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uracil and Leukemia

uracil has been researched along with Leukemia in 37 studies

2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"5-Fluorouracil (5-FU) is an antimetabolite that interferes with DNA synthesis and has been widely used as a chemotherapeutic drug in various types of cancers."5.56New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line. ( Długosz-Pokorska, A; Janecka, A; Janecki, T; Kędzia, J; Pięta, M, 2020)
"Cyclopentenylcytosine (CPE-C), a synthetic cytidine analogue with significant preclinical antitumor activity against both solid tumor xenografts and 1-beta-D-arabinofuranosylcytosine resistant murine leukemia cell lines, will soon enter phase I clinical trials."3.68Modulation of the cytotoxic effect of cyclopentenylcytosine by its primary metabolite, cyclopentenyluridine. ( Adamson, PC; Balis, FM; Blaney, SM; Cole, DE; Grem, J; Poplack, DG, 1992)
"5-Fluorouracil (5-FU) is an antimetabolite that interferes with DNA synthesis and has been widely used as a chemotherapeutic drug in various types of cancers."1.56New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line. ( Długosz-Pokorska, A; Janecka, A; Janecki, T; Kędzia, J; Pięta, M, 2020)
"The dose-response curves for the inhibition of equilibrative uridine transport by dilazep, dipyridamole and nitrobenzylthioinosine (NBMPR) in undifferentiated HL-60 cells were biphasic."1.29Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C. ( Lee, CW, 1994)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199029 (78.38)18.7374
1990's4 (10.81)18.2507
2000's2 (5.41)29.6817
2010's1 (2.70)24.3611
2020's1 (2.70)2.80

Authors

AuthorsStudies
Długosz-Pokorska, A1
Pięta, M1
Kędzia, J1
Janecki, T1
Janecka, A1
Pivovarova, AI1
MacGregor, GG1
HORRIGAN, DL1
MOKEEVA, RA1
VISHNIAKOVA, EG1
EIDINOFF, ML1
CHEONG, L1
GURPIDE, EG1
BENUA, RS1
ELLISON, RR1
FREIREICH, EJ1
FREI, E1
HOLLAND, JF1
PINKEL, D1
SELAWRY, O1
ROTHBERG, H1
HAURANI, F1
TAYLOR, R1
GEHAN, EA2
KENNEDY, BJ3
THEOLOGIDES, A3
MISAROVA, Z1
ELIS, J1
INNES, J1
COOPER, EH1
MILTON, JD1
HANDSCHUMACHER, RE1
SATO, K1
LEPAGE, GA1
OBRECHT, P1
PETROV, KIa1
SAMPEY, JR1
Parry, TE4
Cleverley, J1
McCaffrey, R1
Bell, R1
Lillquist, A1
Wright, G1
Baril, E1
Minowada, J1
Lee, CW1
Ferrari, MB1
Fava, GG1
Leporati, E1
Pelosi, G1
Rossi, R1
Tarasconi, P1
Albertini, R1
Bonati, A1
Lunghi, P1
Pinelli, S1
Blaney, SM1
Balis, FM1
Grem, J1
Cole, DE1
Adamson, PC1
Poplack, DG1
Herrala, AM1
Vilpo, JA1
Arakawa, T1
Wada, Y1
Hayashi, T1
Kakizaki, R1
Chida, N1
Chiba, R1
Konno, T1
Schmähl, D1
Viola, MV1
Dexter, DL1
Wolberg, WH1
Ansfield, FJ1
Helson, L1
Heidelberger, C1
Wacker, A1
Rabinowitz, Y1
Farmer, R1
Czebotar, V1
Reĭzinger, MA1
Morozova, VT1
Miroshnichenko, IS1
Terent'eva, NI1

Reviews

2 reviews available for uracil and Leukemia

ArticleYear
Mutagenic mechanisms in leukemia and cancer: a new concept Cytosine lack could be as mutagenic as cytosine deamination.
    Leukemia research, 2006, Volume: 30, Issue:9

    Topics: Cytosine; Deamination; DNA Methylation; DNA Repair; Humans; Leukemia; Point Mutation; Ultraviolet Ra

2006
[Recent aspects of antiviral therapy].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1971, Volume: 77

    Topics: Animals; Antibody Formation; Cattle; Chick Embryo; Chickens; Child; Herpes Zoster Ophthalmicus; Huma

1971

Trials

1 trial available for uracil and Leukemia

ArticleYear
The clinical pharmacology of 5-trifluoromethyl-2'-deoxyuridine.
    Cancer research, 1972, Volume: 32, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Carbon Dioxide; Carbon Isotopes; Carcinoma, Hepatocellular; Clin

1972

Other Studies

34 other studies available for uracil and Leukemia

ArticleYear
New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line.
    BMC pharmacology & toxicology, 2020, 03-02, Volume: 21, Issue:1

    Topics: Antimetabolites, Antineoplastic; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil;

2020
Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 98

    Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Glucose; Growth Inhibitors; Humans; K562 Cells; Leuke

2018
Urinary excretion of nucleic acid derivatives in persons with myeloid leukemia.
    The Journal of clinical investigation, 1954, Volume: 33, Issue:6

    Topics: Body Fluids; Humans; Leukemia; Leukemia, Myeloid; Nucleic Acids; Uracil; Urine

1954
[Result of use of dopan in treatment of chronic myeloleukosis].
    Sovetskaia meditsina, 1958, Volume: 22, Issue:9

    Topics: Humans; Leukemia; Leukemia, Myeloid; Mechlorethamine; Nitrogen Mustard Compounds; Uracil; Uracil Mus

1958
[First results of dopane therapy of chronic myeloid leukemia and of certain malignant tumors].
    Voprosy onkologii, 1958, Volume: 4, Issue:5

    Topics: Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Mechlorethami

1958
Incorporation of 5-iodouracil labelled with iodine-131 into the deoxyribonucleic acid of human leukaemic leucocytes following in vivo administration of 5-iododeoxyuridine labelled with iodine-131.
    Nature, 1959, Jun-13, Volume: 183, Issue:4676

    Topics: DNA; Idoxuridine; Iodine; Leukemia; Leukocytes; Nucleosides; Nucleotides; Uracil

1959
Evaluation of a new chemotherapeutic agent in patients with 'advanced refractory' acute leukemia. Studies of 6-azauracil.
    Blood, 1960, Volume: 16

    Topics: Acute Disease; Antineoplastic Agents; Humans; Leukemia; Uracil

1960
Effect of uracil mustard in chronic lymphatic leukemia and malignant lymphoma.
    Cancer chemotherapy reports, 1961, Volume: 11

    Topics: Antineoplastic Agents; Hodgkin Disease; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia,

1961
Uracil mustard, a new alkylating agent for oral administration in the management of patients with leukemia and lymphoma.
    The New England journal of medicine, 1961, Apr-20, Volume: 264

    Topics: Administration, Oral; Alkylating Agents; Antineoplastic Agents; Humans; Leukemia; Lymphoma; Uracil;

1961
Effect of uracil mustard in malignant lymphoma and chronic lymphatic leukemia.
    Minnesota medicine, 1962, Volume: 45

    Topics: Leukemia; Leukemia, Lymphoid; Lymphoma; Mechlorethamine; Minnesota; Nitrogen Mustard Compounds; Urac

1962
[AZAURACIL RIBOSIDE AND AZAURACIL RIBOSIDE TRIACETATE IN THE THERAPY OF LEUKEMIA IN CHILDREN].
    Ceskoslovenska pediatrie, 1964, Volume: 19

    Topics: Adolescent; Antineoplastic Agents; Child; Leukemia; Mercaptopurine; Nucleosides; Prednisone; Uracil

1964
ANTI-LEUKAEMIC DRUGS.
    The Practitioner, 1964, Volume: 193

    Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; M

1964
THE INCORPORATION AND DEGRADATION OF PYRIMIDINE DNA PRECURSORS BY HUMAN LEUCOCYTES.
    British journal of cancer, 1964, Volume: 18

    Topics: Autoradiography; Carbon Isotopes; Cytosine Nucleotides; Deoxyuridine; DNA; Humans; Infectious Mononu

1964
OXONATE AND OTHER RELATED ANTIMETABOLITES OF THE SYNTHESIS DE NOVO OF PYRIMIDINE NUCLEOTIDES.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Antimetabolites; Autoradiography; Leukemia; Leukemia, Experimental; Liver; Liver Extracts; Metabolis

1964
METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS.
    Cancer research, 1965, Volume: 25

    Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neopla

1965
[Problems in chemotherapy illustrated by the cytostatic 5-fluoruracil and the leukemias].
    Strahlentherapie, 1961, Volume: Suppl 48

    Topics: Antineoplastic Agents; Cytostatic Agents; Fluorouracil; Leukemia; Uracil

1961
[On dopan therapy of patients with lymphogranulomatosis, chronic lymphatic leukemia and other systemic blood diseases].
    Sovetskaia meditsina, 1961, Volume: 25

    Topics: Antineoplastic Agents; Hematologic Diseases; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphocyti

1961
Management of human leukemias and Hodgkin's disease with Dopan (uracil mustard).
    Journal of the South Carolina Medical Association, 1962, Volume: 58

    Topics: Disease Management; Hodgkin Disease; Humans; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds;

1962
American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA.
    IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:8

    Topics: Clinical Trials as Topic; Cytarabine; Drug Combinations; Gossypol; Humans; Leukemia; Mastocytosis, S

2006
Design of controlled clinical trials: use of historical controls.
    Cancer treatment reports, 1982, Volume: 66, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Daunorubic

1982
Selective killing of leukemia cells by inhibition of TdT.
    Haematology and blood transfusion, 1983, Volume: 28

    Topics: Animals; Cell Line; Cell Survival; DNA Nucleotidylexotransferase; DNA Nucleotidyltransferases; DNA-D

1983
Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C.
    The Biochemical journal, 1994, Jun-01, Volume: 300 ( Pt 2)

    Topics: Affinity Labels; Alkaloids; Binding Sites; Biological Transport; Cell Differentiation; Dilazep; Dipy

1994
Two possible metabolic blocks in DNA synthesis that could be mutagenic.
    Leukemia research, 1994, Volume: 18, Issue:3

    Topics: Amination; DNA, Neoplasm; Humans; Hypoxanthines; Leukemia; Mutation; Uracil

1994
Synthesis, characterisation and biological activity of three copper (II) complexes with a modified nitrogenous base: 5-formyluracil thiosemicarbazone.
    Journal of inorganic biochemistry, 1998, Volume: 70, Issue:2

    Topics: Apoptosis; Cell Division; Cell Survival; Copper; Crystallography, X-Ray; Humans; Leukemia; Models, M

1998
Serum uracil levels in acute childhood leukaemia.
    British journal of haematology, 1978, Volume: 39, Issue:2

    Topics: Acute Disease; Adult; Child; Female; Humans; Leukemia; Leukemia, Myeloid, Acute; Leukocyte Count; Ma

1978
Modulation of the cytotoxic effect of cyclopentenylcytosine by its primary metabolite, cyclopentenyluridine.
    Cancer research, 1992, Jun-15, Volume: 52, Issue:12

    Topics: Cell Survival; Cytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Leu

1992
Template-primer activity of 5-(hydroxymethyl)uracil-containing DNA for prokaryotic and eukaryotic DNA and RNA polymerases.
    Biochemistry, 1989, Oct-17, Volume: 28, Issue:21

    Topics: Bacillus subtilis; Bacteriophages; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; DNA, V

1989
Adenosine deaminase (ADA) in leukemia: clinical value of plasma ADA activity and characterization of leukemic cell ADA.
    American journal of hematology, 1986, Volume: 21, Issue:4

    Topics: Adenosine Deaminase; Adult; Child; Humans; Leukemia; Lymphocytes; Mutation; Nucleoside Deaminases; U

1986
Uracil-uric refractory anemia with peroxidase negative neutrophils.
    The Tohoku journal of experimental medicine, 1965, Oct-25, Volume: 87, Issue:1

    Topics: Anemia, Hypochromic; Anemia, Macrocytic; Blood Cell Count; Bone Marrow; Child; Chromatography; Chrom

1965
[Examination of 1,3-dimethyl-4-amino-5-nitroso-uracile for carcinogenic effect in rats (author's transl)].
    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1973, Dec-28, Volume: 80, Issue:4

    Topics: Animals; Chemical Phenomena; Chemistry; Fibrosarcoma; Injections, Intraperitoneal; Leukemia; Lymphom

1973
Acute leukemia and infection.
    JAMA, 1967, Sep-18, Volume: 201, Issue:12

    Topics: Acute Disease; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Agranulocytosis; Aspergillosis;

1967
Deoxycytidine pathway in separated normal and leukemic leukocytes with effects of cell culture.
    Blood, 1971, Volume: 38, Issue:3

    Topics: Chromatography, Paper; Culture Techniques; Cytosine Nucleotides; Deoxyuridine; Humans; Lectins; Leuk

1971
[Some peculiarities in the course of systemic diseases of haematopoietic organs in the process of chemotherapy].
    Voprosy onkologii, 1966, Volume: 12, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Blood Transfusion; Female; Humans; Leukemia; Lymphatic Diseases; Lym

1966
[The treatment of subleukemic myeloleukosis with Dopan].
    Terapevticheskii arkhiv, 1967, Volume: 39, Issue:2

    Topics: Aged; Female; Humans; Leukemia; Middle Aged; Nitrogen Mustard Compounds; Uracil

1967