Page last updated: 2024-10-20

uracil and Cytomegalovirus

uracil has been researched along with Cytomegalovirus in 12 studies

2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder

Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.

Research Excerpts

ExcerptRelevanceReference
"Here, we report the molecular characterization of the human cytomegalovirus uracil DNA glycosylase (UNG) UL114."7.74Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44). ( Bjørås, M; Dale, HA; Luna, L; Ranneberg-Nilsen, T; Rollag, H; Slettebakk, R; Sundheim, O, 2008)
" Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives--previously reported inhibitors of human cytomegalovirus (HCMV)."3.81Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides. ( Andrei, G; Babkov, DA; Chizhov, AO; Khandazhinskaya, AL; Novikov, MS; Seley-Radtke, KL; Snoeck, R, 2015)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's5 (41.67)29.6817
2010's4 (33.33)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Paramonova, MP3
Gureeva, ES2
Ozerov, AA3
Snoeck, R5
Andrei, G7
Alexandrov, DA1
Handazinskaya, AL1
Novikov, MS4
Kochetkov, SN2
Aleksandrov, DA1
Khandazhinskaya, AL3
Nishio-Nagai, M1
Suzuki, S1
Yoshikawa, K1
Ueda, R1
Kazaoka, Y1
Roche, KL1
Nukui, M1
Krishna, BA1
O'Connor, CM1
Murphy, EA1
Babkov, DA2
Chizhov, AO2
Balzarini, J4
Seley-Radtke, KL2
Ranneberg-Nilsen, T2
Dale, HA2
Luna, L2
Slettebakk, R2
Sundheim, O1
Rollag, H2
Bjørås, M2
Maruyama, T3
Kozai, S3
Yamasaki, T1
Witvrouw, M3
Pannecouque, C3
De Clercq, E3
Seeberg, E1
Demizu, Y2
Snoecks, R2
Slusarchyk, WA1
Bisacchi, GS1
Field, AK1
Hockstein, DR1
Jacobs, GA1
McGeever-Rubin, B1
Tino, JA1
Tuomari, AV1
Yamanaka, GA1
Young, MG1

Other Studies

12 other studies available for uracil and Cytomegalovirus

ArticleYear
Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication.
    Doklady. Biochemistry and biophysics, 2022, Volume: 507, Issue:1

    Topics: Antiviral Agents; Cytomegalovirus; Humans; Structure-Activity Relationship; Uracil

2022
Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-naphthalenylmethyl Derivatives of Uracil and Their Analogues As Probable Inhibitors of Human Cytomegalovirus Replication.
    Doklady. Biochemistry and biophysics, 2023, Volume: 509, Issue:1

    Topics: Antiviral Agents; Cytomegalovirus; Humans; Structure-Activity Relationship; Uracil

2023
Adoptive immunotherapy combined with FP treatment for head and neck cancer: An in vitro study.
    International journal of oncology, 2017, Volume: 51, Issue:5

    Topics: Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Prolifera

2017
Selective 4-Thiouracil Labeling of RNA Transcripts within Latently Infected Cells after Infection with Human Cytomegalovirus Expressing Functional Uracil Phosphoribosyltransferase.
    Journal of virology, 2018, 11-01, Volume: 92, Issue:21

    Topics: Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Humans; Pentosyltransferases; RNA, Vir

2018
Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof.
    Bioorganic & medicinal chemistry, 2013, Jul-15, Volume: 21, Issue:14

    Topics: Antiviral Agents; Cells, Cultured; Cytomegalovirus; Humans; Receptors, Virus; Structure-Activity Rel

2013
Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.
    Bioorganic & medicinal chemistry, 2015, Nov-01, Volume: 23, Issue:21

    Topics: Acetamides; Antiviral Agents; Cell Line; Cell Proliferation; Cytomegalovirus; DNA Viruses; Drug Eval

2015
Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44).
    Journal of molecular biology, 2008, Aug-29, Volume: 381, Issue:2

    Topics: Binding Sites; Cells, Cultured; Cytomegalovirus; DNA; DNA-Binding Proteins; Electrophoresis, Polyacr

2008
Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV.
    Antiviral chemistry & chemotherapy, 2003, Volume: 14, Issue:5

    Topics: Antiviral Agents; Cytomegalovirus; HIV-1; Humans; Inhibitory Concentration 50; Microbial Sensitivity

2003
Human cytomegalovirus infection modulates DNA base excision repair in fibroblast cells.
    Virology, 2006, May-10, Volume: 348, Issue:2

    Topics: Base Sequence; Cell Cycle; Cells, Cultured; Cytomegalovirus; DNA Damage; DNA Repair; DNA Replication

2006
Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives.
    Chemical & pharmaceutical bulletin, 2006, Volume: 54, Issue:3

    Topics: Anti-HIV Agents; Cytomegalovirus; HIV Reverse Transcriptase; HIV-1; Indicators and Reagents; Ligands

2006
Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.
    Nucleosides, nucleotides & nucleic acids, 2007, Volume: 26, Issue:10-12

    Topics: Adenosine; Antiviral Agents; Cytomegalovirus; HIV-1; Humans; Ribonucleosides; Uracil

2007
Synthesis and antiviral activity of 1-cyclobutyl-5-(2-bromovinyl)uracil nucleoside analogues and related compounds.
    Journal of medicinal chemistry, 1992, May-15, Volume: 35, Issue:10

    Topics: Antiviral Agents; Cells, Cultured; Cyclobutanes; Cytomegalovirus; Herpesvirus 3, Human; Phosphorylat

1992