uracil has been researched along with Leukemia L 1210 in 38 studies
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dosage of the oral clinical use for human cancer of 5-FU, HCFU, 5'-DFUR and UFT as tegafur (FT) is 200-300mg/d, 600mg/d, 800-1,200mg/d and 300-600mg/d respectively." | 1.31 | Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine. ( Higashigawa, M; Kagawa, Y; Kakito, H; Kawasaki, H; Kojima, M; Ohkubo, T; Ooi, A; Sakurai, M, 2001) |
| " Dose-response characteristics of the inhibition were determined." | 1.29 | Cyclopentenyl uracil: an effective inhibitor of uridine salvage in vivo. ( August, EM; Cysyk, RL; Malinowski, N; Marquez, V; Moyer, JD; Zaharevitz, D, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (76.32) | 18.7374 |
| 1990's | 8 (21.05) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peri, G | 2 |
| Polentarutti, N | 1 |
| Filippeschi, S | 2 |
| Malfiore, C | 1 |
| Amato, G | 1 |
| Pepe, S | 1 |
| Bonati, M | 1 |
| Garattini, S | 2 |
| Mantovani, A | 2 |
| Erba, E | 1 |
| Morasca, L | 1 |
| Spreafico, F | 1 |
| Arnaud, M | 1 |
| Okada, J | 2 |
| Nakano, K | 2 |
| Miyake, H | 2 |
| Yasufuku, S | 2 |
| Schroeder, AC | 1 |
| Bloch, A | 1 |
| Perman, JL | 1 |
| Bobek, M | 2 |
| Kagawa, Y | 3 |
| Ohkubo, T | 3 |
| Higashigawa, M | 3 |
| Ido, M | 1 |
| Kakito, H | 3 |
| Inagaki, S | 2 |
| Kojima, M | 2 |
| Ooi, K | 2 |
| Sakurai, M | 3 |
| Cysyk, RL | 1 |
| Malinowski, N | 1 |
| Marquez, V | 1 |
| Zaharevitz, D | 1 |
| August, EM | 1 |
| Moyer, JD | 1 |
| Azuma, A | 1 |
| Nakajima, Y | 1 |
| Nishizono, N | 1 |
| Minakawa, N | 2 |
| Suzuki, M | 1 |
| Hanaoka, K | 1 |
| Kobayashi, T | 1 |
| Tanaka, M | 2 |
| Sasaki, T | 3 |
| Matsuda, A | 3 |
| Dan, A | 1 |
| Tregear, SJ | 1 |
| Okazaki, S | 1 |
| Sugimoto, Y | 1 |
| Sumida, K | 1 |
| Kundu, NG | 1 |
| Das, P | 1 |
| Balzarini, J | 1 |
| De Clercq, E | 2 |
| Hattori, H | 1 |
| Nozawa, E | 1 |
| Iino, T | 1 |
| Yoshimura, Y | 1 |
| Shuto, S | 1 |
| Shimamoto, Y | 1 |
| Nomura, M | 1 |
| Fukushima, M | 1 |
| Ochocki, J | 1 |
| Graczyk, J | 1 |
| Ooi, A | 1 |
| Kawasaki, H | 1 |
| Choi, S | 1 |
| Kalman, TI | 1 |
| Bardos, TJ | 1 |
| Ujházy, V | 2 |
| Balázová, E | 1 |
| Stoychkov, JN | 1 |
| Mircheva, JJ | 1 |
| Delia, TJ | 1 |
| Scovill, JP | 1 |
| Munslow, WD | 1 |
| Burckhalter, JH | 1 |
| Vogel, FS | 1 |
| Kemper, LA | 1 |
| McGarry, SJ | 1 |
| Graham, DG | 1 |
| Reiner, P | 1 |
| Farkas, J | 1 |
| Skoda, J | 1 |
| Kumar, R | 1 |
| Wiebe, LI | 1 |
| Knaus, EE | 1 |
| Allen, TM | 1 |
| Fathi-Afshar, R | 1 |
| Tovell, DR | 1 |
| Tyrrell, DL | 1 |
| An, SH | 1 |
| Skrincosky, D | 1 |
| Bernacki, RJ | 1 |
| Kawaguchi, T | 2 |
| Saito, M | 2 |
| Saneyoshi, M | 2 |
| Kato, T | 1 |
| Ota, K | 1 |
| Bernier, JL | 1 |
| Hénichart, JP | 1 |
| Warin, V | 1 |
| Trentesaux, C | 1 |
| Jardillier, JC | 1 |
| Hayakawa, M | 1 |
| Morise, K | 1 |
| Oka, Y | 1 |
| Saito, H | 1 |
| Suga, S | 1 |
| Kimura, K | 1 |
| Iwase, H | 1 |
| Ina, K | 1 |
| Takada, N | 1 |
| Matsuoka, S | 1 |
| Matsuura, T | 1 |
| Yamada, K | 1 |
| Horiuchi, T | 1 |
| Hashizume, H | 1 |
| Denny, GH | 1 |
| Ryder, MA | 1 |
| Kessel, D | 2 |
| Dodd, DC | 1 |
| Wilkoff, LJ | 1 |
| Dulmadge, EA | 1 |
| Lloyd, HH | 1 |
| Wallerstein, H | 1 |
| Slater, LM | 1 |
| Eng, B | 1 |
| Calman, N | 1 |
| Garg, HG | 1 |
| Sharma, RA | 1 |
| Falco, EA | 1 |
| Fox, JJ | 2 |
| Yamaoka, N | 1 |
| Otter, BA | 1 |
| O'Brien, DE | 1 |
| Weinstock, LT | 1 |
| Cheng, CC | 1 |
| Myers, M | 1 |
| Wodinsky, I | 1 |
| Goldberg, AR | 1 |
| Machledt, JH | 1 |
| Pardee, AB | 1 |
38 other studies available for uracil and Leukemia L 1210
| Article | Year |
|---|---|
In vitro and in vivo cytotoxicity of possible uracil metabolites of methylxanthines.
Topics: Animals; Caffeine; Cartilage; In Vitro Techniques; Leukemia L1210; Lymphocyte Activation; Mice; Rats | 1983 |
In vitro and in vivo cytotoxicity of 6 amino-5-formyl-methylamino-1,3-dimethyl uracil, a uracilic metabolite of caffeine.
Topics: Animals; Caffeine; Cell Division; Female; Humans; In Vitro Techniques; Leukemia L1210; Mice; Mice, I | 1982 |
Uracil derivatives. III. Synthesis and growth-inhibitory activity against L-1210 cells of 5,6-disubstituted uracils.
Topics: Animals; Antineoplastic Agents; In Vitro Techniques; Leukemia L1210; Mice; Uracil | 1982 |
Synthesis and biological evaluation of 6-ethynyluracil, a thiol-specific alkylating pyrimidine.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; L | 1982 |
Uracil derivatives. II. Syntheses and growth-inhibitory activity against L-1210 cells of 5-(4-substituted-phenylthiomethyl)-6-carbamoyluracils.
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Mice; Uracil | 1981 |
Effects of UFT (mixed compound of tegafur and uracil) on cell kinetics and inhibition of thymidylate synthase in L1210 ascites tumor.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Deoxyuridine; Drug Combinations; Leukemia L1210; Male; M | 1995 |
Cyclopentenyl uracil: an effective inhibitor of uridine salvage in vivo.
Topics: Animals; Leukemia L1210; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Pyrimidine Nucleotides; Uracil | 1995 |
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; L | 1993 |
Nucleosides and nucleotides. 123. Synthesis of 1-(2-deoxy-2-isocyano-beta-D-arabinofuranosyl)cytosine and related nucleosides as potential antitumor agents.
Topics: Animals; Antineoplastic Agents; Cytarabine; Deoxycytidine; Drug Stability; Humans; Isocyanates; Leuk | 1993 |
Effects of 5-fluorouracil and a combination of tegafur and uracil (UFT) on nucleotide metabolism in L1210 ascites tumor.
Topics: Animals; Deoxyribonucleotides; Fluorouracil; Injections, Intraperitoneal; Leukemia L1210; Male; Mice | 1993 |
Palladium-catalyzed synthesis of [E]-6-(2-acylvinyl)uracils and [E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils--their antiviral and cytotoxic activities.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Catalysis; Humans; Leukemia L1210; Mammary Neoplas | 1997 |
Nucleosides and nucleotides. 175. Structural requirements of the sugar moiety for the antitumor activities of new nucleoside antimetabolites, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and -uracil1.
Topics: Animals; Antimetabolites, Antineoplastic; Carbohydrate Sequence; Cell Division; Cytosine; Drug Scree | 1998 |
Investigations on the influence of cisplatin on the antitumor effect of novel phosphonate derivatives of uracil and thymine.
Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Interactions; Leukemia L1210; Male; Mice; Organophos | 1998 |
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; F | 2001 |
Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate.
Topics: Animals; Deoxyuracil Nucleotides; Deoxyuridine; In Vitro Techniques; Lacticaseibacillus casei; Leuke | 1979 |
[Some properties of the new antimetabolite--3-oxauracil (author's transl)].
Topics: Animals; Antimetabolites; Female; Leukemia L1210; Mice; Mice, Inbred Strains; Oxazines; Uracil | 1978 |
Testing of 2,3-dihydro-1,3-6H-oxazine-dione (3-oxauracil) in mouse L1210 leukemia and 37 sarcoma.
Topics: Animals; Drug Evaluation, Preclinical; Female; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Oxa | 1978 |
Synthesis of 5-substituted aminomethyluracils via the Mannich reaction.
Topics: Animals; Chickens; Leukemia L1210; Magnetic Resonance Spectroscopy; Malaria; Malaria, Avian; Mice; P | 1976 |
Cytostatic, cytocidal and potential antitumor properties of a class of quinoid compounds, initiators of the dormant state in the spores of Agaricus bisporus.
Topics: Amino Acids; Animals; Antineoplastic Agents; Autoradiography; Basidiomycota; Carcinoma, Ehrlich Tumo | 1975 |
Effect of "3-oxauracil" (2,3-dihydro-1,3-6H-oxazine-dione) in L1210 leukemia.
Topics: Animals; Female; In Vitro Techniques; Leukemia L1210; Mice; Mice, Inbred DBA; Oxazines; Time Factors | 1977 |
Synthesis, cytotoxic and antiviral activity of uracils containing 5-(1-hydroxy-2-haloethyl)- and 5-(1-methoxy-2-haloethyl) substituents.
Topics: Animals; Antiviral Agents; Cell Survival; Leukemia L1210; Mice; Structure-Activity Relationship; Tum | 1989 |
2'-Fluorinated isonucleosides. 1. Synthesis and biological activity of some methyl 2'-deoxy-2'-fluoro-2'-pyrimidinyl-D-arabinopyranosides.
Topics: Animals; Arabinonucleosides; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Female; F | 1989 |
Potentiation by acyclothymidine esters of the antitumor effect of orally administered 5-fluoro-2'-deoxyuridine esters on L1210 in mice.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxu | 1986 |
[Effects of derivatives of Ara-C, 5-fluorouracil and nitrosourea against intracerebral implanted L1210 leukemia].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; | 1987 |
Potentiation of the antitumor effect of 5-fluoro-2'-deoxyuridine esters in combination with acyclothymidine esters on L1210 in mice via oral administration.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Dogs; Drug Synergism; Floxu | 1988 |
5-Cinnamoyl-6-aminouracil derivatives as novel anticancer agents. Synthesis, biological evaluation, and structure-activity relationships.
Topics: Animals; Antineoplastic Agents; Cinnamates; DNA; Electron Spin Resonance Spectroscopy; Leukemia L121 | 1985 |
[Combination chemotherapy of UFT, etoposide and CDDP in advanced gastric cancer].
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; | 1987 |
[UFT, UFTM, and UFTM-Dpc treatment of gastric cancer].
Topics: Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Humans; Leukemia L1210; Male; Mice; M | 1985 |
Alpha-(Ureidomethylene)lactones and derived 5-(hydroxyalkyl)uracils.
Topics: Animals; Lactones; Leukemia L1210; Spectrophotometry, Ultraviolet; Uracil; Urea | 1974 |
Effects of persantin on several transport systems of murine leukemias.
Topics: Adenine; Adenosine; Amino Acids; Animals; Biological Transport; Cell Line; Cyclopentanes; Cytidine; | 1972 |
Kinetics of effect of 1-beta-D-arabinofuranosylcytosine, its 5'-palmitoyl ester, 1-beta-D-arabinofuranosyluracil, and tritiated thymidine on the viability of cultured leukemia L1210 cells.
Topics: Animals; Arabinose; Cell Survival; Cells, Cultured; Depression, Chemical; Esters; Half-Life; In Vitr | 1972 |
Reversal of resistance to methotrexate in L1210 murine leukemia by uracil.
Topics: Animals; DNA; Drug Resistance; Leukemia L1210; Mercaptopurine; Methotrexate; Nucleic Acids; Tetrahyd | 1971 |
Potential antineoplastics. 8. Synthesis and pharmacology of 6-methyl-2-thio-5-arylazouracils.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Leukemia L1210; Sulfhydryl Compounds; Uracil | 1971 |
Nucleosides. 48. Synthesis of 1-(5-deoxy-beta-D-arabinosyl)cytosine and related compounds.
Topics: Animals; Burkitt Lymphoma; Carbonates; Cytarabine; Humans; Leukemia L1210; Methods; Mice; Nucleoside | 1968 |
Nucleosides. XLV. 1-alpha-L-aldo-pentofuranosylpyrimidines.
Topics: Animals; Antineoplastic Agents; Arabinose; Burkitt Lymphoma; Culture Techniques; Cytosine; Humans; K | 1968 |
Pyrimidines. XXII. 2,4-Diamino-6-aryl-amino-5-pyrimidinecarboxaldehydes and related compounds.
Topics: Aldehydes; Amines; Aniline Compounds; Animals; Carcinoma 256, Walker; Leukemia L1210; Pyrimidines; U | 1968 |
Accumulation of two alkylating agents, nitrogen mustard and busulfan, by murine leukemia cells in vitro.
Topics: Amines; Animals; Busulfan; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Mechloretham | 1969 |
On the action of fluorouracil on leukemia cells.
Topics: Animals; Culture Techniques; DNA, Neoplasm; Fluorouracil; Leukemia L1210; Mice; Phosphorus Isotopes; | 1966 |