uracil has been researched along with Leucocythaemia in 37 studies
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU) is an antimetabolite that interferes with DNA synthesis and has been widely used as a chemotherapeutic drug in various types of cancers." | 5.56 | New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line. ( Długosz-Pokorska, A; Janecka, A; Janecki, T; Kędzia, J; Pięta, M, 2020) |
| "Cyclopentenylcytosine (CPE-C), a synthetic cytidine analogue with significant preclinical antitumor activity against both solid tumor xenografts and 1-beta-D-arabinofuranosylcytosine resistant murine leukemia cell lines, will soon enter phase I clinical trials." | 3.68 | Modulation of the cytotoxic effect of cyclopentenylcytosine by its primary metabolite, cyclopentenyluridine. ( Adamson, PC; Balis, FM; Blaney, SM; Cole, DE; Grem, J; Poplack, DG, 1992) |
| "5-Fluorouracil (5-FU) is an antimetabolite that interferes with DNA synthesis and has been widely used as a chemotherapeutic drug in various types of cancers." | 1.56 | New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line. ( Długosz-Pokorska, A; Janecka, A; Janecki, T; Kędzia, J; Pięta, M, 2020) |
| "The dose-response curves for the inhibition of equilibrative uridine transport by dilazep, dipyridamole and nitrobenzylthioinosine (NBMPR) in undifferentiated HL-60 cells were biphasic." | 1.29 | Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C. ( Lee, CW, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (78.38) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 2 (5.41) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Długosz-Pokorska, A | 1 |
| Pięta, M | 1 |
| Kędzia, J | 1 |
| Janecki, T | 1 |
| Janecka, A | 1 |
| Pivovarova, AI | 1 |
| MacGregor, GG | 1 |
| HORRIGAN, DL | 1 |
| MOKEEVA, RA | 1 |
| VISHNIAKOVA, EG | 1 |
| EIDINOFF, ML | 1 |
| CHEONG, L | 1 |
| GURPIDE, EG | 1 |
| BENUA, RS | 1 |
| ELLISON, RR | 1 |
| FREIREICH, EJ | 1 |
| FREI, E | 1 |
| HOLLAND, JF | 1 |
| PINKEL, D | 1 |
| SELAWRY, O | 1 |
| ROTHBERG, H | 1 |
| HAURANI, F | 1 |
| TAYLOR, R | 1 |
| GEHAN, EA | 2 |
| KENNEDY, BJ | 3 |
| THEOLOGIDES, A | 3 |
| MISAROVA, Z | 1 |
| ELIS, J | 1 |
| INNES, J | 1 |
| COOPER, EH | 1 |
| MILTON, JD | 1 |
| HANDSCHUMACHER, RE | 1 |
| SATO, K | 1 |
| LEPAGE, GA | 1 |
| OBRECHT, P | 1 |
| PETROV, KIa | 1 |
| SAMPEY, JR | 1 |
| Parry, TE | 4 |
| Cleverley, J | 1 |
| McCaffrey, R | 1 |
| Bell, R | 1 |
| Lillquist, A | 1 |
| Wright, G | 1 |
| Baril, E | 1 |
| Minowada, J | 1 |
| Lee, CW | 1 |
| Ferrari, MB | 1 |
| Fava, GG | 1 |
| Leporati, E | 1 |
| Pelosi, G | 1 |
| Rossi, R | 1 |
| Tarasconi, P | 1 |
| Albertini, R | 1 |
| Bonati, A | 1 |
| Lunghi, P | 1 |
| Pinelli, S | 1 |
| Blaney, SM | 1 |
| Balis, FM | 1 |
| Grem, J | 1 |
| Cole, DE | 1 |
| Adamson, PC | 1 |
| Poplack, DG | 1 |
| Herrala, AM | 1 |
| Vilpo, JA | 1 |
| Arakawa, T | 1 |
| Wada, Y | 1 |
| Hayashi, T | 1 |
| Kakizaki, R | 1 |
| Chida, N | 1 |
| Chiba, R | 1 |
| Konno, T | 1 |
| Schmähl, D | 1 |
| Viola, MV | 1 |
| Dexter, DL | 1 |
| Wolberg, WH | 1 |
| Ansfield, FJ | 1 |
| Helson, L | 1 |
| Heidelberger, C | 1 |
| Wacker, A | 1 |
| Rabinowitz, Y | 1 |
| Farmer, R | 1 |
| Czebotar, V | 1 |
| Reĭzinger, MA | 1 |
| Morozova, VT | 1 |
| Miroshnichenko, IS | 1 |
| Terent'eva, NI | 1 |
2 reviews available for uracil and Leucocythaemia
| Article | Year |
|---|---|
Mutagenic mechanisms in leukemia and cancer: a new concept Cytosine lack could be as mutagenic as cytosine deamination.
Topics: Cytosine; Deamination; DNA Methylation; DNA Repair; Humans; Leukemia; Point Mutation; Ultraviolet Ra | 2006 |
[Recent aspects of antiviral therapy].
Topics: Animals; Antibody Formation; Cattle; Chick Embryo; Chickens; Child; Herpes Zoster Ophthalmicus; Huma | 1971 |
1 trial available for uracil and Leucocythaemia
| Article | Year |
|---|---|
The clinical pharmacology of 5-trifluoromethyl-2'-deoxyuridine.
Topics: Adult; Aged; Antineoplastic Agents; Carbon Dioxide; Carbon Isotopes; Carcinoma, Hepatocellular; Clin | 1972 |
34 other studies available for uracil and Leucocythaemia
| Article | Year |
|---|---|
New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line.
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; | 2020 |
Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Glucose; Growth Inhibitors; Humans; K562 Cells; Leuke | 2018 |
Urinary excretion of nucleic acid derivatives in persons with myeloid leukemia.
Topics: Body Fluids; Humans; Leukemia; Leukemia, Myeloid; Nucleic Acids; Uracil; Urine | 1954 |
[Result of use of dopan in treatment of chronic myeloleukosis].
Topics: Humans; Leukemia; Leukemia, Myeloid; Mechlorethamine; Nitrogen Mustard Compounds; Uracil; Uracil Mus | 1958 |
[First results of dopane therapy of chronic myeloid leukemia and of certain malignant tumors].
Topics: Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Mechlorethami | 1958 |
Incorporation of 5-iodouracil labelled with iodine-131 into the deoxyribonucleic acid of human leukaemic leucocytes following in vivo administration of 5-iododeoxyuridine labelled with iodine-131.
Topics: DNA; Idoxuridine; Iodine; Leukemia; Leukocytes; Nucleosides; Nucleotides; Uracil | 1959 |
Evaluation of a new chemotherapeutic agent in patients with 'advanced refractory' acute leukemia. Studies of 6-azauracil.
Topics: Acute Disease; Antineoplastic Agents; Humans; Leukemia; Uracil | 1960 |
Effect of uracil mustard in chronic lymphatic leukemia and malignant lymphoma.
Topics: Antineoplastic Agents; Hodgkin Disease; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, | 1961 |
Uracil mustard, a new alkylating agent for oral administration in the management of patients with leukemia and lymphoma.
Topics: Administration, Oral; Alkylating Agents; Antineoplastic Agents; Humans; Leukemia; Lymphoma; Uracil; | 1961 |
Effect of uracil mustard in malignant lymphoma and chronic lymphatic leukemia.
Topics: Leukemia; Leukemia, Lymphoid; Lymphoma; Mechlorethamine; Minnesota; Nitrogen Mustard Compounds; Urac | 1962 |
[AZAURACIL RIBOSIDE AND AZAURACIL RIBOSIDE TRIACETATE IN THE THERAPY OF LEUKEMIA IN CHILDREN].
Topics: Adolescent; Antineoplastic Agents; Child; Leukemia; Mercaptopurine; Nucleosides; Prednisone; Uracil | 1964 |
ANTI-LEUKAEMIC DRUGS.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; M | 1964 |
THE INCORPORATION AND DEGRADATION OF PYRIMIDINE DNA PRECURSORS BY HUMAN LEUCOCYTES.
Topics: Autoradiography; Carbon Isotopes; Cytosine Nucleotides; Deoxyuridine; DNA; Humans; Infectious Mononu | 1964 |
OXONATE AND OTHER RELATED ANTIMETABOLITES OF THE SYNTHESIS DE NOVO OF PYRIMIDINE NUCLEOTIDES.
Topics: Antimetabolites; Autoradiography; Leukemia; Leukemia, Experimental; Liver; Liver Extracts; Metabolis | 1964 |
METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS.
Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neopla | 1965 |
[Problems in chemotherapy illustrated by the cytostatic 5-fluoruracil and the leukemias].
Topics: Antineoplastic Agents; Cytostatic Agents; Fluorouracil; Leukemia; Uracil | 1961 |
[On dopan therapy of patients with lymphogranulomatosis, chronic lymphatic leukemia and other systemic blood diseases].
Topics: Antineoplastic Agents; Hematologic Diseases; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphocyti | 1961 |
Management of human leukemias and Hodgkin's disease with Dopan (uracil mustard).
Topics: Disease Management; Hodgkin Disease; Humans; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds; | 1962 |
American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA.
Topics: Clinical Trials as Topic; Cytarabine; Drug Combinations; Gossypol; Humans; Leukemia; Mastocytosis, S | 2006 |
Design of controlled clinical trials: use of historical controls.
Topics: Acute Disease; Adolescent; Adult; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Daunorubic | 1982 |
Selective killing of leukemia cells by inhibition of TdT.
Topics: Animals; Cell Line; Cell Survival; DNA Nucleotidylexotransferase; DNA Nucleotidyltransferases; DNA-D | 1983 |
Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C.
Topics: Affinity Labels; Alkaloids; Binding Sites; Biological Transport; Cell Differentiation; Dilazep; Dipy | 1994 |
Two possible metabolic blocks in DNA synthesis that could be mutagenic.
Topics: Amination; DNA, Neoplasm; Humans; Hypoxanthines; Leukemia; Mutation; Uracil | 1994 |
Synthesis, characterisation and biological activity of three copper (II) complexes with a modified nitrogenous base: 5-formyluracil thiosemicarbazone.
Topics: Apoptosis; Cell Division; Cell Survival; Copper; Crystallography, X-Ray; Humans; Leukemia; Models, M | 1998 |
Serum uracil levels in acute childhood leukaemia.
Topics: Acute Disease; Adult; Child; Female; Humans; Leukemia; Leukemia, Myeloid, Acute; Leukocyte Count; Ma | 1978 |
Modulation of the cytotoxic effect of cyclopentenylcytosine by its primary metabolite, cyclopentenyluridine.
Topics: Cell Survival; Cytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Leu | 1992 |
Template-primer activity of 5-(hydroxymethyl)uracil-containing DNA for prokaryotic and eukaryotic DNA and RNA polymerases.
Topics: Bacillus subtilis; Bacteriophages; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; DNA, V | 1989 |
Adenosine deaminase (ADA) in leukemia: clinical value of plasma ADA activity and characterization of leukemic cell ADA.
Topics: Adenosine Deaminase; Adult; Child; Humans; Leukemia; Lymphocytes; Mutation; Nucleoside Deaminases; U | 1986 |
Uracil-uric refractory anemia with peroxidase negative neutrophils.
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Blood Cell Count; Bone Marrow; Child; Chromatography; Chrom | 1965 |
[Examination of 1,3-dimethyl-4-amino-5-nitroso-uracile for carcinogenic effect in rats (author's transl)].
Topics: Animals; Chemical Phenomena; Chemistry; Fibrosarcoma; Injections, Intraperitoneal; Leukemia; Lymphom | 1973 |
Acute leukemia and infection.
Topics: Acute Disease; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Agranulocytosis; Aspergillosis; | 1967 |
Deoxycytidine pathway in separated normal and leukemic leukocytes with effects of cell culture.
Topics: Chromatography, Paper; Culture Techniques; Cytosine Nucleotides; Deoxyuridine; Humans; Lectins; Leuk | 1971 |
[Some peculiarities in the course of systemic diseases of haematopoietic organs in the process of chemotherapy].
Topics: Adrenal Cortex Hormones; Adult; Blood Transfusion; Female; Humans; Leukemia; Lymphatic Diseases; Lym | 1966 |
[The treatment of subleukemic myeloleukosis with Dopan].
Topics: Aged; Female; Humans; Leukemia; Middle Aged; Nitrogen Mustard Compounds; Uracil | 1967 |