Page last updated: 2024-10-20

uracil and Invasiveness, Neoplasm

uracil has been researched along with Invasiveness, Neoplasm in 30 studies

2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder

Research Excerpts

ExcerptRelevanceReference
"This phase II study evaluated the efficacy and safety of anastrozole concurrent with tegafur/uracil (UFT) as neoadjuvant therapy for ER-positive postmenopausal breast cancer."9.27Randomized phase II study of anastrozole plus tegafur-uracil as neoadjuvant therapy for ER-positive breast cancer in postmenopausal Japanese women (Neo-ACET BC). ( Aono, T; Ito, T; Kagimura, T; Masuda, N; Matsunami, N; Miyoshi, Y; Nakayama, T; Noguchi, S; Sagara, Y; Taguchi, T; Takashima, T, 2018)
"The high mortality of epithelial ovarian cancer (EOC) is primarily due to vast intraperitoneal dissemination."5.511-calcium phosphate-uracil inhibits intraperitoneal metastasis by suppressing FAK in epithelial ovarian cancer. ( Gao, H; Guo, X; Li, X; Liu, N; Peng, J; Yang, X, 2019)
"This phase II study evaluated the efficacy and safety of anastrozole concurrent with tegafur/uracil (UFT) as neoadjuvant therapy for ER-positive postmenopausal breast cancer."5.27Randomized phase II study of anastrozole plus tegafur-uracil as neoadjuvant therapy for ER-positive breast cancer in postmenopausal Japanese women (Neo-ACET BC). ( Aono, T; Ito, T; Kagimura, T; Masuda, N; Matsunami, N; Miyoshi, Y; Nakayama, T; Noguchi, S; Sagara, Y; Taguchi, T; Takashima, T, 2018)
"The objectives of this study were to evaluate the efficacy and toxicity of a fixed dose-rate infusion of gemcitabine associated with uracil/tegafur (UFT) in patients with advanced adenocarcinoma of the pancreas."5.10Phase II study of a fixed dose-rate infusion of gemcitabine associated with uracil/tegafur in advanced carcinoma of the pancreas. ( Bolaños, M; Borrega, P; Castro, J; Dorta, J; Escudero, P; Espinosa, E; Feliu, J; González Barón, M; López Gómez, L; Mel, R; Vázquez-Estévez, SE, 2002)
"Metronomic chemotherapy using the 5-FU prodrug uracil-tegafur (UFT) and cyclophosphamide (CTX) was previously shown to only modestly delay primary tumor growth, but nevertheless markedly suppressed the development of micro-metastasis in an orthotopic breast cancer xenograft model, using the metastatic variant of the MDA-MB-231 cell line, 231/LM2-4."3.91Suppressive impact of metronomic chemotherapy using UFT and/or cyclophosphamide on mediators of breast cancer dissemination and invasion. ( Cruz-Muñoz, W; Hileeto, D; Kerbel, RS; Man, S; Muñoz, R; Viloria-Petit, A; Wood, GA; Xu, P, 2019)
"The high mortality of epithelial ovarian cancer (EOC) is primarily due to vast intraperitoneal dissemination."1.511-calcium phosphate-uracil inhibits intraperitoneal metastasis by suppressing FAK in epithelial ovarian cancer. ( Gao, H; Guo, X; Li, X; Liu, N; Peng, J; Yang, X, 2019)
"These findings were observed in breast cancer cell lines with an invasive phenotype and were further confirmed in ZFP36-knockout mouse fibroblasts."1.39miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer. ( Al-Ahmadi, W; Al-Ghamdi, M; Al-Souhibani, N; Khabar, KS, 2013)
"Herein, we report a bladder cancer case with multiple metastases which were controlled by low-dose UFT."1.37[A case of marked efficacy of low-dose UFT against metastatic bladder cancer]. ( Arai, Y; Ito, A; Kuwahara, M; Nakano, O; Satoh, M, 2011)
" The regimen of pre-op CCRT was a radiation dosage of 45  Gy in 20 fractions and oral tegafur-uracil (UFUR) and leucovorin."1.36The impact of preoperative chemoradiotherapy on advanced low rectal cancer. ( Chang, SC; Chen, WS; Jiang, JK; Kao, PS; Lee, RC; Liang, WY; Lin, JK; Lin, TC; Wang, HS; Wang, LW; Yang, SH, 2010)
"We present a case of esophageal cancer with multiple lymph node metastases successfully performed early response evaluation for preoperative chemotherapy by FDG-PET."1.35[Case of esophageal cancer successfully performed in early response evaluation for preoperative chemotherapy by FDG-PET]. ( Arakaki, K; Isa, T; Kaneshiro, T; Nakachi, A; Nishimaki, T; Shiroma, H; Teruya, T; Yamamoto, H, 2008)
"A resected case of squamous cell carcinoma associated with ductal carcinoma in the hemilateral breast successfully treated by FU plus cisplatin (CDDP) adjuvant therapy against recurrent metastases is reported with some discussion."1.34[A resected case of squamous cell carcinoma of the breast successfully treated by FU plus cisplatin (CDDP) adjuvant therapy against recurrent metastases]. ( Akagawa, T; Fujioka, S; Hara, T; Hiramatsu, K; Hirata, A; Ito, T; Kato, K; Kutsuna, Y; Machiki, Y; Matsuba, H; Miyata, T, 2007)
"The data on 307 patients with colorectal cancer at stage II or III, who underwent potentially curative resection with lymphadenectomy, were reviewed."1.33The MMP-9 expression determined the efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer. ( Ikeda, S; Ishibashi, N; Matono, K; Mizobe, T; Ogata, Y; Ogo, S; Ohkita, A; Ozasa, H; Sasatomi, T; Shirouzu, K, 2006)
"In stage 3 gastric cancer, the overall survival rates following surgery was significantly (p < 0."1.31Postsurgical sequential methotrexate, fluorouracil, and leucovorin for stages 3 and 4 gastric carcinoma: A preliminary study. ( Kitaoka, A; Ohsumi, K; Tokuka, A; Tokunaga, Y; Yagi, T, 2000)
"Macroscopically it was gastric cancer with P0H3N1T3M0, Stage IV b, histologically small cell carcinoma, intermed, INF gamma, ss, ly1, v3, n1(+), ow(-), aw(-)."1.29[A case of small cell carcinoma of the stomach with multiple liver metastases]. ( Ishizawa, S; Masuyama, K; Oonishi, Y; Sawataishi, M; Suzuki, S; Wakaki, K; Yamazaki, K, 1994)
"A 79-year-old female with hepatocellular carcinoma with portal invasion and right adrenal gland metastasis was treated by low dose UFT (200 mg/day)."1.29[A case of hepatocellular carcinoma with portal invasion and right adrenal gland metastasis showing marked contraction of primary tumor and metastasis with treated by UFT alone]. ( Itoh, Y; Ohkawa, S; Tamai, S; Tarao, K, 1994)
"A diagnosis of hepatocellular carcinoma with extrahepatic portal venous obstruction due to tumor invasion was made."1.27[A case of hepatocellular carcinoma with extrahepatic portal vein obstruction due to tumor invasion, responsive to oral administration of UFT]. ( Kuroda, K; Maeda, S; Nagase, T; Nakagawa, C; Nakanishi, T; Nishikawa, M; Tokunaga, K, 1987)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.33)18.7374
1990's5 (16.67)18.2507
2000's12 (40.00)29.6817
2010's11 (36.67)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Muñoz, R1
Hileeto, D1
Cruz-Muñoz, W1
Wood, GA1
Xu, P1
Man, S1
Viloria-Petit, A1
Kerbel, RS1
Tsuchiya, T2
Kamohara, R2
Muraoka, M2
Nagayasu, T1
Saeki, S1
Takenoyama, M1
Suzuki, M1
Inada, K2
Tokunaga, S1
Hayashi, T1
Urabe, S2
Koga, T1
Akamine, S2
Sugio, K1
Nakayama, T1
Sagara, Y1
Takashima, T1
Matsunami, N1
Masuda, N1
Miyoshi, Y1
Taguchi, T1
Aono, T1
Ito, T2
Kagimura, T1
Noguchi, S1
Peng, J2
Yang, X1
Li, X1
Gao, H1
Liu, N1
Guo, X1
Maeda, T1
Hashimoto, K1
Ishida, T1
Yamashita, Y2
Saeki, H1
Kawanaka, H1
Uchiyama, H1
Ikeda, T1
Tsujitani, S1
Maehara, Y1
Tashiro, J1
Yamaguchi, S1
Ishii, T1
Suzuki, A1
Kondo, H1
Morita, Y1
Hara, K1
Koyama, I1
Chen, X1
Hu, Q1
Yang, M1
Liu, H1
Wei, W1
Liu, S1
Wang, H1
Kim, SG1
Hwang, SH1
Tanaka, S1
Iwamoto, M1
Kimura, K1
Takahashi, Y1
Fujioka, H1
Sato, N1
Terasawa, R1
Kawaguchi, K1
Ikari, A1
Tominaga, T1
Maezawa, S1
Umezaki, N1
Matsuda, J1
Uchiyama, K1
Isa, T1
Kaneshiro, T1
Yamamoto, H1
Nakachi, A1
Teruya, T1
Shiroma, H1
Arakaki, K1
Nishimaki, T1
Kao, PS1
Chang, SC1
Wang, LW1
Lee, RC1
Liang, WY1
Lin, TC1
Chen, WS1
Jiang, JK1
Yang, SH1
Wang, HS1
Lin, JK1
Satoh, M1
Nakano, O1
Kuwahara, M1
Ito, A1
Arai, Y1
Al-Ahmadi, W1
Al-Ghamdi, M1
Al-Souhibani, N1
Khabar, KS1
Feliu, J1
Mel, R1
Borrega, P1
López Gómez, L1
Escudero, P1
Dorta, J1
Castro, J1
Vázquez-Estévez, SE1
Bolaños, M1
Espinosa, E1
González Barón, M1
Nakayama, H1
Aoki, N1
Hayashi, S1
Wakabayashi, K1
Karube, H1
Ogame, H1
Aoki, H1
Sakamoto, N1
Masuda, H1
Hemmi, A1
Kamoshida, S1
Matsuoka, H1
Ishikawa, T1
Maeda, K1
Shimomura, R1
Tsutsumi, Y1
Ogata, Y1
Matono, K1
Sasatomi, T1
Ishibashi, N1
Ohkita, A1
Mizobe, T1
Ogo, S1
Ikeda, S1
Ozasa, H1
Shirouzu, K1
Tsuji, K1
Honda, S1
Yamasaki, N1
Hiramatsu, K1
Kato, K1
Hirata, A1
Matsuba, H1
Hara, T1
Miyata, T1
Akagawa, T1
Kutsuna, Y1
Machiki, Y1
Fujioka, S1
Toyooka, M1
Shoji, Y1
Rivera, F1
Vega-Villegas, ME1
López-Brea, M1
Isla, D1
Mayorga, M1
Galdós, P1
Rubio, A1
Del Valle, A1
García-Reija, F1
García-Montesinos, B1
Rodríguez-Iglesias, J1
Mayordomo, J1
Rama, J1
Saiz-Bustillo, R1
Sanz-Ortiz, J1
Masuyama, K1
Oonishi, Y1
Sawataishi, M1
Suzuki, S1
Yamazaki, K1
Ishizawa, S1
Wakaki, K1
Ohkawa, S1
Itoh, Y1
Tamai, S1
Tarao, K1
Yamamoto, S1
Hirata, T1
Yamagishi, S1
Hirano, S1
Kutsukata, N1
Masuda, S1
Hisayoshi, T1
Hioki, M1
Choi, S1
Okada, F1
Kobayashi, M1
Habelhah, H1
Nakae, D1
Konishi, Y1
Totsuka, Y1
Hosokawa, M1
Maeda, O1
Iwase, H1
Mamiya, N1
Nakamura, M1
Mizuno, T1
Nishio, Y1
Ando, T1
Ina, K1
Kusugami, K1
Tokunaga, Y1
Kitaoka, A1
Yagi, T1
Tokuka, A1
Ohsumi, K1
Liu, J1
Ikeguchi, M1
Nakamura, S1
Kaibara, N1
Hayashi, J1
Hidaka, N1
Sanda, M1
Ohashi, N1
Yajima, Y1
Furukawa, Y1
Kato, M1
Nakanishi, T1
Nishikawa, M1
Nagase, T1
Nakagawa, C1
Maeda, S1
Kuroda, K1
Tokunaga, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Adjuvant Chemotherapy Versus Observation in Fully Resected Stage I Lung Adenocarcinoma With High Risk of Post-operative Recurrence[NCT03380468]Phase 2/Phase 3300 participants (Anticipated)Interventional2018-01-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for uracil and Invasiveness, Neoplasm

ArticleYear
A single-arm, phase 2 study of adjuvant chemotherapy with oral tegafur-uracil for pathologically lymphovascular invasion positive stage IA non-small cell lung cancer: LOGIK0602 study.
    BMC cancer, 2020, Dec-04, Volume: 20, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Vessels; Carcinoma, Non-Small-Cell Lung;

2020
Randomized phase II study of anastrozole plus tegafur-uracil as neoadjuvant therapy for ER-positive breast cancer in postmenopausal Japanese women (Neo-ACET BC).
    Cancer chemotherapy and pharmacology, 2018, Volume: 81, Issue:4

    Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplas

2018
A Phase II Study of Adjuvant Chemotherapy of Tegafur-Uracil for Patients with Breast Cancer with HER2-negative Pathologic Residual Invasive Disease After Neoadjuvant Chemotherapy.
    Anticancer research, 2016, Volume: 36, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan

2016
Phase II study of a fixed dose-rate infusion of gemcitabine associated with uracil/tegafur in advanced carcinoma of the pancreas.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2002, Volume: 13, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Deoxycy

2002
Randomized phase II study of cisplatin and 5-FU continuous infusion (PF) versus cisplatin, UFT and vinorelbine (UFTVP) as induction chemotherapy in locally advanced squamous cell head and neck cancer (LA-SCHNC).
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Disease-Free Su

2008

Other Studies

25 other studies available for uracil and Invasiveness, Neoplasm

ArticleYear
Suppressive impact of metronomic chemotherapy using UFT and/or cyclophosphamide on mediators of breast cancer dissemination and invasion.
    PloS one, 2019, Volume: 14, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cycloph

2019
1-calcium phosphate-uracil inhibits intraperitoneal metastasis by suppressing FAK in epithelial ovarian cancer.
    Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:16

    Topics: Animals; Carcinoma, Ovarian Epithelial; Cell Adhesion; Cell Line, Tumor; Female; Focal Adhesion Kina

2019
Repeat hepatectomy for intrahepatic recurrence of cholangiolocellular carcinoma.
    Fukuoka igaku zasshi = Hukuoka acta medica, 2013, Volume: 104, Issue:12

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic;

2013
Inferior oncological prognosis of surgery without oral chemotherapy for stage III colon cancer in clinical settings.
    World journal of surgical oncology, 2014, May-10, Volume: 12

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemot

2014
1‑calcium phosphate‑uracil, a synthesized pyrimidine derivative agent, has anti‑proliferative, pro‑apoptotic and anti‑invasion effects on multiple tumor cell lines.
    Molecular medicine reports, 2014, Volume: 10, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screenin

2014
The association between the duration of fluoropyrimidine-based adjuvant chemotherapy and survival in stage II or III gastric cancer.
    World journal of surgical oncology, 2016, Apr-02, Volume: 14

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cape

2016
[Case of esophageal cancer successfully performed in early response evaluation for preoperative chemotherapy by FDG-PET].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2008, Volume: 105, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Ci

2008
The impact of preoperative chemoradiotherapy on advanced low rectal cancer.
    Journal of surgical oncology, 2010, Dec-01, Volume: 102, Issue:7

    Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Combined Modal

2010
[A case of marked efficacy of low-dose UFT against metastatic bladder cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:6

    Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female

2011
miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer.
    The Journal of pathology, 2013, Volume: 230, Issue:1

    Topics: Adenine; Animals; Breast Neoplasms; ELAV Proteins; Female; Fibroblasts; Gene Expression Regulation,

2013
[A case of long survival with UFT and lentinan treatment in a patient with peritoneal metastasis of gastric carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:2

    Topics: alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoembryo

2004
Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer: implication of TS expression in 5-FU-based adjuvant chemotherapy.
    Japanese journal of clinical oncology, 2004, Volume: 34, Issue:10

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemotherapy, Adjuvant; Colonic Neoplasms; C

2004
The MMP-9 expression determined the efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer.
    Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:5

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemo

2006
Stage IA non-small cell lung cancer: vessel invasion is a poor prognostic factor and a new target of adjuvant chemotherapy.
    Lung cancer (Amsterdam, Netherlands), 2007, Volume: 56, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung;

2007
[A resected case of squamous cell carcinoma of the breast successfully treated by FU plus cisplatin (CDDP) adjuvant therapy against recurrent metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Squamous Cell; C

2007
[A case of effective regimen of tegafur and uracil (UFT)/leucovorin (LV) plus irinotecan (CPT-11) for advanced rectal carcinoma with severe pelvic infiltration to be performed curative resection].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Pr

2007
[A case of small cell carcinoma of the stomach with multiple liver metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:13

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Chemotherapy, Adjuvant;

1994
[A case of hepatocellular carcinoma with portal invasion and right adrenal gland metastasis showing marked contraction of primary tumor and metastasis with treated by UFT alone].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:1

    Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocell

1994
[A case of far-advanced gastric cancer treated with neoadjuvant combination chemotherapy of UFT, low-dose CDDP and leucovorin, followed by subtotal gastrectomy with curative intent].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Chemotherapy, Adjuvant; C

1997
Single treatment with cisplatin or UFT, but not their combination treatment enhances the metastatic capacity of mouse fibrosarcoma cells.
    Anti-cancer drugs, 1999, Volume: 10, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemotaxis; Cisplatin; Clone Cells; Drug Co

1999
Scirrhous cancer of the stomach which survived for more than five years after neoadjuvant chemotherapy with UFT (uracil and tegafur) and cisplatin.
    Internal medicine (Tokyo, Japan), 2000, Volume: 39, Issue:3

    Topics: Adenocarcinoma, Scirrhous; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuv

2000
Postsurgical sequential methotrexate, fluorouracil, and leucovorin for stages 3 and 4 gastric carcinoma: A preliminary study.
    Journal of surgical oncology, 2000, Volume: 75, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Sc

2000
Re-expression of the cadherin-catenin complex in lymph nodes with metastasis in advanced gastric cancer: the relationship with patient survival.
    Journal of experimental & clinical cancer research : CR, 2002, Volume: 21, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; alpha Catenin; Antineoplastic Combined Chemotherapy

2002
[A effective combination preoperative intraarterial infusion chemotherapy and irradiation for advanced sigmoid colon cancer with bladder invasion].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1992, Volume: 89, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Combined Modality

1992
[A case of hepatocellular carcinoma with extrahepatic portal vein obstruction due to tumor invasion, responsive to oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:9

    Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellul

1987