; Li, Y; Shi, L; Wang, J; Yu, G; Zhao, L, 2022)
"One of the systemic complications of acute pancreatitis (AP) is acute kidney injury (AKI)."	1.72	The role of biomarkers in the early diagnosis of acute kidney injury associated with acute pancreatitis: Evidence from 582 cases. ( Tercan, M; Uğurlu, ET, 2022)
"Gentamicin (GM) is an aminoglycoside antibiotic effectively used for severe/life-threatening infections."	1.62	Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity. ( Ali, FEM; El-Bahrawy, AH; Hassanein, EHM; Omar, ZMM; Sayed, AM, 2021)
"The percentage of patients with acute renal failure (ARF) was compared in both groups."	1.62	Renal Involvement in Mediterranean Spotted Fever: Clinical and Histopathological Data. ( Baltadjiev, A; Baltadzhiev, I; Zaprianov, Z, 2021)
"Urea and fluoride were measured in the inflow, outflow and effluent lines to compare sieving coefficients (SC), saturation coefficients (SA) and transmembrane Cls."	1.56	Use of Fluoride as a Marker Solute to Quantify the Current Effective Delivered Dose in Continuous Renal Replacement Therapy: An "in vitro" Study. ( Adembri, C; Angeli, E; Bocciero, V; De Gaudio, AR; Di Filippo, A; Falsini, S; Neri, M; Pomarè Montin, D; Romagnoli, S; Villa, G, 2020)
"(1) Background: Successful treatment of acute kidney injury (AKI)-induced chronic kidney disease (CKD) is unresolved."	1.56	Post-Ischemic Renal Fibrosis Progression Is Halted by Delayed Contralateral Nephrectomy: The Involvement of Macrophage Activation. ( Bukosza, EN; Fintha, A; Hamar, P; Kaucsár, T; Krenács, T; Róka, B; Szénási, G; Tod, P, 2020)
"In male rats, acute renal failure was simulated by clamping the vascular pedicle of the left kidney for 60 or 90 min and right-sided nephrectomy."	1.56	Stimulation of Structural and Functional Recovery of the Kidney in Rats with Postischemic Acute Renal Failure of Different Severity by Embryonic Protein-Peptide Complex Therapy. ( Drozhzheva, VV; Efremov, GD; Golovanov, SA; Kirpatovskii, VI; Samoilova, SI; Sivkov, AV, 2020)
"FEUrea is a promising tool for the differential diagnosis of AKI in patients with cirrhosis."	1.48	Fractional excretion of urea: A simple tool for the differential diagnosis of acute kidney injury in cirrhosis. ( Bajaj, JS; Carl, D; Kang, L; Patidar, KR; Sanyal, AJ, 2018)
"ICU patients admitted with influenza infection without bacterial co-infection."	1.48	Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection. ( Barahona, D; Bodí, M; Díaz, E; Guardiola, J; Martín-Loeches, I; Monclou, J; Restrepo, MI; Reyes, LF; Rodríguez, A; Sirgo, G; Solé-Violán, J; Suberviola, B, 2018)
"We studied 25 patients with sepsis and acute renal failure who were treated with continuous renal-replacement therapy."	1.48	Effect of continuous renal-replacement therapy on paraoxonase-1-related variables in patients with acute renal failure caused by septic shock. ( Cabré, N; Camps, J; Cueto, P; Fort-Gallifa, I; Garcia, E; García-Heredia, A; Garrido, P; Hernández-Aguilera, A; Joven, J; Luciano-Mateo, F; Rovira, C; Vallverdú, I, 2018)
"Glycerol treatment produced significant renal structural abnormalities and functional impairment (increased urea and creatinine)."	1.46	Protective effect of quinacrine against glycerol-induced acute kidney injury in rats. ( Al Asmari, AK; Al Sadoon, KT; Obaid, AA; Tariq, M; Yesunayagam, D, 2017)
" Histopathological and biochemical alterations of post-UN dosing in comparison to control were evaluated."	1.43	Biochemical and histopathological responses of the Swiss albino mice treated with uranyl nitrate and its recovery. ( Arun, AB; Dinesh, U; Rekha, PD; Sangeetha Vijayan, P, 2016)
" Cardiotrophin-1 (CT-1), a member of the IL-6 family of cytokines, has been reported to protect the kidney against toxic and ischemic acute kidney injury (AKI)."	1.43	Cardiotrophin-1 therapy prevents gentamicin-induced nephrotoxicity in rats. ( Blanco-Gozalo, V; López-Hernandez, FJ; López-Novoa, JM; Perez de Obanos, MP; Quirós, Y; Ruiz, J; Sanchez-Gallego, JI, 2016)
" The study concludes that the extract of Alchornea cordifolia leaves has toxic potential at 800 mg kg(-1) and 1600 mg kg(-1) doses, but is safe and has beneficial effects on male reproduction when used at doses equal to or lower than 400 mg kg(-1) ."	1.42	Reproductive and toxic effects of methanol extract of Alchornea cordifolia leaf in male rats. ( Ajibade, TO; Olayemi, FO, 2015)
"Varenicline is a new most effective drug for smoking cessation."	1.42	Nephrotoxic effects of varenicline as the most effective drug used for smoking cessation: a preliminary experimental study. ( Erken, HA; Genç, O; Güçlü, A; Koç, A; Koçak, FE; Önder, GÖ; Sari, E; Şimşek, H; Yay, A, 2015)
"ESRD was declared in 48."	1.42	Predictors and Outcomes of Post-Hospitalization Dialysis Dependent Acute Kidney Injury. ( Abdel-Rahman, EM; Balogun, RA; Brooks, CH; Gautam, SC; Ma, JZ; Xin, W, 2015)
"Chloroquine was administered in doses of 0."	1.40	Acute pretreatment with chloroquine attenuates renal I/R injury in rats. ( Basta-Jovanovic, G; Medic, B; Prostran, M; Radojevic Skodric, S; Rovcanin, B; Stojanovic, R; Todorovic, Z, 2014)
"MSCs ameliorated I/R-induced acute renal failure in rats with similar efficiency whether infused either through the TV or the RA."	1.39	Efficiency of endovenous versus arterial administration of mesenchymal stem cells for ischemia-reperfusion-induced renal dysfunction in rats. ( Fu, Y; Liao, L; Tan, J; Wu, W; Xu, T; Yang, S; Zhuo, W, 2013)
"carota root extract on renal ischemia reperfusion injury in rats."	1.39	Comparison of protective and curative potential of Daucus carota root extract on renal ischemia reperfusion injury in rats. ( Afzal, M; Ahmad, A; Anwar, F; Kaur, R; Kazmi, I; Pravez, M, 2013)
"In conclusion, acute renal failure promotes gastric acid hypersecretion that could potentially be attributed to high levels of gastrin hormone and uremic state per se."	1.39	Gastric acid secretion in experimental acute uremia. ( Ahmed, MA; Ali, RH; Wakim, SA, 2013)
"Sepsis is the most common trigger for acute kidney injury (AKI) in critically ill patients."	1.38	A prospective evaluation of urine microscopy in septic and non-septic acute kidney injury. ( Bagshaw, SM; Bellomo, R; Bennett, M; Devarajan, P; Haase, M; Haase-Fielitz, A, 2012)
"Through gavage, the rats in acute kidney failure and omega-3 groups received 4 mL normal saline or omega-3 fatty acid (0."	1.38	Oral omega-3 fatty acid for reduction of kidney dysfunction induced by reperfusion injury in rats. ( Ashtiyani, SC; Jamebozorky, L; Kabirinia, K; Najafi, H; Vahedi, E, 2012)
" xanthocarpum fruit extract acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GM both in the biochemical and histopathological parameters and thus validates its ethnomedicinal use."	1.38	Nephroprotective activity of Solanum xanthocarpum fruit extract against gentamicin-induced nephrotoxicity and renal dysfunction in experimental rodents. ( Eswaran, B; Gupta, RK; Hussain, T; Rao, CV; Sweety, K; Vijayakumar, M, 2012)
" Dosing of diuretics is difficult in these patients."	1.37	Management of diuretic treatment: a challenge in the obese patient. ( Jespersen, B; Lassen, CK, 2011)
"Renal reperfusion injury is associated with increased mortality and morbidity due to acute kidney failure."	1.37	Preventive effect of garlic juice on renal reperfusion injury. ( Bagheri, F; Dabiri, S; Gol, A; Javadi, A, 2011)
"FeUrea was 39% (28 to 40) in the no-AKI group, 41% (29 to 54) in the transient AKI group and 32% (22 to 51) in the persistent AKI group (P = 0."	1.37	Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study. ( Bernardin, G; Brochard, L; Cohen, Y; Darmon, M; Das, V; Dellamonica, J; Gonzalez, F; Schlemmer, B; Schortgen, F; Vincent, F; Zeni, F, 2011)
"Also, acute renal failure (ARF) is associated with increased mortality, related to pulmonary complications."	1.36	Diesel exhaust particles in the lung aggravate experimental acute renal failure. ( Al Husseni, I; Al-Salam, S; Ali, BH; Nemmar, A; Yasin, J; Zia, S, 2010)
"Furosemide has no effect on both FENa and FE UN."	1.36	The fractional excretion of urea in the differential diagnosis of prerenal failure and acute tubular necrosis in neonates. ( Jungthirapanich, J; Khositseth, S; Srithipsukho, P; Techasatid, W, 2010)
"The effect of experimentally induced acute renal failure (ARF) on neuronal cell activation was investigated by immunohistochemistry for Fos and Fra-2 in the rat brain."	1.35	Neuronal activation in the CNS during different forms of acute renal failure in rats. ( Bahner, U; Boor, P; Gallatz, K; Heidland, A; Klassen, A; Palkovits, M; Sebekova, K, 2009)
"In this study we postulated that during acute renal failure induced by gentamicin the transient or dynamic response of blood vessels could be affected, and that antioxidants can prevent the changes in dynamic responses of blood vessels."	1.35	Dynamic response of blood vessel in acute renal failure. ( Obradovic, Z; Pantovic, S; Rankovic, G; Rosic, G; Rosic, M; Stojiljkovic, N, 2009)
"Blood-side dosing methods may overestimate urea removal in comparison to dialysate-side measurements during intermittent HD (IHD) for acute renal failure (ARF)."	1.35	Dosing intermittent haemodialysis in the intensive care unit patient with acute renal failure--estimation of urea removal and evidence for the regional blood flow model. ( Daugirdas, JT; Depner, TA; Greene, T; Kanagasundaram, NS; Larive, AB; Paganini, EP, 2008)
" (2) 12- to 24 h NHT improved bioavailability of NO in cortices/medullae of kidneys recuperating from haemorrhagic shock."	1.35	Application of normobaric hyperoxia therapy for amelioration of haemorrhagic shock-induced acute renal failure. ( Averbukh, Z; Ben Aharon, G; Berman, S; Efrati, S; Siman-Tov, Y; Weissgarten, J, 2008)
"The negative impact of acute renal failure on mortality has been demonstrated in recent studies."	1.35	[Acute renal failure - how and when to treat?]. ( Hasper, D, 2008)
"Thirty-one patients with multiple organ dysfunction syndrome and acute renal failure requiring intermittent hemodialysis were included."	1.34	Ionic dialysance: a new valid parameter for quantification of dialysis efficiency in acute renal failure? ( Anguel, N; Mercadal, L; Osman, D; Petitclerc, T; Richard, C; Ridel, C; Vinsonneau, C, 2007)
"Acute and chronic kidney failure lead to catabolism with loss of lean body mass."	1.34	Opposite effects on regulation of urea synthesis by early and late uraemia in rats. ( Grøfte, T; Grønbaek, H; Nielsen, SS; Tygstrup, N; Vilstrup, H, 2007)
"Renal ischemia-reperfusion injury affects the long-term outcome of renal graft survival."	1.34	Protective effects of peroxisome proliferator-activated receptor gamma ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injury. ( Arakawa, T; Doi, S; Kawai, T; Kohno, N; Masaki, T; Naito, T; Nakashima, A; Takahashi, S; Yorioka, N, 2007)
"Twenty patients with acute renal failure on mechanical ventilation were treated, four for eight hours, four for 24 hours and 12 as long they needed continuous renal replacement therapy (9."	1.34	Continuous venovenous haemofiltration using a citrate buffered substitution fluid. ( Grabensee, B; Hennersdorf, M; Hetzel, GR; Plum, J; Schmitz, M; Sucker, C; Taskaya, G, 2007)
"For testing this hypothesis ischemic acute renal failure was induced in rats by 40 min of clamping of the left renal artery after right-sided nephrectomy."	1.33	Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. ( Amann, K; Arend, M; Bernhardt, WM; Câmpean, V; Eckardt, KU; Günzler, V; Jürgensen, JS; Kany, S; Klaus, S; Warnecke, C; Weidemann, A; Wiesener, MS; Willam, C, 2006)
"6-Gingerol treatment significantly and dose-dependently restored renal functions, reduced lipid peroxidation and enhanced the levels of reduced glutathione and activities of superoxide dismutase and catalase."	1.33	6-Gingerol prevents cisplatin-induced acute renal failure in rats. ( Chopra, K; Kuhad, A; Pilkhwal, S; Tirkey, N, 2006)
"Pretreatment by quercetin suppressed the arginase activity in the liver (p < 0."	1.32	Role of quercetin on hepatic urea production in acute renal failure. ( Cvetković, T; Nikolić, J; Sokolović, D, 2003)
"95 patients presented acute renal failure with a mortality rate of 57."	1.32	[Isolated acute renal failure is not associated to an increase in mortality of patients in intensive care units]. ( Ben Ammar, MS; Frikha, N; Mebazaa, M; Miraoui, W, 2004)
"Critically ill patients with acute renal failure (ARF) treated with CVVHDF (n = 49) or CVVH (n = 50)."	1.31	Continuous renal replacement therapy: does technique influence azotemic control? ( Bellomo, R; Morimatsu, H; Ronco, C; Uchino, S, 2002)
"The pathogenesis of acute renal failure may involve, among other causes, ischemia, vascular congestion, arachidonic acid pathways, and reactive oxygen metabolites."	1.31	Effect of vitamin E and pentoxifylline on glycerol-induced acute renal failure. ( Akpolat, I; Akpolat, T; Bedir, A; Coşar, AM; Kandemir, B; Oztürk, H; Sarikaya, S, 2000)
"In the treatment of acute renal failure in patients with multiple organ dysfunction syndrome (MODS), continuous renal replacement therapies (CRRT) are increasingly used because of excellent volume control in the presence of improved cardiovascular stability."	1.31	Extended daily veno-venous high-flux haemodialysis in patients with acute renal failure and multiple organ dysfunction syndrome using a single path batch dialysis system. ( Brunkhorst, R; Floege, J; Kliem, V; Koch, KM; Lonnemann, G, 2000)
"Acute kidney insufficiency is exact defined organ insufficiency."	1.31	[Acute renal failure in severe forms of peritonitis]. ( Stoĭkov, D, 2001)
"Critically ill patients with acute renal failure are traditionally treated with low-protein diets to help control uremia."	1.30	A prospective comparative study of moderate versus high protein intake for critically ill patients with acute renal failure. ( Bellomo, R; Boyce, N; Daskalakis, M; Farmer, M; Parkin, G; Seacombe, J; Wright, C, 1997)
"Gentamicin was given i."	1.30	Kidney ectopeptidases in gentamicin and mercuric chloride-induced acute renal failure. ( Ilić, S; Mitić-Zlatković, M; Savić, V; Stefanović, V; Vlahović, P, 1998)
"Recent studies in patients with acute renal failure (ARF) have shown a relationship between the delivered dose of dialysis and patient survival."	1.30	Measurement of the delivery of dialysis in acute renal failure. ( Evanson, JA; Hakim, RM; Himmelfarb, J; Ikizler, TA; Knights, S; Schulman, G; Shyr, Y; Wingard, R, 1999)
"Acute renal failure was induced in rat with a hypertonic glycerol solution and endothelin-1 (ET-1) binding was measured in kidney membrane preparations."	1.29	Upregulation of renal endothelin receptors in glycerol-induced acute renal failure in the rat. ( Braquet, P; Chabrier, PE; Cornet, S; Guilmard, C; Pirotzky, E; Plas, P; Roubert, P, 1993)
"BW B70C treatment did not improve the long-term viability of transplanted kidneys: 2/6 rabbits showed no symptoms of renal failure after 3 weeks."	1.29	Inhibition of leukotriene B4 synthesis does not prevent development of acute renal failure following storage and transplantation. ( Fuller, BJ; Green, CJ; Lane, NJ; Manek, S; Thorniley, MS, 1994)
"24 patients with stable chronic renal failure (CRF), matched for degree of renal impairment, were also studied."	1.29	Differentiation of acute from chronic renal impairment by detection of carbamylated haemoglobin. ( Astley, JP; Davenport, A; Goel, S; Hartog, M; Jones, SR, 1993)
"Acute renal failure was produced in male Sprague-Dawley rats by clamping both renal arteries for 45 min."	1.29	Effects of insulin-like growth factor-I peptides in rats with acute renal failure. ( Ballard, FJ; Gillespie, CM; Martin, AA; Moore, L; Read, LC, 1994)
" Maternal toxicity and developmental toxicity should not be etiologically linked solely because of their concurrent appearance on the dose-response curve."	1.29	Fetal development in the rat following disruption of maternal renal function during pregnancy. ( Gray, JA; Kavlock, RJ; Logsdon, T, 1993)
"The pregnancy was managed by the 32-nd week and then cesarean section was performed because of increasing levels of creatinine and urea in the serum and enlargement of hydronephrosis."	1.29	[Pregnancy and labor in a pregnant woman with nephrocalcinosis complicated by renal failure]. ( Cyrkowicz, A; Dwornik, D; Kosarzycki, J; Przybycień, J; Rytwińska, E, 1996)
"Prediction of outcome of acute renal failure (ARF), particularly in patients with multisystem organ failure (MSOF), is a very important issue and a very difficult task."	1.29	Acute renal failure in polytraumatized patients: prediction of outcome. ( Djukanović, L; Ostrić, V; Radović, M; Stanojevic, P, 1996)
"We studied 38 patients with acute renal failure (ARF) due to malaria over a 5-year period between 1990 and 1994 at the Institute of Urology and Transplantation."	1.29	Predictors of outcome in malarial renal failure. ( Abbas, K; Ahmad, E; Akhtar, F; Naqvi, A; Naqvi, R; Rizvi, A; Yazdani, I, 1996)
"Cisplatin-induced acute renal failure has been associated with morphological and functional alterations in renal cortex mitochondrial (RCM)."	1.29	Renal insufficiency induced by cisplatin in rats is ameliorated by cyclosporin A. ( al-Nasser, IA; Campbell, PI, 1996)
"Treatment of glycerol-injected rats with 0."	1.28	Further characterization of the protective effect of 8-cyclopentyl-1,3-dipropylxanthine on glycerol-induced acute renal failure in the rat. ( Bowmer, CJ; Collis, MG; Munsey, TS; Panjehshahin, MR; Yates, MS, 1992)
"A study of the effect of acute renal failure (ARF) on the growth of the skeletal units of the mandible was performed."	1.28	Growth of the skeletal units of the rat mandible in acute renal failure experimental model. ( Arrizurieta, E; Frid, A; Giglio, MJ; Leal, T; Sanz, A, 1992)
"Ten anuric acute renal failure patients in the intensive care unit were studied."	1.28	Solute clearances with high dialysate flow rates and glucose absorption from the dialysate in continuous arteriovenous hemodialysis. ( Bonnardeaux, A; Cardinal, J; Geadah, D; Habel, F; Ouimet, D; Pichette, V, 1992)
"Acute renal failure was induced by uranyl acetate in 32 rats, divided into 4 groups, each consisted of 8 rats."	1.28	[The effect of thyroxine on renal function in experimental acute renal insufficiency]. ( Bogićević, M; Ilić, S; Savić, V; Stefanović, V; Vlahović, P, 1990)
" Additional nutritional factors may play a crucial role in achieving the amelioration of this model of toxic nephropathy."	1.28	The effect of oral calcium load or verapamil on gentamicin-induced nephrotoxicity. ( Aladjem, M; Bogin, E; Tamir, A, 1989)
"The empirical dialysis therapy of acute renal failure should be replaced by modern scientific methods of treatment."	1.28	[Optimizing dialysis treatment in acute renal failure]. ( Lopot, F; Válek, A, 1989)
"SHR with acute renal failure had significantly lower mean arterial blood pressures and heart rates."	1.27	Cardiovascular responses in spontaneously hypertensive rats with acute renal failure. ( Bowmer, CJ; Brown, GM; Yates, MS, 1984)
"The effect of acute renal failure (ARF) on the metabolism and covalent binding to plasma proteins (PP) of [14C]captopril [( 14C]CP) was investigated in the Wistar rat in vivo and in vitro using human and rat plasma."	1.27	Drug-protein conjugates--IV. The effect of acute renal failure on the disposition of [14C]captopril in the rat. ( Breckenridge, AM; Park, BK; Yeung, JH, 1983)
" In the electron microscope mitochondrial swelling was seen 1 and 2 h after dosing in the S1 and S2 segments of the proximal tubule, whereas by 4 and 8 h the major pathological changes were confined to the lower S2 and S3 segments and consisted of mitochondrial swelling and cellular necrosis."	1.27	Hexachloro-1:3-butadiene-induced renal tubular necrosis in the mouse. ( Ishmael, J; Lock, EA; Pratt, I, 1984)
"Hydrochlorothiazide treatment compared with vehicle treatment did not ameliorate any index of renal function but resulted in significant elevations in plasma urea and creatinine levels."	1.27	Effect of 8-phenyltheophylline, enprofylline and hydrochlorothiazide on glycerol-induced acute renal failure in the rat. ( Bowmer, CJ; Collis, MG; Kellett, R; Yates, MS, 1987)
"Three patient groups compensated acute renal failure and previous surgery were evaluated, who had been nourished isocaloric (1700 kcal) and practically isonitrogen (33-35 g amino acid), but of various mixtures of amino acids."	1.27	[Amino acid administration in acute, compensated renal failure in the post-traumatic phase]. ( Bock, E, 1986)
"In three premature infants with acute renal failure of different etiology (two newborns with severe Rh-erythroblastosis, 1 premature infant with hypoproteinemia) 13 single-needle hemofiltrations and 6 single-needle plasmaphereses were performed with double head pump, special tube systems, and small modules."	1.27	Hemofiltration and plasmapheresis in premature infants and newborns. ( Bambauer, R; Jesberger, HJ; Jutzler, GA; Limbach, HG; Philippi, H; Pieroth, W; Richter, J; Sitzmann, FC, 1988)
"glycerol was significantly greater in rats dosed i."	1.27	Effect of the adenosine antagonist 8-phenyltheophylline on glycerol-induced acute renal failure in the rat. ( Bowmer, CJ; Collis, MG; Yates, MS, 1986)
"Functional acute renal failure (ARF) was induced within 24 h following i."	1.27	Endotoxin-induced acute renal failure in mice. Effects of indomethacin and the thromboxane-synthetase antagonist UK 38.485. ( Hirschberg, R; Höfer, W; Schaefer, K, 1985)
"In the oliguric phase of acute renal failure, before and 4 hours after haemodialysis a direct dependence was found between fraction 5 and serum urea."	1.26	Middle molecular substances in acute renal failure. ( Derzsiová, K; Dzúrik, R; Mydlík, M; Spustová, V, 1982)
"In the group with the mixed form of hepatic coma creatinine clearance was pathological in 3 cases, in 6 cases hyperaldosteronism was diagnosed; necrosis of the tubules could not be found in this group; 4 patients had overt renal failure."	1.26	[Disorders of kidney function in hepatic coma]. ( Druml, W; Kleinberger, G; Lochs, H, 1982)
"of carbromal is described, in which an acute renal failure and bilateral deep vein thromboses occurred."	1.26	[Bromureide intoxication with acute renal failure and bilateral deep vein thrombosis (author's transl)]. ( Fuchs, C; Poser, W; Rumpf, KW; Scheler, F, 1977)
"In 7 patients in which acute renal failure had occurred the progression of pulmonary failure could not be interrupted."	1.26	[The therapeutic use of streptokinase in the treatment of shock lung (author's transl)]. ( Harke, H, 1979)
"3 Glycerol-induced acute renal failure produced a significant increase in the unbound fractions of o-methyl red, methyl orange, bromocresol green (BCG), 2-(4'-hydroxybenzeneazo) benzoic acid (HABA), phenytoin and salicylic acid."	1.26	Decreased binding of drugs and dyes to plasma proteins from rats with acute renal failure: effects of ureter ligation and intramuscular injection of glycerol. ( Bowmer, CJ; Lindup, WE, 1979)
"Furosemide (20 mg/kg) was injected intraperitoneally daily and for the first time 24 h after injection of glycerol Mortality and azotemia of acute renal failure was not improved by this drug."	1.26	[Action of furosemide in experimental acute renal failure (author's transl)]. ( Greven, J; Kölling, B, 1978)
"5."	1.26	Effect of saralasin and serum in myohaemoglobinuric acute renal failure of rats. ( Bauereiss, K; Gross, F; Hofbauer, KG; Konrads, A, 1978)
"Warm ischemic (90 minutes) acute renal failure (ARF) was evaluated in the dog and found to cause polyuric ARF in the injured kidney if the opposite normal kidney was removed."	1.26	Mechanisms for oliguria in acute renal failure. ( Crawford, DG; Hermreck, AS; Meisel, RL; Proberts, KS; Ruiz-Ocana, FM, 1977)
"Congestive heart failure was the most common identifiable cause of a raised plasma urea concentration in the 100 unselected patients (36%)."	1.26	Plasma creatinine and urea: creatinine ratio in patients with raised plasma urea. ( Carver, ME; Morgan, DB; Payne, RB, 1977)
"However, in the patients with possible protein deficiency and normal renal function, an elevation of plasma ribonuclease is, in general, associated with a decrease in serum albumin, transferrin and cholinesterase."	1.26	An assessment of the clinical usefulness of plasma ribonuclease assays. ( Citrin, DL; Rowan, RM; Shenkin, A, 1976)
"Acute renal failure was produced in rats by right nephrectomy and total occlusion of the left renal artery for 70 min."	1.26	High renin activity accompanying angiotensin II inhibition in rats with ischemic renal failure. ( Eliahou, HE; Iaina, A; Shapira, J; Solomon, S, 1976)
"1."	1.25	The renin-angiotensin system in acute renal failure of rats. ( Dietz, R; Gross, F; Oster, P; Rauh, W, 1975)
"Although acute renal failure is a well recognized complication of several extra-hepatic biliary tract diseases especially biliary tract surgery in the presence of obstructive jaundice, there is little information concerning renal failure in acute cholecystitis."	1.25	Acute reversible renal failure in patients with acute cholecystitis and cholangitis. ( ABER, GM; Ash, DV; Boyd, WN; Burden, RP; Gray, JG, 1975)
"In 15 out of 35 patients with myelomatosis histological examination showed intravascular fibrin within the glomeruli, and this was associated with proliferation of the mesangial complex in 12."	1.25	The kidney and intravascular coagulation in myelomatosis. ( Preston, FE; Ward, AM, 1974)

Research

Studies (760)

Authors

Clinical Trials (28)

Trial Overview

Trial Outcomes

Urine Volume

Timeframe	Studies, this research(%)	All Research%
pre-1990	379 (49.87)	18.7374
1990's	69 (9.08)	18.2507
2000's	100 (13.16)	29.6817
2010's	159 (20.92)	24.3611
2020's	53 (6.97)	2.80

Authors	Studies
Fatimah, SN	1
Usman, SM	1
Lindner, G	1
Wolfensberger, A	1
Exadaktylos, AK	1
Schwarz, C	1
Funk, GC	1
Ravioli, S	1
Xu, Q	1
Jiang, B	1
Li, J	9
Lu, W	1
Fisher, C	1
Baldwin, I	5
Fealy, N	4
Naorungroj, T	1
Bellomo, R	14
Abdel-Rahman Mohamed, A	1
Khater, SI	1
Metwally, MMM	1
Bin Emran, T	1
Nassan, MA	1
Abd El-Emam, MM	1
Mostafa-Hedeab, G	1
El-Shetry, ES	1
Whiting, L	1
Bianchi, NA	1
Alouazen, K	1
Joannes-Boyau, O	2
Chiche, JD	1
Schneider, A	1
Josa-Laorden, C	1
Rubio-Gracia, J	1
Sánchez-Marteles, M	1
Torcal, P	1
Garcés-Horna, V	1
Sola-Martínez, A	1
Íñigo, P	1
Giménez-López, I	1
Pérez-Calvo, JI	1
Ali, A	1
Khan, H	1
Kahrizi, D	1
Pervez, S	1
Alotaibi, G	1
Rastrelli, L	1
Boskabadi, J	1
Yousefi-Mazhin, E	1
Salehifar, E	1
Yen, TH	1
Chang, CW	1
Tsai, HR	1
Fu, JF	1
Yen, HC	1
Altındağ, F	1
Ergen, H	1
Tonnus, W	1
Maremonti, F	1
Belavgeni, A	1
Latk, M	1
Kusunoki, Y	1
Brucker, A	1
von Mässenhausen, A	1
Meyer, C	2
Locke, S	1
Gembardt, F	1
Beer, K	1
Hoppenz, P	1
Becker, JU	1
Hugo, C	1
Anders, HJ	1
Bornstein, SR	1
Shao, F	1
Linkermann, A	1
Brasileiro-Martins, LM	1
Nascimento, TP	1
Silva-Neto, AV	1
Martins, F	1
Cavalcante, SA	1
Martins, RB	1
Marques, H	1
Colombini, M	1
Martins, M	1
Sartim, MA	1
Wen, FH	1
Carlos de Lima Ferreira, L	1
de Almeida Gonçalves Sachett, J	1
Moura-da-Silva, AM	1
Ferreira de Aquino, P	1
Monteiro, WM	1
Alshogran, OY	1
Al Tahrawi, AY	1
Nusair, SD	1
Wu, J	2
Huang, J	2
Chen, E	1
Zheng, X	1
Chen, H	3
Klainbart, S	1
Kelmer, E	1
Segev, G	2
Xu, XJ	1
Zhang, ML	1
Hou, YM	1
Zhang, K	1
Yao, DH	1
Li, GY	1
Kou, WB	1
Wang, HY	1
Wang, JH	2
Yu, G	1
Wang, J	5
Jian, T	1
Shi, L	1
Zhao, L	1
Li, Y	7
Gao, Y	3
Kan, B	1
Jian, X	1
Shiri, S	2
Naik, NM	2
Av, L	2
Vasudevan, A	2
Uğurlu, ET	1
Tercan, M	1
Zhai, B	1
Ma, LS	1
Shen, RQ	1
Yu, J	1
Tao, YN	1
Xu, AP	1
Shao, DC	1
Diao, HY	1
Zhu, W	2
Liu, J	2
Yin, S	1
Li, CL	1
Vetter, CAM	1
Lourenço, BN	1
Meindl, AG	1
Mees, A	1
Stone, A	1
Farnsworth, R	1
Everett, SE	1
Gonzalez, SE	1
Roth, IG	1
Schmiedt, C	1
Hamadah, A	1
Gharaibeh, K	1
Aron, AW	1
Amatruda, JG	1
Brown, RS	1
Lievre, L	1
Dupont, V	1
Kanagaratnam, L	1
Faroux, L	1
Debrumetz, A	1
Rieu, P	1
Wynckel, A	2
Wang, Q	4
Qi, G	1
Zhou, H	1
Cheng, F	1
Yang, X	3
Liu, X	2
Wang, R	1
Aliu, R	1
Jalo, I	1
Olatoke, L	1
Asabe, I	1
Bello, A	1
Abdel Moneim, LM	1
Helmy, MW	1
El-Abhar, HS	1
Sullivan, K	1
Chami, R	1
Pearl, R	1
Wołyniec, W	2
Kasprowicz, K	2
Giebułtowicz, J	1
Korytowska, N	1
Zorena, K	1
Bartoszewicz, M	1
Rita-Tkachenko, P	1
Renke, M	2
Ratkowski, W	2
Shebeko, SK	1
Zupanets, IA	1
Tarasenko, OO	1
Grist, JT	1
Mariager, CØ	1
Qi, H	1
Nielsen, PM	2
Laustsen, C	2
Hussein, RH	1
Calice-Silva, V	4
Evans, R	3
Levin, NW	3
Ellidir, RA	1
Ali, EM	1
Bakhiet, Y	1
Ahmed, A	1
Abdelkareem, A	1
Abdelraheem, MB	1
Kotanko, P	4
Pecoits-Filho, R	4
Raimann, JG	4
Silva, CBP	1
Gómez, JPS	1
do Vale, GT	1
Simplicio, JA	1
Gonzaga, NA	1
Tirapelli, CR	1
Ibrahim, YF	1
Fadl, RR	1
Ibrahim, S	1
Gayyed, MF	1
Bayoumi, A	1
Refaie, M	1
Hashish, EA	1
Elgaml, SA	1
El-Fattah, A	1
Shalaby, SI	1
Abdelaziz, S	1
Gyurászová, M	2
Gurecká, R	1
Bábíčková, J	1
Tóthová, Ľ	2
Villa, G	2
Bocciero, V	1
Neri, M	4
Pomarè Montin, D	1
Angeli, E	1
Di Filippo, A	1
Falsini, S	1
Adembri, C	1
De Gaudio, AR	2
Romagnoli, S	2
Xu, H	1
Min, X	1
Yang, L	2
Ren, Y	2
Dunaevich, A	1
Apfelbaum, N	1
Kuzi, S	1
Mazaki-Tovi, M	1
Aroch, I	1
Tod, P	1
Bukosza, EN	1
Róka, B	1
Kaucsár, T	1
Fintha, A	1
Krenács, T	1
Szénási, G	1
Hamar, P	1
Neamatallah, T	1
El-Shitany, N	1
Abbas, A	1
Eid, BG	1
Harakeh, S	1
Ali, S	1
Mousa, S	1
Nguépy Keubo, FR	1
Mboua, PC	1
Djifack Tadongfack, T	1
Fokouong Tchoffo, E	1
Tasson Tatang, C	1
Ide Zeuna, J	1
Noupoue, EM	1
Tsoplifack, CB	1
Folefack, GO	1
Kettani, M	1
Bandelier, P	1
Huo, J	1
Li, H	4
Yu, D	1
Arulsamy, N	1
AlAbbad, S	1
Sardot, T	1
Lekashvili, O	1
Decato, D	1
Lelj, F	1
Alexander Ross, JB	1
Rosenberg, E	1
Nazir, H	1
Muthuswamy, N	1
Louis, C	1
Jose, S	1
Prakash, J	1
Buan, MEM	1
Flox, C	1
Chavan, S	1
Shi, X	1
Kauranen, P	1
Kallio, T	1
Maia, G	1
Tammeveski, K	1
Lymperopoulos, N	1
Carcadea, E	1
Veziroglu, E	1
Iranzo, A	1
M Kannan, A	1
Arunamata, A	1
Tacy, TA	1
Kache, S	1
Mainwaring, RD	1
Ma, M	1
Maeda, K	1
Punn, R	1
Noguchi, S	1
Hahn, S	3
Iwasa, Y	3
Ling, J	2
Voccio, JP	2
Kim, Y	3
Song, J	3
Bascuñán, J	2
Chu, Y	1
Tomita, M	1
Cazorla, M	1
Herrera, E	1
Palomeque, E	1
Saud, N	1
Hoplock, LB	1
Lobchuk, MM	1
Lemoine, J	1
Li, X	11
Henson, MA	1
Unsihuay, D	1
Qiu, J	1
Swaroop, S	1
Nagornov, KO	1
Kozhinov, AN	1
Tsybin, YO	1
Kuang, S	1
Laskin, J	1
Zin, NNINM	1
Mohamad, MN	1
Roslan, K	1
Abdul Wafi, S	1
Abdul Moin, NI	1
Alias, A	1
Zakaria, Y	1
Abu-Bakar, N	1
Naveed, A	1
Jilani, K	1
Siddique, AB	1
Akbar, M	1
Riaz, M	1
Mushtaq, Z	1
Sikandar, M	1
Ilyas, S	1
Bibi, I	1
Asghar, A	1
Rasool, G	1
Irfan, M	1
Li, XY	1
Zhao, S	1
Fan, XH	1
Chen, KP	1
Hua, W	1
Liu, ZM	1
Xue, XD	1
Zhou, B	1
Zhang, S	2
Xing, YL	1
Chen, MA	1
Sun, Y	3
Neradilek, MB	1
Wu, XT	1
Zhang, D	2
Huang, W	1
Cui, Y	1
Yang, QQ	1
Li, HW	1
Zhao, XQ	1
Hossein Rashidi, B	1
Tarafdari, A	1
Ghazimirsaeed, ST	1
Shahrokh Tehraninezhad, E	1
Keikha, F	1
Eslami, B	1
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Jafarabadi, M	1
Silvani, Y	1
Lovita, AND	1
Maharani, A	1
Wiyasa, IWA	1
Sujuti, H	1
Ratnawati, R	1
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Lemin, AS	1
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Pangarah, CA	1
Kiyu, A	1
Zeng, C	2
Du, H	1
Lin, D	1
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Zhao, H	2
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Huang, G	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
Dietary Restriction in Vascular Surgery[NCT04013412]		19 participants (Actual)	Interventional	2018-12-31	Completed
Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease[NCT05457881]		226 participants (Anticipated)	Interventional	2024-03-01	Not yet recruiting
Short-Term Endogenous Hydrogen Sulfide Upregulation[NCT03303534]		9 participants (Actual)	Interventional	2017-09-14	Completed
Correction of Hypernatremia by Intravenous Hypotonic Solution Compared to Enteral Water, Randomized Clinical Trial[NCT06061783]		178 participants (Anticipated)	Interventional	2023-11-30	Not yet recruiting
Daily Urinary Urea Excretion to Guide Renal Replacement Therapy Weaning in Intensive Care Units[NCT03763188]		260 participants (Actual)	Observational	2016-09-01	Completed
The Effects of Levosimendan on Renal Function in Patients With Low Ejection Fraction Undergoing Mitral Valve Surgery.[NCT01969071]	Phase 4	140 participants (Actual)	Interventional	2009-07-31	Completed
Early Detection and Intervention of Acute Contrast Media Induced Nephropathy Using Neutrophil Gelatinase-associated Lipocalin (NGAL) May Improve Renal Outcome: A Study in Patients Undergoing Intra-arterial Angiography.[NCT01292317]		819 participants (Actual)	Interventional	2011-01-31	Completed
PrEvalence of Acute and Chronic Kidney Disease Treated by Renal Replacement Therapy in the ICU Environment[NCT02341885]		2,000 participants (Actual)	Observational	2015-03-31	Completed
Efficacy of Combined Low- and High- Frequency Stimulation in Peripheral Muscle Function During Hemodialysis[NCT03779126]		56 participants (Anticipated)	Interventional	2018-02-01	Recruiting
Simplified Regional Citrate Anticoagulation Protocols for CVVH, CVVHDF and SLED Focused on the Prevention of RRT-related Hypophosphatemia and Optimization of Acid-base Balance: a Pilot Study[NCT03976440]		30 participants (Anticipated)	Observational	2019-06-01	Active, not recruiting
Cerebral Oximetry and Perioperative Outcome in Non-Cardiac Surgery[NCT01838733]		200 participants (Anticipated)	Observational	2014-04-30	Recruiting
The Role of Serum Neutrophil Gelatinase Associated Lipocalin in Predicting Acute Kidney Injury in Patients With Coronary Artery Disease[NCT03266367]		45 participants (Anticipated)	Observational	2017-09-15	Not yet recruiting
Retrospective Analysis of Aminoglycoside-associated Acute Renal Injury in Septic Critically Ill Patients[NCT01932814]		317 participants (Actual)	Observational	2012-09-30	Completed
"Early and Late Timing Indication for Starting Renal Replacement Therapy in Acute Renal Failure After Cardiac Surgery: a Prospective, Controlled, Interventional, Single-center Trial"[NCT01961999]		1,800 participants (Actual)	Interventional	2011-07-31	Completed
Impact of a Continuous Dialysis Technique Associated With Adsorption Capacity Membranes in Patients With Sepsis Associated - Acute Kidney Injury.[NCT01790620]		110 participants (Actual)	Interventional	2013-05-31	Completed
ACTION-1: ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair, a Randomised Trial.[NCT04061798]	Phase 4	750 participants (Anticipated)	Interventional	2020-03-02	Recruiting
Predicted Long Term Renal Outcome After Medical or Postcardiotomy Refractory Cardiogenic Shock Requiring Renal Replacement Therapy Concomitant With Venoarterial Extracorporeal Membrane Oxygenation[NCT05788211]		100 participants (Anticipated)	Observational	2022-01-01	Recruiting
Soluble Urokinase Plasminogen Activator Receptor (suPAR) in the Early Diagnosis of Acute Kidney Injury After On-Pump Cardiac Surgery[NCT02921113]		105 participants (Actual)	Observational	2016-04-30	Completed
Evaluating the Role of Cystatin C and Creatinine as Markers of Renal Recovery in Critically Ill Patients After Acute Kidney Injury.[NCT02894164]		336 participants (Actual)	Observational [Patient Registry]	2008-01-31	Completed
Multi-Drug Resistant Organism Network - MDRO Network[NCT03646227]		6,496 participants (Actual)	Observational	2016-06-16	Completed
Acute Kidney Injury and Nonsteroidal Anti-inflammatory Drugs in Patients Undergoing High-risk Abdominal or Thoracic Surgery[NCT02553174]		50 participants (Actual)	Observational	2016-06-01	Terminated (stopped due to unable to recruit sufficient patients to satisfy study protocols)
Vancomycin De-escalation Therapy in Patients With Pneumonia and Negative MRSA Nasal Swab[NCT03586362]		278 participants (Anticipated)	Observational	2018-02-08	Active, not recruiting
Protocol to Assess the Severity of Acute Kidney Injury[NCT00673244]		77 participants (Actual)	Interventional	2008-04-30	Completed
Influence of Elevated Baseline Serum Creatinine and Body Composition on Acute Kidney Injury in Cardiac Surgery - The InCreAS Trial[NCT02598271]		200 participants (Actual)	Observational	2016-10-31	Completed
Local Assessment of Ventilatory Management During General Anesthesia for Surgery - a Prospective Observational Multi-center Cohort Study[NCT01601223]		10,690 participants (Actual)	Observational	2013-01-31	Completed
Renal Insufficiency Following Contrast Media Administration Trial II (Remedial II): The RenalGuard System in High-Risk Patients for Contrast-Induced Acute Kidney Injury[NCT01098032]	Phase 3	294 participants (Actual)	Interventional	2009-01-31	Completed
[NCT00451373]		300 participants	Interventional	2006-07-31	Recruiting
Evaluation of a Simplified Protocol for Regional Citrate Anticoagulation in Continuous Venovenous Hemodiafiltration[NCT00583765]		20 participants (Actual)	Observational	2005-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Urine output measured in ml/hr for first 6 hours after furosemide administration (NCT00673244)
Timeframe: Time from furosemide administration to 6 hours after furosemide administration

Number of Participants With Contrast-induced Acute Kidney Injury

Intervention	ml (Mean)
	Urine Volume - Hour 1	Urine Volume - Hour 2	Urine Volume - Hour 3	Urine Volume - Hour 4	Urine Volume - Hour 5	Urine Volume - Hour 6
Did Not Progress to AKIN Stage-III	329	392	311	265	219	194
Progressed to AKIN Stage III	89	96	109	88	83	75

The primary outcome measure will be the rate of development of CI-AKI in the 2 study arms (number of participants). CI-AKI is defined as an increase in the serum creatinine concentration >=0.3 mg/dL from the baseline value at 48 hours after administration of the contrast media or the need for dialysis. (NCT01098032)
Timeframe: at 48 hours following contrast exposure

Intervention	participants (Number)
Systemic Alone Therapy Group	146
RenalGuard System Group	146

Article	Year
Comparison of filter life span and solute removal during continuous renal replacement therapy: convection versus diffusion - A randomized controlled trial. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2022, Volume: 26, Issue:5 Topics: Acute Kidney Injury; Continuous Renal Replacement Therapy; Convection; Creatinine; Hemodiafiltration	2022
Rosiglitazone Alleviates Contrast-Induced Acute Kidney Injury in Rats via the PPAR Disease markers, 2022, Volume: 2022 Topics: Acute Kidney Injury; Animals; Caspase 3; Creatinine; Furosemide; Interleukin-10; Iohexol; Kidney; Ni	2022
Diagnosis of Acute Kidney Injury in Children Hospitalized in a Sub-Saharan African Unit by Saliva Urea Nitrogen Dipstick Test. Blood purification, 2020, Volume: 49, Issue:1-2 Topics: Acute Kidney Injury; Adolescent; Africa South of the Sahara; Child; Child, Preschool; Female; Follow	2020
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli	2021
Evaluation of urea and creatinine change during continuous renal replacement therapy: effect of blood flow rate. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2018, Volume: 20, Issue:1 Topics: Acute Kidney Injury; Adult; Blood Flow Velocity; Creatinine; Critical Illness; Humans; Prospective S	2018
Continuous Veno-Venous High Cut-Off Hemodialysis Compared to Continuous Veno-Venous Hemodiafiltration in Intensive Care Unit Acute Kidney Injury Patients. Blood purification, 2018, Volume: 46, Issue:3 Topics: Acute Kidney Injury; Aged; beta 2-Microglobulin; Creatinine; Critical Care; Cross-Sectional Studies;	2018
Urea reduction ratio may be a simpler approach for measurement of adequacy of intermittent hemodialysis in acute kidney injury. BMC nephrology, 2019, 03-06, Volume: 20, Issue:1 Topics: Acute Kidney Injury; Aged; Biomarkers; Critical Illness; Female; Humans; Male; Middle Aged; Renal Di	2019
Usefulness of N-acetylcysteine or ascorbic acid versus placebo to prevent contrast-induced acute kidney injury in patients undergoing elective cardiac catheterization: a single-center, prospective, randomized, double-blind, placebo-controlled trial. The Journal of invasive cardiology, 2013, Volume: 25, Issue:6 Topics: Acetylcysteine; Acute Kidney Injury; Administration, Intravenous; Aged; Ascorbic Acid; Cardiac Cathe	2013
Risk Stratification of Acute Kidney Injury Using the Blood Urea Nitrogen/Creatinine Ratio in Patients With Acute Decompensated Heart Failure. Circulation journal : official journal of the Japanese Circulation Society, 2015, Volume: 79, Issue:7 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Biomarkers; Creatinine; Female; Heart Failure; Humans;	2015
Extended daily dialysis in acute renal failure: a new therapeutic approach. Iranian journal of kidney diseases, 2007, Volume: 1, Issue:2 Topics: Acute Kidney Injury; Adult; Blood Pressure; Female; Hemodiafiltration; Humans; Hydrogen-Ion Concentr	2007
Evaluation of a new polysulfone hemofilter for continuous renal replacement therapy. Blood purification, 2011, Volume: 32, Issue:2 Topics: Acute Kidney Injury; Adsorption; beta 2-Microglobulin; Creatinine; Hemodynamics; Hemofiltration; Hum	2011
Solute clearance in CRRT: prescribed dose versus actual delivered dose. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:3 Topics: Acute Kidney Injury; Blood Urea Nitrogen; Creatinine; Critical Illness; Female; Hemodiafiltration; H	2012
High-frequency external muscle stimulation in acute kidney injury (AKI): potential shortening of its clinical course. Clinical nephrology, 2013, Volume: 79 Suppl 1 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Combined Modality Therapy; Creatinine; Diuresis; Elect	2013
Citrate vs. heparin for anticoagulation in continuous venovenous hemofiltration: a prospective randomized study. Intensive care medicine, 2004, Volume: 30, Issue:2 Topics: Acute Kidney Injury; Adult; Anticoagulants; Citric Acid; Creatinine; Critical Care; Female; Hemofilt	2004
Urea space and total body water measurements by stable isotopes in patients with acute renal failure. Kidney international, 2004, Volume: 65, Issue:2 Topics: Acute Kidney Injury; Aged; Body Water; Carbon Isotopes; Deuterium; Electric Impedance; Female; Human	2004
Effect of N-acetylcysteine for prevention of contrast nephropathy in patients with moderate to severe renal insufficiency: a randomized trial. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2004, Volume: 43, Issue:5 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Cardiovascular Diseases; Comorbidity; Contrast Media; Cor	2004
Ascorbic acid prevents contrast-mediated nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. Circulation, 2004, Nov-02, Volume: 110, Issue:18 Topics: Acute Kidney Injury; Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Antioxidants; Ascor	2004
Effects of different energy intakes on nitrogen balance in patients with acute renal failure: a pilot study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:9 Topics: Acute Kidney Injury; Cross-Over Studies; Dietary Proteins; Energy Intake; Energy Metabolism; Humans;	2005
Efficacy of cellulose triacetate dialyzer and polysulfone synthetic hemofilter for continuous venovenous hemofiltration in acute renal failure. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2006, Volume: 89 Suppl 2 Topics: Acute Kidney Injury; Analysis of Variance; Cellulose; Creatinine; Female; Hemodiafiltration; Humans;	2006
Randomized clinical trial comparing the effects on renal function of hydroxyethyl starch or gelatine during aortic aneurysm surgery. The British journal of surgery, 2007, Volume: 94, Issue:4 Topics: Acute Kidney Injury; Aged; Analysis of Variance; Aortic Aneurysm, Abdominal; Creatinine; Female; Gel	2007
Effect of intraoperative fluid optimisation on renal function in patients undergoing emergency abdominal surgery: a randomised controlled pilot study (ISRCTN 11799696). International journal of surgery (London, England), 2008, Volume: 6, Issue:3 Topics: Acute Kidney Injury; Aged; Blood Pressure; Cardiac Output; Creatinine; Cystatin C; Cystatins; Digest	2008
Comparative clearance performance of two dialyser units used in the CVVHD mode. Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 1995, Volume: 8, Issue:2 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Female; Hemodiafiltration; Humans; Male; Middle Aged;	1995
The outcome of critically ill elderly patients with severe acute renal failure treated by continuous hemodiafiltration. The International journal of artificial organs, 1994, Volume: 17, Issue:9 Topics: Acute Kidney Injury; Aged; Bicarbonates; Confidence Intervals; Creatinine; Hemodiafiltration; Humans	1994
A comparison of molecular clearance rates during continuous hemofiltration and hemodialysis with a novel volumetric continuous renal replacement system. Artificial organs, 1994, Volume: 18, Issue:6 Topics: Acute Kidney Injury; Creatinine; Hemofiltration; Humans; Molecular Weight; Renal Dialysis; Urea; Uri	1994
Use of urinary parameters in the diagnosis of total acute renal artery occlusion. Nephron, 1994, Volume: 66, Issue:2 Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Creatinine; Diagnosis, Differential; Female; Hu	1994
A comparison of metabolic control by continuous and intermittent therapies in acute renal failure. Journal of the American Society of Nephrology : JASN, 1994, Volume: 4, Issue:7 Topics: Acute Kidney Injury; Adult; Aged; Computer Simulation; Hemofiltration; Humans; Kinetics; Middle Aged	1994
Pharmacokinetics of ciprofloxacin in ICU patients on continuous veno-venous haemodiafiltration. Intensive care medicine, 2001, Volume: 27, Issue:4 Topics: Acute Kidney Injury; Adult; Aged; Anti-Infective Agents; Area Under Curve; Ciprofloxacin; Female; He	2001
Sustained low-efficiency dialysis for critically ill patients requiring renal replacement therapy. Kidney international, 2001, Volume: 60, Issue:2 Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anticoagulants; APACHE; Blood Pressure; Critica	2001
Intermittent hemodiafiltration in acute renal failure in critically ill patients. Clinical nephrology, 2001, Volume: 56, Issue:4 Topics: Acute Kidney Injury; Adult; Aged; Calcium; Creatinine; Critical Illness; Female; Hemodiafiltration;	2001
Correlates of urea kinetic modeling during hemodialysis in patients with acute renal failure. Blood purification, 2002, Volume: 20, Issue:2 Topics: Acute Kidney Injury; Aged; Analysis of Variance; Female; Humans; Kinetics; Male; Membranes, Artifici	2002
Effects of L-thyroxine in acute renal failure. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1976, Aug-25, Volume: 168, Issue:2 Topics: Acute Kidney Injury; Clinical Trials as Topic; Creatinine; Glomerular Filtration Rate; Humans; Thyro	1976
The effect of prophylactic use of furosemide on renal function during open heart surgery. Annales chirurgiae et gynaecologiae, 1976, Volume: 65, Issue:4 Topics: Acute Kidney Injury; Adult; Cardiac Surgical Procedures; Creatinine; Diuresis; Extracorporeal Circul	1976
Continuous arteriovenous hemodialysis: effect of dialyzer geometry. Kidney international, 1992, Volume: 42, Issue:2 Topics: Acute Kidney Injury; Aged; Critical Care; Evaluation Studies as Topic; Female; Humans; Kidneys, Arti	1992
[Benziodarone in hyperuricemia due to renal insufficiency]. Minerva medica, 1973, Jan-20, Volume: 64, Issue:4 Topics: Acute Kidney Injury; Adult; Aged; Allopurinol; Benzofurans; Clinical Trials as Topic; Gout; Humans;	1973
Decreased drug binding by serum albumin during renal failure. Toxicology and applied pharmacology, 1973, Volume: 25, Issue:3 Topics: Acute Kidney Injury; Azo Compounds; Blood Protein Electrophoresis; Clinical Trials as Topic; Colorin	1973
Bumetanide, a new diuretic. International urology and nephrology, 1974, Volume: 6, Issue:1 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Benzoates; Bumetanide; Butylamines; Chlorides; Clinica	1974
Letter: High-dose frusemide in renal failure. British medical journal, 1974, Feb-09, Volume: 1, Issue:5901 Topics: Acute Kidney Injury; Furosemide; Humans; Urea; Urination	1974

urea and Acute Kidney Failure