Page last updated: 2024-10-20

uracil and Vomiting

uracil has been researched along with Vomiting in 22 studies

2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder

Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.

Research Excerpts

ExcerptRelevanceReference
"Although combination chemotherapy with trifluridine/tipiracil (TAS-102) and bevacizumab (BEV) is highly effective for metastatic unresectable colorectal cancer (mCRC), this combination chemotherapy often induces nausea and vomiting."8.31Emetogenicity and Risk Factors of Nausea and Vomiting in Patients With Metastatic Colorectal Cancer Receiving Trifluridine/Tipiracil and Bevacizumab Chemotherapy. ( Fujii, H; Hirose, C; Iihara, H; Kiyama, S; Kobayashi, R; Makiyama, A; Matsuhashi, N; Matsuoka, S; Ohata, K; Sadaka, S; Suzuki, A; Takahashi, T; Watanabe, D, 2023)
" In a previous study, the authors demonstrated that the combination of uracil and tegafur (UFT) with leucovorin (LV) was active and well tolerated in patients with advanced colorectal carcinoma (ACC)."7.69Uracil and tegafur modulated with leucovorin: an effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly. Oncopaz Cooperative Group. ( Colmenarejo, A; de Castro, J; de la Gándara, I; Espinosa, E; Espinosa, J; Feliu, J; Fernández, Y; García Girón, C; González Barón, M; Jalón, JI, 1997)
"The purpose of this study was to evaluate the efficacy, assessed as response rate, and toxicity of UFT (Tegafur-Uracil) in combination with oxaliplatin as first-line treatment of advanced colorectal cancer (CRC)."5.11Phase II study of UFT and oxaliplatin in first-line treatment of advanced colorectal cancer. ( Antón-Aparicio, L; Aparicio, J; Constela, M; Dorta, FJ; Feliu, J; Fonseca, E; García-Girón, C; Gonzalez-Baron, M; Lomas, M; Vicent, JM, 2004)
"Although combination chemotherapy with trifluridine/tipiracil (TAS-102) and bevacizumab (BEV) is highly effective for metastatic unresectable colorectal cancer (mCRC), this combination chemotherapy often induces nausea and vomiting."4.31Emetogenicity and Risk Factors of Nausea and Vomiting in Patients With Metastatic Colorectal Cancer Receiving Trifluridine/Tipiracil and Bevacizumab Chemotherapy. ( Fujii, H; Hirose, C; Iihara, H; Kiyama, S; Kobayashi, R; Makiyama, A; Matsuhashi, N; Matsuoka, S; Ohata, K; Sadaka, S; Suzuki, A; Takahashi, T; Watanabe, D, 2023)
" In a previous study, the authors demonstrated that the combination of uracil and tegafur (UFT) with leucovorin (LV) was active and well tolerated in patients with advanced colorectal carcinoma (ACC)."3.69Uracil and tegafur modulated with leucovorin: an effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly. Oncopaz Cooperative Group. ( Colmenarejo, A; de Castro, J; de la Gándara, I; Espinosa, E; Espinosa, J; Feliu, J; Fernández, Y; García Girón, C; González Barón, M; Jalón, JI, 1997)
"Forty-eight patients with unresectable gastric cancer were enrolled for a randomized trial of FP (n = 24) vs FEP (n = 24) combination chemotherapy with respect to their effects on survival period."2.68[Combination chemotherapy with FP versus FEP in patients with advanced gastric cancer. Research group of gastric cancer chemotherapy]. ( Horiuchi, Y; Ina, K; Iwase, H; Kaneko, H; Kuroiwa, A; Kusugami, K; Morise, K; Oka, Y; Shinoda, M; Suga, S, 1995)
" Intolerance to single dosing was clearly demonstrated, and only the split dosing was advanced to 500 mg/m2/day."2.68Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil. ( Chan, KK; Groshen, S; Jeffers, S; Leichman, CG; Leichman, L; Muggia, FM; Spicer, D; Wu, X, 1996)
" Adverse events to TAS-102 monotherapy were observed in 22 out of 23 cases (95."1.43Safety of an oral anticancer agent (trifluridine/tipiracil combination tablet) in patients with advanced and recurrent colorectal cancer. ( Asano, H; Go, M; Ito, D; Iwai, M; Kimura, M; Teramachi, H; Usami, E; Yoshimura, T, 2016)
"Despite this preventative treatment, nausea and/or vomiting occurred in over one-third of all the courses."1.28[Treatment of nausea and vomiting induced by a 24-hour i.v. infusion of cisplatin]. ( Aoki, Y; Horiuchi, Y; Kamikawa, R; Kyokane, K; Miwa, Y; Nagai, H; Ninomiya, E; Noro, T; Suga, S; Yasue, K, 1990)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19903 (13.64)18.7374
1990's15 (68.18)18.2507
2000's2 (9.09)29.6817
2010's1 (4.55)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Matsuoka, S1
Fujii, H1
Iihara, H1
Ohata, K1
Hirose, C1
Watanabe, D1
Sadaka, S1
Kiyama, S1
Makiyama, A1
Takahashi, T1
Kobayashi, R1
Matsuhashi, N1
Suzuki, A1
Kimura, M2
Go, M1
Iwai, M1
Ito, D1
Asano, H1
Usami, E1
Teramachi, H1
Yoshimura, T1
VIETTI, TJ1
BERRY, DH1
FERNBACH, DJ1
LUSHER, J1
SUTOW, WW1
Feliu, J2
Vicent, JM1
García-Girón, C1
Constela, M1
Fonseca, E1
Aparicio, J1
Lomas, M1
Antón-Aparicio, L1
Dorta, FJ1
Gonzalez-Baron, M1
Brussel, W1
van Kuilenburg, AB1
Janssens, PM1
Sato, A1
Hasegawa, K2
Kurihara, M2
Takahashi, M1
Akazawa, S1
Fukuyama, Y1
Koizumi, W1
Hayakawa, M1
Sasai, T1
Kimura, K1
Sanchiz, F1
Milla, A1
Shinoda, M1
Morise, K1
Kusugami, K2
Iwase, H2
Ina, K1
Kaneko, H1
Horiuchi, Y2
Kuroiwa, A1
Suga, S3
Oka, Y1
Daniels, M1
Díaz-Rubio, E1
Guillem, V1
Montero, JM1
García-Conde, J1
Estapé, J1
Martín, M1
Herranz, C1
Ordoñez, A1
Galán, A1
Shimada, M1
Nishio, Y1
Ichihara, T1
Ichihara, S1
Saito, H1
González Barón, M1
Espinosa, E1
García Girón, C1
de la Gándara, I1
Espinosa, J1
Colmenarejo, A1
Jalón, JI1
Fernández, Y1
de Castro, J1
Kurokawa, H1
Miura, K1
Yamashita, Y1
Tokudome, S1
Murata, T1
Kajiyama, M1
Ichinose, Y1
Yano, T1
Kudoh, S1
Yoshimori, K1
Morikawa, T1
Kuba, M1
Niitani, H2
Horikoshi, N1
Aiba, K1
Kanamaru, R1
Takeda, S1
Taguchi, T1
Furue, H1
Ogawa, M1
Abe, T1
Muggia, FM1
Wu, X1
Spicer, D1
Groshen, S1
Jeffers, S1
Leichman, CG1
Leichman, L1
Chan, KK1
DeMario, MD1
Ratain, MJ1
Vogelzang, NJ1
Mani, S1
Vokes, EE1
Fleming, GF1
Melton, K1
Johnson, S1
Benner, S1
Lebwohl, D1
Sakata, Y1
Chiba, Y1
Sato, T1
Fukushi, G1
Matsukawa, M1
Wada, K1
Aoyama, H1
Sawada, Y1
Fukushi, M1
Ohyama, M1
Matsumura, M1
Katsuta, K1
Nobori, T1
Matsuyama, H1
Fukami, K1
Kiyota, R1
Yano, H1
Shima, T1
Ogawa, K1
Nagai, H1
Kyokane, K1
Miwa, Y1
Aoki, Y1
Yasue, K1
Noro, T1
Kamikawa, R1
Ninomiya, E1
Kikuchi, K1
Wakui, A1
Niijima, T1
Aso, Y1
Akaza, H1
Kameyama, S1
Koiso, K1
Kawabe, K1
Kawamura, T1
Isurugi, K1
Yokoyama, M1
Shoji, F1

Trials

13 trials available for uracil and Vomiting

ArticleYear
Phase II study of UFT and oxaliplatin in first-line treatment of advanced colorectal cancer.
    British journal of cancer, 2004, Nov-15, Volume: 91, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diarrhea; Drug Ad

2004
[Combination chemotherapy with tegafur-uracil (UFT) and cisplatin (CDDP) for advanced gastric cancer. UFTP Study Group].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:10

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug A

1995
Tegafur-uracil (UFT) plus folinic acid in advanced rectal cancer.
    Japanese journal of clinical oncology, 1994, Volume: 24, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Humans; L

1994
[Combination chemotherapy with FP versus FEP in patients with advanced gastric cancer. Research group of gastric cancer chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:4

    Topics: Adenocarcinoma; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Admi

1995
Phase II trial of UFT activity in pretreated breast cancer patients.
    Japanese journal of clinical oncology, 1993, Volume: 23, Issue:6

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; A

1993
Neoadjuvant chemotherapy in scirrhous cancer of the stomach using uracil and tegafur and cisplatin.
    Internal medicine (Tokyo, Japan), 1996, Volume: 35, Issue:12

    Topics: Adenocarcinoma, Scirrhous; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

1996
[Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell;

1997
UFT plus cisplatin in advanced non-small-cell lung cancer: interim analysis of 67 patients.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cispla

1997
[Phase I study of orally administered UFT plus l-leucovorin].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protoc

1998
Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:9

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Cohor

1996
A phase I study of oral uracil/ftorafur (UFT) plus leucovorin and bis-acetato-ammine-dichloro-cyclohexylamine-platinum IV (JM-216) each given over 14 days every 28 days.
    Cancer chemotherapy and pharmacology, 1999, Volume: 43, Issue:5

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule;

1999
[Comparative study of UFT plus mitomycin C and UFT plus doxorubicin in adenocarcinoma. Hirosaki Cooperative Group of Cancer Chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Combined Chemotherapy Proto

1992
[Cooperative research of UFT E phase II study. Cooperative Study Group of UFT E in Tohoku Area].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:11

    Topics: Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule;

1990

Other Studies

9 other studies available for uracil and Vomiting

ArticleYear
Emetogenicity and Risk Factors of Nausea and Vomiting in Patients With Metastatic Colorectal Cancer Receiving Trifluridine/Tipiracil and Bevacizumab Chemotherapy.
    Anticancer research, 2023, Volume: 43, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colonic Neoplasms; Colorectal Neoplasms

2023
Safety of an oral anticancer agent (trifluridine/tipiracil combination tablet) in patients with advanced and recurrent colorectal cancer.
    Die Pharmazie, 2016, Volume: 71, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Drug Combinations; Female;

2016
URACIL MUSTARY THERAPY IN METASTATIC WILMS'S TUMOR.
    American journal of diseases of children (1960), 1964, Volume: 108

    Topics: Anemia; Child; Drug Therapy; Leukopenia; Nausea; Neoplasm Metastasis; Nitrogen Mustard Compounds; Th

1964
A neonate with recurrent vomiting and generalized hypotonia diagnosed with a deficiency of dihydropyrimidine dehydrogenase.
    Nucleosides, nucleotides & nucleic acids, 2006, Volume: 25, Issue:9-11

    Topics: Developmental Disabilities; Dihydrouracil Dehydrogenase (NADP); Female; Homozygote; Humans; Infant;

2006
[UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:8

    Topics: Anorexia; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combina

1984
Uracil and tegafur modulated with leucovorin: an effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly. Oncopaz Cooperative Group.
    Cancer, 1997, May-15, Volume: 79, Issue:10

    Topics: Administration, Oral; Aged; Aged, 80 and over; Ambulatory Care; Antidotes; Antimetabolites, Antineop

1997
[A comparative study of UFT enteric-coated granules with UFT capsules on the occurrence of side effects in patients with head and neck cancers--a special attention to the upper gastrointestinal tract disorders].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capsules; Diarrhea;

1990
[Treatment of nausea and vomiting induced by a 24-hour i.v. infusion of cisplatin].
    Gan no rinsho. Japan journal of cancer clinics, 1990, Volume: 36, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dexamethasone; Drug Therapy, Combination;

1990
[Collaborative study of UFT in far-advanced renal cell carcinoma. Urological Cooperative UFT Study Group].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:1

    Topics: Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Drug A

1988