uracil has been researched along with Disease Models, Animal in 72 studies
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we evaluated the efficacy of alogliptin (DPP-4 inhibitor) on hippocampal insulin resistance and associated AD complications." | 7.96 | Alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of Alzheimer's disease. ( Akhtar, M; Akhter, M; Kaundal, M; Najmi, AK; Panda, BP; Parvez, S; Rahman, SO; Salman, M; Shrivastava, A, 2020) |
| "The upp (Rv3309c)-encoded uracil phosphoribosyltransferase from Mycobacterium tuberculosis (MtUPRT) converts uracil and 5-phosphoribosyl-α-1-pyrophosphate into pyrophosphate and uridine 5΄-monophosphate, the precursor of all pyrimidine nucleotides." | 7.85 | Analysis of uracil phosphoribosyltransferase expression in Mycobacterium tuberculosis and evaluation of upp knockout strain in infected mice. ( Basso, LA; Campos, MM; Grzegorzewicz, AE; Jackson, M; Jones, V; Pham, H; Rodrigues-Junior, VD; Santos, DS; Villela, AD, 2017) |
| "The results indicate that alogliptin improves stress-induced prothrombotic state and insulin resistance; suggesting that alogliptin could have beneficial therapeutic effects against cardiovascular complications in diabetic patients under stress." | 7.83 | Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model. ( Cheng, XW; Hao, CN; Hayashi, M; Kikuchi, R; Matsushita, T; Murohara, T; Nakamura, S; Nakayama, T; Takeshita, K; Uchida, Y; Wu, H; Yamamoto, K; Yisireyili, M, 2016) |
| " We aimed to test the hypothesis that the DPP-4 inhibitor, alogliptin, attenuates vascular oxidative stress and thus inhibits abdominal aortic aneurysm (AAA) formation." | 7.80 | Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats. ( Bao, W; Hasegawa, T; Hirata, K; Morimoto, K; Okada, K; Okita, Y; Sasaki, N; Yamashita, T, 2014) |
| "The purpose of this study is to investigate the effect of uracil which is an immunonutrient on bacterial translocation using rats with intestinal obstruction as a model." | 7.79 | Influence of uracil on bacterial translocation in an intestinal obstruction model in rats. ( Çıtak, A; Lambrecht, FY; Ozbal, S; Pekçetin, Ç; Yilmaz, O, 2013) |
| "The influence of photochemically activated 40% solution of Levomecol ointment toward the tissue apoptosis while occurrence of ischemic complications of diabetes mellitus was studied in experiment on 184 adult mongrel white male rats weighted 250-310 g." | 7.73 | [The influence of photochemically activated 40% solution of levomecol ointment toward apoptosis in muscles of the rats posterior extremities in inflammatory-purulent complications of diabetes mellitus]. ( Babenkov, HD; Dolhopolov, VV; Peleshenko, OS; Potiĭ, VV; Shypilov, KV, 2006) |
| "KK‑Ay mice were used to produce an NAFLD model via administration of a choline‑deficient (CD) diet." | 5.48 | Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver. ( Ishihara, S; Ishimura, N; Kinoshita, Y; Mishiro, T; Sato, S; Tobita, H; Yazaki, T, 2018) |
| "To evaluate the antitumor efficacy against metastatic breast cancer of fluoropyrimidines alone and combined with other chemotherapeutic agents, we developed a murine model of breast cancer metastatic to the lung by orthotopically implanting MDA-MB-435S breast tumors into mice." | 5.31 | [Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung]. ( Fujioka, A; Fukushima, M; Nakagawa, F; Nukatsuka, M; Ohshimo, H, 2002) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| " In this study, we evaluated the efficacy of alogliptin (DPP-4 inhibitor) on hippocampal insulin resistance and associated AD complications." | 3.96 | Alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of Alzheimer's disease. ( Akhtar, M; Akhter, M; Kaundal, M; Najmi, AK; Panda, BP; Parvez, S; Rahman, SO; Salman, M; Shrivastava, A, 2020) |
| "The upp (Rv3309c)-encoded uracil phosphoribosyltransferase from Mycobacterium tuberculosis (MtUPRT) converts uracil and 5-phosphoribosyl-α-1-pyrophosphate into pyrophosphate and uridine 5΄-monophosphate, the precursor of all pyrimidine nucleotides." | 3.85 | Analysis of uracil phosphoribosyltransferase expression in Mycobacterium tuberculosis and evaluation of upp knockout strain in infected mice. ( Basso, LA; Campos, MM; Grzegorzewicz, AE; Jackson, M; Jones, V; Pham, H; Rodrigues-Junior, VD; Santos, DS; Villela, AD, 2017) |
| "The results indicate that alogliptin improves stress-induced prothrombotic state and insulin resistance; suggesting that alogliptin could have beneficial therapeutic effects against cardiovascular complications in diabetic patients under stress." | 3.83 | Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model. ( Cheng, XW; Hao, CN; Hayashi, M; Kikuchi, R; Matsushita, T; Murohara, T; Nakamura, S; Nakayama, T; Takeshita, K; Uchida, Y; Wu, H; Yamamoto, K; Yisireyili, M, 2016) |
| " We aimed to test the hypothesis that the DPP-4 inhibitor, alogliptin, attenuates vascular oxidative stress and thus inhibits abdominal aortic aneurysm (AAA) formation." | 3.80 | Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats. ( Bao, W; Hasegawa, T; Hirata, K; Morimoto, K; Okada, K; Okita, Y; Sasaki, N; Yamashita, T, 2014) |
| "The purpose of this study is to investigate the effect of uracil which is an immunonutrient on bacterial translocation using rats with intestinal obstruction as a model." | 3.79 | Influence of uracil on bacterial translocation in an intestinal obstruction model in rats. ( Çıtak, A; Lambrecht, FY; Ozbal, S; Pekçetin, Ç; Yilmaz, O, 2013) |
| "The influence of photochemically activated 40% solution of Levomecol ointment toward the tissue apoptosis while occurrence of ischemic complications of diabetes mellitus was studied in experiment on 184 adult mongrel white male rats weighted 250-310 g." | 3.73 | [The influence of photochemically activated 40% solution of levomecol ointment toward apoptosis in muscles of the rats posterior extremities in inflammatory-purulent complications of diabetes mellitus]. ( Babenkov, HD; Dolhopolov, VV; Peleshenko, OS; Potiĭ, VV; Shypilov, KV, 2006) |
| "A hairless mouse-herpes simplex virus skin infection experimental model was used to evaluate the efficacy of the antiviral compounds 9-beta-d-arabinofuranosyladenine (ara-A), 5-iodo-2'-deoxyuridine (IUdR), and 6-azauridine (aza-U)." | 3.65 | Herpes simplex virus skin infection in hairless mice: treatment with antiviral compounds. ( Brady, E; Friedman-Kien, AE; Klein, RJ, 1974) |
| "Treatment of 'metastasis', in retrospect, usually involves minimal residual disease and therapy naïve tumors." | 2.44 | On the development of models in mice of advanced visceral metastatic disease for anti-cancer drug testing. ( Kerbel, RS; Man, S; Munoz, R, 2007) |
| "Alogliptin treatment alleviated LPS-induced cognitive impairment as assessed by Morris water maze and novel object recognition tests." | 1.62 | Alogliptin Attenuates Lipopolysaccharide-Induced Neuroinflammation in Mice Through Modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 Signaling Pathways. ( Ahmed, LA; El Sayed, NS; El-Sahar, AE; Shiha, NA, 2021) |
| " Treatment with GC-1 upregulated the transcription of CPT1A in the human hepatocyte-derived Huh-7 cell line with a dose-response comparable to that of the native THR ligand, triiodothyronine (T3)." | 1.56 | Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH). ( Beigelman, LN; Blatt, LM; Chanda, S; Deval, J; Gupta, K; Jekle, A; Lin, TI; Luong, XG; McGowan, D; Misner, D; Mukherjee, S; Raboisson, P; Stevens, SK; Stoycheva, A; Symons, JA; Vandyck, K; Williams, C, 2020) |
| "Alogliptin is a commonly prescribed drug treating patients with type 2 diabetes." | 1.51 | Alogliptin improves survival and health of mice on a high-fat diet. ( Chen, L; Dong, J; Guo, B; Li, H; Li, Y; Liang, M; Liu, M; Mei, W; Wang, L; Xiang, G; Xiang, L; Zhang, J; Zhu, B, 2019) |
| "Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones." | 1.48 | Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents. ( Ali, SA; Awad, SM; Mahgoub, S; Said, AM; Zohny, YM, 2018) |
| "KK‑Ay mice were used to produce an NAFLD model via administration of a choline‑deficient (CD) diet." | 1.48 | Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver. ( Ishihara, S; Ishimura, N; Kinoshita, Y; Mishiro, T; Sato, S; Tobita, H; Yazaki, T, 2018) |
| "Uracil was the most effective tumor promoter in our study and increased the incidence of papillomas (90%) and TCC (74%)." | 1.48 | Evaluation of Uracil, Sodium Ascorbate, and Rosiglitazone as Promoters of Urinary Bladder Transitional Cell Carcinomas in Male Sprague-Dawley Rats. ( Attalla, B; Bergholm, AM; Billger, M; Chadwick, KD; Chen, SJ; Czajkowski, M; Dorr, T; Foster, JR; Granaldi, K; Graziano, M; Haile, S; Janovitz, E; Mangipudy, R; Söderberg, M; Song, Y; Tirmenstein, M, 2018) |
| "Epilepsy is a chronic neurological disorder that affects approximately 50 million people worldwide." | 1.46 | Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters. ( Becker, HM; Deitmer, JW; Forero-Quintero, LS, 2017) |
| " Here we demonstrate that early, chronic administration of MYK-461 suppresses the development of ventricular hypertrophy, cardiomyocyte disarray, and myocardial fibrosis and attenuates hypertrophic and profibrotic gene expression in mice harboring heterozygous human mutations in the myosin heavy chain." | 1.43 | A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. ( Anderson, RL; Evanchik, MJ; Gorham, JM; Green, EM; Harrison, BC; Henze, M; Kawas, R; Leinwand, LA; McDowell, RS; Oslob, JD; Rodriguez, HM; Seidman, CE; Seidman, JG; Song, Y; Spudich, JA; Wakimoto, H; Wan, W, 2016) |
| "In the present study, we used colorectal cancer xenografts to assess whether the efficacy of TAS-102 could be improved by combining it with bevacizumab, cetuximab or panitumumab." | 1.42 | Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts. ( Ishida, K; Matsuo, K; Nakagawa, F; Okabe, H; Sakamoto, K; Takechi, T; Tanaka, N; Tsukihara, H; Uchida, J, 2015) |
| "Pioglitazone treatment also resulted in increased expression of markers of mitochondrial biogenesis in brown adipose tissue and white adipose tissue, with mild elevations observed in animals treated with alogliptin alone." | 1.40 | Administration of pioglitazone alone or with alogliptin delays diabetes onset in UCD-T2DM rats. ( Bettaieb, A; Cummings, BP; Graham, JL; Haj, FG; Havel, PJ; Stanhope, K, 2014) |
| "Injury to the CNS leads to formation of scar tissue, which is important in sealing the lesion and inhibiting axon regeneration." | 1.39 | Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury. ( Blumenthal, E; Bray, E; Krishnan, V; Lai-Hsu, C; Lee, JK; Luo, X; Lyapichev, K; Park, KK; Ramos, J; Soderblom, C; Tsoulfas, P, 2013) |
| "In a rat model of chronic renal failure, 5/6-nephrectomized [5/6N] rats were treated orally with DPP-4 inhibitors (linagliptin, sitagliptin, alogliptin) or placebo once daily for 4 days from 8 weeks after surgery, to identify the most appropriate treatment for cardiac dysfunction associated with CKD." | 1.37 | Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy. ( Alter, M; Chaykovska, L; Fuchs, H; Heiden, S; Hocher, B; Klein, T; Rahnenführer, J; Runge, F; von Websky, K, 2011) |
| " Absolute oral bioavailability of alogliptin in rats, dogs, and monkeys was 45%, 86%, and 72% to 88%, respectively." | 1.35 | Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys. ( Asakawa, T; Christopher, RJ; Kassel, DB; Lee, B; Shi, L; Takeuchi, K, 2008) |
| " Since clinical studies have demonstrated that bisphosphonates (BPs), specific inhibitors of osteoclastic bone resorption, are beneficial for breast cancer patients with bone metastases, we next examined the effects of UFT combined with the BP zoledronic acid (ZOL) on established bone metastases." | 1.32 | Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer. ( Hata, K; Hiraga, T; Ikeda, F; Tamura, D; Ueda, A; Williams, PJ; Yoneda, T, 2003) |
| "The T-cell-mediated contact hypersensitivity reaction (CHR) is thought to be involved in the pathogenesis of clinical cutaneous disorders including atopic dermatitis." | 1.31 | Suppressive effect of topically applied CX-659S, a novel diaminouracil derivative, on the contact hypersensitivity reaction in various animal models. ( Furue, M; Goto, Y; Hayashi, H; Inoue, Y; Isobe, M; Tsuchiya, M; Uchi, H; Ueno, T, 2000) |
| "To evaluate the antitumor efficacy against metastatic breast cancer of fluoropyrimidines alone and combined with other chemotherapeutic agents, we developed a murine model of breast cancer metastatic to the lung by orthotopically implanting MDA-MB-435S breast tumors into mice." | 1.31 | [Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung]. ( Fujioka, A; Fukushima, M; Nakagawa, F; Nukatsuka, M; Ohshimo, H, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.17) | 18.7374 |
| 1990's | 3 (4.17) | 18.2507 |
| 2000's | 17 (23.61) | 29.6817 |
| 2010's | 35 (48.61) | 24.3611 |
| 2020's | 14 (19.44) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Caddeo, A | 1 |
| Kowalik, MA | 1 |
| Serra, M | 1 |
| Runfola, M | 1 |
| Bacci, A | 1 |
| Rapposelli, S | 1 |
| Columbano, A | 1 |
| Perra, A | 1 |
| Semenov, VE | 5 |
| Zueva, IV | 5 |
| Lushchekina, SV | 5 |
| Suleimanov, EG | 3 |
| Gubaidullina, LM | 4 |
| Shulaeva, MM | 3 |
| Lenina, OA | 4 |
| Petrov, KA | 5 |
| Liu, Y | 1 |
| Li, X | 1 |
| Li, A | 1 |
| Li, K | 1 |
| Qin, X | 1 |
| Weber, BS | 1 |
| De Jong, AM | 1 |
| Guo, ABY | 1 |
| Dharavath, S | 1 |
| French, S | 1 |
| Fiebig-Comyn, AA | 1 |
| Coombes, BK | 1 |
| Magolan, J | 1 |
| Brown, ED | 1 |
| Mabuza, LP | 1 |
| Gamede, MW | 1 |
| Maikoo, S | 1 |
| Booysen, IN | 1 |
| Ngubane, PS | 1 |
| Khathi, A | 1 |
| Yu, H | 1 |
| Yang, A | 1 |
| Liu, L | 1 |
| Mak, JYW | 1 |
| Fairlie, DP | 1 |
| Cowley, S | 1 |
| Rahman, SO | 1 |
| Kaundal, M | 1 |
| Salman, M | 1 |
| Shrivastava, A | 1 |
| Parvez, S | 1 |
| Panda, BP | 1 |
| Akhter, M | 1 |
| Akhtar, M | 1 |
| Najmi, AK | 1 |
| Mukhamedyarov, MA | 2 |
| Petukhova, EO | 2 |
| Krylova, ES | 1 |
| Saifina, LF | 2 |
| El-Sahar, AE | 1 |
| Shiha, NA | 1 |
| El Sayed, NS | 1 |
| Ahmed, LA | 1 |
| Luong, XG | 1 |
| Stevens, SK | 1 |
| Jekle, A | 1 |
| Lin, TI | 1 |
| Gupta, K | 1 |
| Misner, D | 1 |
| Chanda, S | 1 |
| Mukherjee, S | 1 |
| Williams, C | 1 |
| Stoycheva, A | 1 |
| Blatt, LM | 1 |
| Beigelman, LN | 1 |
| Symons, JA | 1 |
| Raboisson, P | 1 |
| McGowan, D | 1 |
| Vandyck, K | 1 |
| Deval, J | 1 |
| Awinda, PO | 1 |
| Watanabe, M | 1 |
| Bishaw, Y | 1 |
| Huckabee, AM | 1 |
| Agonias, KB | 1 |
| Kazmierczak, K | 1 |
| Szczesna-Cordary, D | 1 |
| Tanner, BCW | 1 |
| Wang, J | 1 |
| Fan, S | 1 |
| Xiong, Q | 1 |
| Niu, Y | 1 |
| Zhang, X | 1 |
| Qin, J | 1 |
| Shi, Y | 1 |
| Zhang, L | 1 |
| Whon, TW | 1 |
| Shin, NR | 1 |
| Jung, MJ | 1 |
| Hyun, DW | 1 |
| Kim, HS | 1 |
| Kim, PS | 1 |
| Bae, JW | 1 |
| Forero-Quintero, LS | 1 |
| Deitmer, JW | 1 |
| Becker, HM | 1 |
| Petrov, K | 1 |
| Zueva, I | 1 |
| Kovyazina, I | 1 |
| Sedov, I | 1 |
| Lushchekina, S | 1 |
| Kharlamova, A | 1 |
| Lenina, O | 1 |
| Koshkin, S | 1 |
| Shtyrlin, Y | 1 |
| Nikolsky, E | 1 |
| Masson, P | 2 |
| Tirmenstein, M | 1 |
| Janovitz, E | 1 |
| Dorr, T | 1 |
| Song, Y | 2 |
| Chen, SJ | 1 |
| Granaldi, K | 1 |
| Chadwick, KD | 1 |
| Mangipudy, R | 1 |
| Graziano, M | 1 |
| Attalla, B | 1 |
| Haile, S | 1 |
| Czajkowski, M | 1 |
| Foster, JR | 1 |
| Bergholm, AM | 1 |
| Billger, M | 1 |
| Söderberg, M | 1 |
| Tobita, H | 1 |
| Sato, S | 1 |
| Yazaki, T | 1 |
| Mishiro, T | 1 |
| Ishimura, N | 1 |
| Ishihara, S | 1 |
| Kinoshita, Y | 1 |
| Mamidi, R | 1 |
| Li, J | 2 |
| Doh, CY | 1 |
| Verma, S | 1 |
| Stelzer, JE | 1 |
| Awad, SM | 1 |
| Zohny, YM | 1 |
| Ali, SA | 1 |
| Mahgoub, S | 1 |
| Said, AM | 1 |
| Zhu, B | 2 |
| Li, Y | 2 |
| Mei, W | 2 |
| He, M | 1 |
| Ding, Y | 1 |
| Meng, B | 1 |
| Zhao, H | 1 |
| Xiang, G | 2 |
| Xiang, L | 2 |
| Zhang, J | 1 |
| Wang, L | 1 |
| Guo, B | 1 |
| Liang, M | 1 |
| Chen, L | 1 |
| Dong, J | 1 |
| Liu, M | 1 |
| Li, H | 1 |
| Yang, D | 1 |
| Nakajo, Y | 1 |
| Iihara, K | 1 |
| Kataoka, H | 1 |
| Yanamoto, H | 1 |
| Bao, W | 1 |
| Morimoto, K | 1 |
| Hasegawa, T | 1 |
| Sasaki, N | 1 |
| Yamashita, T | 1 |
| Hirata, K | 1 |
| Okita, Y | 1 |
| Okada, K | 1 |
| Raza, A | 1 |
| Ericson, ME | 1 |
| Nugent, JS | 1 |
| Dreis, CD | 1 |
| Vince, R | 1 |
| Soderblom, C | 1 |
| Luo, X | 1 |
| Blumenthal, E | 1 |
| Bray, E | 1 |
| Lyapichev, K | 1 |
| Ramos, J | 1 |
| Krishnan, V | 1 |
| Lai-Hsu, C | 1 |
| Park, KK | 1 |
| Tsoulfas, P | 1 |
| Lee, JK | 1 |
| MacFarlane, AJ | 2 |
| McEntee, MF | 2 |
| Stover, PJ | 3 |
| Cummings, BP | 1 |
| Bettaieb, A | 1 |
| Graham, JL | 1 |
| Stanhope, K | 1 |
| Haj, FG | 1 |
| Havel, PJ | 1 |
| Liu, P | 1 |
| Wu, C | 1 |
| Song, W | 1 |
| Yu, L | 1 |
| Yang, X | 1 |
| Xiang, R | 1 |
| Wang, F | 1 |
| Yang, J | 1 |
| Higashijima, Y | 1 |
| Tanaka, T | 1 |
| Yamaguchi, J | 1 |
| Tanaka, S | 1 |
| Nangaku, M | 1 |
| Akita, K | 1 |
| Isoda, K | 1 |
| Shimada, K | 1 |
| Daida, H | 1 |
| Tsukihara, H | 1 |
| Nakagawa, F | 2 |
| Sakamoto, K | 1 |
| Ishida, K | 1 |
| Tanaka, N | 1 |
| Okabe, H | 1 |
| Uchida, J | 1 |
| Matsuo, K | 1 |
| Takechi, T | 1 |
| Martiniova, L | 1 |
| Field, MS | 1 |
| Finkelstein, JL | 1 |
| Perry, CA | 2 |
| Kharlamova, AD | 1 |
| Mikhailov, AS | 1 |
| Podyachev, SN | 1 |
| Minnekhanova, OA | 1 |
| Zobov, VV | 1 |
| Nikolsky, EE | 1 |
| Reznik, VS | 1 |
| Aoyama, M | 1 |
| Kawase, H | 1 |
| Bando, YK | 1 |
| Monji, A | 1 |
| Murohara, T | 2 |
| Guo, Q | 1 |
| Wei, Y | 1 |
| Xia, B | 1 |
| Jin, Y | 1 |
| Liu, C | 1 |
| Pan, X | 1 |
| Shi, J | 1 |
| Zhu, F | 1 |
| Qian, L | 1 |
| Liu, X | 1 |
| Cheng, Z | 1 |
| Jin, S | 1 |
| Lin, J | 1 |
| Wu, W | 1 |
| Green, EM | 2 |
| Wakimoto, H | 1 |
| Anderson, RL | 1 |
| Evanchik, MJ | 2 |
| Gorham, JM | 1 |
| Harrison, BC | 1 |
| Henze, M | 1 |
| Kawas, R | 1 |
| Oslob, JD | 1 |
| Rodriguez, HM | 1 |
| Wan, W | 1 |
| Leinwand, LA | 1 |
| Spudich, JA | 1 |
| McDowell, RS | 1 |
| Seidman, JG | 1 |
| Seidman, CE | 1 |
| Yisireyili, M | 1 |
| Takeshita, K | 1 |
| Hayashi, M | 1 |
| Wu, H | 1 |
| Uchida, Y | 1 |
| Yamamoto, K | 1 |
| Kikuchi, R | 1 |
| Hao, CN | 1 |
| Nakayama, T | 1 |
| Cheng, XW | 1 |
| Matsushita, T | 1 |
| Nakamura, S | 1 |
| Stern, JA | 1 |
| Markova, S | 1 |
| Ueda, Y | 1 |
| Kim, JB | 1 |
| Pascoe, PJ | 1 |
| Harris, SP | 1 |
| Uchida, T | 1 |
| Oda, T | 1 |
| Matsubara, H | 1 |
| Watanabe, A | 1 |
| Takechi, H | 1 |
| Oshima, N | 1 |
| Sakurai, Y | 1 |
| Kumagai, H | 1 |
| Villela, AD | 1 |
| Pham, H | 1 |
| Jones, V | 1 |
| Grzegorzewicz, AE | 1 |
| Rodrigues-Junior, VD | 1 |
| Campos, MM | 1 |
| Basso, LA | 1 |
| Jackson, M | 1 |
| Santos, DS | 1 |
| Lee, B | 1 |
| Shi, L | 1 |
| Kassel, DB | 1 |
| Asakawa, T | 1 |
| Takeuchi, K | 2 |
| Christopher, RJ | 1 |
| Kido, M | 1 |
| Takeuchi, S | 1 |
| Esaki, H | 1 |
| Hayashida, S | 1 |
| Furue, M | 2 |
| Lin, DM | 1 |
| Fujita, T | 1 |
| Hiroi, S | 1 |
| Shah, Z | 1 |
| Kampfrath, T | 1 |
| Deiuliis, JA | 1 |
| Zhong, J | 1 |
| Pineda, C | 1 |
| Ying, Z | 1 |
| Xu, X | 1 |
| Lu, B | 1 |
| Moffatt-Bruce, S | 1 |
| Durairaj, R | 1 |
| Sun, Q | 1 |
| Mihai, G | 1 |
| Maiseyeu, A | 1 |
| Rajagopalan, S | 1 |
| Chaykovska, L | 1 |
| von Websky, K | 1 |
| Rahnenführer, J | 1 |
| Alter, M | 1 |
| Heiden, S | 1 |
| Fuchs, H | 1 |
| Runge, F | 1 |
| Klein, T | 1 |
| Hocher, B | 1 |
| Duncan, GE | 1 |
| Koller, BH | 1 |
| Moy, SS | 1 |
| Çıtak, A | 1 |
| Yilmaz, O | 1 |
| Pekçetin, Ç | 1 |
| Ozbal, S | 1 |
| Lambrecht, FY | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical and Imaging Biomarker Trial of Uridine for Veterans With Suicidal Ideation[NCT03265964] | Phase 4 | 90 participants (Anticipated) | Interventional | 2018-04-02 | Recruiting | ||
| Effects of Vildagliptin/Metformin Combination on Markers of Atherosclerosis, Thrombosis, and Inflammation in Diabetic Patients With Coronary Artery Disease[NCT01604213] | Phase 4 | 60 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420] | Phase 1 | 4 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| High Dose Supplements to Reduce Homocysteine and Slow the Rate of Cognitive Decline in Alzheimer's Disease (Vitamins to Slow Alzheimer's - VITAL)[NCT00056225] | Phase 3 | 340 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for uracil and Disease Models, Animal
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
[Pharmacological and clinical profile of alogliptin benzoate (NESINA®)].
Topics: Adult; Animals; Clinical Trials, Phase II as Topic; Diabetes Mellitus, Type 2; Disease Models, Anima | 2011 |
On the development of models in mice of advanced visceral metastatic disease for anti-cancer drug testing.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cyclophosphamide; Disease Models, Animal; Drug Com | 2007 |
1 trial available for uracil and Disease Models, Animal
69 other studies available for uracil and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression R | 2021 |
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzoates; Disease Models, Animal; Memory Disorder | 2022 |
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzoates; Disease Models, Animal; Memory Disorder | 2022 |
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzoates; Disease Models, Animal; Memory Disorder | 2022 |
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzoates; Disease Models, Animal; Memory Disorder | 2022 |
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzoates; Disease Models, Animal; Memory Disorder | 2022 |
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzoates; Disease Models, Animal; Memory Disorder | 2022 |
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzoates; Disease Models, Animal; Memory Disorder | 2022 |
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzoates; Disease Models, Animal; Memory Disorder | 2022 |
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzoates; Disease Models, Animal; Memory Disorder | 2022 |
UHPLC Q-Exactive MS-based spleen metabolomics and lipidomics to explore the effect mechanisms of Danggui Buxue Decoction in anemia mice.
Topics: Anemia; Animals; Biomarkers; Chromatography, High Pressure Liquid; Cytosine; Disease Models, Animal; | 2020 |
Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; DNA Damage; Drug Approval; Female; Genetic T | 2020 |
Amelioration of risk factors associated with diabetic nephropathy in diet-induced pre-diabetic rats by an uracil-derived diimine ruthenium(II) compound.
Topics: Albuminuria; Aldosterone; Animals; Biomarkers; Cell Adhesion Molecules; Creatinine; Diabetic Nephrop | 2020 |
CXCL16 Stimulates Antigen-Induced MAIT Cell Accumulation but Trafficking During Lung Infection Is CXCR6-Independent.
Topics: Administration, Intranasal; Animals; Cell Proliferation; Cells, Cultured; Chemokine CXCL16; Chemotax | 2020 |
Alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Dipeptidyl-Peptidase IV Inhibitors; Dise | 2020 |
Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Ammonium Compounds; Animals; Anions; Behavior, Animal; Bind | 2020 |
Alogliptin Attenuates Lipopolysaccharide-Induced Neuroinflammation in Mice Through Modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 Signaling Pathways.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Dipeptidyl-Peptidase IV Inhibitors; Disease Models | 2021 |
Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).
Topics: Acetates; Angiopoietin-Like Protein 4; Animals; Cell Line, Tumor; Cholesterol, LDL; Diet, High-Fat; | 2020 |
Mavacamten decreases maximal force and Ca
Topics: Animals; Benzylamines; Calcium Signaling; Cardiomyopathy, Hypertrophic; Disease Models, Animal; Enzy | 2021 |
Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways.
Topics: Adenylate Kinase; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Cardiome | 2021 |
Conditionally Pathogenic Gut Microbes Promote Larval Growth by Increasing Redox-Dependent Fat Storage in High-Sugar Diet-Fed Drosophila.
Topics: Animals; Bacteria; Disease Models, Animal; Drosophila melanogaster; Gastrointestinal Tract; Germ-Fre | 2017 |
Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters.
Topics: 3-Hydroxybutyric Acid; Animals; Astrocytes; Brain; Diet, Ketogenic; Disease Models, Animal; Epilepsy | 2017 |
C-547, a 6-methyluracil derivative with long-lasting binding and rebinding on acetylcholinesterase: Pharmacokinetic and pharmacodynamic studies.
Topics: Acetylcholinesterase; Albumins; Animals; Cholinesterase Inhibitors; Diffusion; Disease Models, Anima | 2018 |
Evaluation of Uracil, Sodium Ascorbate, and Rosiglitazone as Promoters of Urinary Bladder Transitional Cell Carcinomas in Male Sprague-Dawley Rats.
Topics: Animals; Ascorbic Acid; Carcinogens; Carcinoma, Transitional Cell; Disease Models, Animal; Male; Rat | 2018 |
Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver.
Topics: AMP-Activated Protein Kinases; Animals; Carnitine O-Palmitoyltransferase; Disease Models, Animal; Ge | 2018 |
Impact of the Myosin Modulator Mavacamten on Force Generation and Cross-Bridge Behavior in a Murine Model of Hypercontractility.
Topics: Actins; Animals; Benzylamines; Calcium; Cardiomyopathy, Hypertrophic; Carrier Proteins; Disease Mode | 2018 |
Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents.
Topics: Animals; Antithyroid Agents; Binding Sites; Disease Models, Animal; Hydrophobic and Hydrophilic Inte | 2018 |
Alogliptin improves endothelial function by promoting autophagy in perivascular adipose tissue of obese mice through a GLP-1-dependent mechanism.
Topics: Adipokines; Adipose Tissue; Animals; Aorta, Thoracic; Autophagy; Dipeptidyl-Peptidase IV Inhibitors; | 2019 |
Alogliptin improves survival and health of mice on a high-fat diet.
Topics: Animals; Autophagy; Diet, High-Fat; Disease Models, Animal; Health; Liver; Longevity; Male; Mice; Mi | 2019 |
Alogliptin, a dipeptidylpeptidase-4 inhibitor, for patients with diabetes mellitus type 2, induces tolerance to focal cerebral ischemia in non-diabetic, normal mice.
Topics: Analysis of Variance; Animals; Brain Edema; Brain Infarction; Brain Ischemia; Brain-Derived Neurotro | 2013 |
Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Animals; Antioxidants; Aorta, Abdominal; Aortic A | 2014 |
A bio-mimetic approach to DNA photoprotection.
Topics: Abdomen; Animals; Biomimetics; Disease Models, Animal; DNA Damage; Humans; Mice; Mice, Hairless; Nuc | 2014 |
Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury.
Topics: Analysis of Variance; Animals; Antigens; Blood Vessels; CD13 Antigens; Cell Count; Cicatrix; Collage | 2013 |
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
Topics: Animals; Azoxymethane; Carcinogenesis; Choline Deficiency; Colon; Colonic Neoplasms; Crosses, Geneti | 2014 |
Administration of pioglitazone alone or with alogliptin delays diabetes onset in UCD-T2DM rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Huma | 2014 |
Uridine decreases morphine-induced behavioral sensitization by decreasing dorsal striatal dopamine release possibly via agonistic effects at GABAA receptors.
Topics: Analgesics, Opioid; Animals; Animals, Inbred Strains; beta-Alanine; Bicuculline; Corpus Striatum; Di | 2014 |
Anti-inflammatory role of DPP-4 inhibitors in a nondiabetic model of glomerular injury.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antilymp | 2015 |
Dipeptidyl-peptidase-4 inhibitor, alogliptin, attenuates arterial inflammation and neointimal formation after injury in low-density lipoprotein (LDL) receptor-deficient mice.
Topics: Actins; Animals; Anti-Inflammatory Agents; Arteritis; Atherosclerosis; Biomarkers; Blood Glucose; Ce | 2015 |
Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts.
Topics: Administration, Oral; Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocol | 2015 |
Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.
Topics: Animals; Deoxyuridine; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Glycine Hy | 2015 |
6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors | 2015 |
Dipeptidyl Peptidase 4 Inhibition Alleviates Shortage of Circulating Glucagon-Like Peptide-1 in Heart Failure and Mitigates Myocardial Remodeling and Apoptosis via the Exchange Protein Directly Activated by Cyclic AMP 1/Ras-Related Protein 1 Axis.
Topics: Animals; Apoptosis; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipeptidyl Peptidase 4; Dipept | 2016 |
Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Disease Models, Animal; Drug Discovery; Drug Resistance, B | 2016 |
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.
Topics: Adenosine Triphosphatases; Animals; Benzylamines; Cardiac Myosins; Cardiomyopathy, Hypertrophic, Fam | 2016 |
Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model.
Topics: Adipose Tissue; Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, | 2016 |
A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy.
Topics: Animals; Benzylamines; Cardiac Surgical Procedures; Cardiomyopathy, Hypertrophic; Cats; Disease Mode | 2016 |
Renoprotective effects of a dipeptidyl peptidase 4 inhibitor in a mouse model of progressive renal fibrosis.
Topics: Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Urea Nitrogen; Calci | 2017 |
Analysis of uracil phosphoribosyltransferase expression in Mycobacterium tuberculosis and evaluation of upp knockout strain in infected mice.
Topics: Animals; Bacterial Proteins; Disease Models, Animal; Gene Expression; Gene Knockout Techniques; Mice | 2017 |
Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys.
Topics: Administration, Oral; Animals; Biological Availability; Blood Glucose; Dipeptidyl Peptidase 4; Dipep | 2008 |
Scratching behavior does not necessarily correlate with epidermal nerve fiber sprouting or inflammatory cell infiltration.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epidermis; Female; Haptens; Inflammation; | 2010 |
Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.
Topics: Aminohydrolases; Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Carcinogens | 2011 |
Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Blood Pressure; Cell Movement; Chemotaxis; Dipeptidyl-P | 2011 |
Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy.
Topics: Animals; Area Under Curve; Cardiomyopathies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibit | 2011 |
Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function.
Topics: Alanine; Animals; Antipsychotic Agents; Carrier Proteins; Disease Models, Animal; Gene Knockdown Tec | 2012 |
Influence of uracil on bacterial translocation in an intestinal obstruction model in rats.
Topics: Analysis of Variance; Animals; Bacterial Translocation; Diagnostic Techniques, Radioisotope; Disease | 2013 |
Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Bo | 2003 |
Effects of hypothyroidism induced by 6-n-propylthiouracil and its reversal by T3 on rat heart superoxide dismutase, catalase and lipid peroxidation.
Topics: Animals; Catalase; Disease Models, Animal; Hyperthyroidism; Hypothyroidism; Lipid Peroxidation; Male | 2003 |
Oral administration of uracil-tegafur (UFT) inhibits liver micrometastasis of human colon cancer in an orthotopic nude mouse model and its early detection system.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy | 2004 |
[Application of photochemically activated ointment based on polyethylene oxides for treatment of peritonitis].
Topics: Animals; Anti-Infective Agents, Local; Chloramphenicol; Chlorhexidine; Disease Models, Animal; Drain | 2005 |
[The influence of photochemically activated 40% solution of levomecol ointment toward apoptosis in muscles of the rats posterior extremities in inflammatory-purulent complications of diabetes mellitus].
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Chloramphenicol; Combined Modality Therapy; Diabetes Comp | 2006 |
Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Colonic Neoplasms; Disease Models, Animal; Dr | 2007 |
Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection.
Topics: Adenylyl Cyclases; Animals; Animals, Genetically Modified; Antigens, Protozoan; Cyclic AMP; Disease | 2008 |
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
Topics: 2-Acetylaminofluorene; Adenine; Aging; Animals; Antineoplastic Agents; Disease Models, Animal; DNA D | 1995 |
Oral administration of BOF-A2 to rats with lung transplanted tumors results in increased 5-fluorouracil levels.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Combinations; Dru | 1994 |
Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens).
Topics: Acute Disease; Animals; Chronic Disease; Disease Models, Animal; Granuloma; Hydrocortisone; Injectio | 1997 |
UFT and its metabolites inhibit cancer-induced angiogenesis. Via a VEGF-related pathway.
Topics: Air Sacs; Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Assay; Carcinoma, Rena | 2000 |
A novel weekday-on/weekend-off UFT schedule.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy | 2000 |
Suppressive effect of topically applied CX-659S, a novel diaminouracil derivative, on the contact hypersensitivity reaction in various animal models.
Topics: Administration, Topical; Animals; Base Sequence; Dermatitis, Contact; Dinitrochlorobenzene; Disease | 2000 |
Animal model of para-aortic lymph node metastasis.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Aorta; Carcinoma, Squamous | 2001 |
Treatment of tamoxifen-refractory breast cancer--approach by animal models.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Hormonal; | 2001 |
[Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung].
Topics: Aminoacridines; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brea | 2002 |
Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cells, Cultured; Diet; | 2002 |
[Prophylactic efficiency of tietasol and oxymethyluracyl against chlorphenols exposure in experimental and real conditions].
Topics: Acetates; Animals; Antidotes; Benzimidazoles; Chlorophenols; Disease Models, Animal; Mice; Occupatio | 2002 |
Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Disea | 1989 |
In vitro and in vivo studies on a phage type 71 staphylococcal bacteriocin.
Topics: Ammonium Sulfate; Animals; Antibiosis; Bacteria; Bacterial Proteins; Bacteriocins; Bacteriophage Typ | 1973 |
Herpes simplex virus skin infection in hairless mice: treatment with antiviral compounds.
Topics: Adenine; Animals; Antiviral Agents; Arabinose; Azauridine; Disease Models, Animal; Female; Herpes Si | 1974 |