uracil has been researched along with Deficiency, Folic Acid in 31 studies
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study aimed to evaluate the effect of early life stage folic acid deficiency on de novo telomere synthesis, neurobehavioral development, and the cognitive function of offspring rats." | 8.12 | Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis. ( Huang, G; Li, W; Li, Z; Sun, Y; Yan, J; Zhou, D, 2022) |
| "DNA uracil content was not different between the two groups at any of the folic acid concentrations (two-way ANOVA: media [folic acid], P < 0." | 5.31 | Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. ( Ames, BN; Crott, JW; Fenech, MF; Mashiyama, ST, 2001) |
| "In a randomized controlled trial conducted at a single Dublin hospital between April 2002 and March 2004, we assessed the effect of folic acid supplementation on tissue folate, uracil misincorporation into DNA, and global DNA hypomethylation in colonocytes isolated from sites of adenomatous polyps and from histologically normal tissue adjacent and 10-15 cm distal to them." | 5.22 | Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site. ( Downes, CS; McGlynn, AP; McKerr, G; McNulty, H; Molloy, AM; O'Reilly, SL; Reynolds, J; Scott, JM; Strain, JJ; Ward, M; Wasson, GR; Weir, DG, 2016) |
| " This study aimed to evaluate the effect of early life stage folic acid deficiency on de novo telomere synthesis, neurobehavioral development, and the cognitive function of offspring rats." | 4.12 | Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis. ( Huang, G; Li, W; Li, Z; Sun, Y; Yan, J; Zhou, D, 2022) |
| " Because the metabolic pathways of folate and other methyl donors are closely coupled, the effects of methionine and choline deficiency alone or in combination with folate deficiency were determined." | 3.70 | Increased uracil misincorporation in lymphocytes from folate-deficient rats. ( Duthie, SJ; Grant, G; Narayanan, S, 2000) |
| " The supply of folate depends primarily on the quantity and bioavailability of ingested folate and the rate of loss by urinary and fecal routes and through catabolism." | 2.41 | Prevention of pathologies associated with oxidative stress and dietary intake deficiencies: folate deficiency and requirements. ( Gaté, L; Machover, D; Tapiero, H; Tew, KD, 2001) |
| "We investigated the hypotheses that the genomic instability observed under conditions of folate deficiency in other cell types extends to skin, adversely effecting cellular capacity to handle UVR insult and that optimizing folate levels in skin is beneficial in preventing or repairing the pro-carcinogenic effects of UVR exposure." | 1.36 | Photobiological implications of folate depletion and repletion in cultured human keratinocytes. ( Jacobson, MK; Williams, JD, 2010) |
| "DNA uracil content was not different between the two groups at any of the folic acid concentrations (two-way ANOVA: media [folic acid], P < 0." | 1.31 | Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. ( Ames, BN; Crott, JW; Fenech, MF; Mashiyama, ST, 2001) |
| "Uracil was excised from DNA using uracil DNA glycosylase." | 1.31 | Uracil in human DNA from subjects with normal and impaired folate status as determined by high-performance liquid chromatography-tandem mass spectrometry. ( Refsum, H; Ren, J; Ueland, PM; Ulvik, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.23) | 18.7374 |
| 1990's | 9 (29.03) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 9 (29.03) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, D | 1 |
| Li, Z | 1 |
| Sun, Y | 1 |
| Yan, J | 1 |
| Huang, G | 1 |
| Li, W | 1 |
| Catala, GN | 1 |
| Bestwick, CS | 1 |
| Russell, WR | 1 |
| Tortora, K | 1 |
| Giovannelli, L | 1 |
| Moyer, MP | 1 |
| Lendoiro, E | 1 |
| Duthie, SJ | 5 |
| Fiddler, JL | 1 |
| Xiu, Y | 1 |
| Blum, JE | 1 |
| Lamarre, SG | 2 |
| Phinney, WN | 1 |
| Stabler, SP | 1 |
| Brosnan, ME | 2 |
| Brosnan, JT | 2 |
| Thalacker-Mercer, AE | 1 |
| Field, MS | 3 |
| Bull, CF | 1 |
| Mayrhofer, G | 1 |
| O'Callaghan, NJ | 1 |
| Au, AY | 1 |
| Pickett, HA | 1 |
| Low, GK | 1 |
| Zeegers, D | 1 |
| Hande, MP | 1 |
| Fenech, MF | 2 |
| MacFarlane, AJ | 1 |
| McEntee, MF | 1 |
| Stover, PJ | 3 |
| Kamynina, E | 1 |
| Agunloye, OC | 1 |
| Liebenthal, RP | 1 |
| Martiniova, L | 1 |
| Finkelstein, JL | 1 |
| Perry, CA | 1 |
| O'Reilly, SL | 2 |
| McGlynn, AP | 2 |
| McNulty, H | 2 |
| Reynolds, J | 1 |
| Wasson, GR | 2 |
| Molloy, AM | 2 |
| Strain, JJ | 2 |
| Weir, DG | 2 |
| Ward, M | 2 |
| McKerr, G | 2 |
| Scott, JM | 2 |
| Downes, CS | 2 |
| Berger, SH | 1 |
| Pittman, DL | 1 |
| Wyatt, MD | 1 |
| Linhart, HG | 1 |
| Troen, A | 1 |
| Bell, GW | 1 |
| Cantu, E | 1 |
| Chao, WH | 1 |
| Moran, E | 1 |
| Steine, E | 1 |
| He, T | 1 |
| Jaenisch, R | 1 |
| Williams, JD | 1 |
| Jacobson, MK | 1 |
| Fenech, M | 2 |
| Chang, CK | 1 |
| Hoey, L | 1 |
| LEEVY, CM | 1 |
| TEN-HOVE, W | 1 |
| FRANK, O | 1 |
| BAKER, H | 1 |
| Mashiyama, ST | 2 |
| Courtemanche, C | 1 |
| Elson-Schwab, I | 1 |
| Crott, J | 1 |
| Lee, BL | 1 |
| Ong, CN | 1 |
| Ames, BN | 6 |
| Cabelof, DC | 1 |
| Raffoul, JJ | 1 |
| Nakamura, J | 1 |
| Kapoor, D | 1 |
| Abdalla, H | 1 |
| Heydari, AR | 1 |
| Wickramasinghe, SN | 2 |
| Fida, S | 1 |
| Blount, BC | 4 |
| Mack, MM | 1 |
| Wehr, CM | 1 |
| MacGregor, JT | 1 |
| Hiatt, RA | 1 |
| Wang, G | 1 |
| Everson, RB | 1 |
| Koury, MJ | 1 |
| Horne, DW | 1 |
| Brown, ZA | 1 |
| Pietenpol, JA | 1 |
| Hard, R | 1 |
| Koury, ST | 1 |
| McMillan, P | 1 |
| Pogribny, IP | 2 |
| Muskhelishvili, L | 1 |
| Miller, BJ | 2 |
| James, SJ | 2 |
| Hawdon, A | 1 |
| Melnyk, S | 1 |
| Pogribna, M | 1 |
| Basnakian, AG | 1 |
| Grant, G | 1 |
| Narayanan, S | 2 |
| Blum, S | 1 |
| Pirie, L | 1 |
| Brand, GM | 1 |
| Crott, JW | 1 |
| Tapiero, H | 1 |
| Tew, KD | 1 |
| Gaté, L | 1 |
| Machover, D | 1 |
| Ren, J | 1 |
| Ulvik, A | 1 |
| Refsum, H | 1 |
| Ueland, PM | 1 |
| Kruman, II | 1 |
| Kumaravel, TS | 1 |
| Lohani, A | 1 |
| Pedersen, WA | 1 |
| Cutler, RG | 1 |
| Kruman, Y | 1 |
| Haughey, N | 1 |
| Lee, J | 1 |
| Evans, M | 1 |
| Mattson, MP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Folates in the Care of the Male Infertility[NCT01407432] | Phase 3 | 162 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| High Dose Supplements to Reduce Homocysteine and Slow the Rate of Cognitive Decline in Alzheimer's Disease (Vitamins to Slow Alzheimer's - VITAL)[NCT00056225] | Phase 3 | 340 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for uracil and Deficiency, Folic Acid
| Article | Year |
|---|---|
Folate, genomic stability and colon cancer: The use of single cell gel electrophoresis in assessing the impact of folate in vitro, in vivo and in human biomonitoring.
Topics: Biological Monitoring; Cell Line; Colonic Neoplasms; Comet Assay; DNA Breaks; DNA Methylation; DNA R | 2019 |
Uracil in DNA: consequences for carcinogenesis and chemotherapy.
Topics: Animals; Antineoplastic Agents; DNA; DNA Damage; Folic Acid Deficiency; Humans; Neoplasms; Uracil | 2008 |
Folate, DNA damage and the aging brain.
Topics: Aging; Animals; Brain; Cell Nucleus; Cytosine; DNA; DNA Damage; Folic Acid; Folic Acid Deficiency; M | 2010 |
DNA damage in folate deficiency.
Topics: DNA Damage; Folic Acid Deficiency; Humans; Models, Theoretical; Uracil | 1995 |
Prevention of pathologies associated with oxidative stress and dietary intake deficiencies: folate deficiency and requirements.
Topics: Animals; Diet; DNA; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lipid Peroxidation; Neo | 2001 |
1 trial available for uracil and Deficiency, Folic Acid
| Article | Year |
|---|---|
Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site.
Topics: Adenomatous Polyps; Aged; Biomarkers; Body Mass Index; Colon; Colonic Neoplasms; Colonoscopy; Comet | 2016 |
25 other studies available for uracil and Deficiency, Folic Acid
| Article | Year |
|---|---|
Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis.
Topics: Animals; Cognition; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Rats; Telomere; | 2022 |
Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA.
Topics: Animals; DNA, Mitochondrial; Fibroblasts; Folic Acid; Folic Acid Deficiency; Mice; Mitochondria; Res | 2021 |
Folate deficiency induces dysfunctional long and short telomeres; both states are associated with hypomethylation and DNA damage in human WIL2-NS cells.
Topics: Azacitidine; Biomarkers; Chromosomal Instability; Cytokinesis; Decitabine; Diet; DNA Damage; DNA Met | 2014 |
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
Topics: Animals; Azoxymethane; Carcinogenesis; Choline Deficiency; Colon; Colonic Neoplasms; Crosses, Geneti | 2014 |
Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency.
Topics: Animals; Cell Cycle Checkpoints; Cell Line; Cell Nucleus; Coenzymes; Diet; DNA; Female; Folic Acid; | 2014 |
Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.
Topics: Animals; Deoxyuridine; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Glycine Hy | 2015 |
Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations.
Topics: Animals; CpG Islands; DNA; DNA Methylation; Folic Acid Deficiency; Homocysteine; Lymphoma, Follicula | 2009 |
Photobiological implications of folate depletion and repletion in cultured human keratinocytes.
Topics: Cell Line; Comet Assay; DNA Damage; Folic Acid; Folic Acid Deficiency; Genomic Instability; Humans; | 2010 |
Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum.
Topics: Adenomatous Polyps; Adult; Aged; Base Pair Mismatch; Biomarkers; Case-Control Studies; Colon; Coloni | 2013 |
FOLIC ACID DEFICIENCY AND HEPATIC DNA SYNTHESIS.
Topics: Avitaminosis; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; DNA; Folic Aci | 1964 |
Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes.
Topics: Cells, Cultured; DNA; DNA Damage; Folic Acid; Folic Acid Deficiency; Gas Chromatography-Mass Spectro | 2004 |
Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency.
Topics: Animal Feed; Animals; Blotting, Western; Cell Nucleus; Dietary Supplements; DNA; DNA Damage; DNA Gly | 2004 |
Bone marrow cells from vitamin B12- and folate-deficient patients misincorporate uracil into DNA.
Topics: Adult; Aged; Aged, 80 and over; Bone Marrow; Bone Marrow Cells; DNA; Female; Folic Acid Deficiency; | 1994 |
Development of a sensitive assay for detection of uracil in DNA.
Topics: Animals; DNA; Folic Acid; Folic Acid Deficiency; Indicators and Reagents; Liver; Mass Spectrometry; | 1993 |
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage.
Topics: Chromosome Aberrations; DNA; DNA Damage; Folic Acid Deficiency; Humans; Micronucleus Tests; Neoplasm | 1997 |
Apoptosis of late-stage erythroblasts in megaloblastic anemia: association with DNA damage and macrocyte production.
Topics: Anemia, Megaloblastic; Animals; Apoptosis; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; C | 1997 |
Uracil misincorporation in human DNA detected using single cell gel electrophoresis.
Topics: Cell Division; Cells, Cultured; DNA; DNA Damage; DNA Glycosylases; Electrophoresis, Agar Gel; Folic | 1997 |
Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats.
Topics: Animals; Carbon-Oxygen Lyases; Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA Damage; DNA-(Apurin | 1997 |
DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro.
Topics: Adult; DNA Damage; DNA Glycosylases; DNA Repair; DNA Replication; Folic Acid Deficiency; Humans; In | 1998 |
Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells.
Topics: Animals; Aspartic Acid; Cell Death; Cell Division; Cell Transformation, Neoplastic; CHO Cells; Crice | 1999 |
Increased uracil misincorporation in lymphocytes from folate-deficient rats.
Topics: Animals; Choline Deficiency; Comet Assay; DNA; DNA Damage; Erythrocytes; Folic Acid; Folic Acid Defi | 2000 |
Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells.
Topics: Aged; Antigens, Polyomavirus Transforming; Cells, Cultured; Colon; Colorectal Neoplasms; Culture Med | 2000 |
Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro.
Topics: DNA; Folic Acid Deficiency; Humans; Lymphocytes; Methylenetetrahydrofolate Reductase (NADPH2); Oxido | 2001 |
Uracil in human DNA from subjects with normal and impaired folate status as determined by high-performance liquid chromatography-tandem mass spectrometry.
Topics: Base Composition; Chromatography, High Pressure Liquid; DNA; Folic Acid Deficiency; Humans; Mass Spe | 2002 |
Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cells, Cultured; Diet; | 2002 |