uracil has been researched along with HIV in 11 studies
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder
HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human immune cells infected by HIV naturally contain high uracil content, and HIV reverse transcriptase (RT) does not distinguish between dUTP and dTTP." | 7.77 | HIV DNA is heavily uracilated, which protects it from autointegration. ( Engelman, A; Lieberman, J; O'Day, E; Wheeler, LA; Yan, N, 2011) |
| "In this article, we report the synthesis of hitherto unknown 5-haloethynyl and 5-(1,2-dihalo)vinyluracil nucleosides in the 2'-deoxy, 3'-deoxy- and ribosyl series, and we discuss their in vitro anti-HIV and anti-HCV activities and cellular toxicitites." | 3.73 | Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: antiviral activity and cellular toxicity. ( Agrofoglio, LA; Aucagne, V; Durantel, D; Escuret, V; Joubert, N; Rapp, KL; Schinazi, RF; Zoulim, F, 2005) |
| "We have investigated viral breakthrough during a long-term culture of HIV-1-infected cells with the non-nucleoside reverse transcriptase inhibitors (NNRTIs) 6-benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442), nevirapine and loviride (alpha-APA)." | 3.69 | Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells. ( Baba, M; Makino, M; Nakade, K; Okamoto, M; Yamada, K; Yuasa, S, 1996) |
| "Increased extracellular concentrations of uridine (Urd) have been reported to reduce, in vitro, azidothymidine (AZT)-induced inhibition of human granulocyte-macrophage progenitor cells without impairment of its antihuman immunodeficiency virus (HIV) activity." | 3.68 | Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity. ( Calabresi, P; Chu, SH; Darnowski, JW; Falcone, A; St Clair, MH; Wiemann, MC, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Maslova, AA | 1 |
| Matyugina, ES | 1 |
| Snoeck, R | 1 |
| Andrei, G | 1 |
| Kochetkov, SN | 1 |
| Khandazhinskaya, AL | 1 |
| Novikov, MS | 1 |
| Ngwaga, T | 1 |
| Kong, L | 1 |
| Lin, D | 1 |
| Schoborg, C | 1 |
| Taylor, LE | 1 |
| Mayer, KH | 1 |
| Klein, RS | 1 |
| Celentano, DD | 1 |
| Sobel, JD | 1 |
| Jamieson, DJ | 1 |
| King, CC | 1 |
| Tavis, JE | 1 |
| Blackard, JT | 1 |
| Wu, J | 1 |
| Huang, P | 1 |
| Fan, H | 1 |
| Tian, T | 1 |
| Xia, X | 1 |
| Fu, Z | 1 |
| Wang, Y | 1 |
| Ye, X | 1 |
| Yue, M | 1 |
| Zhang, Y | 1 |
| Yan, N | 1 |
| O'Day, E | 1 |
| Wheeler, LA | 1 |
| Engelman, A | 1 |
| Lieberman, J | 1 |
| Escuret, V | 1 |
| Aucagne, V | 1 |
| Joubert, N | 1 |
| Durantel, D | 1 |
| Rapp, KL | 1 |
| Schinazi, RF | 1 |
| Zoulim, F | 1 |
| Agrofoglio, LA | 1 |
| Racha, S | 1 |
| Vargeese, C | 1 |
| Vemishetti, P | 1 |
| El-Subbagh, HI | 1 |
| Abushanab, E | 1 |
| Panzica, RP | 1 |
| Okamoto, M | 1 |
| Makino, M | 1 |
| Yamada, K | 1 |
| Nakade, K | 1 |
| Yuasa, S | 1 |
| Baba, M | 1 |
| Titmuss, SJ | 1 |
| Keller, PA | 1 |
| Griffith, R | 1 |
| Duval, X | 1 |
| Calabresi, P | 1 |
| Falcone, A | 1 |
| St Clair, MH | 1 |
| Wiemann, MC | 1 |
| Chu, SH | 1 |
| Darnowski, JW | 1 |
| Webb, TR | 1 |
| Mitsuya, H | 1 |
| Broder, S | 1 |
11 other studies available for uracil and HIV
| Article | Year |
|---|---|
Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties.
Topics: Antiviral Agents; Cell Line; Drug Design; Herpesviridae; HIV; HIV Reverse Transcriptase; Humans; Mol | 2020 |
Diversity of the hepatitis C virus NS5B gene during HIV co-infection.
Topics: 2-Naphthylamine; Adult; AIDS-Related Opportunistic Infections; Amino Acid Sequence; Antiviral Agents | 2020 |
Effectiveness of ombitasvir/paritaprevir/ritonavir, dasabuvir for HCV in HIV/HCV coinfected subjects: a comprehensive analysis.
Topics: 2-Naphthylamine; Adult; Anilides; Antiviral Agents; Carbamates; Clinical Trials as Topic; Coinfectio | 2019 |
HIV DNA is heavily uracilated, which protects it from autointegration.
Topics: CD4-Positive T-Lymphocytes; DNA, Viral; HIV; Humans; Immune System; Macrophages; Mutation; Plasmids; | 2011 |
Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: antiviral activity and cellular toxicity.
Topics: Antiviral Agents; Cell Line; Cell Survival; Hepacivirus; HIV; Molecular Structure; Nucleosides; Stru | 2005 |
Synthesis and biological evaluation of1',2'-seconucleo-5'- phosphonates.
Topics: Adenine; Adenoviruses, Human; Antiviral Agents; Cystine; HIV; Molecular Structure; Nucleotides; Orga | 1996 |
Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells.
Topics: Acetamides; Acetophenones; Cell Line, Transformed; HIV; HIV Core Protein p24; HIV-1; Humans; Nevirap | 1996 |
Docking experiments in the flexible non-nucleoside inhibitor binding pocket of HIV-1 reverse transcriptase.
Topics: Binding Sites; Databases, Factual; HIV; HIV Reverse Transcriptase; Ligands; Molecular Structure; Nev | 1999 |
[The 39th ICAAC (San Francisco) and the 7th European Conference on Clinical Aspects and Treatment of HIV-infection (Lisbon). HIV infection: antiretroviral agents in the development and trial stage].
Topics: Alkynes; Animals; Anti-HIV Agents; Antiviral Agents; Benzoxazines; Clinical Trials as Topic; Cyclopr | 2000 |
Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity.
Topics: Anemia; Animals; Cell Line; Cytopathogenic Effect, Viral; Female; HIV; Leukopenia; Mice; Mice, Inbre | 1990 |
1-(2,3-Anhydro-beta-D-lyxofuranosyl)cytosine derivatives as potential inhibitors of the human immunodeficiency virus.
Topics: Ancitabine; Chemical Phenomena; Chemistry; Cytarabine; Cytidine; HIV; Magnetic Resonance Spectroscop | 1988 |