uracil has been researched along with Leukemia in 37 studies
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU) is an antimetabolite that interferes with DNA synthesis and has been widely used as a chemotherapeutic drug in various types of cancers." | 5.56 | New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line. ( Długosz-Pokorska, A; Janecka, A; Janecki, T; Kędzia, J; Pięta, M, 2020) |
| "Cyclopentenylcytosine (CPE-C), a synthetic cytidine analogue with significant preclinical antitumor activity against both solid tumor xenografts and 1-beta-D-arabinofuranosylcytosine resistant murine leukemia cell lines, will soon enter phase I clinical trials." | 3.68 | Modulation of the cytotoxic effect of cyclopentenylcytosine by its primary metabolite, cyclopentenyluridine. ( Adamson, PC; Balis, FM; Blaney, SM; Cole, DE; Grem, J; Poplack, DG, 1992) |
| "5-Fluorouracil (5-FU) is an antimetabolite that interferes with DNA synthesis and has been widely used as a chemotherapeutic drug in various types of cancers." | 1.56 | New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line. ( Długosz-Pokorska, A; Janecka, A; Janecki, T; Kędzia, J; Pięta, M, 2020) |
| "The dose-response curves for the inhibition of equilibrative uridine transport by dilazep, dipyridamole and nitrobenzylthioinosine (NBMPR) in undifferentiated HL-60 cells were biphasic." | 1.29 | Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C. ( Lee, CW, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (78.38) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 2 (5.41) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Długosz-Pokorska, A | 1 |
| Pięta, M | 1 |
| Kędzia, J | 1 |
| Janecki, T | 1 |
| Janecka, A | 1 |
| Pivovarova, AI | 1 |
| MacGregor, GG | 1 |
| HORRIGAN, DL | 1 |
| MOKEEVA, RA | 1 |
| VISHNIAKOVA, EG | 1 |
| EIDINOFF, ML | 1 |
| CHEONG, L | 1 |
| GURPIDE, EG | 1 |
| BENUA, RS | 1 |
| ELLISON, RR | 1 |
| FREIREICH, EJ | 1 |
| FREI, E | 1 |
| HOLLAND, JF | 1 |
| PINKEL, D | 1 |
| SELAWRY, O | 1 |
| ROTHBERG, H | 1 |
| HAURANI, F | 1 |
| TAYLOR, R | 1 |
| GEHAN, EA | 2 |
| KENNEDY, BJ | 3 |
| THEOLOGIDES, A | 3 |
| MISAROVA, Z | 1 |
| ELIS, J | 1 |
| INNES, J | 1 |
| COOPER, EH | 1 |
| MILTON, JD | 1 |
| HANDSCHUMACHER, RE | 1 |
| SATO, K | 1 |
| LEPAGE, GA | 1 |
| OBRECHT, P | 1 |
| PETROV, KIa | 1 |
| SAMPEY, JR | 1 |
| Parry, TE | 4 |
| Cleverley, J | 1 |
| McCaffrey, R | 1 |
| Bell, R | 1 |
| Lillquist, A | 1 |
| Wright, G | 1 |
| Baril, E | 1 |
| Minowada, J | 1 |
| Lee, CW | 1 |
| Ferrari, MB | 1 |
| Fava, GG | 1 |
| Leporati, E | 1 |
| Pelosi, G | 1 |
| Rossi, R | 1 |
| Tarasconi, P | 1 |
| Albertini, R | 1 |
| Bonati, A | 1 |
| Lunghi, P | 1 |
| Pinelli, S | 1 |
| Blaney, SM | 1 |
| Balis, FM | 1 |
| Grem, J | 1 |
| Cole, DE | 1 |
| Adamson, PC | 1 |
| Poplack, DG | 1 |
| Herrala, AM | 1 |
| Vilpo, JA | 1 |
| Arakawa, T | 1 |
| Wada, Y | 1 |
| Hayashi, T | 1 |
| Kakizaki, R | 1 |
| Chida, N | 1 |
| Chiba, R | 1 |
| Konno, T | 1 |
| Schmähl, D | 1 |
| Viola, MV | 1 |
| Dexter, DL | 1 |
| Wolberg, WH | 1 |
| Ansfield, FJ | 1 |
| Helson, L | 1 |
| Heidelberger, C | 1 |
| Wacker, A | 1 |
| Rabinowitz, Y | 1 |
| Farmer, R | 1 |
| Czebotar, V | 1 |
| Reĭzinger, MA | 1 |
| Morozova, VT | 1 |
| Miroshnichenko, IS | 1 |
| Terent'eva, NI | 1 |
2 reviews available for uracil and Leukemia
| Article | Year |
|---|---|
Mutagenic mechanisms in leukemia and cancer: a new concept Cytosine lack could be as mutagenic as cytosine deamination.
Topics: Cytosine; Deamination; DNA Methylation; DNA Repair; Humans; Leukemia; Point Mutation; Ultraviolet Ra | 2006 |
[Recent aspects of antiviral therapy].
Topics: Animals; Antibody Formation; Cattle; Chick Embryo; Chickens; Child; Herpes Zoster Ophthalmicus; Huma | 1971 |
1 trial available for uracil and Leukemia
| Article | Year |
|---|---|
The clinical pharmacology of 5-trifluoromethyl-2'-deoxyuridine.
Topics: Adult; Aged; Antineoplastic Agents; Carbon Dioxide; Carbon Isotopes; Carcinoma, Hepatocellular; Clin | 1972 |
34 other studies available for uracil and Leukemia
| Article | Year |
|---|---|
New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line.
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; | 2020 |
Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Glucose; Growth Inhibitors; Humans; K562 Cells; Leuke | 2018 |
Urinary excretion of nucleic acid derivatives in persons with myeloid leukemia.
Topics: Body Fluids; Humans; Leukemia; Leukemia, Myeloid; Nucleic Acids; Uracil; Urine | 1954 |
[Result of use of dopan in treatment of chronic myeloleukosis].
Topics: Humans; Leukemia; Leukemia, Myeloid; Mechlorethamine; Nitrogen Mustard Compounds; Uracil; Uracil Mus | 1958 |
[First results of dopane therapy of chronic myeloid leukemia and of certain malignant tumors].
Topics: Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Mechlorethami | 1958 |
Incorporation of 5-iodouracil labelled with iodine-131 into the deoxyribonucleic acid of human leukaemic leucocytes following in vivo administration of 5-iododeoxyuridine labelled with iodine-131.
Topics: DNA; Idoxuridine; Iodine; Leukemia; Leukocytes; Nucleosides; Nucleotides; Uracil | 1959 |
Evaluation of a new chemotherapeutic agent in patients with 'advanced refractory' acute leukemia. Studies of 6-azauracil.
Topics: Acute Disease; Antineoplastic Agents; Humans; Leukemia; Uracil | 1960 |
Effect of uracil mustard in chronic lymphatic leukemia and malignant lymphoma.
Topics: Antineoplastic Agents; Hodgkin Disease; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, | 1961 |
Uracil mustard, a new alkylating agent for oral administration in the management of patients with leukemia and lymphoma.
Topics: Administration, Oral; Alkylating Agents; Antineoplastic Agents; Humans; Leukemia; Lymphoma; Uracil; | 1961 |
Effect of uracil mustard in malignant lymphoma and chronic lymphatic leukemia.
Topics: Leukemia; Leukemia, Lymphoid; Lymphoma; Mechlorethamine; Minnesota; Nitrogen Mustard Compounds; Urac | 1962 |
[AZAURACIL RIBOSIDE AND AZAURACIL RIBOSIDE TRIACETATE IN THE THERAPY OF LEUKEMIA IN CHILDREN].
Topics: Adolescent; Antineoplastic Agents; Child; Leukemia; Mercaptopurine; Nucleosides; Prednisone; Uracil | 1964 |
ANTI-LEUKAEMIC DRUGS.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; M | 1964 |
THE INCORPORATION AND DEGRADATION OF PYRIMIDINE DNA PRECURSORS BY HUMAN LEUCOCYTES.
Topics: Autoradiography; Carbon Isotopes; Cytosine Nucleotides; Deoxyuridine; DNA; Humans; Infectious Mononu | 1964 |
OXONATE AND OTHER RELATED ANTIMETABOLITES OF THE SYNTHESIS DE NOVO OF PYRIMIDINE NUCLEOTIDES.
Topics: Antimetabolites; Autoradiography; Leukemia; Leukemia, Experimental; Liver; Liver Extracts; Metabolis | 1964 |
METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS.
Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neopla | 1965 |
[Problems in chemotherapy illustrated by the cytostatic 5-fluoruracil and the leukemias].
Topics: Antineoplastic Agents; Cytostatic Agents; Fluorouracil; Leukemia; Uracil | 1961 |
[On dopan therapy of patients with lymphogranulomatosis, chronic lymphatic leukemia and other systemic blood diseases].
Topics: Antineoplastic Agents; Hematologic Diseases; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphocyti | 1961 |
Management of human leukemias and Hodgkin's disease with Dopan (uracil mustard).
Topics: Disease Management; Hodgkin Disease; Humans; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds; | 1962 |
American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA.
Topics: Clinical Trials as Topic; Cytarabine; Drug Combinations; Gossypol; Humans; Leukemia; Mastocytosis, S | 2006 |
Design of controlled clinical trials: use of historical controls.
Topics: Acute Disease; Adolescent; Adult; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Daunorubic | 1982 |
Selective killing of leukemia cells by inhibition of TdT.
Topics: Animals; Cell Line; Cell Survival; DNA Nucleotidylexotransferase; DNA Nucleotidyltransferases; DNA-D | 1983 |
Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C.
Topics: Affinity Labels; Alkaloids; Binding Sites; Biological Transport; Cell Differentiation; Dilazep; Dipy | 1994 |
Two possible metabolic blocks in DNA synthesis that could be mutagenic.
Topics: Amination; DNA, Neoplasm; Humans; Hypoxanthines; Leukemia; Mutation; Uracil | 1994 |
Synthesis, characterisation and biological activity of three copper (II) complexes with a modified nitrogenous base: 5-formyluracil thiosemicarbazone.
Topics: Apoptosis; Cell Division; Cell Survival; Copper; Crystallography, X-Ray; Humans; Leukemia; Models, M | 1998 |
Serum uracil levels in acute childhood leukaemia.
Topics: Acute Disease; Adult; Child; Female; Humans; Leukemia; Leukemia, Myeloid, Acute; Leukocyte Count; Ma | 1978 |
Modulation of the cytotoxic effect of cyclopentenylcytosine by its primary metabolite, cyclopentenyluridine.
Topics: Cell Survival; Cytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Leu | 1992 |
Template-primer activity of 5-(hydroxymethyl)uracil-containing DNA for prokaryotic and eukaryotic DNA and RNA polymerases.
Topics: Bacillus subtilis; Bacteriophages; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; DNA, V | 1989 |
Adenosine deaminase (ADA) in leukemia: clinical value of plasma ADA activity and characterization of leukemic cell ADA.
Topics: Adenosine Deaminase; Adult; Child; Humans; Leukemia; Lymphocytes; Mutation; Nucleoside Deaminases; U | 1986 |
Uracil-uric refractory anemia with peroxidase negative neutrophils.
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Blood Cell Count; Bone Marrow; Child; Chromatography; Chrom | 1965 |
[Examination of 1,3-dimethyl-4-amino-5-nitroso-uracile for carcinogenic effect in rats (author's transl)].
Topics: Animals; Chemical Phenomena; Chemistry; Fibrosarcoma; Injections, Intraperitoneal; Leukemia; Lymphom | 1973 |
Acute leukemia and infection.
Topics: Acute Disease; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Agranulocytosis; Aspergillosis; | 1967 |
Deoxycytidine pathway in separated normal and leukemic leukocytes with effects of cell culture.
Topics: Chromatography, Paper; Culture Techniques; Cytosine Nucleotides; Deoxyuridine; Humans; Lectins; Leuk | 1971 |
[Some peculiarities in the course of systemic diseases of haematopoietic organs in the process of chemotherapy].
Topics: Adrenal Cortex Hormones; Adult; Blood Transfusion; Female; Humans; Leukemia; Lymphatic Diseases; Lym | 1966 |
[The treatment of subleukemic myeloleukosis with Dopan].
Topics: Aged; Female; Humans; Leukemia; Middle Aged; Nitrogen Mustard Compounds; Uracil | 1967 |