uracil and Sarcoma 180 studies

uracil and Sarcoma 180

uracil has been researched along with Sarcoma 180 in 26 studies

2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder

Sarcoma 180: An experimental sarcoma of mice.

Research Excerpts

Excerpt	Relevance	Reference
"Combinations of 6-thioguanine and uracil mustard produced greater inhibition of the growth of sarcoma 180 than that equivalent to the sum of the inhibitory effects caused by the optimum levels of the individual drugs."	7.64	Sarcoma 180 inhibition by combinations of 6-thioguanine and uracil mustard. ( BOOTH, BA; SARTORELLI, AC, 1962)
"Combinations of 6-thioguanine and uracil mustard produced greater inhibition of the growth of sarcoma 180 than that equivalent to the sum of the inhibitory effects caused by the optimum levels of the individual drugs."	3.64	Sarcoma 180 inhibition by combinations of 6-thioguanine and uracil mustard. ( BOOTH, BA; SARTORELLI, AC, 1962)

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (88.46)	18.7374
1990's	3 (11.54)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

23 (88.46)

18.7374

1990's

3 (11.54)

18.2507

2000's

0 (0.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
EVANS, JS	1
MENGEL, GD	1
ANIGSTEIN, L	1
ANIGSTEIN, DM	1
RENNELS, EG	1
BOOTH, BA	1
SARTORELLI, AC	1
ADAMS, DH	1
STANISLAVSKAIA, MS	1
AKSAMITNAIA, Ia	1
SATO, K	1
LEPAGE, GA	1
Watson, JD	1
Ralph, RK	1
Nakamura, H	2
Yu-Qin, W	1
Miyauchi, S	1
Nishioka, N	1
Tanaka, H	1
Harada, N	1
Shirasaka, T	5
Fujii, S	6
Kitano, S	2
Ikenaka, K	3
Fukushima, M	4
Maehara, Y	1
Kanazawa, Y	1
Kurogi, S	1
Shinohara, S	1
Noda, Y	1
Masuda, K	1
Hattori, H	1
Nozawa, E	1
Iino, T	1
Yoshimura, Y	1
Shuto, S	1
Shimamoto, Y	1
Nomura, M	1
Tanaka, M	1
Sasaki, T	1
Matsuda, A	1
Chowdhury, K	1
Neogy, RK	1
Singh, UP	1
Singh, BN	1
Ghose, AK	1
Singh, RK	1
Sodhi, A	1
Miwa, M	1
Eda, H	1
Fukuda, H	1
Fujimoto, K	1
Ishitsuka, H	1
Tatsumi, K	1
Aoike, A	1
Hosokawa, T	1
Koyama, K	1
Rokutan, K	1
Nishi, Y	1
Yoshida, A	1
Nakamura, K	1
Kawai, K	1
Severin, E	1
Hagenhoff, B	1
Lin, TS	1
Liu, MC	1
Gerns, FR	1
Perrotta, A	1
Hitchings, GH	1
Terent'eva, TG	1
Fomina, IP	1
Navashin, SM	1
Pol'kina, RI	1
Giner-Sorolla, A	1
Medrek, L	1

Studies

EVANS, JS

MENGEL, GD

ANIGSTEIN, L

ANIGSTEIN, DM

RENNELS, EG

BOOTH, BA

SARTORELLI, AC

ADAMS, DH

STANISLAVSKAIA, MS

AKSAMITNAIA, Ia

SATO, K

LEPAGE, GA

Watson, JD

Ralph, RK

Nakamura, H

Yu-Qin, W

Miyauchi, S

Nishioka, N

Tanaka, H

Harada, N

Shirasaka, T

Fujii, S

Kitano, S

Ikenaka, K

Fukushima, M

Maehara, Y

Kanazawa, Y

Kurogi, S

Shinohara, S

Noda, Y

Masuda, K

Hattori, H

Nozawa, E

Iino, T

Yoshimura, Y

Shuto, S

Shimamoto, Y

Nomura, M

Tanaka, M

Sasaki, T

Matsuda, A

Chowdhury, K

Neogy, RK

Singh, UP

Singh, BN

Ghose, AK

Singh, RK

Sodhi, A

Miwa, M

Eda, H

Fukuda, H

Fujimoto, K

Ishitsuka, H

Tatsumi, K

Aoike, A

Hosokawa, T

Koyama, K

Rokutan, K

Nishi, Y

Yoshida, A

Nakamura, K

Kawai, K

Severin, E

Hagenhoff, B

Lin, TS

Liu, MC

Gerns, FR

Perrotta, A

Hitchings, GH

Terent'eva, TG

Fomina, IP

Navashin, SM

Pol'kina, RI

Giner-Sorolla, A

Medrek, L

Clinical Trials (1)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Phase III Trial of S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for First Line Treatment of Advanced Gastric Cancer[NCT01671449]	Phase 3	338 participants (Actual)	Interventional	2012-12-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

Phase III Trial of S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for First Line Treatment of Advanced Gastric Cancer[NCT01671449]

Phase 3

338 participants (Actual)

Interventional

2012-12-31

Completed

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

26 other studies available for uracil and Sarcoma 180

Article	Year
Antitumor activity of 5-bis(2-chloroethyl) amino uracil against sarcoma 180 and Ehrlich carcinoma. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1958, Volume: 99, Issue:3 Topics: Animals; Carcinoma; Mechlorethamine; Nitrogen Mustard Compounds; Sarcoma 180; Uracil	1958
Growth inhibition of sarcoma 180 by hormone antisera and 5-fluor-ouracil. Acta endocrinologica, 1963, Volume: 42 Topics: Animals; Fluorouracil; Growth Hormone; Human Growth Hormone; Humans; Immune Sera; Sarcoma 180; Uraci	1963
Sarcoma 180 inhibition by combinations of 6-thioguanine and uracil mustard. Science (New York, N.Y.), 1962, Oct-26, Volume: 138, Issue:3539 Topics: Animals; Antineoplastic Agents; Mercaptopurine; Sarcoma 180; Thioguanine; Uracil; Uracil Mustard	1962
THE UPTAKE OF FUANINE, URACIL, LYSINE AND GLYCINE BY ASCITES CELLS PRETREATED WITH AZASERINE AND 6-THIOGUANINE. The Biochemical journal, 1963, Volume: 89 Topics: Animals; Antineoplastic Agents; Ascites; Azaserine; Carbon Isotopes; DNA; DNA, Neoplasm; Glycine; Gu	1963
[EXPERIMENTAL STUDIES ON THE ANTINEOPLASTIC EFFECT OF OLIVOMYCIN IN ASSOCIATION WITH SOME SYNTHETIC CYTOSTATIC DRUGS IN CROCKER'S SARCOMA]. Antibiotiki, 1963, Volume: 8 Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Busulfan; Cytost	1963
[EFFECT OF SOME PYRIMIDINE DERIVATIVES ON THE GROWTH OF CROCKER'S SARCOMA]. Voprosy onkologii, 1963, Volume: 9 Topics: Animals; Antineoplastic Agents; Cytosine; Mice; Neoplasms; Pharmacology; Pyrimidines; Research; Sarc	1963
METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS. Cancer research, 1965, Volume: 25 Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neopla	1965
DNA-associated RNA from sarcoma 180 cells. Biochimica et biophysica acta, 1967, Mar-29, Volume: 138, Issue:1 Topics: Adenine; Animals; Cytosine; Dactinomycin; DNA, Neoplasm; Guanine; Kinetics; Mice; Nucleotidyltransfe	1967
[Studies on the mechanism of antitumor activity of 5-FU and its derivatives--relationship between the inhibition of tumor growth and the inhibition of thymidylate synthetase in vivo]. Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:5 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; DNA,	1984
Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil. Gan, 1980, Volume: 71, Issue:1 Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism;	1980
In vivo 19F NMR comparative study of 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and an FT-uracil coadministration system in mouse tumors. Chemical & pharmaceutical bulletin, 1994, Volume: 42, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorine; Fluorouracil; Liver; Magnetic Res	1994
Nucleosides and nucleotides. 175. Structural requirements of the sugar moiety for the antitumor activities of new nucleoside antimetabolites, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and -uracil1. Journal of medicinal chemistry, 1998, Jul-16, Volume: 41, Issue:15 Topics: Animals; Antimetabolites, Antineoplastic; Carbohydrate Sequence; Cell Division; Cytosine; Drug Scree	1998
Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents. Gan, 1979, Volume: 70, Issue:2 Topics: Administration, Oral; Animals; Cytosine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Li	1979
Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil. Gan, 1978, Volume: 69, Issue:6 Topics: Animals; Drug Therapy, Combination; Fluorouracil; Liver Neoplasms, Experimental; Male; Mice; Rats; S	1978
Mode of action of Withaferin A and Withanolide D. Biochemical pharmacology, 1975, Apr-15, Volume: 24, Issue:8 Topics: Animals; Antineoplastic Agents; Cholestenes; Cholestenones; Depression, Chemical; Ethers, Cyclic; La	1975
Synthesis, characterization, and antitumor activity of 5-iodouracil complexes. Journal of inorganic biochemistry, 1991, Volume: 44, Issue:4 Topics: Animals; Antineoplastic Agents; Cadmium; Cobalt; Copper; Electron Spin Resonance Spectroscopy; Femal	1991
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents]. Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorou	1987
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors]. Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:5 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci	1988
Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts. Japanese journal of cancer research : Gann, 1987, Volume: 78, Issue:7 Topics: Animals; Barbiturates; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NAD+); Flu	1987
[Effect of fluoropyrimidine, drugs of tegafur and UFT on transplanted tumor in liver-damaged mice]. Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:10 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical an	1988
[Synchronization of tumor cells with 5-fluorouracil plus uracil and with vinblastine and irradiation of the synchronized cultures. A contribution to combined radio-chemotherapy]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1988, Volume: 164, Issue:3 Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Combined Modality Therapy; Fluorouracil; In Vitro	1988
Synthesis of 1-[[2-hydroxy-1-(hydroxymethyl)ethoxy] methyl]-5-benzyluracil and its amino analogue, new potent uridine phosphorylase inhibitors with high water solubility. Journal of medicinal chemistry, 1985, Volume: 28, Issue:7 Topics: Animals; Chemical Phenomena; Chemistry; Mice; Pentosyltransferases; Sarcoma 180; Solubility; Uracil;	1985
5-Arylaminopyrimidines. Journal of medicinal chemistry, 1966, Volume: 9, Issue:1 Topics: Animals; Antimetabolites; Chemistry, Organic; Enterobacter; Enterococcus faecalis; Escherichia coli;	1966
[Experimental study of the antineoplastic effect of the antibiotic polymycin]. Antibiotiki, 1970, Volume: 15, Issue:5 Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antifungal Agents; Antiviral Agents; As	1970
[Effect of 4-methyluracil on the antineoplastic and toxic effect of 6-mercaptopurine]. Voprosy onkologii, 1971, Volume: 17, Issue:1 Topics: Animals; Drug Synergism; Lymphoma, Non-Hodgkin; Mercaptopurine; Mice; Neoplasm Transplantation; Neop	1971
Synthesis and properties of 5-mercaptomethyluracil and related derivatives. Journal of medicinal chemistry, 1966, Volume: 9, Issue:1 Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Chemistry, Organic; Mi	1966

Article

Year

Antitumor activity of 5-bis(2-chloroethyl) amino uracil against sarcoma 180 and Ehrlich carcinoma.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1958, Volume: 99, Issue:3

Topics: Animals; Carcinoma; Mechlorethamine; Nitrogen Mustard Compounds; Sarcoma 180; Uracil

1958

Growth inhibition of sarcoma 180 by hormone antisera and 5-fluor-ouracil.

Acta endocrinologica, 1963, Volume: 42

Topics: Animals; Fluorouracil; Growth Hormone; Human Growth Hormone; Humans; Immune Sera; Sarcoma 180; Uraci

1963

Sarcoma 180 inhibition by combinations of 6-thioguanine and uracil mustard.

Science (New York, N.Y.), 1962, Oct-26, Volume: 138, Issue:3539

Topics: Animals; Antineoplastic Agents; Mercaptopurine; Sarcoma 180; Thioguanine; Uracil; Uracil Mustard

1962

THE UPTAKE OF FUANINE, URACIL, LYSINE AND GLYCINE BY ASCITES CELLS PRETREATED WITH AZASERINE AND 6-THIOGUANINE.

The Biochemical journal, 1963, Volume: 89

Topics: Animals; Antineoplastic Agents; Ascites; Azaserine; Carbon Isotopes; DNA; DNA, Neoplasm; Glycine; Gu

1963

[EXPERIMENTAL STUDIES ON THE ANTINEOPLASTIC EFFECT OF OLIVOMYCIN IN ASSOCIATION WITH SOME SYNTHETIC CYTOSTATIC DRUGS IN CROCKER'S SARCOMA].

Antibiotiki, 1963, Volume: 8

Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Busulfan; Cytost

1963

[EFFECT OF SOME PYRIMIDINE DERIVATIVES ON THE GROWTH OF CROCKER'S SARCOMA].

Voprosy onkologii, 1963, Volume: 9

Topics: Animals; Antineoplastic Agents; Cytosine; Mice; Neoplasms; Pharmacology; Pyrimidines; Research; Sarc

1963

METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS.

Cancer research, 1965, Volume: 25

Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neopla

1965

DNA-associated RNA from sarcoma 180 cells.

Biochimica et biophysica acta, 1967, Mar-29, Volume: 138, Issue:1

Topics: Adenine; Animals; Cytosine; Dactinomycin; DNA, Neoplasm; Guanine; Kinetics; Mice; Nucleotidyltransfe

1967

[Studies on the mechanism of antitumor activity of 5-FU and its derivatives--relationship between the inhibition of tumor growth and the inhibition of thymidylate synthetase in vivo].

Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:5

Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; DNA,

1984

Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.

Gan, 1980, Volume: 71, Issue:1

Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism;

1980

In vivo 19F NMR comparative study of 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and an FT-uracil coadministration system in mouse tumors.

Chemical & pharmaceutical bulletin, 1994, Volume: 42, Issue:4

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorine; Fluorouracil; Liver; Magnetic Res

1994

Nucleosides and nucleotides. 175. Structural requirements of the sugar moiety for the antitumor activities of new nucleoside antimetabolites, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and -uracil1.

Journal of medicinal chemistry, 1998, Jul-16, Volume: 41, Issue:15

Topics: Animals; Antimetabolites, Antineoplastic; Carbohydrate Sequence; Cell Division; Cytosine; Drug Scree

1998

Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents.

Gan, 1979, Volume: 70, Issue:2

Topics: Administration, Oral; Animals; Cytosine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Li

1979

Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil.

Gan, 1978, Volume: 69, Issue:6

Topics: Animals; Drug Therapy, Combination; Fluorouracil; Liver Neoplasms, Experimental; Male; Mice; Rats; S

1978

Mode of action of Withaferin A and Withanolide D.

Biochemical pharmacology, 1975, Apr-15, Volume: 24, Issue:8

Topics: Animals; Antineoplastic Agents; Cholestenes; Cholestenones; Depression, Chemical; Ethers, Cyclic; La

1975

Synthesis, characterization, and antitumor activity of 5-iodouracil complexes.

Journal of inorganic biochemistry, 1991, Volume: 44, Issue:4

Topics: Animals; Antineoplastic Agents; Cadmium; Cobalt; Copper; Electron Spin Resonance Spectroscopy; Femal

1991

[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].

Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7

Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorou

1987

[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].

Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:5

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci

1988

Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.

Japanese journal of cancer research : Gann, 1987, Volume: 78, Issue:7

Topics: Animals; Barbiturates; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NAD+); Flu

1987

[Effect of fluoropyrimidine, drugs of tegafur and UFT on transplanted tumor in liver-damaged mice].

Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:10

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical an

1988

[Synchronization of tumor cells with 5-fluorouracil plus uracil and with vinblastine and irradiation of the synchronized cultures. A contribution to combined radio-chemotherapy].

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1988, Volume: 164, Issue:3

Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Combined Modality Therapy; Fluorouracil; In Vitro

1988

Synthesis of 1-[[2-hydroxy-1-(hydroxymethyl)ethoxy] methyl]-5-benzyluracil and its amino analogue, new potent uridine phosphorylase inhibitors with high water solubility.

Journal of medicinal chemistry, 1985, Volume: 28, Issue:7

Topics: Animals; Chemical Phenomena; Chemistry; Mice; Pentosyltransferases; Sarcoma 180; Solubility; Uracil;

1985

5-Arylaminopyrimidines.

Journal of medicinal chemistry, 1966, Volume: 9, Issue:1

Topics: Animals; Antimetabolites; Chemistry, Organic; Enterobacter; Enterococcus faecalis; Escherichia coli;

1966

[Experimental study of the antineoplastic effect of the antibiotic polymycin].

Antibiotiki, 1970, Volume: 15, Issue:5

Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antifungal Agents; Antiviral Agents; As

1970

[Effect of 4-methyluracil on the antineoplastic and toxic effect of 6-mercaptopurine].

Voprosy onkologii, 1971, Volume: 17, Issue:1

Topics: Animals; Drug Synergism; Lymphoma, Non-Hodgkin; Mercaptopurine; Mice; Neoplasm Transplantation; Neop

1971

Synthesis and properties of 5-mercaptomethyluracil and related derivatives.

Journal of medicinal chemistry, 1966, Volume: 9, Issue:1

Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Chemistry, Organic; Mi

1966