Page last updated: 2024-10-20

uracil and HIV

uracil has been researched along with HIV in 11 studies

2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder

HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Research Excerpts

ExcerptRelevanceReference
"Human immune cells infected by HIV naturally contain high uracil content, and HIV reverse transcriptase (RT) does not distinguish between dUTP and dTTP."7.77HIV DNA is heavily uracilated, which protects it from autointegration. ( Engelman, A; Lieberman, J; O'Day, E; Wheeler, LA; Yan, N, 2011)
"In this article, we report the synthesis of hitherto unknown 5-haloethynyl and 5-(1,2-dihalo)vinyluracil nucleosides in the 2'-deoxy, 3'-deoxy- and ribosyl series, and we discuss their in vitro anti-HIV and anti-HCV activities and cellular toxicitites."3.73Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: antiviral activity and cellular toxicity. ( Agrofoglio, LA; Aucagne, V; Durantel, D; Escuret, V; Joubert, N; Rapp, KL; Schinazi, RF; Zoulim, F, 2005)
"We have investigated viral breakthrough during a long-term culture of HIV-1-infected cells with the non-nucleoside reverse transcriptase inhibitors (NNRTIs) 6-benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442), nevirapine and loviride (alpha-APA)."3.69Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells. ( Baba, M; Makino, M; Nakade, K; Okamoto, M; Yamada, K; Yuasa, S, 1996)
"Increased extracellular concentrations of uridine (Urd) have been reported to reduce, in vitro, azidothymidine (AZT)-induced inhibition of human granulocyte-macrophage progenitor cells without impairment of its antihuman immunodeficiency virus (HIV) activity."3.68Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity. ( Calabresi, P; Chu, SH; Darnowski, JW; Falcone, A; St Clair, MH; Wiemann, MC, 1990)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's4 (36.36)18.2507
2000's2 (18.18)29.6817
2010's2 (18.18)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Maslova, AA1
Matyugina, ES1
Snoeck, R1
Andrei, G1
Kochetkov, SN1
Khandazhinskaya, AL1
Novikov, MS1
Ngwaga, T1
Kong, L1
Lin, D1
Schoborg, C1
Taylor, LE1
Mayer, KH1
Klein, RS1
Celentano, DD1
Sobel, JD1
Jamieson, DJ1
King, CC1
Tavis, JE1
Blackard, JT1
Wu, J1
Huang, P1
Fan, H1
Tian, T1
Xia, X1
Fu, Z1
Wang, Y1
Ye, X1
Yue, M1
Zhang, Y1
Yan, N1
O'Day, E1
Wheeler, LA1
Engelman, A1
Lieberman, J1
Escuret, V1
Aucagne, V1
Joubert, N1
Durantel, D1
Rapp, KL1
Schinazi, RF1
Zoulim, F1
Agrofoglio, LA1
Racha, S1
Vargeese, C1
Vemishetti, P1
El-Subbagh, HI1
Abushanab, E1
Panzica, RP1
Okamoto, M1
Makino, M1
Yamada, K1
Nakade, K1
Yuasa, S1
Baba, M1
Titmuss, SJ1
Keller, PA1
Griffith, R1
Duval, X1
Calabresi, P1
Falcone, A1
St Clair, MH1
Wiemann, MC1
Chu, SH1
Darnowski, JW1
Webb, TR1
Mitsuya, H1
Broder, S1

Other Studies

11 other studies available for uracil and HIV

ArticleYear
Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties.
    Molecules (Basel, Switzerland), 2020, Jul-23, Volume: 25, Issue:15

    Topics: Antiviral Agents; Cell Line; Drug Design; Herpesviridae; HIV; HIV Reverse Transcriptase; Humans; Mol

2020
Diversity of the hepatitis C virus NS5B gene during HIV co-infection.
    PloS one, 2020, Volume: 15, Issue:8

    Topics: 2-Naphthylamine; Adult; AIDS-Related Opportunistic Infections; Amino Acid Sequence; Antiviral Agents

2020
Effectiveness of ombitasvir/paritaprevir/ritonavir, dasabuvir for HCV in HIV/HCV coinfected subjects: a comprehensive analysis.
    Virology journal, 2019, 01-17, Volume: 16, Issue:1

    Topics: 2-Naphthylamine; Adult; Anilides; Antiviral Agents; Carbamates; Clinical Trials as Topic; Coinfectio

2019
HIV DNA is heavily uracilated, which protects it from autointegration.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, May-31, Volume: 108, Issue:22

    Topics: CD4-Positive T-Lymphocytes; DNA, Viral; HIV; Humans; Immune System; Macrophages; Mutation; Plasmids;

2011
Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: antiviral activity and cellular toxicity.
    Bioorganic & medicinal chemistry, 2005, Nov-01, Volume: 13, Issue:21

    Topics: Antiviral Agents; Cell Line; Cell Survival; Hepacivirus; HIV; Molecular Structure; Nucleosides; Stru

2005
Synthesis and biological evaluation of1',2'-seconucleo-5'- phosphonates.
    Journal of medicinal chemistry, 1996, Mar-01, Volume: 39, Issue:5

    Topics: Adenine; Adenoviruses, Human; Antiviral Agents; Cystine; HIV; Molecular Structure; Nucleotides; Orga

1996
Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells.
    Antiviral research, 1996, Volume: 31, Issue:1-2

    Topics: Acetamides; Acetophenones; Cell Line, Transformed; HIV; HIV Core Protein p24; HIV-1; Humans; Nevirap

1996
Docking experiments in the flexible non-nucleoside inhibitor binding pocket of HIV-1 reverse transcriptase.
    Bioorganic & medicinal chemistry, 1999, Volume: 7, Issue:6

    Topics: Binding Sites; Databases, Factual; HIV; HIV Reverse Transcriptase; Ligands; Molecular Structure; Nev

1999
[The 39th ICAAC (San Francisco) and the 7th European Conference on Clinical Aspects and Treatment of HIV-infection (Lisbon). HIV infection: antiretroviral agents in the development and trial stage].
    Presse medicale (Paris, France : 1983), 2000, Feb-12, Volume: 29, Issue:5

    Topics: Alkynes; Animals; Anti-HIV Agents; Antiviral Agents; Benzoxazines; Clinical Trials as Topic; Cyclopr

2000
Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity.
    Blood, 1990, Dec-01, Volume: 76, Issue:11

    Topics: Anemia; Animals; Cell Line; Cytopathogenic Effect, Viral; Female; HIV; Leukopenia; Mice; Mice, Inbre

1990
1-(2,3-Anhydro-beta-D-lyxofuranosyl)cytosine derivatives as potential inhibitors of the human immunodeficiency virus.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:7

    Topics: Ancitabine; Chemical Phenomena; Chemistry; Cytarabine; Cytidine; HIV; Magnetic Resonance Spectroscop

1988