urea and Acidosis, Diabetic

urea has been researched along with Acidosis, Diabetic in 28 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Research

Studies (28)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Arginine Vasopressin and Copeptin Response

Primary analysis is time trends (i.e. ANOVA effects), supported by indices of the response trends (e.g. iAUC, time to peak). Bloods drawn pre-biopsy, pre-OGTT, and then 15 minutely for 120 minutes, and then 10 minutely after the ad libitum meal test. (NCT02841449)
Timeframe: Measured on day 5 on both trial arms, using the blood sample drawn before the glucose beverage is consumed and the blood samples drawn for the subsequent 120 minutes (please note: may measure copeptin as a marker of arginine vasopressin)

Body Water Content

Taken from bioelectrical impedance weighing scales (NCT02841449)
Timeframe: Daily (i.e. 5 consecutive days for each trial arm)

Energy Intake

Differences in energy intake between the hypohydrated and rehydrated groups (two-tailed t-test) (NCT02841449)
Timeframe: Measured on day 5 on both trial arms from the pasta test meal

Ghrelin Response

Primary analysis is time trends (i.e. ANOVA effects), supported by indices of the response trend (e.g. iAUC, time to peak). Due to funding limitations, we only took one 60 minute postprandial measure of ghrelin. (NCT02841449)
Timeframe: Measured on day 5 on both trial arms, using the blood sample drawn before the participant starts eating the buffet and the subsequent post-buffet blood samples

Glycemic Response

Primary analysis is time trends (i.e. ANOVA effects), supported by indices of the glycemic response (e.g. iAUC, time to peak). Blood was taken pre-muscle biopsy (if participants opted in for a muscle biopsy), before consuming the glucose drink (after the biopsy, where applicable), then at 15 minutely samples for 120 minutes. After the meal test, blood was drawn at 10 minutely intervals for 60 minutes, starting 30 minutes after commencement of eating. (NCT02841449)
Timeframe: Measured on day 5 on both trial arms, using the blood sample drawn before the glucose beverage is consumed and the blood samples drawn for the subsequent 120 minutes

Insulinemic Response

Primary analysis is time trends (i.e. ANOVA effects), supported by indices of the insulinemic response (e.g. iAUC, time to peak). Bloods drawn at pre-biopsy, pre-OGTT, 15, 30, 45, 60, 90, 120 min and 0, 30, 60 minutes after the ad libitum meal test. (NCT02841449)
Timeframe: Measured on day 5 on both trial arms, using the blood sample drawn before the glucose beverage is consumed and the blood samples drawn for the subsequent 120 minutes

Metabolic Rate

Comparing respiratory quotient and metabolic rate (NCT02841449)
Timeframe: Using the metabolic rate data collected on day 5 on both trial arms

Muscle Volume

Comparing muscle size in the dehydrated and rehydrated state.Taken from the pQCT scans (NCT02841449)
Timeframe: pQCT scans on day 4 of the trial before the dehydration protocol in the heat tent, and on day 5 before the OGTT

Serum Osmolality

Change from baseline (NCT02841449)
Timeframe: Measured from the blood samples on day 4 and day 5 on both trial arms

Subjective Appetite Ratings

Comparing appetite response. Scales were visual analogue scales of hunger, fullness, how much you feel you can eat, thirst, and desire for sweet, salty, savoury and fatty foods. Scales were 0-100 mm vertical lines which participants marked where 0 = not at all/no desire and 100 = extremely/very high desire) (NCT02841449)
Timeframe: Collected on day 5 of both trial arms during the buffet

Trials

1 trial available for urea and Acidosis, Diabetic

Other Studies

27 other studies available for urea and Acidosis, Diabetic