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urea and Abnormalities, Drug-Induced

urea has been researched along with Abnormalities, Drug-Induced in 34 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
"Eleven urea compounds were administered individually as a single oral dose to rats either on day 12 or 14 and to mice on day 10 of pregnancy."3.66Correlation between the molecular structure of N-alkylureas and N-alkylthioureas and their teratogenic properties. ( Aoyama, H; Kaneda, M; Shirasu, Y; Teramoto, S, 1981)
"Valproic acid (VPA) is a major antiepileptic drug (AED); however, its use is limited by two life-threatening side effects: teratogenicity and hepatotoxicity."1.34Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid. ( Bialer, M; Finnell, RH; Shimshoni, JA; Wlodarczyk, B; Yagen, B, 2007)
" Unlike general toxicity data, their prenatal toxic effects were not extensively studied before."1.33Comparison of developmental toxicity of selective and non-selective cyclooxygenase-2 inhibitors in CRL:(WI)WUBR Wistar rats--DFU and piroxicam study. ( Burdan, F, 2005)
" The LD50 of Hg2+ (mg/kg total body weight), however, remains essentially constant (1."1.27The toxicity and teratogenicity of mercuric mercury in the pregnant rat. ( Holt, D; Webb, M, 1986)
" No remarkable changes were investigated in findings at near-term caesarean section in any dosed group including 400 mg/kg/day."1.27[Reproduction study of 1,1,3-trimethyl-5-phenylbiuret (ST-281): teratological study in rabbits by oral administration]. ( Imamura, K; Kashihara, A; Koida, M; Morita, K; Shinomiya, M; Yamakita, O; Yoshida, R, 1986)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199028 (82.35)18.7374
1990's0 (0.00)18.2507
2000's6 (17.65)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Burdan, F2
Szumilo, J1
Klepacz, R1
Okada, A2
Noyori, H1
Yagen, B3
Shimshoni, JA2
Bialer, M3
Fujiwara, M2
MURPHY, ML2
CHAUBE, S2
Onishi, Y1
Aoki, Y1
Sobol, E1
Wlodarczyk, B1
Finnell, RH1
von Kreybig, T5
Schmidt, W2
L'Abbé, KA1
Hoey, JR1
Teramoto, S1
Kaneda, M1
Aoyama, H1
Shirasu, Y1
Solomon, HM1
Wier, PJ1
Johnson, CM1
Posobiec, LM1
Rendemonti, JE1
Rumberger, DF1
Kennedy, GL1
Lu, MH1
McAlack, JW1
Holt, D1
Webb, M1
Yamakita, O1
Yoshida, R1
Shinomiya, M1
Koida, M1
Imamura, K1
Kashihara, A1
Morita, K1
Hafen, P1
Koblitz, V1
Atzeroth, R1
Napalkov, NP1
Alexandrov, VA2
Preussmann, R1
von Kreybig, I1
Johnson, EM1
Lambert, C1
Cros, S1
Moisand, C1
Tollon, Y1
Lipson, ML1
Jänisch, W1
Kupfer, M2
Kupfer, G2
Baeder, C1
Sakaguchi, T2
Nothdurft, H1
Hebold, G1
Mizukami, K1
Miyamoto, M1
Hayashi, S1
Kobayashi, T1
Sakurai, M1
Ehrentraut, W1
Juhls, H1
Zintzsch, J1
Rommel, P1
Wähmer, M1
Schnurrbusch, U1
Möckel, P1
Koyama, T2
Handa, J1
Handa, H1
Matsumoto, S1
Meng, K1
Kroneberg, G1
Hodge, HC1
Downs, WL1
Smith, DW1
Maynard, EA1
Clayton, JW1
Pease, HL1
Robens, JF1
Givelber, HM1
DiPaolo, JA1

Reviews

2 reviews available for urea and Abnormalities, Drug-Induced

ArticleYear
Review of the health effects of urea-formaldehyde foam insulation.
    Environmental research, 1984, Volume: 35, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Air Pollutants; Animals; Construction Materials; Dermatitis, Con

1984
Toxicity of systemic agents.
    International ophthalmology clinics, 1971, Volume: 11, Issue:2

    Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antineoplastic Agents;

1971

Other Studies

32 other studies available for urea and Abnormalities, Drug-Induced

ArticleYear
Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development.
    Reproductive toxicology (Elmsford, N.Y.), 2009, Volume: 28, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Blood Proteins; Cyclooxygenase Inhibitors; Embryo Loss; Embryo

2009
Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2009, Volume: 86, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Deep Sedation; Differential T

2009
PRELIMINARY SURVEY OF HYDROXYUREA (NSC-32065) AS A TERATOGEN.
    Cancer chemotherapy reports, 1964, Volume: 40

    Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Data Collection; Echinodermata; Embryo, Mammalia

1964
Comparison of developmental toxicity of selective and non-selective cyclooxygenase-2 inhibitors in CRL:(WI)WUBR Wistar rats--DFU and piroxicam study.
    Toxicology, 2005, Jul-01, Volume: 211, Issue:1-2

    Topics: Abdominal Wall; Abnormalities, Drug-Induced; Alanine Transaminase; Animals; Aspartate Aminotransfera

2005
Teratology study of derivatives of tetramethylcyclopropyl amide analogues of valproic acid in mice.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2006, Volume: 77, Issue:3

    Topics: Abnormalities, Drug-Induced; Amides; Animals; Body Weight; Cesarean Section; Cyclopropanes; Female;

2006
Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid.
    Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy, Complex Partial; Mice; Rats; Stereo

2007
[Experimental animal teratology and drug tests].
    Medizinische Klinik, 1966, Sep-16, Volume: 61, Issue:37

    Topics: Abnormalities, Drug-Induced; Amides; Animals; Brain; Colchicine; Cyclophosphamide; Female; Limb Defo

1966
[On chemical teratogenesis in the rat].
    Arzneimittel-Forschung, 1966, Volume: 16, Issue:8

    Topics: Abnormalities, Drug-Induced; Animals; Cyclophosphamide; Female; Male; Nitroso Compounds; Pregnancy;

1966
Correlation between the molecular structure of N-alkylureas and N-alkylthioureas and their teratogenic properties.
    Teratology, 1981, Volume: 23, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Methylurea Compounds; Mice; Pregnancy; Rats; St

1981
Benzofuranyl ureas with potent cardiovascular teratogenicity in rats.
    Teratology, 2000, Volume: 61, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Aorta, Thoracic; Benzofurans; Cardiovascular System; Cryptorch

2000
Teratogenic evaluation of 1,1,3,3-tetrabutylurea in the rat following dermal exposure.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1987, Volume: 25, Issue:2

    Topics: Abnormalities, Drug-Induced; Administration, Topical; Animals; Body Weight; Bone and Bones; Female;

1987
The toxicity and teratogenicity of mercuric mercury in the pregnant rat.
    Archives of toxicology, 1986, Volume: 58, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Biological Transport, Active; Female; Gestational Age; Glomeru

1986
[Reproduction study of 1,1,3-trimethyl-5-phenylbiuret (ST-281): teratological study in rabbits by oral administration].
    The Journal of toxicological sciences, 1986, Volume: 11 Suppl 2

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anti-Inflammatory Agents; Biuret; Body W

1986
[Endogenous nitrosation of n-alkyl-ureas and n-alkyl-carbonamides as teratogenic factor in rat and mouse (author's transl)].
    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1973, Dec-28, Volume: 80, Issue:4

    Topics: Abnormalities, Drug-Induced; Alkylating Agents; Amides; Animals; Carbon Dioxide; Female; Head; Hemor

1973
On the effects of blastomogenic substances on the organism during embryogenesis.
    Zeitschrift fur Krebsforschung, 1968, Volume: 71, Issue:1

    Topics: Abnormalities, Drug-Induced; Aniline Compounds; Animals; Benz(a)Anthracenes; Carcinoma; Carcinoma, S

1968
[Chemical constitution and teratogenic effect in rats. II. N-alkylurea, N-alkylsulfonamide, N,N-dialkylacetamide, N-methylthioacetamide, chloracetamide].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:7

    Topics: Abnormalities, Drug-Induced; Amides; Animals; Chemical Phenomena; Chemistry; Edema; Embryo, Mammalia

1969
Effects of N-nitroso-N-methylurea on enzymatic ontogeny associated with teratogenesis.
    Teratology, 1968, Volume: 1, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Clubfoot; Electrophoresis, Disc; Esterases; Fema

1968
[Tetramethylurea action on the embryonic development of the mouse].
    Annales pharmaceutiques francaises, 1972, Volume: 30, Issue:9

    Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Dose-Response Relationship, Drug; Embryo, Mamm

1972
[Teratogenic effect of ethylurea and nitrite in rats].
    Experientia, 1971, May-15, Volume: 27, Issue:5

    Topics: Abnormalities, Drug-Induced; Anencephaly; Animals; Embryo, Mammalian; Female; Hernia, Ventral; Hydro

1971
[Various effects of N-methyl-N-nitrosourea in rats. II. Fertility disorders and malformations].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1971, Volume: 114, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fertility; Infertility; Libido; Male; Maternal-Fetal E

1971
[Teratologic studies with HB 419].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:8

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Depression, Chemical; Female; Fetal Death; Fetus;

1969
[Fertility studies with HB 419].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:8

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Body Weight; Female; Fertility; Hypoglycemic

1969
[Toxicological studies of N-4-2-(5-chloro-2-methoxybenzamido)-ethyl-phenylsulfonyl-n'-cyclohexylurea (HB 419)].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:8

    Topics: Abnormalities, Drug-Induced; Adrenal Glands; Animals; Blood; Body Weight; Brain; Female; Fetus; Geni

1969
[Experimental malformations in swine fetuses caused by intravenous administration of N-ethyl-N-nitroso-urea].
    Archiv fur Geschwulstforschung, 1969, Volume: 33, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Female; Fetus; Gestational Age; Kidney; Live

1969
Methylnitrosourea-induced malformations of brain in SD-JCL rat.
    Archives of neurology, 1970, Volume: 22, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Ataxia; Brain; Embryo, Mammalian; Encephalocele; Female; Gesta

1970
[Teratogenic effects of neurotropic carcinogens, methyl-nitroso-urea and ethyl-nitroso-urea on the brain of SD-JCL rats].
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1970, Oct-01, Volume: 39, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Ataxia; Brain; Carcinogens; Female; Hydrocephalus; Male; Nitro

1970
[Chemically induced fetopathies in the rat. Experimental studies on the effect of cyclophosphamide and N-methyl-N-nitroso-urea after administration on day 15 or 16 of gestation].
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:9

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Cartilage; Cyclophosphamide; Female; Fetus; Gestational

1967
[Pharmacology of N-(4'-chlore-3'-sulfameyl-benzelsulfenyl)-N-methyl-2-aminomethyl-2-methyl-tetrahydrefuran, a new diuretically active compound].
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:6

    Topics: Abnormalities, Drug-Induced; Aminohippuric Acids; Animals; Antihypertensive Agents; Benzothiadiazine

1967
Oral toxicity of linuron (3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea) in rats and dogs.
    Food and cosmetics toxicology, 1968, Volume: 6, Issue:2

    Topics: Abnormalities, Drug-Induced; Anemia, Hemolytic; Animals; Body Weight; Chemical Phenomena; Chemistry;

1968
Teratologic studies of carbaryl, diazinon, norea, disulfiram, and thiram in small laboratory animals.
    Toxicology and applied pharmacology, 1969, Volume: 15

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Infective Agents, Local; Bone and Bones; Carbamates; Cric

1969
Teratogenic effects of N-ethyl-N-nitrosourea in the Syrian hamster.
    Cancer research, 1969, Volume: 29, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; Female; Injections, Intraperitoneal; Neoplasms, Ex

1969
The effects of hydroxyurea and related compounds on the rat fetus.
    Cancer research, 1966, Volume: 26, Issue:7

    Topics: Abnormalities, Drug-Induced; Animals; Hydroxamic Acids; Rats; Urea; Urethane

1966