uracil has been researched along with Liver Diseases in 19 studies
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 3,5-diiodothyronine (T2) has been used with success in rat models of dyslipidemia and NAFLD, but the outcome of a clinical trial with a synthetic T2 analogue was disappointing." | 5.05 | Thyroid Hormone Analogues: An Update. ( Zucchi, R, 2020) |
| "Uracil fed as 3% of the diet to rats produces urinary calculi and consequent proliferative lesions of the bladder epithelium, including papillomatosis." | 3.67 | Uracil-induced calculi and proliferative lesions of the mouse urinary bladder. ( Cohen, SM; Masui, T; Sakata, T; St John, M, 1988) |
| "0%) had at least 1 adverse event leading to study discontinuation." | 2.90 | Open-label study to evaluate trifluridine/tipiracil safety, tolerability and pharmacokinetics in patients with advanced solid tumours and hepatic impairment. ( Bebeau, P; Becerra, C; Rosen, L; Rudek, MA; Saif, MW; Shepard, DR; Sun, W; Winkler, R; Yamashita, F, 2019) |
| " Dasabuvir exhibits linear pharmacokinetics with a terminal half-life of approximately 5-8 h, allowing for twice-daily dosing." | 2.55 | Clinical Pharmacokinetics of Dasabuvir. ( Dutta, S; Khatri, A; King, JR; Menon, RM; Zha, J, 2017) |
| "Advanced or recurrent pancreatic cancer can sometimes cause obstruction or stenosis of the portal vein (PV), resulting in various symptoms of portal hypertension (PH), such as ascites, pancytopenia, hemorrhagic tendencies and liver dysfunction." | 1.35 | Placement of an expandable metallic stent improves the efficacy of chemoradiotherapy for pancreatic cancer with malignant portal vein stenosis or obstruction. ( Endo, S; Hashimoto, K; Iguchi, C; Itakura, M; Koike, M; Nio, Y; Nishi, T; Omori, H; Sato, Y; Takamura, M; Takeda, H, 2009) |
| "Uracil was previously shown by us to be the active principle of Trionyx carapax." | 1.29 | Effect of pretreatment of rats with uracil on liver injuries induced by D-galactosamine and allyl alcohol. ( Ariyoshi, T; Kitajima, S; Ogawa, N, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (57.89) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Zucchi, R | 1 |
| Poupon, R | 1 |
| Saif, MW | 1 |
| Rosen, L | 1 |
| Rudek, MA | 1 |
| Sun, W | 1 |
| Shepard, DR | 1 |
| Becerra, C | 1 |
| Yamashita, F | 2 |
| Bebeau, P | 1 |
| Winkler, R | 1 |
| King, JR | 1 |
| Zha, J | 1 |
| Khatri, A | 1 |
| Dutta, S | 1 |
| Menon, RM | 1 |
| Nio, Y | 1 |
| Iguchi, C | 1 |
| Itakura, M | 1 |
| Nishi, T | 1 |
| Hashimoto, K | 1 |
| Takeda, H | 1 |
| Takamura, M | 1 |
| Omori, H | 1 |
| Sato, Y | 1 |
| Koike, M | 1 |
| Endo, S | 1 |
| FRITZSON, P | 2 |
| BEHKI, RM | 1 |
| MORGAN, WS | 1 |
| LEEVY, CM | 1 |
| TEN-HOVE, W | 1 |
| FRANK, O | 1 |
| BAKER, H | 1 |
| KIM, S | 1 |
| COHEN, PP | 1 |
| Malinovsky, NN | 1 |
| Vinnitsky, LI | 1 |
| Zhidkov, IL | 1 |
| Kitajima, S | 1 |
| Ogawa, N | 1 |
| Ariyoshi, T | 1 |
| Sumi, S | 1 |
| Kidouchi, K | 1 |
| Hayashi, K | 1 |
| Imaeda, M | 1 |
| Asai, M | 1 |
| Wada, Y | 1 |
| Tanaka, M | 1 |
| Fukumori, K | 1 |
| Ando, E | 1 |
| Yano, Y | 1 |
| Kato, O | 1 |
| Yamamoto, H | 1 |
| Fukuda, H | 1 |
| Kusaba, T | 1 |
| Tanikawa, K | 1 |
| Sata, M | 1 |
| Aoike, A | 1 |
| Hosokawa, T | 1 |
| Koyama, K | 1 |
| Rokutan, K | 1 |
| Nishi, Y | 1 |
| Yoshida, A | 1 |
| Nakamura, K | 1 |
| Kawai, K | 1 |
| Sakata, T | 1 |
| Masui, T | 1 |
| St John, M | 1 |
| Cohen, SM | 1 |
| Postovit, VA | 1 |
| Fedulova, EG | 1 |
| Babak, VI | 1 |
| Maksimets, VG | 1 |
| Surminskaia, IS | 1 |
| Heirwegh, KP | 1 |
| Ramboer, C | 1 |
| De Groote, J | 1 |
| Vitlin, VI | 1 |
3 reviews available for uracil and Liver Diseases
| Article | Year |
|---|---|
Thyroid Hormone Analogues: An Update.
Topics: Acetates; Anilides; Animals; Central Nervous System Diseases; Clinical Trials as Topic; Diiodothyron | 2020 |
Clinical Pharmacokinetics of Dasabuvir.
Topics: 2-Naphthylamine; Animals; Antiviral Agents; Drug Interactions; Drug Therapy, Combination; Hepaciviru | 2017 |
[Use of pentoxyl and methyluracil (methacil) in liver diseases (literature review)].
Topics: Animals; Chemical and Drug Induced Liver Injury; Child; Cholestasis; Humans; Liver Diseases; Liver R | 1971 |
2 trials available for uracil and Liver Diseases
| Article | Year |
|---|---|
Open-label study to evaluate trifluridine/tipiracil safety, tolerability and pharmacokinetics in patients with advanced solid tumours and hepatic impairment.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Bilirubin; Drug Administration Schedule; D | 2019 |
A crossover study of oral administration of UFT in chronic liver disease: comparison of continuous and intermittent schedules.
Topics: Administration, Oral; Aged; Area Under Curve; Carcinoma, Hepatocellular; Chronic Disease; Cross-Over | 1998 |
14 other studies available for uracil and Liver Diseases
| Article | Year |
|---|---|
Therapeutics Highlights from ILC 2018, the EASL annual congress.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antiviral Agents; Bezafibrate; Budesoni | 2018 |
Placement of an expandable metallic stent improves the efficacy of chemoradiotherapy for pancreatic cancer with malignant portal vein stenosis or obstruction.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Con | 2009 |
The relation between uracil-catabolizing enzymes and rate of rat liver regeneration.
Topics: Animals; Enzymes; Hyperplasia; Liver; Liver Diseases; Liver Regeneration; Rats; Regeneration; Uracil | 1962 |
STUDIES ON THE PHOSPHORYLATION OF THYMIDINE IN REGENERATING RAT LIVER.
Topics: Cytosine; DNA; Fluorides; Liver Diseases; Liver Regeneration; Nucleosides; Nucleotidases; Oxidative | 1964 |
FOLIC ACID DEFICIENCY AND HEPATIC DNA SYNTHESIS.
Topics: Avitaminosis; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; DNA; Folic Aci | 1964 |
DELAYED SYNTHESIS OF URACIL-DEGRADING ENZYMES IN REGENERATION RAT LIVER.
Topics: Fluorenes; Liver; Liver Diseases; Liver Regeneration; Metabolism; Nucleosides; Oxidoreductases; Phar | 1964 |
TRANSCARBAMYLASE ACTIVITY IN FETAL LIVER AND IN LIVER OF PARTIALLY HEPATECTOMIZED PARABIOTIC RATS.
Topics: Cell Division; Enzyme Precursors; Erythrocyte Count; Fetus; Guinea Pigs; Hepatectomy; Ligases; Liver | 1965 |
Assessment of hepatic tissue blood flow with 133Xe clearance technique.
Topics: Animals; Dogs; Liver; Liver Diseases; Male; Microcirculation; Orotic Acid; Rats; Uracil; Xenon Radio | 1981 |
Effect of pretreatment of rats with uracil on liver injuries induced by D-galactosamine and allyl alcohol.
Topics: 1-Propanol; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Li | 1994 |
Urinary screening for pyrimidine metabolism disorders. Reference ranges for dihydrouracil, uracil, and dihydrouracil/uracil ratio.
Topics: Adult; Cerebral Infarction; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Hypertension; Liver | 1998 |
[Effect of fluoropyrimidine, drugs of tegafur and UFT on transplanted tumor in liver-damaged mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical an | 1988 |
Uracil-induced calculi and proliferative lesions of the mouse urinary bladder.
Topics: Animals; Cell Division; DNA; Dose-Response Relationship, Drug; Female; Hydronephrosis; Kidney Diseas | 1988 |
[On the treatment of typho-paratyphoid bacterial carrier state].
Topics: Adult; Aged; Ampicillin; Anti-Bacterial Agents; Carrier State; Cholecystitis; Female; gamma-Globulin | 1968 |
Purine and pyrimidine excretion. I. Chromatographic separation and identification of purine and pyrimidine metabolites in human urine.
Topics: Adenine; Chromatography; Chromatography, Paper; Creatine; Diet; Humans; Hypoxanthines; Liver Disease | 1967 |